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WO2000023429A3 - Stereoselective process for producing cryptophycins - Google Patents

Stereoselective process for producing cryptophycins Download PDF

Info

Publication number
WO2000023429A3
WO2000023429A3 PCT/US1999/024410 US9924410W WO0023429A3 WO 2000023429 A3 WO2000023429 A3 WO 2000023429A3 US 9924410 W US9924410 W US 9924410W WO 0023429 A3 WO0023429 A3 WO 0023429A3
Authority
WO
WIPO (PCT)
Prior art keywords
stereoselective process
cryptophycins
producing
producing cryptophycins
stereoselective
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US1999/024410
Other languages
French (fr)
Other versions
WO2000023429A2 (en
Inventor
James Abraham Aikins
Barbara Shreve Briggs
Tony Yantao Zhang
Milton Joseph Junior Zmijewski
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Hawaii at Manoa
Wayne State University
Eli Lilly and Co
University of Hawaii at Hilo
Original Assignee
University of Hawaii at Manoa
Wayne State University
Eli Lilly and Co
University of Hawaii at Hilo
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of Hawaii at Manoa, Wayne State University, Eli Lilly and Co, University of Hawaii at Hilo filed Critical University of Hawaii at Manoa
Priority to KR1020017004775A priority Critical patent/KR20010099699A/en
Priority to HU0104027A priority patent/HUP0104027A3/en
Priority to CA002347246A priority patent/CA2347246A1/en
Priority to EP99955034A priority patent/EP1127055A2/en
Priority to IL14256599A priority patent/IL142565A0/en
Priority to BR9916051-0A priority patent/BR9916051A/en
Priority to JP2000577157A priority patent/JP2002527509A/en
Priority to AU11232/00A priority patent/AU1123200A/en
Publication of WO2000023429A2 publication Critical patent/WO2000023429A2/en
Publication of WO2000023429A3 publication Critical patent/WO2000023429A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D273/00—Heterocyclic compounds containing rings having nitrogen and oxygen atoms as the only ring hetero atoms, not provided for by groups C07D261/00 - C07D271/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D273/00—Heterocyclic compounds containing rings having nitrogen and oxygen atoms as the only ring hetero atoms, not provided for by groups C07D261/00 - C07D271/00
    • C07D273/08—Heterocyclic compounds containing rings having nitrogen and oxygen atoms as the only ring hetero atoms, not provided for by groups C07D261/00 - C07D271/00 having two nitrogen atoms and more than one oxygen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Epoxy Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Pyrane Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

Abstract

This invention provides processes for preparing cryptophycin compounds of formula (II).
PCT/US1999/024410 1998-10-16 1999-10-15 Stereoselective process for producing cryptophycins Ceased WO2000023429A2 (en)

Priority Applications (8)

Application Number Priority Date Filing Date Title
KR1020017004775A KR20010099699A (en) 1998-10-16 1999-10-15 Stereoselective Process for Producing Cryptophycins
HU0104027A HUP0104027A3 (en) 1998-10-16 1999-10-15 Stereoselective process for producing cryptophycin
CA002347246A CA2347246A1 (en) 1998-10-16 1999-10-15 Stereoselective process for producing cryptophycins
EP99955034A EP1127055A2 (en) 1998-10-16 1999-10-15 Stereoselective process for producing cryptophycins
IL14256599A IL142565A0 (en) 1998-10-16 1999-10-15 Stereoselective process for producing antineoplastic agents
BR9916051-0A BR9916051A (en) 1998-10-16 1999-10-15 Stereoselective process to produce antineoplastic agents
JP2000577157A JP2002527509A (en) 1998-10-16 1999-10-15 Stereoselective methods for producing antitumor agents
AU11232/00A AU1123200A (en) 1998-10-16 1999-10-15 Stereoselective process for producing antineoplastic agents

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US10466498P 1998-10-16 1998-10-16
US60/104,664 1998-10-16

Publications (2)

Publication Number Publication Date
WO2000023429A2 WO2000023429A2 (en) 2000-04-27
WO2000023429A3 true WO2000023429A3 (en) 2000-07-27

Family

ID=22301706

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1999/024410 Ceased WO2000023429A2 (en) 1998-10-16 1999-10-15 Stereoselective process for producing cryptophycins

Country Status (10)

Country Link
EP (1) EP1127055A2 (en)
JP (1) JP2002527509A (en)
KR (1) KR20010099699A (en)
AU (1) AU1123200A (en)
BR (1) BR9916051A (en)
CA (1) CA2347246A1 (en)
HU (1) HUP0104027A3 (en)
IL (1) IL142565A0 (en)
TR (1) TR200101084T2 (en)
WO (1) WO2000023429A2 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102448927A (en) * 2009-04-01 2012-05-09 力奇制药公司 Method for dimethylation of active methylene groups
FR2947269B1 (en) 2009-06-29 2013-01-18 Sanofi Aventis NEW ANTICANCER COMPOUNDS
CN102140068B (en) * 2010-01-30 2015-03-11 浙江华海药业股份有限公司 Preparation method of Aliskiren intermediate 3-amino-2,2-dimethylpropionamide

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996040184A1 (en) * 1995-03-07 1996-12-19 University Of Hawaii New cryptophycins from synthesis
EP0792875A1 (en) * 1996-02-27 1997-09-03 Eli Lilly And Company Cryptophycin derivatives and their use as anti-microtubule agents
WO1998009974A1 (en) * 1996-09-06 1998-03-12 Eli Lilly And Company Process and novel intermediates
EP0861838A2 (en) * 1997-02-26 1998-09-02 Eli Lilly And Company Process and intermediates for preparing cryptophycin compounds

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996040184A1 (en) * 1995-03-07 1996-12-19 University Of Hawaii New cryptophycins from synthesis
EP0792875A1 (en) * 1996-02-27 1997-09-03 Eli Lilly And Company Cryptophycin derivatives and their use as anti-microtubule agents
WO1998009974A1 (en) * 1996-09-06 1998-03-12 Eli Lilly And Company Process and novel intermediates
EP0861838A2 (en) * 1997-02-26 1998-09-02 Eli Lilly And Company Process and intermediates for preparing cryptophycin compounds

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
BARROW R A ET AL: "TOTAL SYNTHESIS OF CRYPTOPHYCINS. REVISION OF THE STRUCTURES OF CRYPTOPHYCINS A AND C", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY,US,AMERICAN CHEMICAL SOCIETY, WASHINGTON, DC, vol. 117, no. 9, 8 March 1995 (1995-03-08), pages 2479 - 2490, XP002066281, ISSN: 0002-7863 *
SALAMONCZYK G ET AL: "TOTAL SYNTHESIS OF CRYPTOPHYCINS VIA A CHEMOENZYMATIC APPROACH", JOURNAL OF ORGANIC CHEMISTRY,US,AMERICAN CHEMICAL SOCIETY. EASTON, vol. 61, no. 20, 1 October 1996 (1996-10-01), pages 6893 - 6900, XP000674616, ISSN: 0022-3263 *

Also Published As

Publication number Publication date
WO2000023429A2 (en) 2000-04-27
BR9916051A (en) 2001-08-14
TR200101084T2 (en) 2001-09-21
AU1123200A (en) 2000-05-08
CA2347246A1 (en) 2000-04-27
IL142565A0 (en) 2002-03-10
KR20010099699A (en) 2001-11-09
HUP0104027A2 (en) 2002-03-28
EP1127055A2 (en) 2001-08-29
HUP0104027A3 (en) 2002-08-28
JP2002527509A (en) 2002-08-27

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