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WO2001049361A1 - Raccord pour flacon - Google Patents

Raccord pour flacon Download PDF

Info

Publication number
WO2001049361A1
WO2001049361A1 PCT/US2001/000373 US0100373W WO0149361A1 WO 2001049361 A1 WO2001049361 A1 WO 2001049361A1 US 0100373 W US0100373 W US 0100373W WO 0149361 A1 WO0149361 A1 WO 0149361A1
Authority
WO
WIPO (PCT)
Prior art keywords
vial
receptacle
vials
adapter ring
loading unit
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2001/000373
Other languages
English (en)
Inventor
Clifford L. Emmons
Donald S. Wilson
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
United States Surgical Corp
Original Assignee
United States Surgical Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by United States Surgical Corp filed Critical United States Surgical Corp
Priority to AU27654/01A priority Critical patent/AU2765401A/en
Publication of WO2001049361A1 publication Critical patent/WO2001049361A1/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2096—Combination of a vial and a syringe for transferring or mixing their contents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2089—Containers or vials which are to be joined to each other in order to mix their contents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2003—Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
    • A61J1/2006—Piercing means
    • A61J1/201—Piercing means having one piercing end
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2003—Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
    • A61J1/2006—Piercing means
    • A61J1/2013—Piercing means having two piercing ends
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2003—Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
    • A61J1/2048—Connecting means
    • A61J1/2058—Connecting means having multiple connecting ports
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2003—Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
    • A61J1/2048—Connecting means
    • A61J1/2065—Connecting means having aligning and guiding means

Definitions

  • This disclosure relates to a vial coupler apparatus that mechanically mates and fluidly connects vials with a multiple syringe apparatus for the dispensing of a protein solution.
  • Different standard sized vials may be emplaced within the vial coupler for preparing, mixing, and transferring independent solutions, such as protein solutions, to the multiple syringe apparatus.
  • Fibrin is a biological adhesive formed by mixing two protein components, namely, fibrinogen and thrombin.
  • protein component is derived from human plasma and is subjected to virus elimination procedures. "The components are typically individually dehydrated and stored in separate standardized vials as sterile freeze-dried powders.
  • mixture and dispenser assembly for mixing a first protein component with sterile water to form a first protein solution and for dispensing the firsfprotein solution.
  • the first protein solution forms
  • a biological adhesive when intermixed with a second protein solution on an application site.
  • the second protein solution is preferably mixed and dispensed by a similar fibrin mixture and dispenser assembly.
  • the two fibrin mixture and dispenser assemblies can be housed within a single housing.
  • This PCT application is hereby incorporated into this application by reference.
  • International application No. PCT/US98/27079 to Roby et al. describes two applicator embodiments for dispensing a first and a second protein solution to form a biological adhesive.
  • the protein solutions can be deflected during dispensing in order for the adhesive to cover a broad area.
  • the applicator includes a housing configured to receive a plurality of reservoirs each having a sealable opening therein; a conduit assembly having a pair of conduits in respective fluid communication with separate reservoirs; an activator assembly provided on the housing having an activator moveable from a first position to a second position to pressurize each of the plurality of reservoirs to dispense the biological adhesive
  • a vial coupler having at least one adapter ring is provided for the transfer of fluids between fluid containment devices.
  • the vial coupler provides for the sterile transfer
  • the first set of two vials are then withdrawn with their adapter rings.
  • the adapter rings engage
  • the vial coupler then can accommodate and provide for the transfer of the fluid
  • the biological adhesives and fluid are mixed in the second set of vials and then
  • the first and second receptacles of the vial coupler are divided by a septum having sharps on the vial side and fluid outlets on the loading unit side.
  • FIG. 1 is an enlarged perspective view of one embodiment of the vial coupler
  • FIG. 2 is an enlarged cross sectional view of one embodiment of the vial coupler
  • FIG. 3 is an enlarged elevated perspective view of an adapter ring
  • FIG. 4A is an enlarged elevated front perspective view of the loading unit in an extended position
  • FIG. 4B is an enlarged elevated perspective view of one embodiment of the vial coupler.
  • FIG. 5 is an enlarged perspective view with a partial cross section of one
  • vial coupler with one second standard sized vial emplaced in a receptacle, another second standard sized vial about to be emplaced in receptacle, and a loading unit installed.
  • a vial coupler 100 that includes a housing or
  • Housing 125 composed of a first side 110 and a second side 120. Housing 125 is preferably made of
  • Vial coupler 100 contains a first portion with a
  • housing 125 has a septum 150 that divides the first
  • Each receptacle 140 is configured with an adapter ring 160 and a sharp 152 that is positioned to provide a fluid connection through septum 150.
  • a pair of opposing adapter ring release levers 122 are on first side 110 and second side 120.
  • a loading unit release lever 130 is located on the lower portion of vial coupler 100, adjacent receptacle 170.
  • Housing 125 also defines four sets of through holes 124 for assembling first side 110 and second side 120 together with mechanical devices 126 in common usage such
  • housing 125 and septum 150 configurations and means of assembly are envisioned to include a single monolithic structure, bonded materials, or
  • a first set of two standard sized single dose vials 190 are sealed by a cap 192 that is approximately 0.68 inch in diameter with a center of resilient penetrable material 194.
  • cap 192 As cap 192 is emplaced into receptacle 140, it begins to engage adapter ring 160 that is positioned approximately at the base of receptacle 140 and aligned by at least one tab 162.
  • sharp 152 When cap 192 is fully seated into adapter ring 160 and becomes fixedly engaged therewith, sharp 152 has penetrated through penetrable material 194 and fluid communication is established between sharp 152 and vial 190.
  • first set of vials 190 as single dose vials with a cap 192 of an approximate size
  • the vial coupler 100 receptacle and adapter ring 160 are capable of being sized to interface with a broad range of standard and non-standard container sizes to support a variety of functions and the applications
  • adapter ring 160 is made of medical grade plastics and has a circular band shape. In the present configuration, two opposing positioning
  • Adapter ring 160 defines a hole 164 with a central longitudinal axis 165 which is aligned with the emplacement of cap 192.
  • Lateral axis 167 is perpendicular to lateral axis 166. Axes 166 and
  • Adapter ring 160 has at least one slot 168 and at least one partial cut out 170 which provides, strain relief and results in additional
  • Adapter ring 160 defines a lip 172 with two inward directing
  • tabs 174 are positioned at
  • loading unit 50 contains a reservoir assembly 52 and a dispensing assembly 54 that provides the pressure required for application.
  • dispensing assembly 54 defines a hole 58 that provides a locking mechanism with vial coupler
  • Each loading device 55 contains a cone shaped tip 60 with a resilient coating 62 on the surface.
  • Each cone shaped tip 60 defines a circular, hole 57 that is connected to reservoir
  • Loading unit 50 is made of a
  • Loading unit 50 preferably contains two dispenser devices 55, but can be configured with any number of dispenser devices 55 or different sizes of dispenser devices to engage with the at least two receptacles 180 of vial coupler 100.
  • the second portion of vial coupler 100 contains the set of at least two receptacles 180 for interfacing with at least two loading devices 55 and front 56 of loading unit 50.
  • the second portion contains two receptacles 180 with two fluid outlets 154 that are at the opposing ends of sharps 152 (See FIG. 5).
  • Septum 150 provides a conical receptacle 156 for engaging cone 60 of loading device 55.
  • Circular hole 57 at the end of each cone 60 of loading device 55, is positioned to make a seal around and establish a fluid connection with fluid outlet 154.
  • Housing 125 contains loading unit release lever 130 which is connected to a tab 112 that contains a lip 114. As front 56 of the loading unit 50 is emplaced into receptacle 180, lip 114 of tab 112 is positioned to pass through hole 58 and lock with front 56 of dispenser assembly 54. This locking action provides the force necessary to sustain a seal between fluid outlet 154 and hole 57.
  • vials 190 can be removed from vial coupler 100.
  • Vials 190 can be pulled directly from their emplacement without any additional steps. The force to remove vial 190, now with adapter ring 160 attached, may be reduced by simultaneously pressing inwardly adapter ring release lever 122. Forcing release levers 122 together simultaneously compresses adapter ring 160 along axis 167, at the point where retaining tabs 174 are located, and enhances the retentive ability of adapter ring 160 to lock with cap 190 as it is being withdrawn from vial coupler 100. Vial 190 with adapter ring 160 can then be discarded.
  • Second standard sized vials 200 contain second components, such as fibrinogen and thrombin as sterile freeze-dried powders.
  • a cap 202 approximately 0.82 inch in diameter seals vial 200 and has a resilient penetrable material 204 in its center that can be pierced by sharp 152.
  • second standard sized vial 200 is precluded from engaging sharp 152 because the diameter of cap 202 exceeds the diameter of adapter ring 160 sufficiently that it blocks any further movement into receptacle 140.
  • second standard sized vial 200 with larger diameter cap 202 can now be fully emplaced into receptacle
  • vials 200 of fibrinogen and thrombin Once the sterile water is sufficiently mixed within the individual second vials 200 of fibrinogen and thrombin, they can then be transferred through vial coupler 100 into loading unit 50 for dispensing as protein solutions. Loading unit 50 is then
  • Dispensing is accomplished by forwarding the reservoir assembly 52 relative to dispensing assembly 54 to force the simultaneous dispensing of the two protein solutions.

Landscapes

  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)

Abstract

L'invention concerne un raccord (100) conçu pour loger et pour fournir un élément de connexion destiné au transfert stérile de fluide entre différents flacons (190, 200) de taille standard et un appareil de chargement (50). Le mode de réalisation de la présente invention concerne des récipients (140) destinés à deux flacons (190, 200), chaque récipient (140) contenant un anneau de fixation (160) qui vient se fixer sur le bouchon (192) d'un premier flacon (190) de taille standard, mais empêche la mise en place prématurée d'un bouchon (202) de plus grand diamètre d'un second flacon (200) de taille standard. Le premier flacon (190) de taille standard contient un premier composant alors que le second flacon (200) de taille standard contient un second composant. Une fois que le premier composant est transféré du premier flacon (190) standard à travers le raccord (100) vers l'unité de chargement (50), le premier flacon (190) de taille standard et les anneaux de fixation (192) sont retirés du raccord (100). Les récipients (140) du raccord (100) peuvent alors recevoir les bouchons (202) de diamètre plus large des seconds flacons (200) de taille standard. Le premier composant est alors transféré depuis l'unité de chargement (50) à travers le raccord (100) vers le second flacon (200) de taille standard. Les solutions du premier et du second composant standard sont alors transférées à travers le raccord (100) dans l'unité de chargement (50) et ultérieurement distribuées depuis celui-ci.
PCT/US2001/000373 2000-01-05 2001-01-05 Raccord pour flacon Ceased WO2001049361A1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU27654/01A AU2765401A (en) 2000-01-05 2001-01-05 Vial coupler

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US17463700P 2000-01-05 2000-01-05
US60/174,637 2000-01-05

Publications (1)

Publication Number Publication Date
WO2001049361A1 true WO2001049361A1 (fr) 2001-07-12

Family

ID=22636911

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2001/000373 Ceased WO2001049361A1 (fr) 2000-01-05 2001-01-05 Raccord pour flacon

Country Status (2)

Country Link
AU (1) AU2765401A (fr)
WO (1) WO2001049361A1 (fr)

Cited By (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6471670B1 (en) * 1998-10-05 2002-10-29 Karl Enrenfels Fibrin sealant applicator system
WO2005011781A1 (fr) * 2003-07-22 2005-02-10 Barry Peter Liversidge Systeme d'aiguille medicale
JP2009153720A (ja) * 2007-12-26 2009-07-16 Terumo Corp 接続具
US7780958B2 (en) 2000-08-25 2010-08-24 Contura Sa Polyacrylamide hydrogel for the treatment of incontinence and vesicouretal reflux
WO2010120953A3 (fr) * 2009-04-14 2011-03-03 Yukon Medical, Llc Dispositif de transfert de fluide
USD655017S1 (en) 2010-06-17 2012-02-28 Yukon Medical, Llc Shroud
EP2462913A1 (fr) * 2010-12-10 2012-06-13 Fresenius Medical Care Deutschland GmbH Insert et flacon pour l'infusion de liquides
USD681230S1 (en) 2011-09-08 2013-04-30 Yukon Medical, Llc Shroud
US8667996B2 (en) 2009-05-04 2014-03-11 Valeritas, Inc. Fluid transfer device
CN104434519A (zh) * 2013-09-23 2015-03-25 贝克顿迪金森法国公司 用来将适配器与医用容器相联接的组件
WO2016041948A1 (fr) * 2014-09-18 2016-03-24 Fresenius Medical Care Deutschland Gmbh Dispositif pour relier une bouteille perforée à un récipient ou à un conduit de fluide et pour transférer le contenu de la bouteille perforée dans un récipient ou un conduit de fluide, ainsi que procédé associé et utilisation d'un tel dispositif
USD769444S1 (en) 2012-06-28 2016-10-18 Yukon Medical, Llc Adapter device
DE102015218723A1 (de) 2015-09-29 2017-03-30 Transcoject Gmbh Füllhilfe
US11660255B1 (en) 2019-12-23 2023-05-30 Marco Navarro Liquid medication dispenser
WO2023187530A1 (fr) * 2022-03-31 2023-10-05 Ethicon, Inc. Systèmes, dispositifs et procédés pour reconstituer des poudres thérapeutiques, mélanger des solutions précurseurs et exprimer des colles pour réguler le saignement et sceller des fuites de fluide et d'air
US12114843B2 (en) 2022-03-31 2024-10-15 Ethicon, Inc. Sealant applicators having mixing and spraying assemblies with malleable sections and spray tips having reduced dimensions

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5304165A (en) * 1991-12-09 1994-04-19 Habley Medical Technology Corporation Syringe-filling medication dispenser
US5466220A (en) * 1994-03-08 1995-11-14 Bioject, Inc. Drug vial mixing and transfer device
US5562616A (en) * 1995-03-01 1996-10-08 Habley Medical Technology Corporation Semi-automatic reconstituting system for binary oncolytic pharmaceuticals

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5304165A (en) * 1991-12-09 1994-04-19 Habley Medical Technology Corporation Syringe-filling medication dispenser
US5466220A (en) * 1994-03-08 1995-11-14 Bioject, Inc. Drug vial mixing and transfer device
US5562616A (en) * 1995-03-01 1996-10-08 Habley Medical Technology Corporation Semi-automatic reconstituting system for binary oncolytic pharmaceuticals

Cited By (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6471670B1 (en) * 1998-10-05 2002-10-29 Karl Enrenfels Fibrin sealant applicator system
US7780958B2 (en) 2000-08-25 2010-08-24 Contura Sa Polyacrylamide hydrogel for the treatment of incontinence and vesicouretal reflux
WO2005011781A1 (fr) * 2003-07-22 2005-02-10 Barry Peter Liversidge Systeme d'aiguille medicale
JP2009153720A (ja) * 2007-12-26 2009-07-16 Terumo Corp 接続具
US9345640B2 (en) 2009-04-14 2016-05-24 Yukon Medical, Llc Fluid transfer device
WO2010120953A3 (fr) * 2009-04-14 2011-03-03 Yukon Medical, Llc Dispositif de transfert de fluide
US9833383B2 (en) 2009-05-04 2017-12-05 Valeritas, Inc. Fluid transfer device
US9376224B2 (en) 2009-05-04 2016-06-28 Valeritas, Inc. Fluid transfer device
US8667996B2 (en) 2009-05-04 2014-03-11 Valeritas, Inc. Fluid transfer device
USD655017S1 (en) 2010-06-17 2012-02-28 Yukon Medical, Llc Shroud
EP2462913A1 (fr) * 2010-12-10 2012-06-13 Fresenius Medical Care Deutschland GmbH Insert et flacon pour l'infusion de liquides
EA025310B1 (ru) * 2010-12-10 2016-12-30 Фрезениус Медикал Кэа Дойчланд Гмбх Вводное устройство и флакон для хранения и доставки жидкости
WO2012076386A1 (fr) * 2010-12-10 2012-06-14 Fresenius Medical Care Deutschland Gmbh Insert et flacon pour la perfusion de liquides
US9539387B2 (en) 2010-12-10 2017-01-10 Fresenius Medical Care Deutschalnd Gmbh Insert and vial for the infusion of liquids
USD681230S1 (en) 2011-09-08 2013-04-30 Yukon Medical, Llc Shroud
USD769444S1 (en) 2012-06-28 2016-10-18 Yukon Medical, Llc Adapter device
KR20160061333A (ko) * 2013-09-23 2016-05-31 벡톤 디킨슨 프랑스 어댑터를 의료 용기와 결합시키기 위한 조립체
CN104434519A (zh) * 2013-09-23 2015-03-25 贝克顿迪金森法国公司 用来将适配器与医用容器相联接的组件
KR102274243B1 (ko) 2013-09-23 2021-07-07 벡톤 디킨슨 프랑스 어댑터를 의료 용기와 결합시키기 위한 조립체
WO2016041948A1 (fr) * 2014-09-18 2016-03-24 Fresenius Medical Care Deutschland Gmbh Dispositif pour relier une bouteille perforée à un récipient ou à un conduit de fluide et pour transférer le contenu de la bouteille perforée dans un récipient ou un conduit de fluide, ainsi que procédé associé et utilisation d'un tel dispositif
US10441711B2 (en) 2014-09-18 2019-10-15 Fresenius Medical Care Deutschland Gmbh Device for connecting a vial to a container or to a fluid line and transferring the contents of a vial to a container or a fluid line as well as a method for doing so and use of such a device
DE102015218723A1 (de) 2015-09-29 2017-03-30 Transcoject Gmbh Füllhilfe
US11660255B1 (en) 2019-12-23 2023-05-30 Marco Navarro Liquid medication dispenser
WO2023187530A1 (fr) * 2022-03-31 2023-10-05 Ethicon, Inc. Systèmes, dispositifs et procédés pour reconstituer des poudres thérapeutiques, mélanger des solutions précurseurs et exprimer des colles pour réguler le saignement et sceller des fuites de fluide et d'air
US12114843B2 (en) 2022-03-31 2024-10-15 Ethicon, Inc. Sealant applicators having mixing and spraying assemblies with malleable sections and spray tips having reduced dimensions
US12220118B2 (en) 2022-03-31 2025-02-11 Ethicon, Inc. Systems, devices and methods for reconstituting therapeutic powders, mixing precursor solutions, and expressing sealants for controlling bleeding and sealing fluid and air leaks

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Publication number Publication date
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