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WO2001052817A3 - Nouvelles formulations cochleaires, procede de preparation et utilisation de celles-ci dans l'administration de molecules biologiquement utiles - Google Patents

Nouvelles formulations cochleaires, procede de preparation et utilisation de celles-ci dans l'administration de molecules biologiquement utiles Download PDF

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Publication number
WO2001052817A3
WO2001052817A3 PCT/US2001/002299 US0102299W WO0152817A3 WO 2001052817 A3 WO2001052817 A3 WO 2001052817A3 US 0102299 W US0102299 W US 0102299W WO 0152817 A3 WO0152817 A3 WO 0152817A3
Authority
WO
WIPO (PCT)
Prior art keywords
biologically relevant
cochleate
relevant molecules
delivering biologically
cochleates
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2001/002299
Other languages
English (en)
Other versions
WO2001052817A2 (fr
Inventor
Leila Zarif
Tuo Jin
Ignacio Segarra
Raphael J Mannino
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Rutgers State University of New Jersey
Biodelivery Sciences Inc
Rutgers Health
Original Assignee
University of Medicine and Dentistry of New Jersey
Rutgers State University of New Jersey
Biodelivery Sciences Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/US2000/001684 external-priority patent/WO2000042989A2/fr
Application filed by University of Medicine and Dentistry of New Jersey, Rutgers State University of New Jersey, Biodelivery Sciences Inc filed Critical University of Medicine and Dentistry of New Jersey
Priority to EP01903273A priority Critical patent/EP1259224A2/fr
Priority to CA002397792A priority patent/CA2397792A1/fr
Priority to AU31114/01A priority patent/AU3111401A/en
Priority to JP2001552865A priority patent/JP2003529557A/ja
Publication of WO2001052817A2 publication Critical patent/WO2001052817A2/fr
Publication of WO2001052817A3 publication Critical patent/WO2001052817A3/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A61K9/1274—Non-vesicle bilayer structures, e.g. liquid crystals, tubules, cubic phases or cochleates; Sponge phases
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/02—Nutrients, e.g. vitamins, minerals

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nutrition Science (AREA)
  • Dispersion Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Manufacturing Of Micro-Capsules (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)

Abstract

L'invention concerne un procédé de production d'une structure cochléaire de petite taille à base de lipide. Les structures cochléaires sont obtenues à partir de liposomes qui sont mis en suspension dans une solution aqueuse polymère à deux phases, ce qui permet de séparer de manière différentielle les structures à base de molécules polaires par séparation de phases. La solution polymère à deux phases contenant des liposomes, traitée à l'aide de molécules chargées positivement telles que Ca?2+ ou Zn2+¿, forme un précipité de structures cochléaires présentant des dimensions de particules inférieures à un micron. Le procédé peut être utilisé pour produire des structures cochléaires contenant des molécules biologiquement utiles.
PCT/US2001/002299 2000-01-24 2001-01-24 Nouvelles formulations cochleaires, procede de preparation et utilisation de celles-ci dans l'administration de molecules biologiquement utiles Ceased WO2001052817A2 (fr)

Priority Applications (4)

Application Number Priority Date Filing Date Title
EP01903273A EP1259224A2 (fr) 2000-01-24 2001-01-24 Nouvelles formulations cochleaires, procede de preparation et utilisation de celles-ci dans l'administration de molecules biologiquement utiles
CA002397792A CA2397792A1 (fr) 2000-01-24 2001-01-24 Nouvelles formulations cochleaires, procede de preparation et utilisation de celles-ci dans l'administration de molecules biologiquement utiles
AU31114/01A AU3111401A (en) 2000-01-24 2001-01-24 New cochleate formulations, process of preparation and their use for the delivery of biologically relevant molecules
JP2001552865A JP2003529557A (ja) 2000-01-24 2001-01-24 コクリエート製剤、その調製方法および生物学的関連分子投与のための用途

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
PCT/US2000/001684 WO2000042989A2 (fr) 1999-01-22 2000-01-24 Nouvelles formulations de structures cochleaires isolees dans des hydrogels, procede de preparation et utilisation de celles-ci pour administrer des molecules biologiquement utiles
USPCT/US00/01684 2000-01-24
US09/613,840 2000-07-11
US09/613,840 US6592894B1 (en) 1999-01-22 2000-07-11 Hydrogel-isolated cochleate formulations, process of preparation and their use for the delivery of biologically relevant molecules

Publications (2)

Publication Number Publication Date
WO2001052817A2 WO2001052817A2 (fr) 2001-07-26
WO2001052817A3 true WO2001052817A3 (fr) 2002-02-21

Family

ID=26680118

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2001/002299 Ceased WO2001052817A2 (fr) 2000-01-24 2001-01-24 Nouvelles formulations cochleaires, procede de preparation et utilisation de celles-ci dans l'administration de molecules biologiquement utiles

Country Status (5)

Country Link
EP (1) EP1259224A2 (fr)
JP (1) JP2003529557A (fr)
AU (1) AU3111401A (fr)
CA (1) CA2397792A1 (fr)
WO (1) WO2001052817A2 (fr)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030219473A1 (en) * 2002-03-26 2003-11-27 Leila Zarif Cochleates made with purified soy phosphatidylserine
WO2004064805A1 (fr) * 2003-01-15 2004-08-05 Biodelivery Sciences International, Inc. Preparations cochleaires de nutriants fragiles
US20050013854A1 (en) * 2003-04-09 2005-01-20 Mannino Raphael J. Novel encochleation methods, cochleates and methods of use
JP4789208B2 (ja) 2003-04-09 2011-10-12 バイオデリバリー サイエンシーズ インターナショナル インコーポレイティッド タンパク質発現に向けられた渦巻型組成物
JP4627727B2 (ja) * 2003-10-15 2011-02-09 株式会社ナノエッグ 多価金属無機塩被覆レチノイン酸ナノ粒子含有組成物
JP4422681B2 (ja) * 2003-10-15 2010-02-24 株式会社ナノエッグ 多価金属無機塩被覆レチノイン酸ナノ粒子の製造方法および当該製造方法により得られたナノ粒子
WO2008070982A1 (fr) 2006-12-15 2008-06-19 National Research Council Of Canada Agrégats de lipides polaires d'archaea pour administration à des animaux
AU2012250568B2 (en) * 2011-05-05 2017-06-29 Matinas Biopharma Nanotechnologies, Inc. Cochleate compositions and methods of making and using same
EP3285874B1 (fr) * 2015-04-22 2021-03-17 Matinas BioPharma Nanotechnologies, Inc. Compositions et méthodes pour le traitement d'infections et de maladies pulmonaires à mycobactéries
AU2016280276A1 (en) * 2015-06-18 2017-12-07 Matinas Biopharma Nanotechnologies, Inc. Compositions and methods for treating inflammatory disease or conditions
KR20190029642A (ko) * 2016-07-12 2019-03-20 마티나스 바이오파마 나노테크놀로지스, 인코포레이티드 중추 신경계 전달 및 크립토코커스(cryptococcus) 감염의 치료를 위한 코클리에이트화된(encochleated) 항진균 화합물
KR101989789B1 (ko) * 2017-11-30 2019-06-18 (주) 에이치엔에이파마켐 포스파티딜세린/음이온계면활성제/염화칼슘을 이용한 코킬레이트

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997030725A1 (fr) * 1996-02-22 1997-08-28 Raphael James Mannino Vecteurs d'apport de structures cochleaires
US5994318A (en) * 1993-10-04 1999-11-30 Albany Medical College Cochleate delivery vehicles
WO2000042989A2 (fr) * 1999-01-22 2000-07-27 Biodelivery Sciences, Inc. Nouvelles formulations de structures cochleaires isolees dans des hydrogels, procede de preparation et utilisation de celles-ci pour administrer des molecules biologiquement utiles

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5994318A (en) * 1993-10-04 1999-11-30 Albany Medical College Cochleate delivery vehicles
WO1997030725A1 (fr) * 1996-02-22 1997-08-28 Raphael James Mannino Vecteurs d'apport de structures cochleaires
WO2000042989A2 (fr) * 1999-01-22 2000-07-27 Biodelivery Sciences, Inc. Nouvelles formulations de structures cochleaires isolees dans des hydrogels, procede de preparation et utilisation de celles-ci pour administrer des molecules biologiquement utiles

Also Published As

Publication number Publication date
JP2003529557A (ja) 2003-10-07
EP1259224A2 (fr) 2002-11-27
WO2001052817A2 (fr) 2001-07-26
AU3111401A (en) 2001-07-31
CA2397792A1 (fr) 2001-07-26

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