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WO2001051920A3 - Procede de commande optimise pour colonnes de chromatographie - Google Patents

Procede de commande optimise pour colonnes de chromatographie Download PDF

Info

Publication number
WO2001051920A3
WO2001051920A3 PCT/EP2001/000389 EP0100389W WO0151920A3 WO 2001051920 A3 WO2001051920 A3 WO 2001051920A3 EP 0100389 W EP0100389 W EP 0100389W WO 0151920 A3 WO0151920 A3 WO 0151920A3
Authority
WO
WIPO (PCT)
Prior art keywords
control method
chromatography columns
optimized control
substances
separated
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/EP2001/000389
Other languages
German (de)
English (en)
Other versions
WO2001051920A2 (fr
Inventor
Roland Hagemann
Dirk Pfestorf
Hagen Kniep
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Siemens Axiva GmbH and Co KG
Original Assignee
Siemens Axiva GmbH and Co KG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Siemens Axiva GmbH and Co KG filed Critical Siemens Axiva GmbH and Co KG
Publication of WO2001051920A2 publication Critical patent/WO2001051920A2/fr
Publication of WO2001051920A3 publication Critical patent/WO2001051920A3/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/80—Fraction collectors
    • G01N30/82—Automatic means therefor
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/86—Signal analysis
    • G01N30/8658—Optimising operation parameters
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/86—Signal analysis
    • G01N30/8624—Detection of slopes or peaks; baseline correction
    • G01N30/8631—Peaks
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/86—Signal analysis
    • G01N30/8675—Evaluation, i.e. decoding of the signal into analytical information
    • G01N30/8689—Peak purity of co-eluting compounds
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/86—Signal analysis
    • G01N30/8693—Models, e.g. prediction of retention times, method development and validation

Landscapes

  • Physics & Mathematics (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Treatment Of Liquids With Adsorbents In General (AREA)

Abstract

L'invention concerne un procédé de commande pour colonnes chromatographiques dans lesquelles les substances à séparer sont liées à une phase stationnaire et sont éluées par une phase fluide. Selon ce procédé, pour amorcer le fractionnement, il est prévu d'utiliser une valeur auxiliaire. Ce procédé se caractérise en ce que la valeur auxiliaire utilisée dans le fluide est une concentration calculée en ligne d'un ou de plusieurs constituants des substances à séparer. Il intervient ensuite le calcul de la concentration par combinaison d'un modèle rigoureux et entraîné par données, pour décrire la séparation chromatographique des constituants du mélange.
PCT/EP2001/000389 2000-01-14 2001-01-15 Procede de commande optimise pour colonnes de chromatographie Ceased WO2001051920A2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE2000101273 DE10001273A1 (de) 2000-01-14 2000-01-14 Optimiertes Steuerverfahren für Chromatographiesäulen
DE10001273.6 2000-01-14

Publications (2)

Publication Number Publication Date
WO2001051920A2 WO2001051920A2 (fr) 2001-07-19
WO2001051920A3 true WO2001051920A3 (fr) 2001-12-20

Family

ID=7627469

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2001/000389 Ceased WO2001051920A2 (fr) 2000-01-14 2001-01-15 Procede de commande optimise pour colonnes de chromatographie

Country Status (2)

Country Link
DE (1) DE10001273A1 (fr)
WO (1) WO2001051920A2 (fr)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2012022620A1 (fr) * 2010-08-17 2012-02-23 Grünenthal GmbH Procédé et dispositif d'alimentation d'appareils d'analyse et de systèmes de manutention de liquides avec des liquides

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
FABRE H ET AL: "Evaluation of different techniques for peak purity assessment on a diode-array detector in liquid chromatography", JOURNAL OF CHROMATOGRAPHY A, ELSEVIER SCIENCE, NL, vol. 697, no. 1, 21 April 1995 (1995-04-21), pages 81 - 88, XP004023036, ISSN: 0021-9673 *
HATANAKA T ET AL: "ANALYSIS OF SEPARATION PERFORMANCE FOR HIGH PERFORMANCE LIQUID CHROMATOGRAPHY", JOURNAL OF CHEMICAL ENGINEERING OF JAPAN, SOCIETY OF CHEMICAL ENGINEERS. TOKYO, JP, vol. 29, no. 2, 1 April 1996 (1996-04-01), pages 336 - 343, XP000623465, ISSN: 0021-9592 *
YUZHU H ET AL: "Assessment of chromatographic peak purity by means of artificial neural networks", JOURNAL OF CHROMATOGRAPHY A, ELSEVIER SCIENCE, NL, vol. 734, no. 2, 24 May 1996 (1996-05-24), pages 259 - 270, XP004039115, ISSN: 0021-9673 *

Also Published As

Publication number Publication date
WO2001051920A2 (fr) 2001-07-19
DE10001273A1 (de) 2001-07-19

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