[go: up one dir, main page]

WO2001054755A1 - Systeme de distribution et son appareil - Google Patents

Systeme de distribution et son appareil Download PDF

Info

Publication number
WO2001054755A1
WO2001054755A1 PCT/AU2001/000065 AU0100065W WO0154755A1 WO 2001054755 A1 WO2001054755 A1 WO 2001054755A1 AU 0100065 W AU0100065 W AU 0100065W WO 0154755 A1 WO0154755 A1 WO 0154755A1
Authority
WO
WIPO (PCT)
Prior art keywords
delivery
storage means
drug
engagement
storage
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/AU2001/000065
Other languages
English (en)
Inventor
Colin Campbell Marshall Moore
Ian Marshall Moore
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
FERRIER INTERNATIONAL Ltd
PROTECTIVE SHIELD Ltd
Original Assignee
FERRIER INTERNATIONAL Ltd
PROTECTIVE SHIELD Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by FERRIER INTERNATIONAL Ltd, PROTECTIVE SHIELD Ltd filed Critical FERRIER INTERNATIONAL Ltd
Priority to AU2001226578A priority Critical patent/AU2001226578A1/en
Publication of WO2001054755A1 publication Critical patent/WO2001054755A1/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/28—Syringe ampoules or carpules, i.e. ampoules or carpules provided with a needle
    • A61M5/285—Syringe ampoules or carpules, i.e. ampoules or carpules provided with a needle with sealing means to be broken or opened
    • A61M5/288—Syringe ampoules or carpules, i.e. ampoules or carpules provided with a needle with sealing means to be broken or opened by piercing without internal pressure increase
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M2005/3128—Incorporating one-way valves, e.g. pressure-relief or non-return valves
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31501—Means for blocking or restricting the movement of the rod or piston
    • A61M2005/31508—Means for blocking or restricting the movement of the rod or piston provided on the piston-rod
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/002—Packages specially adapted therefor, e.g. for syringes or needles, kits for diabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/002—Packages specially adapted therefor, e.g. for syringes or needles, kits for diabetics
    • A61M5/003—Kits for diabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/32—Needles; Details of needles pertaining to their connection with syringe or hub; Accessories for bringing the needle into, or holding the needle on, the body; Devices for protection of needles
    • A61M5/34—Constructions for connecting the needle, e.g. to syringe nozzle or needle hub
    • A61M5/347—Constructions for connecting the needle, e.g. to syringe nozzle or needle hub rotatable, e.g. bayonet or screw

Definitions

  • the present invention relates to a delivery system and apparatus therefor, and in particular to a system particularly suited for use with single use syringes and, more particularly, to syringes which, in at least some embodiments, restrict reflux to a significant extent.
  • Drug delivery and, particularly, drug delivery by way of syringe has heretofore left the way open for unauthorised persons to gain access to the drugs together with the syringes or, alternatively, to obtain access to used syringes for refilling with other drugs.
  • a separate problem concerns mistakes which can arise, even in authorised use by practitioners skilled in the art, whereby incorrect dosages are loaded into the syringe . Mistakes can also occur where the correct dosage is loaded into the syringe but not all of the dosage is delivered. This can happen, for example, where over priming of the syringe occurs prior to use of the syringe for drug delivery resulting in insufficient quantity of drug remaining in the syringe for actual delivery.
  • Australian Patent 708445 there is a perceived requirement for syringes adapted for delivery of drugs in such a way that the syringe, when assembled, can be used but once for the delivery of a drug contained within the syringe. It is further perceived as desirable in some forms that the syringe can never be used in a reverse direction or otherwise permit reflux whereby liquids move within the syringe in a reverse direction to the delivery direction.
  • Australian Patent 708445 discloses a basic assembly which, in at least some embodiments, can provide this type of functionality.
  • the disclosure of Australian Patent 708445 is incorporated herein by cross-reference.
  • a drug delivery system comprising self-contained storage means adapted to sealingly retain a substance of predetermined volume comprising a pre-determined dosage of a drug or drugs for transport from a first location to a second location; said storage means having actuator means engagement means at a first end thereof; said storage means having delivery means engagement means at a second end thereof.
  • said delivery means engagement means includes a frangible seal which maintains said liquid in said storage means during transport; said frangible seal adapted to be breached when delivery means is brought into engagement with said delivery means engagement means.
  • Preferably said system further includes delivery means.
  • said delivery means includes valve means.
  • said valve means is a one-way valve.
  • said delivery means is non-releasably attachable to said second end of said self-contained storage means .
  • said storage means includes one-way valve means integral therewith.
  • said delivery means comprises a needle assembly.
  • said delivery means comprises a connection to another delivery system.
  • said delivery means includes an adapter sleeve; said adapter sleeve including non-releasable engagement means for the non-releasable attachment of said adapter sleeve to said second end of said self-contained storage means .
  • said non-releasable engagement means of said adapter sleeve incorporates a multi-stage, spiral-action locking means .
  • said multi-stage, spiral-action locking means includes tynes associated with said delivery means and said storage means; said tynes profiled so as to permit forward progression of said storage means into engagement with said delivery means but to resist separation of said storage means from said delivery means.
  • said one way valve comprises a bulbous chamber having a ball therein.
  • said one way valve is located within said adapter sleeve.
  • Preferably said one way valve is located within said delivery means.
  • said one way valve is located within said storage means .
  • said system further includes actuator means.
  • said actuator means comprises a plunger.
  • said actuator means includes storage means engagement means for releasable engagement with a moveable seal in said storage means .
  • said system further includes a moveable seal and wherein said moveable seal defines a storage volume within said storage means; the volume of said storage volume varying in accordance with the position of said moveable seal within said storage means.
  • said actuator means includes a moveable barrier which acts to limit actuation on said moveable seal by said actuator means to a pre-load movement whereby movement of said plunger relative to said storage means is stopped at a pre-load position.
  • Preferably said pre-load movement causes priming of said delivery means by the substance located in said storage means .
  • said pre-load position corresponds to a volume of substance in said predetermined volume being said pre-determined dosage of said drug.
  • said actuator means is disengageable from said moveable seal in a manner which prevents said actuator means from causing said moveable seal to move in a way which will increase the volume defined in said storage means.
  • a plunger for use with the above described system.
  • a one-way valve for use with the above described system.
  • a kit incorporating components of the above described system.
  • a single use syringe for use with the above described system; said syringe comprising self-contained storage means adapted to sealingly retain a substance of predetermined volume comprising a pre-determined dosage of a drug; said storage means having actuator means engagement means at a first end thereof; said storage means having delivery means engagement means at a second end thereof.
  • a method of drug delivery comprising the steps of: (a) providing a self-contained storage means of the type described above; (b) transporting said self-contained storage means from said first location to said second location; (c) administering said predetermined volume comprising a predetermined dosage of a drug by the steps of : aa. connecting said delivery means to said storage means; bb. causing said storage means to discharge said predetermined volume comprising a predetermined dosage of a drug through said delivery means thereby to deliver said predetermined volume comprising a predetermined dosage of a drug to a designated source .
  • said designated source is the body of a mammal .
  • a system for the safe delivery of a drug or drugs from a delivery container said container adapted for independent storage from delivery means.
  • each component part of said system including said container and said delivery means is unusable for drug administration in its own right unless and until united by conscious act into a single delivery assembly.
  • Fig. 1 is a block diagram of a drug delivery system according to a first embodiment of the invention
  • Fig. 2 is a side section, exploded view of a single use syringe assembly adopted for use with the system of Fig. 1;
  • Figs. 3A-3I illustrate consecutive steps in the assembly and use for drug delivery of the syringe of Fig. 2 for the system of Fig. 1;
  • Figs. 4A-4L further illustrate steps of assembly and use for injection of the single use syringe assembly of Fig. 2 in the system of Fig. 1;
  • Fig. 5 is a view of a kit for use with the system of Fig. 1.
  • a drug delivery system 1 adapted for transmission of a predetermined quantity of a drug from a first location 2 to a second location 3.
  • the drug dosage is compiled into a discrete quantity suitable for delivery as a single dosage, for example by way of injection into a mammalian body.
  • This predetermined quantity is then loaded into a self contained storage means, in this instance, in the form of a barrel shaped container 4 which has actuator means engagement means in the form of a moveable seal 5 at a first end thereof and, further, has delivery means engagement means in the form of sealed outlet 6 at a second end thereof.
  • the container 4 When it is required to deliver the predetermined quantity 7 of drug or other substance for example to a patient 8 by way of injection at second location 3 then the container 4 is transported to the second location where it has attached to it an appropriate delivery means in the form of needle assembly 9 and an appropriate actuation means in the form of plunger 9A. After priming of the completed syringe assembly 9B injection of the predetermined quantity 7 of drug into patient 8 takes place.
  • the syringe assembly 9B can be deactivated and made safe by, for example, inserting at least the needle portion of needle assembly 9 into a receiving aperture 9C in plunger 9A as illustrated in the inset in Fig. 5.
  • the container 4 can be part of a single use syringe assembly 10 as will now be described with reference to Figs. 2, 3 and 4.
  • liquid is used to describe the substance which is stored in and ultimately delivered by the syringe assembly. It is to be understood that in addition to delivering a liquid the syringe assembly may be utilised for delivering other substances such as, for example, an admixture of a liquid and solid suspension, an admixture of liquids, an admixture of fluids or a combination thereof .
  • the assembly 10 comprises storage means in the form of a barrel-shaped container 11 having a storage volume 12 defined therein.
  • the precise volume of the storage volume 12 is determined by a moveable seal 13 sealingly, slidably moveable along longitudinal axis 14 of container 11 at all times, during movement, retaining sealing contact with inner wall 15 of container 11.
  • First end 16 of container 11 is adapted to slidingly receive therein an elongate plunger 17.
  • the plunger 17 is elongate and adapted to be aligned along its longitudinal axis with axis 14 of container 11 and to be advanced into first end 16 of container 11 such that non-retaining seal connector 18 at a leading edge thereof seats within plunger connector seat 19 located in rear surface 20 of moveable seal 13.
  • the plunger connector seat 19 is in the form of a cavity adapted to receive non-retaining seal connector in the form of a boss or dowel pin 18.
  • the seating of the non-retaining seal connector 18 within the plunger connector seat 19 is such that the plunger 17 can always be withdrawn from its engagement with the moveable seal 13 simply by reversing the movement of plunger 17 so that it moves out of container 11 and away from first end 16 along longitudinal axis 14 and leaving the moveable seal 13 retained within container 11 at the position it was at when the direction of movement of plunger 17 was reversed.
  • the plunger 17 is of sufficient length that it may be utilised to urge moveable seal 13 along longitudinal axis 14 all the way to an end position 21 within container 11 which, in so doing, forces the contents in storage volume 12 in the direction of container outlet 22.
  • the container 11 includes a frangible seal in the form of a membrane 23 which, for transport of container 11, seals container outlet 22 thereby to prevent egress, during transport, of liquid within storage volume 12.
  • Second end 24 (the delivery end) of container 11 also incorporates delivery means engagement means in this instance in the form of first engagement tyne 25 and second engagement tyne 26, both mounted on substantially cylindrical tyne support unit 27 which itself extends from second end 24 of container 11.
  • the tyne support unit 27 includes opposed slots 28 therein which are of sufficient width to allow at least limited flexing inwardly of tynes 25, 26 for the purpose of assisting the engagement of the tynes 25, 26 with the delivery means as to be described and discussed below.
  • the delivery means comprises an adapter sleeve 29 which receives at a first or delivery end 30 thereof a delivery device such as a needle assembly 31 or an infusion connector 32 or connection to another delivery system as can be performed for example by a Luer-type fitting.
  • the adapter sleeve 29 at a second end or receiving end 33 thereof is adapted to non-releasably engage with the delivery means engagement means of the container 11 which, in this instance, comprise the engagement tynes 25, 26 and the container outlet 22.
  • the tynes 25, 26 engage in a spiral shaped channel 34 located on or in the inside wall 35 of sleeve 29 and progress along the channel as and when the container 11 is twisted relative to the sleeve 29 until they encounter first tyne barriers 36. At this point further engagement of the container 11 with the adapter sleeve 29 is achieved by a forward urging of container 11 along longitudinal axis 14 in the direction of sleeve 29 whereby the tynes 25, 26 ride up and over inclined surfaces 37 (refer Fig. 3A) of barriers 36 thereby to permit continued travel of the tynes 25, 26 in channel 34 upon continued twisting movement of container 11 relative to sleeve 29.
  • second tyne barriers 38 are placed further along channel 34 from the first tyne barriers 36, which barriers must also be surmounted by tynes 25, 26 in the manner described in relation to the first tyne barriers 36 before final and complete, sealing and non-releasable engagement of container 11 is achieved with adapter sleeve 29.
  • the delivery means includes, in addition to the sleeve 29, a needle assembly 31 engaged within the first end or delivery end 30 of the adapter sleeve 29.
  • the needle assembly 31 (refer Fig. 2 and Fig. 3A) comprises elongate needle 39 having a contoured tip 40 at a delivery end thereof adapted for facilitating insertion into living tissue.
  • a bulbous chamber 42 adapted to receive valve ball 43 therewithin.
  • the bulbous chamber 42 has sufficient volume compared with the dimensions of the valve ball 43 and is arranged in such a way that the ball 43 cannot impede forward progress of a liquid through chamber 42 in the direction of elongate delivery channel 44 within needle 39.
  • Needle housing 45 grips receiving end 41 of needle 39 and includes adapter sleeve engagement tynes 46 which, upon insertion of the receiving end 41 of needle assembly 31 into the delivery end of adapter sleeve 29 mechanically engage with the adapter sleeve 29 so that the receiving end 41 of the needle assembly 31 is retained within adapter sleeve 29 in a manner whereby delivery channel 44 including bulbous chamber 42 are placed in liquid communication with the delivery end of adapter delivery tube 47 which is housed within and forms part of adapter sleeve 29.
  • valve ball 43 is sized so as to substantially impede if not entirely exclude reflux of liquid within chamber 42 into adapter delivery tube 47.
  • This action is achieved by mechanical sealing of the surface of valve ball 43 against delivery end 48 of adapter delivery tube 47 as ball 43 is urged by the reverse flow of liquid against delivery end 48.
  • This one-way or anti-reflux function can be assisted by biasing the ball in the direction of delivery end 48, for example by means of a spring.
  • Receiving end 49 of adapter delivery tube 47 is profiled so as to include a sharp apex 50 adapted to pierce membrane 23 during engagement of adapter sleeve 29 with container 11 thereby to provide a channel of liquid communication from storage volume 12 of container 11 through adapter delivery tube 47, through bulbous chamber 42 and through needle delivery channel 44 through the needle tip 40.
  • a sharp apex 50 adapted to pierce membrane 23 during engagement of adapter sleeve 29 with container 11 thereby to provide a channel of liquid communication from storage volume 12 of container 11 through adapter delivery tube 47, through bulbous chamber 42 and through needle delivery channel 44 through the needle tip 40.
  • plunger 17 includes moveable barrier 52 which is pivotally connected to plunger 17 so as to perform the function, in an arresting position, of a preload arrestor which prevents sliding movement of plunger 17 into container 11 beyond a predetermined insertion limit.
  • the moveable barrier 52 is shown in its arresting position 53 in Figs. 4G and 4H.
  • the moveable barrier 52 can be rotated about hinge line 54 so that its leading (arresting) edge 55 lies within slot 56 of plunger body 57 in a non-arresting position where it no longer engages with first end 16 of container 11 thereby permitting plunger body 57 to progress into container 11 so as to cause moveable seal 13 to shrink storage volume 12 so as to urge liquid contained therein through container outlet 22, through adapter delivery tube 47, through bulbous chamber 42, through delivery channel 44 and out of tip 40 of needle 39.
  • an intending user of the single use syringe assembly 10 first assembles the components of the assembly by taking a container 11 which is loaded with a drug in liquid form in storage volume 12, being of a predetermined volume and comprising a predetermined dosage of the drug for the particular use intended.
  • the user gains access to and assembles the delivery means by inserting valve ball 43 in bulbous chamber 42 in needle assembly 31, then connecting the needle assembly 31 (this step may be performed in the course of manufacture and prior to delivery to the final user) to the delivery end of adapter sleeve 29 in the manner previously described and as best seen in Figs. 4C and 4D.
  • membrane 23 is pierced by receiving end 49 of the adapter delivery tube 47 thereby bringing storage volume 12 into liquid engagement with needle assembly 31.
  • plunger 17 (with moveable barrier 52 in arresting position 53) into first end 16 of container 11 so that non-retaining seal connector 18 engages in plunger connector seat 19 and so as to urge moveable seal 13 in a delivery direction along axis 14 until moveable barrier 52 encounters container 11.
  • this position of moveable seal 13 will be the position which defines exactly the intended predetermined volume of predetermined dosage of drug within storage volume 12.
  • the user now moves moveable barrier 52 from the arresting position and continues the movement of plunger 17 into container 11 to the full extent of its permitted passage, being to the point wherein moveable seal 13 encounters walls of the container 11 at its delivery end. At this point the predetermined volume of predetermined dosage of drug will have been delivered through tip 40.
  • valve means can be manufactured as an entirely separate entity for separate coupling into the syringe assembly.
  • valve means can be interposed between the needle assembly and the storage means .
  • the frangible seal may take the form of a mechanically operable valve or other device performing an equivalent function.
  • the delivery system 1 thus described can be formulated, in one form, as a kit 60, in this instance comprising a sealable plastic bag 61 into which container 4, plunger 9A and needle assembly 9 are inserted.
  • a user Upon transport to a location where it is desired to inject the predetermined quantity 7 of drug from the container 4 a user first removes the needle assembly 9 from within aperture 9C of plunger 9A, then assembles the syringe assembly in the manner previously described and injects the contents of container 4 in the manner previously described, for example in detail with reference to Figs. 3 and 4.
  • the innovation is applicable to the field of medicine and is particularly applied to syringes and like injection devices .

Landscapes

  • Health & Medical Sciences (AREA)
  • Vascular Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)

Abstract

L'invention concerne un système de distribution de médicament, comprenant des moyens de stockage autonomes conçus pour retenir hermétiquement une substance de volume prédéterminé qui renferment une dose de médicament(s) prédéterminée à transporter d'un premier emplacement vers un second emplacement, lesdits moyens de stockage comprenant des moyens de contact de moyens d'actionnement situés à une première extrémité et des moyens de contact de moyens de distribution situés à une seconde extrémité.
PCT/AU2001/000065 2000-01-25 2001-01-25 Systeme de distribution et son appareil Ceased WO2001054755A1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2001226578A AU2001226578A1 (en) 2000-01-25 2001-01-25 Delivery system and apparatus therefor

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
AUPQ5261A AUPQ526100A0 (en) 2000-01-25 2000-01-25 Improvements in single use syringes
AUPQ5262A AUPQ526200A0 (en) 2000-01-25 2000-01-25 Delivery system and apparatus thereof
AUPQ5262 2000-01-25

Publications (1)

Publication Number Publication Date
WO2001054755A1 true WO2001054755A1 (fr) 2001-08-02

Family

ID=25646249

Family Applications (2)

Application Number Title Priority Date Filing Date
PCT/AU2001/000066 Ceased WO2001054756A1 (fr) 2000-01-25 2001-01-25 Ameliorations de seringues a usage unique
PCT/AU2001/000065 Ceased WO2001054755A1 (fr) 2000-01-25 2001-01-25 Systeme de distribution et son appareil

Family Applications Before (1)

Application Number Title Priority Date Filing Date
PCT/AU2001/000066 Ceased WO2001054756A1 (fr) 2000-01-25 2001-01-25 Ameliorations de seringues a usage unique

Country Status (2)

Country Link
AU (2) AUPQ526200A0 (fr)
WO (2) WO2001054756A1 (fr)

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005062751A3 (fr) * 2003-11-21 2005-11-03 Vasogen Ireland Ltd Systemes de manipulation de substances medicales
WO2008110890A1 (fr) * 2007-03-12 2008-09-18 Gianpaolo Belloli Dispositif d'administration d'un produit
US20100010472A1 (en) * 2004-12-24 2010-01-14 Ian Marshall Moore Safety syringe
CN103508393A (zh) * 2012-06-21 2014-01-15 永克達工業股份有限公司 自行车油压灌入装置
WO2015061386A1 (fr) * 2013-10-24 2015-04-30 Amgen Inc. Injecteur et procédé d'assemblage
US9987428B2 (en) 2011-10-14 2018-06-05 Amgen Inc. Injector and method of assembly
US10850037B2 (en) 2013-03-22 2020-12-01 Amgen Inc. Injector and method of assembly

Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU603862B2 (en) * 1988-02-10 1990-11-29 Astra Pharmaceuticals Pty Ltd Plastic cartridge and syringe
US5019053A (en) * 1989-10-23 1991-05-28 Gte Products Corporation Hypodermic syringe
EP0327910B1 (fr) * 1988-02-10 1992-04-15 D.C.P. Af 1988 A/S Une unité de dosage pour doser un nombre de quantités mesurées d'un liquide, telle une préparation d'insuline à partir d'une cartouche
EP0412283B1 (fr) * 1989-07-27 1993-12-01 Arzneimittel GmbH Apotheker Vetter & Co. Ravensburg Cylindre de seringue à usage médical
WO1997047343A1 (fr) * 1996-06-10 1997-12-18 Gettig Technologies Incorporated Systeme d'injection hypodermique et procede de maintien du systeme a l'etat sterile avant son utilisation
GB2327885A (en) * 1997-08-02 1999-02-10 Nmt Group Plc Filling needle
GB2328432A (en) * 1997-08-23 1999-02-24 Nmt Group Plc Vial
WO1999048547A1 (fr) * 1998-03-20 1999-09-30 Spaeter Berno Dispositif permettant d'administrer, notamment par injection, des quantites predeterminees d'un fluide tel qu'un medicament

Patent Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU603862B2 (en) * 1988-02-10 1990-11-29 Astra Pharmaceuticals Pty Ltd Plastic cartridge and syringe
EP0327910B1 (fr) * 1988-02-10 1992-04-15 D.C.P. Af 1988 A/S Une unité de dosage pour doser un nombre de quantités mesurées d'un liquide, telle une préparation d'insuline à partir d'une cartouche
EP0412283B1 (fr) * 1989-07-27 1993-12-01 Arzneimittel GmbH Apotheker Vetter & Co. Ravensburg Cylindre de seringue à usage médical
US5019053A (en) * 1989-10-23 1991-05-28 Gte Products Corporation Hypodermic syringe
WO1997047343A1 (fr) * 1996-06-10 1997-12-18 Gettig Technologies Incorporated Systeme d'injection hypodermique et procede de maintien du systeme a l'etat sterile avant son utilisation
GB2327885A (en) * 1997-08-02 1999-02-10 Nmt Group Plc Filling needle
GB2328432A (en) * 1997-08-23 1999-02-24 Nmt Group Plc Vial
WO1999048547A1 (fr) * 1998-03-20 1999-09-30 Spaeter Berno Dispositif permettant d'administrer, notamment par injection, des quantites predeterminees d'un fluide tel qu'un medicament

Cited By (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005062751A3 (fr) * 2003-11-21 2005-11-03 Vasogen Ireland Ltd Systemes de manipulation de substances medicales
US20100010472A1 (en) * 2004-12-24 2010-01-14 Ian Marshall Moore Safety syringe
WO2008110890A1 (fr) * 2007-03-12 2008-09-18 Gianpaolo Belloli Dispositif d'administration d'un produit
US11058821B2 (en) 2011-10-14 2021-07-13 Amgen Inc. Injector and method of assembly
US9987428B2 (en) 2011-10-14 2018-06-05 Amgen Inc. Injector and method of assembly
US11160931B2 (en) 2011-10-14 2021-11-02 Amgen Inc. Method of assembling and filling a drug delivery device
US10314976B2 (en) 2011-10-14 2019-06-11 Amgen Inc. Method of assembling and filling a drug delivery device
US10537682B2 (en) 2011-10-14 2020-01-21 Amgen Inc. Injector and method of assembly
US10537681B2 (en) 2011-10-14 2020-01-21 Amgen Inc. Injector and method of assembly
US11129941B2 (en) 2011-10-14 2021-09-28 Amgen Inc. Method of assembling and filling a drug delivery device
CN103508393A (zh) * 2012-06-21 2014-01-15 永克達工業股份有限公司 自行车油压灌入装置
CN113559363B (zh) * 2013-03-22 2023-10-31 美国安进公司 注射器及装配方法
US11759571B2 (en) 2013-03-22 2023-09-19 Amgen Inc. Injector and method of assembly
CN113559363A (zh) * 2013-03-22 2021-10-29 美国安进公司 注射器及装配方法
US10850037B2 (en) 2013-03-22 2020-12-01 Amgen Inc. Injector and method of assembly
AU2019222798B2 (en) * 2013-10-24 2020-09-10 Amgen Inc. Injector and method of assembly
US11097055B2 (en) 2013-10-24 2021-08-24 Amgen Inc. Injector and method of assembly
EP3789064A1 (fr) * 2013-10-24 2021-03-10 Amgen, Inc Injecteur et procédé d'assemblage
WO2015061386A1 (fr) * 2013-10-24 2015-04-30 Amgen Inc. Injecteur et procédé d'assemblage
AU2014340171B2 (en) * 2013-10-24 2019-05-30 Amgen Inc. Injector and method of assembly
EP3421066A1 (fr) * 2013-10-24 2019-01-02 Amgen, Inc Injecteur et procédé d'assemblage
CN105873626A (zh) * 2013-10-24 2016-08-17 美国安进公司 注射器和组装方法
US12427260B2 (en) 2013-10-24 2025-09-30 Amgen Inc. Injector and method of assembly

Also Published As

Publication number Publication date
AUPQ526200A0 (en) 2000-02-17
AUPQ526100A0 (en) 2000-02-17
WO2001054756A1 (fr) 2001-08-02

Similar Documents

Publication Publication Date Title
EP1833532B1 (fr) Seringue de securite
JP4660589B2 (ja) 流体製剤を投与する投与装置
US8372043B2 (en) Devices and methods for fluid administration
US8529517B2 (en) Autoflush syringe
US6681810B2 (en) Filling device for a needleless injector cartridge
CA2207991C (fr) Dispositif de remplissage pour cartouche d'injecteur sans aiguille
EP2195052B1 (fr) Pompe à médicament externe
US20120029471A1 (en) Two chamber syringe with locking mechanism
NZ515785A (en) Self injection device and method for its operation
WO2012006555A1 (fr) Seringue à deux chambres ayant un mécanisme de verrouillage
WO2001054755A1 (fr) Systeme de distribution et son appareil
JP2024009111A (ja) デュアル・ルーメン静脈内セットを有するデュアル・チャンバ・シリンジ
NZ556682A (en) Safety syringe
HK1113659B (en) Safety syringe
MXPA97004576A (en) Filling device for an injector cartridge without ag

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A1

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BY BZ CA CH CN CR CU CZ DE DK DM DZ EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NO NZ PL PT RO RU SD SE SG SI SK SL TJ TM TR TT TZ UA UG US UZ VN YU ZA ZW

AL Designated countries for regional patents

Kind code of ref document: A1

Designated state(s): GH GM KE LS MW MZ SD SL SZ TZ UG ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE TR BF BJ CF CG CI CM GA GN GW ML MR NE SN TD TG

121 Ep: the epo has been informed by wipo that ep was designated in this application
DFPE Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101)
REG Reference to national code

Ref country code: DE

Ref legal event code: 8642

122 Ep: pct application non-entry in european phase
NENP Non-entry into the national phase

Ref country code: JP