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WO2001068569A3 - Il-8 receptor antagonists - Google Patents

Il-8 receptor antagonists Download PDF

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Publication number
WO2001068569A3
WO2001068569A3 PCT/US2001/008186 US0108186W WO0168569A3 WO 2001068569 A3 WO2001068569 A3 WO 2001068569A3 US 0108186 W US0108186 W US 0108186W WO 0168569 A3 WO0168569 A3 WO 0168569A3
Authority
WO
WIPO (PCT)
Prior art keywords
receptor antagonists
chemokine
interleukin
vii
compositions
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2001/008186
Other languages
French (fr)
Other versions
WO2001068569A2 (en
Inventor
Katherine L Widdowson
Qi Jin
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
SmithKline Beecham Corp
Original Assignee
SmithKline Beecham Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by SmithKline Beecham Corp filed Critical SmithKline Beecham Corp
Priority to JP2001567670A priority Critical patent/JP2003527360A/en
Priority to AU2001245724A priority patent/AU2001245724A1/en
Priority to EP01918675A priority patent/EP1274415A4/en
Publication of WO2001068569A2 publication Critical patent/WO2001068569A2/en
Publication of WO2001068569A3 publication Critical patent/WO2001068569A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/30—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/45—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups at least one of the singly-bound nitrogen atoms being part of any of the groups, X being a hetero atom, Y being any atom, e.g. N-acylaminosulfonamides
    • C07C311/47—Y being a hetero atom
    • A—HUMAN NECESSITIES
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Abstract

This invention relates to novel compounds of Formula (I) to (VII), and compositions thereof, useful in the treatment of disease states mediated by the chemokine, Interleukin-8 (IL-8).
PCT/US2001/008186 2000-03-14 2001-03-14 Il-8 receptor antagonists Ceased WO2001068569A2 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
JP2001567670A JP2003527360A (en) 2000-03-14 2001-03-14 IL-8 receptor antagonist
AU2001245724A AU2001245724A1 (en) 2000-03-14 2001-03-14 Il-8 receptor antagonists
EP01918675A EP1274415A4 (en) 2000-03-14 2001-03-14 Il-8 receptor antagonists

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US18917600P 2000-03-14 2000-03-14
US60/189,176 2000-03-14

Publications (2)

Publication Number Publication Date
WO2001068569A2 WO2001068569A2 (en) 2001-09-20
WO2001068569A3 true WO2001068569A3 (en) 2002-04-18

Family

ID=22696240

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2001/008186 Ceased WO2001068569A2 (en) 2000-03-14 2001-03-14 Il-8 receptor antagonists

Country Status (4)

Country Link
EP (1) EP1274415A4 (en)
JP (1) JP2003527360A (en)
AU (1) AU2001245724A1 (en)
WO (1) WO2001068569A2 (en)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR030689A1 (en) * 2000-03-14 2003-09-03 Smithkline Beecham Corp 3-AMINOSULFONIL-2-HYDROXIFENYL UREA COMPOUNDS, PHARMACEUTICAL COMPOSITIONS THAT INCLUDE THEM, AND USE OF SUCH COMPOUNDS IN THE MANUFACTURE OF MEDICINES TO TREAT CHEMIOQUINE MEDIUM DISEASES
US7132445B2 (en) 2001-04-16 2006-11-07 Schering Corporation 3,4-Di-substituted cyclobutene-1,2-diones as CXC-chemokine receptor ligands
US20040106794A1 (en) * 2001-04-16 2004-06-03 Schering Corporation 3,4-Di-substituted cyclobutene-1,2-diones as CXC-chemokine receptor ligands
CA2462862A1 (en) 2001-10-12 2003-04-17 Schering Corporation 3,4-di-substituted maleimide compounds as cxc-chemokine receptor antagonists
US6878709B2 (en) 2002-01-04 2005-04-12 Schering Corporation 3,4-di-substituted pyridazinediones as CXC chemokine receptor antagonists
BR0308739A (en) 2002-03-18 2005-01-11 Schering Corp Combination Treatments for Chemokine Mediated Diseases
JP4664074B2 (en) 2002-10-09 2011-04-06 シェーリング コーポレイション Thiadiazole dioxide and thiadiazole oxide as CXC-chemokine receptor ligand and CC-chemokine receptor ligand
WO2005066147A1 (en) 2003-12-19 2005-07-21 Schering Corporation Thiadiazoles as cxc- and cc- chemokine receptor ligands
CN1918156B (en) 2003-12-22 2010-10-27 先灵公司 Isothiazole dioxides as CXC-and CC-chemokine receptor ligands
DE602006017849D1 (en) 2005-06-29 2010-12-09 Schering Corp 5,6-DISUBSTITUTED OXADIAZOLO PYRAZINES AND THIADIAZOLOPYRACINES AS LIGANDS OF THE CXC CHEMOKIN RECEPTOR
US7718678B2 (en) 2005-06-29 2010-05-18 Schering Corporation Di-substituted oxadiazoles as CXC-chemokine receptor ligands
EP1749523A1 (en) * 2005-07-29 2007-02-07 Neuropharma, S.A. GSK-3 inhibitors
CN110746955B (en) * 2019-09-26 2021-01-12 中国石油天然气股份有限公司 Gemini surfactant for oil displacement, binary composite system and preparation method and application thereof

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997049286A1 (en) * 1996-06-27 1997-12-31 Smithkline Beecham Corporation Il-8 receptor antagonists

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0809492A4 (en) * 1995-02-17 2007-01-24 Smithkline Beecham Corp Il-8 receptor antagonists
UY25842A1 (en) * 1998-12-16 2001-04-30 Smithkline Beecham Corp IL-8 RECEPTOR ANTAGONISTS

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997049286A1 (en) * 1996-06-27 1997-12-31 Smithkline Beecham Corporation Il-8 receptor antagonists

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See also references of EP1274415A4 *

Also Published As

Publication number Publication date
EP1274415A2 (en) 2003-01-15
WO2001068569A2 (en) 2001-09-20
EP1274415A4 (en) 2005-09-07
AU2001245724A1 (en) 2001-09-24
JP2003527360A (en) 2003-09-16

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