[go: up one dir, main page]

WO2001041534A3 - Promedicaments de phosphate pseudomycine - Google Patents

Promedicaments de phosphate pseudomycine Download PDF

Info

Publication number
WO2001041534A3
WO2001041534A3 PCT/US2000/030167 US0030167W WO0141534A3 WO 2001041534 A3 WO2001041534 A3 WO 2001041534A3 US 0030167 W US0030167 W US 0030167W WO 0141534 A3 WO0141534 A3 WO 0141534A3
Authority
WO
WIPO (PCT)
Prior art keywords
pseudomycin
phosphate
phosphate prodrugs
prodrug
methyleneoxycarbamate
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2000/030167
Other languages
English (en)
Other versions
WO2001041534A2 (fr
Inventor
Shu Hui Chen
Xicheng David Sun
Yanzhi Zhang
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eli Lilly and Co
Original Assignee
Eli Lilly and Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eli Lilly and Co filed Critical Eli Lilly and Co
Priority to JP2001542721A priority Critical patent/JP2003515610A/ja
Priority to CA002396513A priority patent/CA2396513A1/fr
Priority to BR0016328-7A priority patent/BR0016328A/pt
Priority to AU30718/01A priority patent/AU3071801A/en
Priority to MXPA02005791A priority patent/MXPA02005791A/es
Publication of WO2001041534A2 publication Critical patent/WO2001041534A2/fr
Publication of WO2001041534A3 publication Critical patent/WO2001041534A3/fr
Priority to NO20022798A priority patent/NO20022798L/no
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)

Abstract

La présente invention concerne un promédicament de pseudomycine, représenté par la structure (A), dans laquelle R1 est une liaison benzyloxycarbamate de phosphate ou méthylèneoxycarbamate de phosphate. Ces promédicaments de phosphate présentent une activité antifongique, avec moins d'effets indésirables que le composé de pseudomycine parent.
PCT/US2000/030167 1999-12-13 2000-11-29 Promedicaments de phosphate pseudomycine Ceased WO2001041534A2 (fr)

Priority Applications (6)

Application Number Priority Date Filing Date Title
JP2001542721A JP2003515610A (ja) 1999-12-13 2000-11-29 シュードマイシンホスフェートプロドラッグ
CA002396513A CA2396513A1 (fr) 1999-12-13 2000-11-29 Promedicaments de phosphate pseudomycine
BR0016328-7A BR0016328A (pt) 1999-12-13 2000-11-29 Pró-drogas de fosfato de pseudomicina
AU30718/01A AU3071801A (en) 1999-12-13 2000-11-29 Pseudomycin phosphate prodrugs
MXPA02005791A MXPA02005791A (es) 1999-12-13 2000-11-29 Profarmacos de fosfato de pseudomicina.
NO20022798A NO20022798L (no) 1999-12-13 2002-06-12 Pseudomycinfosfatprodrug

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US17046699P 1999-12-13 1999-12-13
US60/170,466 1999-12-13

Publications (2)

Publication Number Publication Date
WO2001041534A2 WO2001041534A2 (fr) 2001-06-14
WO2001041534A3 true WO2001041534A3 (fr) 2001-11-22

Family

ID=22619957

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2000/030167 Ceased WO2001041534A2 (fr) 1999-12-13 2000-11-29 Promedicaments de phosphate pseudomycine

Country Status (7)

Country Link
JP (1) JP2003515610A (fr)
AU (1) AU3071801A (fr)
BR (1) BR0016328A (fr)
CA (1) CA2396513A1 (fr)
MX (1) MXPA02005791A (fr)
NO (1) NO20022798L (fr)
WO (1) WO2001041534A2 (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11555019B2 (en) 2019-07-10 2023-01-17 Cybrexa 3, Inc. Peptide conjugates of microtubule-targeting agents as therapeutics

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1191269C (zh) * 1999-04-15 2005-03-02 伊莱利利公司 假单胞霉素的天然产品
PE20211305A1 (es) 2018-01-05 2021-07-20 Cybrexa 1 Inc Compuestos, composiciones y metodos para tratar enfermedades que involucren tejidos con enfermedades acidas o hipoxicas
CR20220058A (es) 2019-07-10 2022-07-19 Cybrexa 2 Inc Conjugados peptídicos de citotoxinas como terapéuticos

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5837685A (en) * 1992-11-30 1998-11-17 Research And Development Institute Inc. At Montana State University Peptides from Pseudomonas syringae possessing broad-spectrum antibiotic activity
WO2001005817A1 (fr) * 1999-07-15 2001-01-25 Eli Lilly And Company Analogues amides et esters de pseudomycine

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5837685A (en) * 1992-11-30 1998-11-17 Research And Development Institute Inc. At Montana State University Peptides from Pseudomonas syringae possessing broad-spectrum antibiotic activity
WO2001005817A1 (fr) * 1999-07-15 2001-01-25 Eli Lilly And Company Analogues amides et esters de pseudomycine

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11555019B2 (en) 2019-07-10 2023-01-17 Cybrexa 3, Inc. Peptide conjugates of microtubule-targeting agents as therapeutics

Also Published As

Publication number Publication date
MXPA02005791A (es) 2002-09-30
WO2001041534A2 (fr) 2001-06-14
JP2003515610A (ja) 2003-05-07
CA2396513A1 (fr) 2001-06-14
NO20022798D0 (no) 2002-06-12
NO20022798L (no) 2002-06-12
AU3071801A (en) 2001-06-18
BR0016328A (pt) 2002-08-27

Similar Documents

Publication Publication Date Title
USD518873S1 (en) Spray gun
SG77195A1 (en) Fungicidal 2-methoxybenzophenones
IT1315276B1 (it) Scarpa con suola presentante una parte per l'avanpiede suddivisa inalmeno due parti.
MY126559A (en) Fungicidal 2-methoxybenzophenones
AU4161800A (en) A beam connection
AUPQ376399A0 (en) A structural member
USD458009S1 (en) Footwear
USD430112S (en) Control panel with pictograms
HK1042036A1 (zh) 钙溶解化合物
WO2001041534A3 (fr) Promedicaments de phosphate pseudomycine
NO20020192L (no) Pseudomycin prodrug
USD514974S1 (en) Middle-case for a watch
AU657397B2 (en) 3,4-diaryl-(5H)-furan-2-one based compounds with fungicidal activity
AU4580000A (en) A control pedal assembly
USD415093S (en) Wheel
USD439615S1 (en) Seven principle motivational guide
AU6932491A (en) Fungicidal active compound combinations
AU7488200A (en) Design for delivering pump light to a laser gain element while maintaining access to the laser beam
CA2320511A1 (fr) Fongicides
CA2395420A1 (fr) Procede de production de n-phosphonomethylglycine
AU1889901A (en) Stabilizers for l-ascorbic acid-2-sodium phosphate
AU3975100A (en) A three-legged assembly
USD435916S1 (en) Lattice panel with octagonal pattern modules
AU1194801A (en) Earth-fixed beams from a space vehicle
USD427959S (en) External window shield for vehicles

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A2

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BY BZ CA CH CN CR CU CZ DE DK DM DZ EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NO NZ PL PT RO RU SD SE SG SI SK SL TJ TM TR TT TZ UA UG US UZ VN YU ZA ZW

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): GH GM KE LS MW MZ SD SL SZ TZ UG ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE TR BF BJ CF CG CI CM GA GN GW ML MR NE SN TD TG

121 Ep: the epo has been informed by wipo that ep was designated in this application
DFPE Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101)
AK Designated states

Kind code of ref document: A3

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BY BZ CA CH CN CR CU CZ DE DK DM DZ EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NO NZ PL PT RO RU SD SE SG SI SK SL TJ TM TR TT TZ UA UG US UZ VN YU ZA ZW

AL Designated countries for regional patents

Kind code of ref document: A3

Designated state(s): GH GM KE LS MW MZ SD SL SZ TZ UG ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE TR BF BJ CF CG CI CM GA GN GW ML MR NE SN TD TG

WWE Wipo information: entry into national phase

Ref document number: 10130835

Country of ref document: US

WWE Wipo information: entry into national phase

Ref document number: 008169756

Country of ref document: CN

WWE Wipo information: entry into national phase

Ref document number: PA/a/2002/005791

Country of ref document: MX

ENP Entry into the national phase

Ref country code: JP

Ref document number: 2001 542721

Kind code of ref document: A

Format of ref document f/p: F

WWE Wipo information: entry into national phase

Ref document number: 2396513

Country of ref document: CA

REG Reference to national code

Ref country code: DE

Ref legal event code: 8642

122 Ep: pct application non-entry in european phase