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WO2001051640A3 - Regulation de la transformylse mitochondriale humaine - Google Patents

Regulation de la transformylse mitochondriale humaine Download PDF

Info

Publication number
WO2001051640A3
WO2001051640A3 PCT/EP2001/000294 EP0100294W WO0151640A3 WO 2001051640 A3 WO2001051640 A3 WO 2001051640A3 EP 0100294 W EP0100294 W EP 0100294W WO 0151640 A3 WO0151640 A3 WO 0151640A3
Authority
WO
WIPO (PCT)
Prior art keywords
transformylase
human mitochondrial
regulation
reagents
regulate
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/EP2001/000294
Other languages
English (en)
Other versions
WO2001051640A2 (fr
Inventor
Shyam Ramakrishnan
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer AG
Original Assignee
Bayer AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer AG filed Critical Bayer AG
Priority to AU2001239220A priority Critical patent/AU2001239220A1/en
Publication of WO2001051640A2 publication Critical patent/WO2001051640A2/fr
Publication of WO2001051640A3 publication Critical patent/WO2001051640A3/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1003—Transferases (2.) transferring one-carbon groups (2.1)
    • C12N9/1014—Hydroxymethyl-, formyl-transferases (2.1.2)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • General Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Microbiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

L'invention concerne des réactifs régulant la transformylase mitochondriale humaine et des réactifs se liant à des produits géniques de la transformylase mitochondriale humaine. Ces réactifs peuvent être utilisés en vue de réguler la prolifération cellulaire, notamment dans des maladies telles que le cancer et d'autres formes de néoplastie.
PCT/EP2001/000294 2000-01-11 2001-01-11 Regulation de la transformylse mitochondriale humaine Ceased WO2001051640A2 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2001239220A AU2001239220A1 (en) 2000-01-11 2001-01-11 Regulation of human mitochondrial transformylase

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US17541800P 2000-01-11 2000-01-11
US60/175,418 2000-01-11

Publications (2)

Publication Number Publication Date
WO2001051640A2 WO2001051640A2 (fr) 2001-07-19
WO2001051640A3 true WO2001051640A3 (fr) 2001-12-20

Family

ID=22640144

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2001/000294 Ceased WO2001051640A2 (fr) 2000-01-11 2001-01-11 Regulation de la transformylse mitochondriale humaine

Country Status (2)

Country Link
AU (1) AU2001239220A1 (fr)
WO (1) WO2001051640A2 (fr)

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4999424A (en) * 1988-11-10 1991-03-12 The Pennsylvania State University GAR transformylase inhibitor

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4999424A (en) * 1988-11-10 1991-03-12 The Pennsylvania State University GAR transformylase inhibitor

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
DATABASE EM_EST [online] embl; 2 November 1999 (1999-11-02), NCI-CGAP: "UI-H-BI1-adw-f-03-0-UI.s1 NCI_CGAP_Sub3 Homo sapiens cDNA clone IMAGE:2718460 3', mRNA sequence", XP002178063, retrieved from EBI accession no. AW139851 Database accession no. AW139851 *
DATABASE EM_EST [online] embl; 8 April 1995 (1995-04-08), HILLIER ET AL.: "yd21e11.r1 Soares fetal liver spleen 1NFLS Homo sapiens cDNA clone IMAGE:108908 5' similar to SP:FMT_YEAST P32785 PROBABLE METHIONYL-TRNA FORMYLTRANSFERASE PRECURSOR ;, mRNA sequence", XP002178062, retrieved from EBI accession no. HS02258 Database accession no. T79022 *
TAKEUCHI ET AL.: "Mammalian mitochondrial methionyl-tRNA transformylase from bovine liver", THE JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 273, no. 24, 12 June 1998 (1998-06-12), pages 15085 - 15090, XP002178061 *

Also Published As

Publication number Publication date
WO2001051640A2 (fr) 2001-07-19
AU2001239220A1 (en) 2001-07-24

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