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WO2001060518A1 - Receptacle pour echantillon de fluide - Google Patents

Receptacle pour echantillon de fluide Download PDF

Info

Publication number
WO2001060518A1
WO2001060518A1 PCT/GB2001/000638 GB0100638W WO0160518A1 WO 2001060518 A1 WO2001060518 A1 WO 2001060518A1 GB 0100638 W GB0100638 W GB 0100638W WO 0160518 A1 WO0160518 A1 WO 0160518A1
Authority
WO
WIPO (PCT)
Prior art keywords
opening
receptacle according
collar
ridge member
fit
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/GB2001/000638
Other languages
English (en)
Inventor
Roy Taylor
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Camlab Ltd
Original Assignee
Camlab Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Camlab Ltd filed Critical Camlab Ltd
Priority to AU33864/01A priority Critical patent/AU3386401A/en
Publication of WO2001060518A1 publication Critical patent/WO2001060518A1/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/508—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above
    • B01L3/5082—Test tubes per se
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/508—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above
    • B01L3/5082—Test tubes per se
    • B01L3/50825—Closing or opening means, corks, bungs
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D41/00—Caps, e.g. crown caps or crown seals, i.e. members having parts arranged for engagement with the external periphery of a neck or wall defining a pouring opening or discharge aperture; Protective cap-like covers for closure members, e.g. decorative covers of metal foil or paper
    • B65D41/32—Caps or cap-like covers with lines of weakness, tearing-strips, tags, or like opening or removal devices, e.g. to facilitate formation of pouring openings
    • B65D41/46—Snap-on caps or cap-like covers
    • B65D41/48—Snap-on caps or cap-like covers non-metallic, e.g. made of paper or plastics
    • B65D41/485—Snap-on caps or cap-like covers non-metallic, e.g. made of paper or plastics with integral internal sealing means

Definitions

  • the present invention relates to receptacles for receiving fluid samples, particularly but not exclusively during laboratory experiments.
  • a receptacle such as the (1.5 ml ⁇ microtuoe - also known as the microcent ⁇ fuge tube or the Eppendorf tube - is a widely used, everyday laboratory commodity which is not application specific.
  • microtubes may be provided with or without caps, the caps may be "snap-fit” or “screw- fit " ; and "cap-locks” may be provided, either of retrofit or integrally mouldec ⁇ esign.
  • the cap- ocks are by there very nature reusable. The present applicant has appreciated that the provision of a tamper-evident feature would be a novel and potentially significant improvement to laboratory receptacles, especially Known microtube designs.
  • Closures for containers which include means for indicating whether the container has been opened after the closure has been applied to the container are known from U.K. patent specif cations GB 698,992, GB 1,128,815 and GB 1,163,203.
  • All tnree documents disclose a cap arrangement for a container wnich includes an inner skirt or plug for bearing against tne inner periphery of the container, and an outer skirt for positively engaging the outer periphery of the container.
  • the outer skirt includes a lower annular section whic ⁇ is connection to an upper annular section cy a tear strip or otner frangible connection.
  • the tear strip provides a secure connection between the upper and lower annular sections until deliberately removed or broken to permit access to container contents. After detachment of tne lower annular section, the upper annular section engages the outer peripnery of the container such that the cap arrangement may be firmly replaced after being removed.
  • tnere _s provided a receptacle (.e.g. microtube for receiving a fluid sample, comprising a first part defining a chamber with an opening, a second part having a stopper for plugging the opening, a collar attached to one cf the parts by at least one frangible connection, and a ridge member associated with the other part, the collar cemg a tight fit over the ridge member when the opening is first plugged, with the at least one frangible connection fracturing when the opening is first unplugged, leaving the collar with the ridge member, characterised m that the first part includes m the chamber a profile configured tc engage with a snap- fit action a corresponding profile on tne stopper when plugging the opening, the profiles providing a re-usable seal between the first and second parts .
  • a receptacle .e.g. microtube for receiving a fluid sample, comprising a first part defining a chamber with an opening, a second part having
  • the ridge member may be associated with or integral with the first part (hereinafter the "body” of the “icrotuoe) ; and the collar may be attached to the second part Hereinafter the “closure cap” of the microtube) .
  • the collar provides for secure closure of the opening m the body; the closure cap is “locked” m the closed position by the collar nesting under the ridge -ember.
  • the closure cap may even be positively biased m tne closed position by making the collar a tight fit under tne ridge member when the opening is first capped. Ir.
  • the collar provides a tamper-evident device; once tne microtube is sealed, the only way to regain access to tne chamber is to break the at least one frangible connection.
  • the secure closure and tamper-evident features cring, for the first time, the benefits of sample integrity as well as a hold- fast arrangement m laboratory applications, e.g. during centrifugmg and cold storage. After detachment of the collar from the closure cap, the microtube may be reused as a conventional product, either with or without the closure cap.
  • the closure cap may be a push fit onto the body m order to cap the opening.
  • a push fit mecnanism provides for single-handed opening and closing cf the icrotu ⁇ e.
  • the closure cap may be connected to the body by a coupling which allows the closure cap to cap and uncap the opening m the body.
  • the coupling may comprise a resilient strip.
  • the coupling may abut the body m a position spaced from the ridge member.
  • the body spacing between the ridge member and the coupling may accommodate the collar when nesting under the ridge member.
  • the collar may have a recess for accommodating part of the coupling, tneredy nelpin ⁇ to reduce the body spacing between the ridge member and the coupling.
  • the ridge member may be integral with a rim around the opening m the body.
  • the closure cap may also include a recess for snap- fit engagement by the rim.
  • the collar may be ring snaped, and may be integrally formed with the closure cap.
  • the at least one frangible connection may be part of an array for frangible connections, fastening the collar to the closure cap prior to first use.
  • the array may comprise two components, distributed on each side of a tab for prising the closure cap off the body. By not having frangible connections under the tab, it may be easier to initiate detachment of the collar from the closure cap.
  • the mterengagmg profiles of the first and second parts may be rib-like, with each one raised proud of its surroundings.
  • the rib-like profiles may be circular, with the inner diameter of the rib- like profile on the first part being less tnan the outer diameter of the rib-like profile on the second part to provide the snap-fit action.
  • a portion of the stopper is a free or loose fit m the opening to facilitate fracturing the at least one frangible connection.
  • the loose fitting portion of the stopper allows sufficient play between the parts to break the at least one frangible connection without having to exert an excessive force to remove the stopper from the opening.
  • the loose fitting portion of the stopper may also assist with re-sealmg and re-separatmg the parts by allowing the profiles to be brought into engagement at a slight angle instead of squarely head-on.
  • a receptacle for storing fluid comprising a first part defining a chamoer witn an opening, a second part for capping the opening, means for coupling the first part to the second part even when the opening is uncapped, a collar attached to one of the parts by at least one frangible connection, and a ridge member integral with the other part, the collar being a tight fit over the ridge member and nesting under the ridge member when the opening is first capped, wherein the at least one frangible connection fractures when the opening is first uncapped, leaving the collar nesting under the ridge member.
  • the receptacle may be laboratory apparatus for use m laboratory experiments, and may even be a microtube.
  • Figure 1 shows a perspective view of a microtube embodying the present invention m the open configuration
  • Figure 2 shows a cross-sectional view through the microtube of Figure 1;
  • Figure 3 shows a bottom plan view of the microtube of Figure 1 (stabilisers omitted for sake of clarity) ;
  • Figure 4 is a side view of a laboratory receptacle according to a second embodiment of the invention.
  • Figure 1 illustrates a microtube (10) embodying the present invention, comprising a body (12) defining a chamber (14) with an opening (16), and a closure cap (18) having as stopper (19) for plugging the opening (16) .
  • the opening ⁇ 16 ) has a ⁇ TM 20) wnich projects radially c ⁇ twardly to provide a step or ridge (22) .
  • the closure cap (18) has a ring-shaped collar (24) attacned tc it by frangible connections (26) .
  • the ring-shaped collar is attacned tc it by frangible connections (26) .
  • the stopper (19) of the closure cap (18) includes a cylindrical portion (30) which extends axially proud of the frangicle connections (26) and collar (24) .
  • the cylindrical portion (30) is a snug fit m the opening (16 cf the body (12), but not a friction fit therein. This relatively free- fitting arrangement enables the stopper
  • a raised, rib-like profile (32) is provided on the curved cuter periphery of the cylindrical portion (30), ad ⁇ acent tne leading end thereof.
  • the rib-like profile (32) extends radially proud of the cylindrical portion (30) and is configured to engage with a snap- fit action a corresponding raised, rib-like profile (34) m the inner periphery (36) of the chamber (14) .
  • the cap (18) is urged into sealing engagement with tne body (12), positively retaining the stopper (19) m place m the opening (16) even m the absence of ring- shaped collar (24) . This may be useful if the microtube (10) is re-used after the tamper-evident feature has been used and discarded.
  • the ring-shaped collar (24) is initially coupled to the closure cap (18) by an array of frangible connections (26 .
  • the ring-shaped collar is integrally moulded with the frangible connection (26) to the closure cap (18) .
  • the array of frangible connections (26) has two components, disposed symmetrically on either side of tab (40) . In the underside plan view, Figure 3, the frangible connections (26) are gust visible through apertures (42) which also highlight the two components of the array either side of tao (40).
  • the ring-shaped collar (24) has a recess (44), tne role of which is explained below.
  • the closure cap (18) is coupled to the body (12) by a resilient strip (50) .
  • the resilient strip (50) engages the body (12) below the rim (20) , leaving a body space (52) between the ridge (22) and point of attachment (54) .
  • the resilient strip (50) acts as a hinge by folding m region F, allowing the closure cap (18) to rotate m direction A relatively to the body (12) to bring ring-shaped collar (24) into position facing the rim (20) .
  • the ring-shaped collar 24) whose inner diameter is the same as, or ever so slightly smaller than, the outer diameter of the rim (20) is a tight, stretch fit over the rim (20) .
  • the ring-shaped collar (24) As the ring- shaped collar (24) is pushed over the rim (20) until it nests under tne rim (22), the ring-shaped collar (24) becomes trapped m the body space (52) between the ridge '22) and the point of attachment (54) where tne resilient strip (50) engages the body (12). In fact, part of the resilient strip (50) is accommodated in recess (44) .
  • the closure cap (18) is removed by applying substantially upward pressure (usually witn the user's thumb) to the tab (40) .
  • substantially upward pressure usually witn the user's thumb
  • the frangible connections (26) come under tension, being stretched between the ring-shaped collar (24) - anchored under the ridge (22) - and the closure cap (18) as it is pushed upwards.
  • the tension causes the frangible couplings (26) to break, leaving the ring-shaped collar (24) under the ridge (22), even though the closure cap has been removed from the opening.
  • Figures 1 and 2 show tne microtube with stabilisers v/nich support the microtube m the upright position, enabling it to be free-standing.
  • the stabilisers are m no way essential to the invention, and the conventional conical bottom microtube (as illustrated m Figure 3) may be the more popular arrangement.
  • Figure 4 shows a second embodiment of the present invention.
  • a laboratory receptacle (110) consists of a body (112) and closure cap (118).
  • the receptacle (110) differs from tne microtube (1C 1 only in that the body (112) and closure cap (118) are not coupled together when the stopper (119) is not plugging the opening (116) m the chamber (114) . Accordingly, features m common between the two embodiments share the same reference numbers, except that features m the second embodiment are prefixed by "1".

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Clinical Laboratory Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Mechanical Engineering (AREA)
  • Closures For Containers (AREA)

Abstract

L'invention concerne un microtube (10) comprenant un corps (12) qui définit un compartiment (14) présentant une ouverture (16), et un capuchon (18) de fermeture. Le capuchon (18) de fermeture comprend une bague (24) annulaire reliée au capuchon par des éléments (26) de connexion frangibles. Cette bague (24) annulaire est dimensionnée de manière à venir s'ajuster étroitement sur une partie (22) saillante entourant le bord (20) de l'ouverture (16). La première fois que l'ouverture (16) est fermée au moyen du capuchon (18), l'accès au compartiment (14) ne peut être effectué que par la rupture des éléments (26) de connexion frangibles. Le capuchon (18) de fermeture comprend un bouchon (19) qui obture l'ouverture (16) par une action à déclic, permettant de réutiliser et de refermer le microtube (10).
PCT/GB2001/000638 2000-02-18 2001-02-16 Receptacle pour echantillon de fluide Ceased WO2001060518A1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU33864/01A AU3386401A (en) 2000-02-18 2001-02-16 Fluid sample receptacle

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB0003882A GB0003882D0 (en) 2000-02-18 2000-02-18 Receptacle
GB0003882.8 2000-02-18

Publications (1)

Publication Number Publication Date
WO2001060518A1 true WO2001060518A1 (fr) 2001-08-23

Family

ID=9885970

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB2001/000638 Ceased WO2001060518A1 (fr) 2000-02-18 2001-02-16 Receptacle pour echantillon de fluide

Country Status (3)

Country Link
AU (1) AU3386401A (fr)
GB (1) GB0003882D0 (fr)
WO (1) WO2001060518A1 (fr)

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1607342A1 (fr) * 2003-12-15 2005-12-21 Createchnic AG Bouchon encliquetable en plastique
WO2007015160A1 (fr) * 2005-08-04 2007-02-08 Gilson S.A.S. Mecanisme d'ouverture de microtube de laboratoire
WO2009021131A3 (fr) * 2007-08-07 2009-04-16 Aleta Behrman Bonner Système et procédé de recueil d'échantillon biologique et détection d'analyte
EP2288900A4 (fr) * 2008-06-06 2011-06-15 Capitol Plastic Products L L C Support avec flacon
EP2486982A1 (fr) * 2010-08-23 2012-08-15 Starplex Scientific Inc. Récipient pour spécimens
CN103529201A (zh) * 2013-04-28 2014-01-22 上海快灵生物科技有限公司 一种封闭式的层析试纸检测装置及其使用方法
CN111408308A (zh) * 2020-03-17 2020-07-14 广州奕昕生物科技有限公司 一种化学发光用磁微粒混匀管

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1163203A (en) * 1966-03-09 1969-09-04 Captocap Ltd Improvements relating to stoppers for the mouths of Necked Containers
US4157144A (en) * 1977-05-11 1979-06-05 Behringwerke Aktiengesellschaft Sterile closure cap
WO1995011083A2 (fr) * 1993-10-22 1995-04-27 Abbott Laboratories Tube de reaction et methode d'utilisation de celui-ci minimisant les contaminations
EP0697343A1 (fr) * 1994-08-06 1996-02-21 Yamamura Glass Co. Ltd. Fermeture antivol en résine synthétique
US5863791A (en) * 1996-07-11 1999-01-26 Eppendorf-Netheler-Hinz Gmbh Cover receptacle assembly
US6145688A (en) * 1996-07-17 2000-11-14 Smith; James C. Closure device for containers

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1163203A (en) * 1966-03-09 1969-09-04 Captocap Ltd Improvements relating to stoppers for the mouths of Necked Containers
US4157144A (en) * 1977-05-11 1979-06-05 Behringwerke Aktiengesellschaft Sterile closure cap
WO1995011083A2 (fr) * 1993-10-22 1995-04-27 Abbott Laboratories Tube de reaction et methode d'utilisation de celui-ci minimisant les contaminations
EP0697343A1 (fr) * 1994-08-06 1996-02-21 Yamamura Glass Co. Ltd. Fermeture antivol en résine synthétique
US5863791A (en) * 1996-07-11 1999-01-26 Eppendorf-Netheler-Hinz Gmbh Cover receptacle assembly
US6145688A (en) * 1996-07-17 2000-11-14 Smith; James C. Closure device for containers

Cited By (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1607342A1 (fr) * 2003-12-15 2005-12-21 Createchnic AG Bouchon encliquetable en plastique
WO2007015160A1 (fr) * 2005-08-04 2007-02-08 Gilson S.A.S. Mecanisme d'ouverture de microtube de laboratoire
FR2889461A1 (fr) * 2005-08-04 2007-02-09 Gilson Sas Soc Par Actions Sim Microtube de laboratoire.
WO2009021131A3 (fr) * 2007-08-07 2009-04-16 Aleta Behrman Bonner Système et procédé de recueil d'échantillon biologique et détection d'analyte
EP2288900A4 (fr) * 2008-06-06 2011-06-15 Capitol Plastic Products L L C Support avec flacon
US8911691B2 (en) 2008-06-06 2014-12-16 Capitol Plastic Products, Llc Rack with vial
EP2486982A1 (fr) * 2010-08-23 2012-08-15 Starplex Scientific Inc. Récipient pour spécimens
US8631966B2 (en) 2010-08-23 2014-01-21 Starplex Scientific Inc. Specimen container with cap having a snap-fit partially open position
CN103529201A (zh) * 2013-04-28 2014-01-22 上海快灵生物科技有限公司 一种封闭式的层析试纸检测装置及其使用方法
CN111408308A (zh) * 2020-03-17 2020-07-14 广州奕昕生物科技有限公司 一种化学发光用磁微粒混匀管

Also Published As

Publication number Publication date
GB0003882D0 (en) 2000-04-05
AU3386401A (en) 2001-08-27

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