[go: up one dir, main page]

WO2000018732A3 - Disubstituted pyrrolidinones, medicaments containing these compounds, their use and the production thereof - Google Patents

Disubstituted pyrrolidinones, medicaments containing these compounds, their use and the production thereof Download PDF

Info

Publication number
WO2000018732A3
WO2000018732A3 PCT/EP1999/007141 EP9907141W WO0018732A3 WO 2000018732 A3 WO2000018732 A3 WO 2000018732A3 EP 9907141 W EP9907141 W EP 9907141W WO 0018732 A3 WO0018732 A3 WO 0018732A3
Authority
WO
WIPO (PCT)
Prior art keywords
compounds
production
medicaments containing
relates
pyrrolidinones
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/EP1999/007141
Other languages
German (de)
French (fr)
Other versions
WO2000018732A2 (en
Inventor
Frank Himmelsbach
Brian Guth
Hans-Dieter Schubert
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Boehringer Ingelheim Pharma GmbH and Co KG
Boehringer Ingelheim Pharmaceuticals Inc
Original Assignee
Boehringer Ingelheim Pharma GmbH and Co KG
Boehringer Ingelheim Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim Pharma GmbH and Co KG, Boehringer Ingelheim Pharmaceuticals Inc filed Critical Boehringer Ingelheim Pharma GmbH and Co KG
Priority to AU60875/99A priority Critical patent/AU6087599A/en
Publication of WO2000018732A2 publication Critical patent/WO2000018732A2/en
Publication of WO2000018732A3 publication Critical patent/WO2000018732A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/24—Oxygen or sulfur atoms
    • C07D207/26—2-Pyrrolidones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Hematology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The invention relates to disubstituted pyrrolidinones of general formula (I) in which R1 and R2 are defined in Claim No. 1. The invention also relates to the tautomers thereof, stereoisomers thereof, including their mixtures and their salts, especially the physiologically compatible salts with inorganic or organic acids or bases which comprise valuable pharmacological properties, preferably antithrombotic effects. In addition, the invention relates to medicaments containing these compounds, to their use and to a method for the production thereof.
PCT/EP1999/007141 1998-09-30 1999-09-25 Disubstituted pyrrolidinones, medicaments containing these compounds, their use and the production thereof Ceased WO2000018732A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU60875/99A AU6087599A (en) 1998-09-30 1999-09-25 Disubstituted pyrrolidinones, medicaments containing these compounds, their use and the production thereof

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19844787A DE19844787A1 (en) 1998-09-30 1998-09-30 Disubstituted pyrrolidinones, medicaments containing them and their use and their preparation
DE19844787.6 1998-09-30

Publications (2)

Publication Number Publication Date
WO2000018732A2 WO2000018732A2 (en) 2000-04-06
WO2000018732A3 true WO2000018732A3 (en) 2000-05-25

Family

ID=7882751

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP1999/007141 Ceased WO2000018732A2 (en) 1998-09-30 1999-09-25 Disubstituted pyrrolidinones, medicaments containing these compounds, their use and the production thereof

Country Status (3)

Country Link
AU (1) AU6087599A (en)
DE (1) DE19844787A1 (en)
WO (1) WO2000018732A2 (en)

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0483667A2 (en) * 1990-11-02 1992-05-06 Dr. Karl Thomae GmbH Cyclic imino derivatives, process for their preparation and drugs containing them
EP0567966A1 (en) * 1992-04-28 1993-11-03 Dr. Karl Thomae GmbH Cyclic imino derivatives, medicaments containing these compounds and processes for the production thereof

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0483667A2 (en) * 1990-11-02 1992-05-06 Dr. Karl Thomae GmbH Cyclic imino derivatives, process for their preparation and drugs containing them
EP0567966A1 (en) * 1992-04-28 1993-11-03 Dr. Karl Thomae GmbH Cyclic imino derivatives, medicaments containing these compounds and processes for the production thereof

Also Published As

Publication number Publication date
DE19844787A1 (en) 2000-04-13
AU6087599A (en) 2000-04-17
WO2000018732A2 (en) 2000-04-06

Similar Documents

Publication Publication Date Title
AU2111992A (en) Cyclic imino derivatives
MX9803954A (en) Amino acid derivatives, pharmaceutical compositions containing these compounds and processes for preparing them.
YU50002A (en) Substituted piperidines, medicaments containing these compounds,and methods for the production thereof
NO934501L (en) Carboxylic acid derivatives, drugs containing these compounds, and process for their preparation
NO940261L (en) 5-membered heterocycles, process for the preparation thereof and drugs containing these compounds
WO1999064409A3 (en) Benzothiepine-1,1-dioxide derivatives, method for producing them, medicaments containing these compounds and their use
BG101582A (en) PIPERAZINE DERIVATIVES, THEIR CONTAINING MEDICINAL FORMS, THEIR APPLICATION AND METHOD FOR RECEIVING THEM
NO923466L (en) Heterocyclic Compounds with 5 Sections, PROCEDURE PREPARATION, AND PHARMACEUTICALS CONTAINING THESE COMPOUNDS
NO933248L (en) Cyclic urea derivatives, drugs containing these compounds, and process for their preparation
TW289757B (en)
UA70951C2 (en) Benzimidazoles and medicament based thereon
AU3822293A (en) Cyclic imino derivatives
MX9700020A (en) Cyclic benzazepine urea derivatives with aggregation-inhibiting effect.
WO2000008014A8 (en) Disubstituted bicyclic heterocycles having, in particular, a thrombin inhibitive effect
GR3026508T3 (en) Cyclic imino derivatives, process for their preparation and drugs containing them
YU30902A (en) Novel cyclopropanes as cgrp antagonists, medicaments containing said compounds and method for the production thereof
NZ332545A (en)
WO2000018732A3 (en) Disubstituted pyrrolidinones, medicaments containing these compounds, their use and the production thereof
YU3701A (en) Substituted phenylamidines with antithrombotic action
AU5500896A (en) Substituted phenylamidines, pharmaceutical compositions containing these compounds and processes for preparing them
WO1997022368A3 (en) Covalent lipid-phosphono-carboxylic acid conjugates and application thereof as antiviral medicaments
MX9803556A (en) Amino acid derivatives, medicaments containing said compounds and methods of producing them.
MX9803557A (en) Amino acid derivatives, medicaments containing said compounds and methods of producing said compounds.
MX9802988A (en) 5-membered heterocycles, pharmaceutical agents containing said compounds and the use thereof and methods of producing them.

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A2

Designated state(s): AE AL AM AT AU AZ BA BB BG BR BY CA CH CN CU CZ DE DK EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MD MG MK MN MW MX NO NZ PL PT RO RU SD SE SG SI SK SL TJ TM TR TT UA UG US UZ VN YU ZA ZW

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): GH GM KE LS MW SD SL SZ TZ UG ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE BF BJ CF CG CI CM GA GN GW ML MR NE SN TD TG

DFPE Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101)
AK Designated states

Kind code of ref document: A3

Designated state(s): AE AL AM AT AU AZ BA BB BG BR BY CA CH CN CU CZ DE DK EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MD MG MK MN MW MX NO NZ PL PT RO RU SD SE SG SI SK SL TJ TM TR TT UA UG US UZ VN YU ZA ZW

AL Designated countries for regional patents

Kind code of ref document: A3

Designated state(s): GH GM KE LS MW SD SL SZ TZ UG ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE BF BJ CF CG CI CM GA GN GW ML MR NE SN TD TG

121 Ep: the epo has been informed by wipo that ep was designated in this application
REG Reference to national code

Ref country code: DE

Ref legal event code: 8642

122 Ep: pct application non-entry in european phase