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WO2001043870A3 - Column and row addressable high density biochip array - Google Patents

Column and row addressable high density biochip array Download PDF

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Publication number
WO2001043870A3
WO2001043870A3 PCT/US2000/034222 US0034222W WO0143870A3 WO 2001043870 A3 WO2001043870 A3 WO 2001043870A3 US 0034222 W US0034222 W US 0034222W WO 0143870 A3 WO0143870 A3 WO 0143870A3
Authority
WO
WIPO (PCT)
Prior art keywords
column
array
high density
biochip array
density biochip
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2000/034222
Other languages
French (fr)
Other versions
WO2001043870A2 (en
Inventor
Song Shi
Peiming Zhang
George N Maracas
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Motorola Solutions Inc
Original Assignee
Motorola Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Motorola Inc filed Critical Motorola Inc
Priority to AU21089/01A priority Critical patent/AU2108901A/en
Priority to EP00984476A priority patent/EP1251955A2/en
Priority to JP2001544994A priority patent/JP2003517149A/en
Priority to CA002393766A priority patent/CA2393766A1/en
Publication of WO2001043870A2 publication Critical patent/WO2001043870A2/en
Publication of WO2001043870A3 publication Critical patent/WO2001043870A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y30/00—Nanotechnology for materials or surface science, e.g. nanocomposites
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J19/0046—Sequential or parallel reactions, e.g. for the synthesis of polypeptides or polynucleotides; Apparatus and devices for combinatorial chemistry or for making molecular arrays
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/28—Electrolytic cell components
    • G01N27/30—Electrodes, e.g. test electrodes; Half-cells
    • G01N27/327—Biochemical electrodes, e.g. electrical or mechanical details for in vitro measurements
    • G01N27/3275—Sensing specific biomolecules, e.g. nucleic acid strands, based on an electrode surface reaction
    • G01N27/3276—Sensing specific biomolecules, e.g. nucleic acid strands, based on an electrode surface reaction being a hybridisation with immobilised receptors
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54366—Apparatus specially adapted for solid-phase testing
    • G01N33/54373—Apparatus specially adapted for solid-phase testing involving physiochemical end-point determination, e.g. wave-guides, FETS, gratings
    • G01N33/5438—Electrodes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00279—Features relating to reactor vessels
    • B01J2219/00306—Reactor vessels in a multiple arrangement
    • B01J2219/00313—Reactor vessels in a multiple arrangement the reactor vessels being formed by arrays of wells in blocks
    • B01J2219/00315—Microtiter plates
    • B01J2219/00317—Microwell devices, i.e. having large numbers of wells
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00497—Features relating to the solid phase supports
    • B01J2219/00511—Walls of reactor vessels
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00653—Making arrays on substantially continuous surfaces the compounds being bound to electrodes embedded in or on the solid supports
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00659—Two-dimensional arrays
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00677—Ex-situ synthesis followed by deposition on the substrate
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/0068—Means for controlling the apparatus of the process
    • B01J2219/00698—Measurement and control of process parameters
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/0068—Means for controlling the apparatus of the process
    • B01J2219/00702—Processes involving means for analysing and characterising the products
    • B01J2219/00704—Processes involving means for analysing and characterising the products integrated with the reactor apparatus
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00718—Type of compounds synthesised
    • B01J2219/0072—Organic compounds

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Physics & Mathematics (AREA)
  • General Physics & Mathematics (AREA)
  • Organic Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Nanotechnology (AREA)
  • Pathology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Biotechnology (AREA)
  • Materials Engineering (AREA)
  • Cell Biology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Composite Materials (AREA)
  • Condensed Matter Physics & Semiconductors (AREA)
  • Microbiology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Electrochemistry (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Investigating Or Analyzing Materials By The Use Of Electric Means (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)

Abstract

The present invention provides a method and apparatus (9) comprising a platform for a column-and-row-addressable high-density biochip array. The apparatus (9) can be used as a high-density biochip array for electronic or electrochemical detection of molecular interactions between probe molecules bound to defined regions of the array and target molecules exposed to the array.
PCT/US2000/034222 1999-12-15 2000-12-14 Column and row addressable high density biochip array Ceased WO2001043870A2 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
AU21089/01A AU2108901A (en) 1999-12-15 2000-12-14 Column and row addressable high density biochip array
EP00984476A EP1251955A2 (en) 1999-12-15 2000-12-14 Column and row addressable high density biochip array
JP2001544994A JP2003517149A (en) 1999-12-15 2000-12-14 High density biochip array with row and column addressability
CA002393766A CA2393766A1 (en) 1999-12-15 2000-12-14 Column and row addressable high density biochip array

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US46450099A 1999-12-15 1999-12-15
US09/464,500 1999-12-15

Publications (2)

Publication Number Publication Date
WO2001043870A2 WO2001043870A2 (en) 2001-06-21
WO2001043870A3 true WO2001043870A3 (en) 2002-02-21

Family

ID=23844193

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2000/034222 Ceased WO2001043870A2 (en) 1999-12-15 2000-12-14 Column and row addressable high density biochip array

Country Status (5)

Country Link
EP (1) EP1251955A2 (en)
JP (1) JP2003517149A (en)
AU (1) AU2108901A (en)
CA (1) CA2393766A1 (en)
WO (1) WO2001043870A2 (en)

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US6824669B1 (en) * 2000-02-17 2004-11-30 Motorola, Inc. Protein and peptide sensors using electrical detection methods
US6824974B2 (en) 2001-06-11 2004-11-30 Genorx, Inc. Electronic detection of biological molecules using thin layers
AU2002363627A1 (en) * 2001-06-11 2003-05-26 Genorx, Inc. Electronic detection of biological molecules using thin layers
GB2377026A (en) * 2001-06-29 2002-12-31 Imp College Innovations Ltd Electrically addressable electrochemical cell array
DE10145700A1 (en) * 2001-09-17 2003-04-10 Infineon Technologies Ag Biochip arrangement, sensor arrangement and method for operating a biochip arrangement
US7074519B2 (en) * 2001-10-26 2006-07-11 The Regents Of The University Of California Molehole embedded 3-D crossbar architecture used in electrochemical molecular memory device
DE10211358B4 (en) * 2002-03-14 2006-10-26 Siemens Ag Vertical impedance sensor assembly and method of fabricating a vertical impedance sensor assembly
FR2839783B1 (en) * 2002-05-17 2004-08-06 Apibio NEW LAYOUT OF BIOCHIP LINK SITES
FR2840072B1 (en) * 2002-05-24 2004-08-06 Apibio BIOPUCE WITH IMPROVED ORGANIZATION
WO2004001405A1 (en) * 2002-06-24 2003-12-31 Infineon Technologies Ag Biosensor array and method for operating a biosensor array
DE10228125A1 (en) * 2002-06-24 2004-01-22 Infineon Technologies Ag Biosensor array comprising a substrate on which biosensors are mounted which have two connectors, one of which is connected to control lead while other is connected to detector lead
DE10228124A1 (en) * 2002-06-24 2004-01-29 Infineon Technologies Ag Biosensor array comprising a substrate on which biosensors are mounted which have two connectors, one of which is connected to control lead while other is connected to detector lead
US6962822B2 (en) 2002-08-07 2005-11-08 International Business Machines Corporation Discrete nano-textured structures in biomolecular arrays, and method of use
EP1548437A4 (en) * 2002-09-17 2006-06-07 Olympus Corp Method and apparatus for arranging liquid reaction components on substrate surface for detecting target substance by reaction among plural reaction components on substrate and article utilized in the method
DE10257604A1 (en) * 2002-12-09 2004-07-22 Axaron Bioscience Ag Capacitive detection of bound molecules
US7138121B2 (en) 2003-01-23 2006-11-21 Spangler Brenda D Biosensors utilizing dendrimer-immobilized ligands and there use thereof
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WO2005037425A1 (en) * 2003-10-15 2005-04-28 Oxford Gene Technology Ip Limited Electrochemical treatment of substrates
KR101165860B1 (en) 2003-10-16 2012-07-13 하이 캉 라이프 코포레이션 리미티드 Apparatus and methods for detecting nucleic acid in biological samples
US7390622B2 (en) 2003-10-16 2008-06-24 Hai Kang Life Corporation Limited Apparatus and methods for detecting nucleic acid in biological samples
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Also Published As

Publication number Publication date
JP2003517149A (en) 2003-05-20
AU2108901A (en) 2001-06-25
CA2393766A1 (en) 2001-06-21
EP1251955A2 (en) 2002-10-30
WO2001043870A2 (en) 2001-06-21

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