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WO2000032751A3 - Mammalian non-neuronal cells that are modified to store and release a neurotransmitter - Google Patents

Mammalian non-neuronal cells that are modified to store and release a neurotransmitter Download PDF

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Publication number
WO2000032751A3
WO2000032751A3 PCT/IB1999/001991 IB9901991W WO0032751A3 WO 2000032751 A3 WO2000032751 A3 WO 2000032751A3 IB 9901991 W IB9901991 W IB 9901991W WO 0032751 A3 WO0032751 A3 WO 0032751A3
Authority
WO
WIPO (PCT)
Prior art keywords
cells
neurotransmitter
modified
store
release
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/IB1999/001991
Other languages
French (fr)
Other versions
WO2000032751A2 (en
Inventor
Maurice Israel
Jean-Leon Tchelingerian
Pierre-Olivier Couraud
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Neurotech Pharmaceuticals Inc
Original Assignee
Neurotech SA France
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Neurotech SA France filed Critical Neurotech SA France
Priority to EP99973063A priority Critical patent/EP1135466A2/en
Priority to AU14044/00A priority patent/AU1404400A/en
Publication of WO2000032751A2 publication Critical patent/WO2000032751A2/en
Publication of WO2000032751A3 publication Critical patent/WO2000032751A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Cell Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Psychiatry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Hospice & Palliative Care (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Immunology (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

Mammalian non-neuronal cells are modified to store and release a neurotransmitter. The cells can be modified by loading the cells, with a neurotransmitter in culture. The cells can be genetically modified to produce, store, and release the neurotransmitters. Also, the neurotransmitter is released selectively by the cells in a quantal fashion. Further disclosed are methods for making such cells and to methods for using such cells to treat neurodegenerative, psychiatric,, and neuromuscular disorders in mammals.
PCT/IB1999/001991 1998-11-30 1999-11-30 Mammalian non-neuronal cells that are modified to store and release a neurotransmitter Ceased WO2000032751A2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
EP99973063A EP1135466A2 (en) 1998-11-30 1999-11-30 Mammalian non-neuronal cells that are modified to store and release a neurotransmitter
AU14044/00A AU1404400A (en) 1998-11-30 1999-11-30 Mammalian non-neuronal cells that are modified to store and release a neurotransmitter

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US11036098P 1998-11-30 1998-11-30
US60/110,360 1998-11-30
US45036099A 1999-11-29 1999-11-29
US09/450,360 1999-11-29

Publications (2)

Publication Number Publication Date
WO2000032751A2 WO2000032751A2 (en) 2000-06-08
WO2000032751A3 true WO2000032751A3 (en) 2000-10-26

Family

ID=26807952

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB1999/001991 Ceased WO2000032751A2 (en) 1998-11-30 1999-11-30 Mammalian non-neuronal cells that are modified to store and release a neurotransmitter

Country Status (3)

Country Link
EP (1) EP1135466A2 (en)
AU (1) AU1404400A (en)
WO (1) WO2000032751A2 (en)

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1991013359A1 (en) * 1990-02-28 1991-09-05 The Du Pont Merck Pharmaceutical Company A method and compositions to screen compounds for enhancement of the cholinergic, dopaminergic and serotonergic function
WO1996011278A1 (en) * 1994-10-10 1996-04-18 Association Pour Le Developpement De L'immunologie Moleculaire-Adim Immortalized lines of endothelial brain cells and therapeutical applications thereof
WO1997040139A1 (en) * 1996-04-19 1997-10-30 Neurotech S.A. Immortalized retinal cell lines and their application

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1991013359A1 (en) * 1990-02-28 1991-09-05 The Du Pont Merck Pharmaceutical Company A method and compositions to screen compounds for enhancement of the cholinergic, dopaminergic and serotonergic function
WO1996011278A1 (en) * 1994-10-10 1996-04-18 Association Pour Le Developpement De L'immunologie Moleculaire-Adim Immortalized lines of endothelial brain cells and therapeutical applications thereof
WO1997040139A1 (en) * 1996-04-19 1997-10-30 Neurotech S.A. Immortalized retinal cell lines and their application

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
ISRAEL M ET AL.,: "Calcium-dependent release specificities of various cell lines loaded with different transmitters", NEUROPHARMACOLOGY, vol. 36, December 1997 (1997-12-01), pages 1789-1793, XP000864562 *
LIU Y AND EDWARDS RE: "Differential localization of vesicular acetylcholine and monoamine transporters in PC12 cells but not CHO cells", THE JOURNAL OF CELL BIOLOGY, vol. 139, no. 4, 17 November 1997 (1997-11-17), pages 907 - 916, XP002135082 *
MAKOTO I ET AL.,: "Transfection analysis of functional roles of complexin I and II in the exocitosis of two different types of secretory vesicles", BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, vol. 265, 30 November 1999 (1999-11-30), pages 691 - 696, XP000891743 *
MALO M ET AL.,: "Evoked acetylcholine release by immortalized brain endothelial cells genetically modified to express choline acetyltransferase and/or the vesicular acetylcholine transporter.", JOURNAL OF NEUROCHEMISTRY, vol. 73, October 1999 (1999-10-01), pages 1483-1491, XP000892933 *
MISAWA H ET AL.,: "Calcium-independent release of acetylcholine from stable cell lines expressing mouse choline acetyltransferase cDNA", JOURNAL OF NEUROCHEMISTRY, vol. 62, 1994, pages 465 - 470, XP000901454 *
VAROQUI H AND ERICKSON JD: "Active transport of acetylcholine by the human vesicular acetylcholine transporter", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 271, no. 44, 1 November 1996 (1996-11-01), pages 27229 - 27232, XP002135081 *

Also Published As

Publication number Publication date
EP1135466A2 (en) 2001-09-26
AU1404400A (en) 2000-06-19
WO2000032751A2 (en) 2000-06-08

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