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WO2000024358A3 - Synthesis and uses of thiopentone enantiomers - Google Patents

Synthesis and uses of thiopentone enantiomers Download PDF

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Publication number
WO2000024358A3
WO2000024358A3 PCT/AU1999/000919 AU9900919W WO0024358A3 WO 2000024358 A3 WO2000024358 A3 WO 2000024358A3 AU 9900919 W AU9900919 W AU 9900919W WO 0024358 A3 WO0024358 A3 WO 0024358A3
Authority
WO
WIPO (PCT)
Prior art keywords
thiopentone
synthesis
enantiomers
relates
present
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/AU1999/000919
Other languages
French (fr)
Other versions
WO2000024358A2 (en
Inventor
Laurence Edward Mather
Colin C Duke
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Sydney
Original Assignee
University of Sydney
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of Sydney filed Critical University of Sydney
Priority to AU11416/00A priority Critical patent/AU1141600A/en
Publication of WO2000024358A2 publication Critical patent/WO2000024358A2/en
Publication of WO2000024358A3 publication Critical patent/WO2000024358A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/60—Three or more oxygen or sulfur atoms
    • C07D239/66—Thiobarbituric acids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

The present invention relates to the synthesis of R- and S- thiopentone and to an improved anaesthetic agent including R-thiopentone.
PCT/AU1999/000919 1998-10-22 1999-10-22 Synthesis and uses of thiopentone enantiomers Ceased WO2000024358A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU11416/00A AU1141600A (en) 1998-10-22 1999-10-22 Synthesis and uses of thiopentone enantiomers

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
AUPP6638A AUPP663898A0 (en) 1998-10-22 1998-10-22 Synthesis and uses of thiopentone enantiomers
AUPP6638 1998-10-22

Publications (2)

Publication Number Publication Date
WO2000024358A2 WO2000024358A2 (en) 2000-05-04
WO2000024358A3 true WO2000024358A3 (en) 2000-08-17

Family

ID=3810858

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/AU1999/000919 Ceased WO2000024358A2 (en) 1998-10-22 1999-10-22 Synthesis and uses of thiopentone enantiomers

Country Status (2)

Country Link
AU (1) AUPP663898A0 (en)
WO (1) WO2000024358A2 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4763462B2 (en) * 2004-02-04 2011-08-31 株式会社エーピーアイ コーポレーション Process for producing optically active alcohol and carboxylic acid
WO2006039841A1 (en) * 2004-10-14 2006-04-20 Wuxi Pharma Tech Co., Ltd. A NOVEL PROCESS FOR THE PREPARATION OF NONRACEMIC LONG CHAIN α-AMINO ACIDS DERIVATIVES

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
C.E. COOK AND C.R. TALENT.: "Synthesis of (R)-5-(2'pentyl)barbituric acid derivatives of high optical purity", JOURNAL OF HETEROCYCLIC CHEMISTRY,, vol. 6, 1969, pages 203 - 206 *
Excerpta Med. Int. Congr. Ser., 1977, 399 (Anaesthesiology) L.C. Mark et al., "Barbiturate Stereoisomers: Direction for the Future?", pages 143-146. *
F.I. CARROLL AND R. MECK.: "Syntheses and optical rotatory dispersion studies of (S)-5-(2'pentyl)-barbituricacid derivatives", JOURNAL OF ORGANIC CHEMISTRY,, vol. 34, 1969, pages 2676 - 2680 *
Martindale: The extrapharmacopoeia. Edition 29, 1989, ed. J.E.F. Reynold. thiopentone sodium, pages 1125-1126. *
T.J. HALEY AND J.T. GIDLEY.: "Pharmacological comparison of R(+),S(-) and racemic thiopentone in mice", EUROPEAN JOURNAL OF PHARMACOLOGY,, vol. 36, 1976, pages 211 - 214 *
The Merck Index, Edition 12, 1996, pages 1595, entry 9487, tiopental sodium. *

Also Published As

Publication number Publication date
AUPP663898A0 (en) 1998-11-12
WO2000024358A2 (en) 2000-05-04

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