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WO2000024870A3 - Nucleic acids and proteins of the human span-x gene and uses thereof - Google Patents

Nucleic acids and proteins of the human span-x gene and uses thereof Download PDF

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Publication number
WO2000024870A3
WO2000024870A3 PCT/US1999/024973 US9924973W WO0024870A3 WO 2000024870 A3 WO2000024870 A3 WO 2000024870A3 US 9924973 W US9924973 W US 9924973W WO 0024870 A3 WO0024870 A3 WO 0024870A3
Authority
WO
WIPO (PCT)
Prior art keywords
span
nucleic acids
present
nucleotides
proteins
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US1999/024973
Other languages
French (fr)
Other versions
WO2000024870A2 (en
Inventor
John C Herr
V Anne Westbrook
Alan B Diekman
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
UVA Licensing and Ventures Group
University of Virginia UVA
Original Assignee
University of Virginia UVA
University of Virginia Patent Foundation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of Virginia UVA, University of Virginia Patent Foundation filed Critical University of Virginia UVA
Priority to AU15175/00A priority Critical patent/AU1517500A/en
Publication of WO2000024870A2 publication Critical patent/WO2000024870A2/en
Publication of WO2000024870A3 publication Critical patent/WO2000024870A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4702—Regulators; Modulating activity

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

The present invention provides the discovery, identification and characterization of nucleotides that encode a novel X-linked spermatozoan nuclear protein, SPAN-X. The invention encompasses nucleotides encoding SPAN-X, proteins encoded by the nucleotides of the present invention, and antibodies and ligands that bind SPAN-X as well as fragments of any of the above having a functional activity of SPAN-X, e.g., a nuclear localization signal activity, etc. The present invention provides screening assays to identify SPAN-X-bearing spermatids. The invention further provides compositions and methods for the use of span-x nucleic acids for heterologous gene expression.
PCT/US1999/024973 1998-10-23 1999-10-22 Nucleic acids and proteins of the human span-x gene and uses thereof Ceased WO2000024870A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU15175/00A AU1517500A (en) 1998-10-23 1999-10-22 Nucleic acids and proteins of the human span-x gene and uses thereof

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US10532498P 1998-10-23 1998-10-23
US60/105,324 1998-10-23

Publications (2)

Publication Number Publication Date
WO2000024870A2 WO2000024870A2 (en) 2000-05-04
WO2000024870A3 true WO2000024870A3 (en) 2000-08-10

Family

ID=22305180

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1999/024973 Ceased WO2000024870A2 (en) 1998-10-23 1999-10-22 Nucleic acids and proteins of the human span-x gene and uses thereof

Country Status (2)

Country Link
AU (1) AU1517500A (en)
WO (1) WO2000024870A2 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005079243A2 (en) * 2004-02-06 2005-09-01 University Of Virginia Patent Foundation Compositions and methods for identifying sperm for forensic applications
US8664183B2 (en) 2009-02-27 2014-03-04 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services SPANX-B polypeptides and their use

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
BOCHE ET AL.: "Nucleocytoplasmic Recycling of the Nuclear Localization Signal Receptor alpha Subunit In Vivo is Dependent on a nuclear Export Signal, Energy and RCC1", J. CELL. BIOL.,, vol. 139, no. 2, 20 October 1997 (1997-10-20), pages 313 - 325, XP002927859 *
BRODER ET AL.: "Translocation of NLS-BSA conjugates into nuclei of permeabilized mammalian cells can be supported by protoplast extract", FEBS LETT.,, vol. 412, 1997, pages 535 - 539, XP002927861 *
DATABASE GENBANK, 18 May 1997 (1997-05-18), HILLIER ET AL.: "WashU-Merck EST Project" *
JANS ET AL.: "A functional bipartite nuclear localisation signal in the cytokine interleukin-5", FEBS LETT.,, vol. 406, 1997, pages 315 - 320, XP002927860 *
LYONS ET AL.: "Pentapeptide Nuclear Localization Signal in Adenovirus EIa", MOLECULAR AND CELLUAR BIOLOGY,, vol. 7, no. 7, July 1987 (1987-07-01), pages 2451 - 2456, XP002927862 *

Also Published As

Publication number Publication date
AU1517500A (en) 2000-05-15
WO2000024870A2 (en) 2000-05-04

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