[go: up one dir, main page]

WO2001051521A3 - Procedes d'identification de modulateurs du recepteur fgf - Google Patents

Procedes d'identification de modulateurs du recepteur fgf Download PDF

Info

Publication number
WO2001051521A3
WO2001051521A3 PCT/US2001/000821 US0100821W WO0151521A3 WO 2001051521 A3 WO2001051521 A3 WO 2001051521A3 US 0100821 W US0100821 W US 0100821W WO 0151521 A3 WO0151521 A3 WO 0151521A3
Authority
WO
WIPO (PCT)
Prior art keywords
methods
fgf receptor
identifying modulators
fragments
present
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2001/000821
Other languages
English (en)
Other versions
WO2001051521A2 (fr
Inventor
Ming-Ming Zhou
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Icahn School of Medicine at Mount Sinai
Original Assignee
Mount Sinai School of Medicine
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mount Sinai School of Medicine filed Critical Mount Sinai School of Medicine
Priority to CA002397135A priority Critical patent/CA2397135A1/fr
Priority to AU2001226387A priority patent/AU2001226387A1/en
Priority to EP01900987A priority patent/EP1246926A2/fr
Publication of WO2001051521A2 publication Critical patent/WO2001051521A2/fr
Publication of WO2001051521A3 publication Critical patent/WO2001051521A3/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/71—Receptors; Cell surface antigens; Cell surface determinants for growth factors; for growth regulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B15/00—ICT specially adapted for analysing two-dimensional or three-dimensional molecular structures, e.g. structural or functional relations or structure alignment
    • G16B15/30—Drug targeting using structural data; Docking or binding prediction
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B15/00—ICT specially adapted for analysing two-dimensional or three-dimensional molecular structures, e.g. structural or functional relations or structure alignment

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Physics & Mathematics (AREA)
  • Engineering & Computer Science (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Toxicology (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Immunology (AREA)
  • Cell Biology (AREA)
  • Theoretical Computer Science (AREA)
  • Medical Informatics (AREA)
  • Evolutionary Biology (AREA)
  • Biotechnology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

L'invention concerne des fragments du SNT et du FGFR pouvant former un complexe de liaison qui se prête aux déterminations structurelles par spectroscopie RMN. L'invention concerne en outre les données structurelles tridimensionnelles correspondantes. L'invention concerne aussi une méthodologie applicable à la conception rationnelle structurelle connexe de médicaments reposant sur les données en question. L'invention concerne également des séquences nucléotidiques et des séquences d'acides aminés de ces fragments.
PCT/US2001/000821 2000-01-12 2001-01-10 Procedes d'identification de modulateurs du recepteur fgf Ceased WO2001051521A2 (fr)

Priority Applications (3)

Application Number Priority Date Filing Date Title
CA002397135A CA2397135A1 (fr) 2000-01-12 2001-01-10 Procedes d'identification de modulateurs du recepteur fgf
AU2001226387A AU2001226387A1 (en) 2000-01-12 2001-01-10 Methods of identifying modulators of the fgf receptor
EP01900987A EP1246926A2 (fr) 2000-01-12 2001-01-10 Procedes d'identification de modulateurs du recepteur fgf

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US17586700P 2000-01-12 2000-01-12
US60/175,867 2000-01-12
US09/757,415 US7108984B2 (en) 2000-01-12 2001-01-09 Methods of identifying modulators of the FGF receptor
US09/757,415 2001-01-09

Publications (2)

Publication Number Publication Date
WO2001051521A2 WO2001051521A2 (fr) 2001-07-19
WO2001051521A3 true WO2001051521A3 (fr) 2001-12-20

Family

ID=26871645

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2001/000821 Ceased WO2001051521A2 (fr) 2000-01-12 2001-01-10 Procedes d'identification de modulateurs du recepteur fgf

Country Status (5)

Country Link
US (2) US7108984B2 (fr)
EP (1) EP1246926A2 (fr)
AU (1) AU2001226387A1 (fr)
CA (1) CA2397135A1 (fr)
WO (1) WO2001051521A2 (fr)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20090171641A1 (en) * 2005-08-17 2009-07-02 Jubilant Biosys Ltd. Novel homology model of the glycogen synthase kinase 3 alpha and its uses thereof
EP2141231B1 (fr) * 2007-03-23 2014-03-12 The University of Tokyo PROCÉDÉ D'INHIBITION DE SIGNALISATION PAR L'INTERMÉDIAIRE D'ErbB2, INHIBITEUR DE SIGNALISATION DESTINÉ À ÊTRE UTILISÉ DANS CE PROCÉDÉ, ET UTILISATION DE L'INHIBITEUR DE SIGNALISATION
JOP20190083A1 (ar) 2008-06-04 2017-06-16 Amgen Inc بولي ببتيدات اندماجية طافرة لـfgf21 واستخداماتها
JP5878757B2 (ja) 2008-10-10 2016-03-08 アムジエン・インコーポレーテツド Ｆｇｆ２１変異体およびその使用
BRPI1011404B1 (pt) 2009-05-05 2022-05-03 Amgen Inc Polipeptídeos mutantes fgf21, polipeptídeo de fusão, multímero, composição farmacêutica, ácido nucleico isolado, vetor e célula hospedeira
JP2012525847A (ja) 2009-05-05 2012-10-25 アムジエン・インコーポレーテツド Ｆｇｆ２１変異体およびその使用
US8324160B2 (en) * 2009-06-17 2012-12-04 Amgen Inc. Chimeric polypeptides and uses thereof
EP2483406A2 (fr) 2009-09-30 2012-08-08 President and Fellows of Harvard College Procédés de modulation de l'autophagie par la modulation de produits géniques inhibant l'autophagie
JP2013512672A (ja) * 2009-12-02 2013-04-18 アムジエン・インコーポレーテツド ヒトＦＧＦＲ１ｃ、ヒトβ−クロト−、ならびにヒトＦＧＦＲ１ｃおよびヒトβ−クロト−の両方に結合する結合タンパク質
UA109888C2 (uk) 2009-12-07 2015-10-26 ІЗОЛЬОВАНЕ АНТИТІЛО АБО ЙОГО ФРАГМЕНТ, ЩО ЗВ'ЯЗУЄТЬСЯ З β-КЛОТО, РЕЦЕПТОРАМИ FGF І ЇХНІМИ КОМПЛЕКСАМИ
MX2012011986A (es) 2010-04-15 2013-03-05 Amgen Inc RECEPTOR FGF HUMANO Y PROTEINAS ENLAZADAS A ß-KLOTHO.
WO2012075206A1 (fr) * 2010-12-01 2012-06-07 The Regents Of The University Of Colorado, A Body Corporate Peptides deutérés
CN105273063B (zh) * 2015-11-30 2018-06-12 中国人民解放军第三军医大学第三附属医院 调节fgfr1活性的多肽及其应用
CN112466390B (zh) * 2020-12-19 2023-11-14 广东众源药业有限公司 可用于纯化人免疫球蛋白g的疏水性环状肽配基

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5229501A (en) * 1991-01-11 1993-07-20 Chiron Corporation Expression and use of human fibroblast growth factor receptor
US5474914A (en) * 1992-07-29 1995-12-12 Chiron Corporation Method of producing secreted CMV glycoprotein H

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
C DHALLUIN ET AL.: "Structural basis of SNT PTB domain interaction with distinct neurotrophic receptors", MOLECULAR CELL., vol. 6, October 2000 (2000-10-01), CELL PRESS, CAMBRIDGE, MA., US, pages 921 - 929, XP002172111, ISSN: 1097-2765 *
DATABASE CHEMABS [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; DHALLUIN, CHRISTOPHE ET AL: "Letter to the Editor: 1H, 13C and 15N resonance assignments of the SNT PT domain in complex with FGFR1 peptide", XP002172113, retrieved from STN Database accession no. 134:126142 CA *
H XU ET AL.: "Novel recognition motif on fibroblast growth factor receptor mediates direct association and activation of SNT adapter proteins", JOURNAL OF BIOLOGICAL CHEMISTRY., vol. 273, no. 27, 17 July 1998 (1998-07-17), AMERICAN SOCIETY OF BIOLOGICAL CHEMISTS, BALTIMORE, MD., US, pages 17987 - 17990, XP002172110, ISSN: 0021-9258 *
H-Y LIN ET AL.: "Identification of the cytoplasmic regions offibroblast growth factor (FGF) receptor1 which play important roles in induction of neurite outgrowth in PC12 cells by FGF-1", MOLECULAR AND CELLULAR BIOLOGY., vol. 18, no. 7, July 1998 (1998-07-01), AMERICAN SOCIETY FOR MICROBIOLOGY, WASHINGTON., US, pages 3762 - 3770, XP002172112, ISSN: 0270-7306 *
J. BIOMOL. NMR (2000), 18(4), 371-372, 2000 *

Also Published As

Publication number Publication date
US7108984B2 (en) 2006-09-19
US20060019296A1 (en) 2006-01-26
AU2001226387A1 (en) 2001-07-24
CA2397135A1 (fr) 2001-07-19
US7645857B2 (en) 2010-01-12
US20030040612A1 (en) 2003-02-27
WO2001051521A2 (fr) 2001-07-19
EP1246926A2 (fr) 2002-10-09

Similar Documents

Publication Publication Date Title
WO2001051521A3 (fr) Procedes d'identification de modulateurs du recepteur fgf
WO2005077091A8 (fr) Compositions de nicotinamide riboside kinase et procedes d'utilisation
WO2006086739A8 (fr) Molecules interferentes d'acide ribonucleique et procedes de generation de sequences de precurseur/sequences matures et de determination de sites cibles
WO2007062037A3 (fr) Compositions et methodes de production de molecules hybrides de fixant a des antigenes, et leurs utilisations
WO2005050171A3 (fr) Procedes et compositions se rapportant a des reactifs centraux simples
WO2006020947A9 (fr) Colorants et conjugues fluorescents phosphonate
AU2001284308A1 (en) Method of nucleic acid typing or sequencing
SI1523496T1 (sl) Rekombinantno proizvajanje zmesi protiteles
AU2003265637A1 (en) Nucleotide sequences encoding cry1bb proteins for enhanced expression in plants
EP4249602A3 (fr) Procédé de préparation de bibliothèques de polynucléotides modèles
AU2002339458A1 (en) Sirna knockout assay method and constructs
WO2005026730A3 (fr) Essais d'analyse d'activite et de liaison multiplex
WO2005116252A3 (fr) Procede d'evaluation de sequences de ribonucleotides
WO2005067648A3 (fr) Profilage spatial multiplex d'expression genique
WO2004029283A3 (fr) Sondes d'adn subtelomeriques et leur procede de production
WO2003012099A1 (fr) Synthase de chondroitine
WO2006054297A3 (fr) Nouvelles sequences nucleotidiques et d'acides amines, et leurs dosages et leurs procedes d'utilisation pour le diagnostic
AU2001238064A1 (en) 18477, a human protein kinase and uses therefor
WO2000065062A3 (fr) Sequence genomique et polypeptides de pyrococcus abissy, leurs fragments et leurs utilisations
WO2001088090A3 (fr) Cng3b: nouveau canal cationique dependant de nucleotides cycliques
AU2003266197A1 (en) Method for the detection of nucleic acid sequences by means of crackable probe molecules
WO2001036463A3 (fr) Genes de mammifere, reactifs associes et procedes
WO2005017112A3 (fr) Methodes d'inhibition de la croissance cancereuse par liaison a des recepteurs nucleaires
WO2001036478A3 (fr) Methodes et compositions se rapportant a des polypeptides et a des polynucleotides similaires au facteur bactericide augmentant la permeabilite
WO2000058472A8 (fr) Adn isole codant pour des regulateurs cullin roc1 et roc2, proteines isolees codees par ledit adn. procedes d'utilisation associes

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A2

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BY BZ CA CH CN CR CU CZ DE DK DM DZ EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NO NZ PL PT RO RU SD SE SG SI SK SL TJ TM TR TT TZ UA UG US UZ VN YU ZA ZW

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): GH GM KE LS MW MZ SD SL SZ TZ UG ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE TR BF BJ CF CG CI CM GA GN GW ML MR NE SN TD TG

121 Ep: the epo has been informed by wipo that ep was designated in this application
DFPE Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101)
AK Designated states

Kind code of ref document: A3

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BY BZ CA CH CN CR CU CZ DE DK DM DZ EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NO NZ PL PT RO RU SD SE SG SI SK SL TJ TM TR TT TZ UA UG US UZ VN YU ZA ZW

AL Designated countries for regional patents

Kind code of ref document: A3

Designated state(s): GH GM KE LS MW MZ SD SL SZ TZ UG ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE TR BF BJ CF CG CI CM GA GN GW ML MR NE SN TD TG

WWE Wipo information: entry into national phase

Ref document number: 2397135

Country of ref document: CA

WWE Wipo information: entry into national phase

Ref document number: 2001900987

Country of ref document: EP

WWP Wipo information: published in national office

Ref document number: 2001900987

Country of ref document: EP

REG Reference to national code

Ref country code: DE

Ref legal event code: 8642

NENP Non-entry into the national phase

Ref country code: JP

WWW Wipo information: withdrawn in national office

Ref document number: 2001900987

Country of ref document: EP