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WO2000015180A1 - Compositions a rheologie modifiee et procedes correspondants - Google Patents

Compositions a rheologie modifiee et procedes correspondants Download PDF

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Publication number
WO2000015180A1
WO2000015180A1 PCT/US1999/021210 US9921210W WO0015180A1 WO 2000015180 A1 WO2000015180 A1 WO 2000015180A1 US 9921210 W US9921210 W US 9921210W WO 0015180 A1 WO0015180 A1 WO 0015180A1
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WO
WIPO (PCT)
Prior art keywords
composition
polysaccharide
oil
skin
modified
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US1999/021210
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English (en)
Inventor
James Edmund Brady
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Hercules LLC
Original Assignee
Hercules LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hercules LLC filed Critical Hercules LLC
Priority to EP99969018A priority Critical patent/EP1112054A1/fr
Priority to CA002341433A priority patent/CA2341433A1/fr
Priority to BR9913617-1A priority patent/BR9913617A/pt
Priority to AU60414/99A priority patent/AU6041499A/en
Publication of WO2000015180A1 publication Critical patent/WO2000015180A1/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/84—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
    • A61K8/89—Polysiloxanes
    • A61K8/891—Polysiloxanes saturated, e.g. dimethicone, phenyl trimethicone, C24-C28 methicone or stearyl dimethicone
    • A61K8/894—Polysiloxanes saturated, e.g. dimethicone, phenyl trimethicone, C24-C28 methicone or stearyl dimethicone modified by a polyoxyalkylene group, e.g. cetyl dimethicone copolyol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
    • A61K8/0208—Tissues; Wipes; Patches
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/34—Alcohols
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
    • A61K8/41—Amines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/46—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing sulfur
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/58—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing atoms other than carbon, hydrogen, halogen, oxygen, nitrogen, sulfur or phosphorus
    • A61K8/585—Organosilicon compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/73—Polysaccharides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/73—Polysaccharides
    • A61K8/737—Galactomannans, e.g. guar; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/84—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
    • A61K8/89—Polysiloxanes
    • A61K8/891—Polysiloxanes saturated, e.g. dimethicone, phenyl trimethicone, C24-C28 methicone or stearyl dimethicone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/84—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
    • A61K8/89—Polysiloxanes
    • A61K8/896—Polysiloxanes containing atoms other than silicon, carbon, oxygen and hydrogen, e.g. dimethicone copolyol phosphate
    • A61K8/898—Polysiloxanes containing atoms other than silicon, carbon, oxygen and hydrogen, e.g. dimethicone copolyol phosphate containing nitrogen, e.g. amodimethicone, trimethyl silyl amodimethicone or dimethicone propyl PG-betaine
    • A—HUMAN NECESSITIES
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    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
    • A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
    • A—HUMAN NECESSITIES
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    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
    • A61K8/925—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of animal origin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q1/00—Make-up preparations; Body powders; Preparations for removing make-up
    • A61Q1/02—Preparations containing skin colorants, e.g. pigments
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q1/00—Make-up preparations; Body powders; Preparations for removing make-up
    • A61Q1/02—Preparations containing skin colorants, e.g. pigments
    • A61Q1/04—Preparations containing skin colorants, e.g. pigments for lips
    • A61Q1/06—Lipsticks
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q1/00—Make-up preparations; Body powders; Preparations for removing make-up
    • A61Q1/14—Preparations for removing make-up
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q13/00—Formulations or additives for perfume preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q15/00—Anti-perspirants or body deodorants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
    • A61Q17/04—Topical preparations for affording protection against sunlight or other radiation; Topical sun tanning preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q5/00—Preparations for care of the hair
    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D17/00—Detergent materials or soaps characterised by their shape or physical properties
    • C11D17/0008—Detergent materials or soaps characterised by their shape or physical properties aqueous liquid non soap compositions
    • C11D17/003—Colloidal solutions, e.g. gels; Thixotropic solutions or pastes
    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
    • C11D3/16—Organic compounds
    • C11D3/20—Organic compounds containing oxygen
    • C11D3/22—Carbohydrates or derivatives thereof
    • C11D3/222—Natural or synthetic polysaccharides, e.g. cellulose, starch, gum, alginic acid or cyclodextrin
    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D7/00—Compositions of detergents based essentially on non-surface-active compounds
    • C11D7/22—Organic compounds
    • C11D7/24—Hydrocarbons
    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D7/00—Compositions of detergents based essentially on non-surface-active compounds
    • C11D7/22—Organic compounds
    • C11D7/26—Organic compounds containing oxygen
    • C11D7/268—Carbohydrates or derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q1/00—Make-up preparations; Body powders; Preparations for removing make-up
    • A61Q1/02—Preparations containing skin colorants, e.g. pigments
    • A61Q1/10—Preparations containing skin colorants, e.g. pigments for eyes, e.g. eyeliner, mascara
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/10—Washing or bathing preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
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    • A61Q5/02—Preparations for cleaning the hair
    • A—HUMAN NECESSITIES
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    • A61Q9/02—Shaving preparations

Definitions

  • the present invention is directed to rheology modified compositions, and to methods for forming the compositions.
  • the compositions and methods are useful in applications including cosmetics, pharmaceuticals, and household products.
  • compositions for use in the intended applications have a desired viscosity.
  • a number of applications require that the compositions used therefor have a relatively high viscosity.
  • the rheology can affect properties such as, for example, ease of application, ease of handling, esthetic appeal, product stability and retention of a product where applied.
  • Personal care formulations such as lotions and creams can contain large amounts of solvent. Such formulations often use an oil or emollient as a solvent or a primary component. While oils possess highly desirable properties for cosmetic use, such as emolliency and the ability to solvate and remove make-up, the presence of oils can be inconvenient in the fluid form and present difficulties in application. Household products such as cleaning products can contain substantial amounts of oil or wax as solvents or major components. It is generally desirable that a cleaning product applied to a surface, particularly a hard surface, not run over the surface before it can be wiped. Products such as furniture polish are often oil or wax-based, and should be thick enough to remain where applied so that polishing can be accomplished.
  • oils or emollients can be decreased or eliminated by rheological modification such as thickening of the oil.
  • a cosmetic formulation can be used in a thickened composition, such as a cream, gel, or a water-in-oil or oil-in-water emulsion, particularly a water-in-oil emulsion.
  • Preparation of water-in-oil emulsions generally requires thickening of the continuous oily phase of the emulsion. Thickening of the oily phase can also be required in preparing cosmetic gels, particularly anhydrous gels.
  • a formulation in the form of an anhydrous gel is useful, for example, if components of the formulation are sensitive to moisture and/or to oxygen.
  • Certain ingredients in cosmetic or pharmaceutical formulations are unstable in water. For example, vitamin C degrades in water relatively rapidly.
  • anhydrous formulations such as an anhydrous gel.
  • Oily compositions, such as oily dispersions are suitable anhydrous formulations; however, in addition to other difficulties associated with oily compositions as discussed herein, such unstable ingredients can be insoluble or insufficiently soluble in oily formulations.
  • Polymers are known for use as thickeners or rheology modifiers in personal care, household and pharmaceutical applications. However, certain polymers can be incompatible with other components in the formulations, such as fragrances in cosmetic formulations. Thickening of oils can also be accomplished by incorporation of silicas, bentonites or metal salts of fatty acids such as aluminum salts, or esterified derivatives of sugars such as dextrin palmitate. Thickening has also been accomplished by incorporation of a wax in the oily phase. However, creams thickened by simply adding waxes, silicas or bentonites can have a texture that is unappealing or difficult to use.
  • U.S. Patent No. 5,318,995 discloses a method for thickening a water-in-oil emulsion by using copolymers containing a slight amount of ionic or ionizable groups.
  • European Patent No. EP 550,745 discloses thickening of the oil phase of a cosmetic composition using a combination of two copolymers.
  • One aspect of the present invention is a composition
  • a composition comprising a rheology modifier, and a solvent mixture comprising a non-polar oil or wax and a miscible hydrogen-bonding compound, wherein the solvent mixture has a polar solubility parameter of less than 6.5 Joules per cubic centimeter (J/cc) 1 2 .
  • the rheology modifier is a modified polysaccharide.
  • the rheological modifier is a polysaccharide alkyl, alkenyl, alkynyl, aryl, arylalkyl, or arylalkenyl ether, or a mixture thereof.
  • compositions comprising a rheology modifier, and a solvent mixture comprising a non-polar oil of animal, petroleum or vegetable origin, or a wax, and a miscible hydrogen-bonding compound.
  • the non-polar oil or wax comprises one or more of: a silicone oil, a mineral oil, an aliphatic hydrocarbon, a natural wax, a petroleum wax, or a synthetic derivative of a natural or petroleum wax.
  • the rheology modifier is a modified polysaccharide.
  • the rheological modifier is a polysaccharide alkyl, alkenyl, alkynyl, aryl, arylalkyl, or arylalkenyl ether, or a mixture thereof.
  • a further aspect of the present invention is a process for forming a composition.
  • the process includes combining a miscible hydrogen-bonding compound and a modified polysaccharide at ambient temperature to form a mixture.
  • the rheology modifier is a polysaccharide alkyl, alkenyl, alkynyl, aryl, arylalkyl, or arylalkenyl ether.
  • the mixture is allowed to stand at ambient temperature until solvation occurs.
  • a non-polar oil or wax is then added to the solvated mixture to form a substantially uniform composition.
  • Another aspect of the present invention is a process for forming a silicone oil composition.
  • the process includes combining a miscible hydrogen-bonding compound and a modified polysaccharide, then adding, at ambient or elevated temperature, a silicone oil to form a substantially uniform composition.
  • the modified polysaccharide ether is a polysaccharide alkyl, alkenyl, alkynyl, aryl, arylalkenyl, or arylalkyl ether.
  • Another aspect of the present invention is an emulsion containing a non-polar oil or wax, a rheology modifier, and a miscible hydrogen-bonding compound, wherein the solvent mixture has a polar solubility parameter of less than 6.5 (J/cc) 1/2 .
  • the rheology modifier is a modified polysaccharide.
  • the modified polysaccharide is polysaccharide alkyl, alkenyl, alkynyl, aryl, arylalkyl, or arylalkenyl ether, or a mixture thereof.
  • the emulsion can be an oil-in-water emulsion or a water-in-oil emulsion. In preferred embodiments, the emulsion is an water-in-oil emulsion.
  • a further aspect of the present invention is a personal care formulation containing a non-polar oil or wax, a rheology modifier, and a miscible hydrogen- bonding compound, wherein the solvent mixture has a polar solubility parameter of less than 6.5 (J/cc) 1/2 .
  • the rheology modifier is a modified polysaccharide.
  • the modified polysaccharide is a polysaccharide alkyl, alkenyl, alkynyl, aryl, arylalkyl, or arylalkenyl ether, or a mixture thereof.
  • the personal care formulation can be applied to the hair, skin, mucous membranes, and/or nails.
  • Another aspect of the present invention is an anhydrous formulation containing a non-polar oil or wax, a rheology modifier, and a miscible hydrogen- bonding , wherein the solvent mixture has a polar solubility parameter of less than 6.5 (J/cc) 1/2 .
  • the rheology modifier is a modified polysaccharide.
  • the rheology modifier is an alkyl, alkenyl, alkynyl, aryl, arylalkyl, or arylalkenyl ether, or a mixture thereof.
  • the present invention provides improved oil-containing compositions for personal care, pharmaceutical, or household applications, and methods for making the compositions. It has been surprisingly and unexpectedly found that the use in such compositions of a rheology modifier and a hydrogen-bonding compound can provide compositions having desired properties, such as viscosity, for use in the intended applications, while reducing undesirable properties often observed in oil- containing compositions. It has further been unexpectedly found that the compositions and methods of the present invention can be used to provide improved optical clarity, as evidenced by measurable decreases in turbidity, of compositions containing organic solvents and polymers. A further unexpected property of the methods and compositions of the present invention is that they can provide improved properties, such as increased viscosity and improved optical clarity, when used at room temperature.
  • compositions of the present invention can be prepared at ambient temperature.
  • the methods and compositions of the present invention can be used, if desired, to provide personal care, pharmaceutical, or household compositions that are solid at room temperature.
  • the use of the compositions and methods of the present invention in formulating solid compositions can provide for reduction of constraints during formulation. For example, it is often necessary that formulations intended to be solid at room temperature be rapidly solidified in order to ensure uniformity and minimize sedimentation. According to the present invention, such rapid solidification may not be required.
  • the invention provides methods for improving optical clarity in oil-containing compositions.
  • Personal care and other formulations that include thickening agents often have an undesirable amount of turbidity. It has been surprisingly and unexpectedly found that the use of a hydrogen-bonding compound in combination with a rheology modifier provides compositions having desired properties for personal care, pharmaceutical or household applications, including viscosity, while also exhibiting reduced turbidity as compared to thickened compositions not containing hydrogen-bonding compounds.
  • the invention provides methods for forming, at ambient temperature, oil-based compositions containing polymeric viscosity- modifying agents. It has been surprisingly and unexpectedly found that the use of a hydrogen-bonding compound, such as an alcohol, reduces or eliminates the need for heat in dissolving the viscosity-modifying agent in the oily phase.
  • a hydrogen-bonding compound such as an alcohol
  • the methods and compositions of the invention are useful, for example, in forming anhydrous formulations.
  • Such anhydrous formulations can contain ingredients that are unstable, insoluble, or minimally soluble in water, such as, for example, vitamins including vitamins A, C, D and E.
  • Personal care compositions includes all oil-containing formulations generally intended for use in the care and/or protection of the skin, hair, nails, mucous membranes, oral cavity or body and generally not used for medicinal or curative effects.
  • personal care compositions includes cosmetic compositions.
  • Household compositions and “household formulations”, as used herein, includes all products used by a consumer in cleaning, repairing, maintaining, remodeling, beautifying, decorating, caring for, improving, or sanitizing a residence and its appliances or contents, contents include kitchen and bathroom fixtures, furniture, dishware, cookware, and clothing.
  • “Pharmaceutical composition” includes compositions comprising drugs, medicaments, medicinal or curative products, tonics, dietary supplements, vitamins, minerals and the like, whether intended to be taken internally or applied topically.
  • Topical application includes application of a personal care or pharmaceutical composition to the skin or mucous membrane.
  • Dermatological formulation or “dermatological treatment”, as used herein, includes all formulations and methods intended for use primarily on the skin, based on their effects thereon, and thus encompasses both cosmetic and pharmaceutical applications.
  • Oil includes oils derived from mineral, vegetable, and animal sources.
  • oil is used broadly and includes petroleum oils, such as long-chain hydrocarbons, and silicone oils.
  • oils such as long-chain hydrocarbons, and silicone oils.
  • such compounds containing hydrocarbon chains of at least 8, 9, 10, 11 , or 12 carbon atoms up to a preferred upper limit of 28, 27, 26, 25, 24, 23, or 22 carbon atoms are oils according to the present invention.
  • “Wax”, as used herein, means an organic compound, preferably a hydrocarbon compound, that is solid at room temperature. In addition to hydrocarbons, waxes include fatty acid-alcohol esters.
  • Alkyl as used herein, includes all saturated hydrocarbon moieties, whether straight, branched, or cyclic.
  • Alkenyl includes all hydrocarbon moieties, whether straight, branched, or cyclic, containing at least one carbon-carbon double bond.
  • Alkynyl includes all hydrocarbon moieties, whether straight, branched or cyclic, containing at least one carbon-carbon triple bond.
  • Hydrogen-bonding compound includes all organic compounds containing at least one electronegative atom such as oxygen, nitrogen, or sulfur and capable of forming non-covalent intermolecular bonds by means of the electronegative atoms. Examples include alcohols, amines, and thiols.
  • Poly solubility parameter represents the cohesive energy density of a fluid due to dipole-dipole and hydrogen bonding interactions. Calculation of the solubility parameter is described in the discussion of Example 3 below.
  • Preferred hydrogen bonding compounds according to the invention are those containing one or more hydroxyl groups.
  • Particularly preferred hydrogen bonding compounds are alcohols. Alcohols having a hydrocarbon chain of at least about 8 carbon atoms are preferred, alcohols having a hydrocarbon chain of from about 8 to about 32 carbon atoms are more preferred, and alcohols having a hydrocarbon chain of from about 10 to about 24 carbon atoms are even more preferred. In particular, in cosmetic applications, alcohols having from 12 to 24 carbon atoms are highly preferred. Guerbet alcohols of total chain length from about 12 to about 32 carbon atoms are well known in the art for use in personal care applications, and are useful in the present invention.
  • Guerbet alcohols are 2-alkyl alkanols, such as, for example, 2-butyl octanol, 2-hexyl decanol, 2-octyl dodecanol.
  • Examples of particularly preferred alcohols for use in the present invention are decanol, dodecanol, hexadecanol, stearyl alcohol, butyl octanol, hexyldecanol, and octyldodecanol.
  • a mixture of two or more hydrogen bonding compounds such as a mixture of alcohols, can be used.
  • Hydrogen bonding compounds such as alcohols
  • the hydrogen bonding compounds are present at from about 1 to about 5 weight percent, more preferably from about 1 to about 4 weight percent, and still more preferably from about 1 to about 3 weight percent.
  • Rheology modifiers are preferably thickening agents, which increase the viscosity of liquids.
  • Rheology modifiers include synthetic polymers and polysaccharides. Modified polysaccharide alkyl, alkenyl, alkynyl, aryl, arylalkyl or arylalkenyl ethers are highly preferred. The modified polysaccharide alkyl, alkenyl, alkynyl, aryl, arylalkyl or arylalkenyl ethers can be neutral or charged.
  • Modified as used herein to describe polysaccharides includes polysaccharide alkyl, alkenyl, alkynyl, aryl, arylalkyl or arylalkenyl ethers, esters, urethanes, amides, carbonates or polysaccharides having any other linkage to the polysaccharide backbone.
  • the modified polysaccharides can have additional substituents which can be cationic, anionic or nonionic. Examples of cationic substituents include quaternary ammonium and phosphonium groups. Examples of anionic substituents include carboxyl, phosphate, sulfate, carboxyalkyl, sulfoalkyl, and phosphoalkyl.
  • nonionic substituents include alkyl, aryl, and hydroxyalkyl.
  • additional substituent is a substituent group formed by reaction of the polysaccharide ether with an alkyl ketene dimer or with an alkyl succinic anhydride.
  • the additional substituent or substituents can be the same as or different from the first alkyl, alkenyl, alkynyl, aryl, or arylalkyl group.
  • neutral polysaccharides are preferred and of these, modified polygalactomannans are highly preferred.
  • Polygalactomannans are known in the art and are polymers comprising, as polymerized units, galactose and mannose.
  • Polygalactomannans differ from each other, inter alia, in the ratio of galactose units to mannose units.
  • the galactose:mannose ratio is determined, in part, by the source of the galactomannan.
  • Polygalactomannans can be obtained from several sources, including guar, tara, fenugreek, and locust bean gum.
  • modified polygalactomannans derived from guar gum, such as alkyl guar, and especially ethyl guar are particularly useful.
  • Modified polygalactomannans preferably have a degree of substitution of greater than 2.4.
  • other modified polygalactomannans can be advantageously used in the compositions and methods of the present invention.
  • Synthetic polymers useful as rheology modifiers include acrylic acid polymers and copolymers, vinylic polymers such as polyvinyl pyrrolidone polymers and copolymers, polyvinyl acetates, and polyalkenes that are oil soluble.
  • Oil phase refers to a uniform phase, in a uniform or non- uniform composition, which contains the oil or wax.
  • oil or wax For certain applications, as will be recognized by those skilled in the art, waxes will be preferred.
  • lipstick formulations often contain one or more waxes or solid oils.
  • oils that are liquids at room temperature will be preferred.
  • the oily phase can comprise any oil or mixture of oils conventionally employed in personal care, household and pharmaceutical formulations.
  • oils include, but are not limited to: hydrocarbons, including the mineral oils, such as the paraffin oils, the petrolatum oils, hydrogenated polyisobutylene, linear or branched hydrocarbons, and triglycerides, particularly vegetable oils.
  • hydrocarbon oils for use in the present invention include isooctane, isododecane, and isohexadecane.
  • vegetable oils include sunflower seed oil, sesame seed oil, linseed oil, tung oil, oiticica oil, soybean oil, cottonseed oil, coconut, rapeseed oil, sweet almond oil, calophyllum oil, palm oil, avocado oil, jojoba oil, olive oil, castor oil, and grain germ oils such as wheat germ oil.
  • oils include various oily esters derived from a long-chain acid and/or alcohol or polyol, such as purcellin oil; capric/caprylic triglyceride, isopropyl, butyl or cetyl myristate; isopropyl, butyl or ethyl-2-hexyl palmitate; isopropyl, butyl octyl, hexadecyl or isocetyl stearate; decyl oleate; hexyl laurate; propylene glycol dicaprylate; diisopropyl adipate; and the mixtures of C 12 -C 15 alkyl benzoate esters commercially available under the trademark FINSOLVTM TN from Finetex.
  • purcellin oil such as purcellin oil
  • capric/caprylic triglyceride isopropyl, butyl or cetyl myristate
  • animal oils such as perhydrosqualene
  • silicone oils such as dimethylpolysiloxanes, phenyldimethicones, trimethyl phenyl silsesquioxane, decamethylcyclopentasiloxane, dodecamethylcyclohexasiloxane, octamethylcyclotetrasiloxane, dimethylcyclosiloxanes, cyclomethicones, alkyldimethicones, and mixtures thereof.
  • Silicone oils are commercially available, for example, from Dow Corning Corporation.
  • Preferred oils are those having more than about 8 carbon atoms and include, but are not limited to, jojoba, sesame, corn, olive, safflower, and rape seed oils; shea butter, and synthetic oils such as purcellin oil, 2-ethyl hexyl palmitate, 2-octyldodecyl stearate, 2- octyldodecyl erucate, isostearyl isostearate, 2-octyldodecyl benzoate, hydrogenated isoparrafin, and silicone oils.
  • the rheology modifier is present in an amount sufficient to achieve the desired thickness for the intended application. In general, it is present in an amount of from about 0.1 % to about 40%, preferably from about 0.3% to about 30%, more preferably from about 0.4% to about 20%, even more preferably from about 0.5 to about 10% by weight, based on the weight of the oil. If the composition is a neat composition, the rheology modifier is present in an amount from about 0.5% to about 8% by weight, based on the weight of the oil.
  • Neat composition as used herein, is intended to mean a composition that is essentially free of water.
  • the rheology modifier is present in an amount from about 0.5 to about 10 % by weight, based on the weight of the oil.
  • the amount of rheology modifier for a particular personal care, household or pharmaceutical application will be determined, in part, upon the form in which the composition is to be provided.
  • the compositions and methods of the present invention are useful in a wide variety of products, including personal care, household, and pharmaceutical products.
  • compositions of the invention can be provided in various forms, such as a liquid, a gel, a solid bar, an emulsion, a paste, an aqueous/alcoholic lotion or dispersion, or an ointment, and can optionally be packaged as an aerosol or dispersed as a foam.
  • the compositions of the invention can contain various additives known in the art including additional rheology modifiers, emulsifiers, thickening agents, such as polyacrylic acids, cellulose derivatives or esters of fatty acids and of polyethylene glycol, sequestering agents, foam reinforcers, preservatives, fragrances, electrolytes, fatty substances such as fatty alcohols, ceramides or mineral, vegetable, animal or synthetic oils or waxes.
  • Amounts of additives and other ingredients can be, for example, from about 0.001% to 20% by weight of the composition.
  • the compositions of the instant invention may optionally contain additives conventionally used in the personal care industry, including but not limited to active ingredients, perfumes, preservatives, fragrance retention agents, fragrance releasing gels, and sunscreen agents.
  • additives and their use in personal care compositions are well known in the art and can be added by known techniques before, during, or after the thickening of the oil.
  • Other ingredients well known to those skilled in the art can also be incorporated into the personal care compositions.
  • Such ingredients include coloring agents, opacifiers, UV screening agents, antioxidants, peariescence agents, biocides, antibacterial agents, antidandruff agents, antiseborrheic agents, antiparasitic agents, repellents, dyes, pigments, oxidizing agents, reducing agents, moisturizers, anionic, nonionic or cationic polymers, vitamins, alpha -hydroxy acids, tocopherol and its esters, fatty esters of ascorbic acid, 18- beta -glycyrrhetinic acid, and ceramides.
  • the emulsion can contain any ingredients known in the art for use in emulsions, such as surfactants and/or dispersing aids.
  • Emulsions can also contain thickeners, which can be, for example, water-soluble or water-swellable polymers contained primarily within the aqueous phase of the emulsion.
  • suitable water-soluble or water-swellable polymers include: hydroxyethylcellulose, hydroxypropylmethylcellulose, cetyl modified hydroxyethylcellulose ⁇ agar, carrageenans, pectins, guars, hydroxypropylcellulose, crosslinked acrylic acid polymers and copolymers, polyethylene glycols, oxyethylene polymers and copolymers, vinylcaprolactam homopolymers and copolymers, vinylmethyl ether co- maleic anhydride polymers, and polyvinylpyrrolidone.
  • Powders can be incorporated into compositions of the invention.
  • powders include chalk, talc, kaolin, starch, smectite clays, chemically modified magnesium aluminum silicate, organically modified montmorillonite clay, hydrated aluminum silicate, fumed silica, aluminum starch octenyl succinate and mixtures thereof.
  • Personal care products made using the compositions and methods of the present invention are useful in a variety of personal care applications such as, for example, treatment of the skin including moisturizing, cleaning, softening, protecting, hydrating, or smoothing the skin; conditioning, softening, cleansing, or styling the hair; minimizing transepidermal water loss; conditioning or treating the nails, or delivering ingredients including sunscreens, vitamins, pigments, dyes, or tints to the hair, skin and/or nails.
  • compositions and methods of the present invention include, for example, moisture retention agents, moist towels, towels for cleansing or moisturizing the skin, towels for make-up application or removal, hair styling agents, skin conditioners, hair conditioners, deodorants, including spray, aerosol, gel and stick deodorants, antiperspirants, including spray, aerosol, gel and stick antiperspirants, sunscreen creams or lotions, emollient lotions, milks or creams, make-up removal creams lotions or milks, foundation bases, lotions, milks or creams for artificial tanning, shaving creams, shaving foams, shaving lotions, after shave lotions, face masks, make-up products for the eyes, lipsticks, lip glosses, colors and foundations for the face, shampoos, bath or shower products, hand cleaning products, and compositions for dyeing, bleaching, curling, or straightening the hair.
  • compositions of the present invention can be incorporated within and/or carried on the surface of the towel.
  • Other personal care products include dentifrices, denture cleaners, denture adhesives, scalp treatment products, blemish treatment products, wound dressings, wound care and treatment products, and oral care products.
  • Such personal care products are generally commercially available to the consumer without a prescription and can be used to treat minor injuries and conditions.
  • Personal care products can optionally contain active ingredients such as antiseptics, anesthetics, and antibiotics, and can be applied to the skin or to the mucous membranes, and can be contained in mucoadhesive compositions.
  • compositions of the present invention can provide advantages in the use and application of personal care formulations.
  • substantially uniform compositions of the invention can provide for improved distribution of ingredients throughout a formulation, thus providing for improved delivery, including more uniform delivery, of effective or active ingredients to the hair, skin, or nails.
  • vehicles for the delivery of cosmetic ingredients can advantageously contain compositions of the invention.
  • ingredients for which the compositions and methods of the invention can provide improved delivery include sunscreens, fragrances, pigments, and agents for treatment of the skin such as those described elsewhere herein.
  • the methods and compositions of the invention can provide enhanced protection of the skin or hair from the sun by providing for improved delivery of suncreens.
  • compositions and methods of the present invention are applicable to household formulations.
  • the compositions and methods of the invention can provide advantages in addition to those already mentioned above, in particular, more uniform delivery of effective or active ingredients.
  • Household products for which the compositions and methods of the invention are useful include cleaning products, pretreatment products, products used in remodeling or decorating the home, and sterilizing products. Also included are pet care and grooming products. Also included within “household products” and “household formulations” are products used in cleaning, repairing, decorating or remodeling an automobile, boat, bicycle or other vehicle, and products used in repairs done in a residence by a consumer, such as lubricants for sawing, drilling, or milling wood or metal. Also included are lubricants for household machinery or equipment such as sewing machines and other small appliances.
  • cleaning products include detergents, stain removers, bleach, glass cleaner, fabric softeners including fabric softener papers, cloths or sponges, oven pretreatment, oven cleaner, cleaners for hard surfaces such as bathroom fixtures and tiles, furniture cleaners and polishes, and cleaners or polishes for wood floors.
  • Remodeling and decorative products include paints, inks, dyes, wood stains, varnishes, and shellacs.
  • compositions can contain buffering agents, chelating agents, codispersants, surfactants, enzymes, fluorescent whitening agents, electrolytes, builders, antioxidants, thickeners, fragrance, dyes, colorants, pigments, defoamers, or mixtures thereof.
  • optional ingredients include bleach scavengers, sodium perborate, reducing sugars, short chain alcohols; solvents and hydrotropes such as ethanol, isopropanol and xylene sulfonates; flow control agents ,enzyme stabilizing agents; soil suspending agents; antiredeposition agents; anti- tarnish agents; anti-corrosion agents; colorants; abrasives, and other functional additives.
  • the pH of the cleaning composition may be adjusted by addition of strong acid or base.
  • buffering agents include sodium carbonate and sodium borate.
  • drug or “pharmacologically active agent” or any other similar term means any chemical or biological material or compound that induces a desired biological or pharmacological effect, including (1 ) affecting living processes, (2) having a prophylactic effect on an organism and preventing an undesired biological effect such as preventing an infection, (3) treating a disease, including alleviating a condition caused by a disease, for example, alleviating pain or inflammation caused as a result of disease, and/or alleviating, reducing, or completely eliminating the disease from the organism.
  • Pharmaceutical applications thus include materials useful in treating diseases or other conditions of the skin, such as, for example, acne, rashes, fungal, viral or bacterial infections, cracking, peeling, burns, lesions, and dermatitis.
  • compositions of the present invention include antiseptics, anesthetics, vitamins and/or minerals especially those prescribed for medical reasons, and drugs for the treatment of disease.
  • Treatment of disease can be accomplished by administering to a patient in need of such treatment a pharmaceutical composition comprising a composition of the present invention.
  • Such administration can include oral administration, topical application, or administration by means of a suppository.
  • the compositions can include such pharmaceutically acceptable additives, ingredients, carriers, extenders, fillers, processing aids, and excipients known in the art.
  • compositions of the invention can contain conventional excipients known for use in the preparation of pharmaceutical formulations, such as thickening agents, emulsifiers, flavoring agents, coloring agents, and the like.
  • compositions and methods of the present invention examples include formulations intended for ingestion and formulations intended for topical application.
  • Ingestible pharmaceutical formulations for which the present invention is useful include dosage forms such as capsules, caplets, tablets, liquids, and gels.
  • Topically applied pharmaceutical formulations for which the invention is useful include creams, lotions, gels, adhesives, ointments, and formulations for transdermal delivery of pharmaceutically active materials.
  • chemical enhancers for facilitating transport of the drug through the skin or mucosa and other additives can be included in the composition.
  • N-Hance® AG-200 polymer from Hercules Incorporated was determined by turbidity measurements.
  • the mixtures were N-Hance® AG-200/alcohol/organic solvent mixtures in which various levels of polymer (AG-200), alcohol (dodecanol or hexadecanol), and organic solvent (Finsolv TN, isopropyl palmitate, or 50:50 FinsolvTN:isopropyl palmitate) were combined.
  • a solution was prepared of N-Hance AG® polymer in 2-butyl octanol (25 wt % N-Hance AG® 50 polymer or 20 wt % N-Hance AG® 200 polymer). 1 or 2 grams of the polymer solution was accurately weight in a scintillation vial. 0 or 2 grams of 2- butyl octanol was accurately weighed into each vial.
  • Primary solvent was accurately weighed into each vial to yield a final total volume of approximately 20 ml.
  • Primary solvents used were: DC-345 (Dow Corning cyclodimethicone), DC-556 (Dow Corning Phenyl trimethicone), P-99A (Permethyl Specialties isododecane), P-101A (Permethyl Specialties isohexadecane).
  • the solvent, polymer, and alcohol were mixed with a magnetic stirrer and heated on a hot plate (95°C) for 1 hour to yield nominal polymer concentrations of 1 -1.5 and 2- 2.5 weight percent with 2-butyl octanol concentrations of 2-10 and 12-24 weight percent.
  • Solution viscosities were measured using a Brookfield LVDV-II+ viscometer with a small sample adapter and a #18 spindle. 8 ml of each sample was added to the sample reservoir of the viscometer and thermostatted at 25°C. The spindle rotation rate was set to the maximum rotation rate that resulted in an on-scale reading. The sample turbidity was directly measured using an Orbeco-Hellige turbidimeter.
  • Component solubility parameters used are listed in Table 4. Also listed in Table 3 are the turbidity, viscosity, and appearance of each composition. Solubility parameters used are those described in CM. Hansen, "The Three- dimensional Solubility Parameters", J. Paint Technol., Vol. 39, p. 105 (1967).
  • ⁇ p value of 0 was assigned to DC-345 and DC-556 based on the solvatochromic response of dimethylsiloxane polymers and low molecular weight linear dimethyl siloxanes relative to linear and cyclic alkanes (see J. E. Brady, D. Bjorkman, C. D. Herter, P. W. Carr; Analytical Chemistry (1984) 56, 278-83 and references cited therein.).
  • Run #1 X31651-67-1A 1. Mixed “B” with “C”, “E”, and “F” for twenty minutes.
  • the NP 330 was dispersed in water. The pH was raised to about 8.0 - 8.5 to dissolve the polymer and mixed for 45 minutes. The methylparaben was added to the finished solution. 2. While slowly stirring the water-soluble polymer solution, the stearalkonium chloride, olefin sulfonate, and glycol stearate were added. The mixture was heated to 80°C until all of the glycol stearate was melted and the solution had turned opaque.
  • the Natrosol 250HR product was dispersed in water. The pH was raised to about 8.0 - 8.5 to dissolve the polymer and mixed for 45 minutes. The methylparaben was added to the finished solution.
  • the surfactant solution was added to the water-soluble polymer solution and mixed until well blended. 4.
  • the disodium EDTA was added and cooled to room temperature.
  • Baby Hair Conditioner Formula Ingredients Weight %
  • the Natrosol was dispersed in water with good agitation.
  • the pH was raised to about 8.0 - 8.5 to dissolve the polymer and mixed for 45 minutes or until fully dissolved.
  • NP 330 and Natrosol 250HHR were dispersed in water with good agitation. The pH was raised to 8.0 - 8.5; the dispersion was mixed until fully dissolved. 2. In a separate vessel, the stearalkonium chloride and propylene glycol were mixed together and heated to 80°C. 3. The other ingredients listed in Phase B were added in the order listed to the mixture of stearalkonium chloride and propylene glycol and mixed well between each addition.
  • the surfactant mixture was added to the HMHEC1 solution, mixed well, and cooled to 35°C.
  • NP 330 CS was dispersed into well agitated water from Part A. Glycerin was added with continued mixing and heated to 80°C. Mixed 15 minutes at 80°C.
  • Part A was added slowly to Part B under good agitation. The temperature of the emulsion was maintained to ⁇ 80°C with constant stirring. 4. Ingredients in C were combined and added to the emulsion. Mixed continuously while cooling to 40°C.
  • Part D serving agent
  • the sodium hydroxide and potassium hydroxide were added to the deionized water in a vessel at room temperature. The temperature of the vessel was then raised to 75°C and stirred for 5 minutes. The stearic acid and coconut acid were separately pre-melted and then each was added to the caustic/water mixture and then stirred for 30 minutes followed by cooling to 55°C. Natrosol 250 HR was slurried in the propylene glycol and added to the mix. Next, one at a time, lauramide DEA (melted), coconut oil, tallow glycerides (melted), N-Hance AG, and a preservative were added to the vessel and stirred for 15 minutes and allowed to cool.
  • the concentrate was transferred to container.
  • For the aerosol cream weigh 225 g into a standard 12-oz shaving cream can.
  • the can is then sealed with a valve assembly using laboratory canning equipment and charged with 9.0 g of propellant.
  • Part III The salts of Part III were added to the water in a vessel while stirring and heated to about 60°C to dissolve. The vessel was covered during heating to prevent moisture loss. 2. Part i. The glycerine was weighed into a beaker and the polymer Natrosol N-
  • Hance AG was dispersed in the glycerin while stirring for about 5 minutes or until adequately dispersed. Sorbitol was added and the mixture was continuously stirred for another 10 minutes. Water was added and stirred for an additional 15 to 30 minutes, making sure that the polymer was completely hydrated (no gels). A warm salt solution was added while stirring continuously for an additional 15 minutes or until homogenous (no lumps or gels). This mixture was then transferred to a toothpaste mixer (Ross double planetary mixer).
  • the mixer was then shut off and the vacuum was broken and the formulation was packed out as a paste.
  • the petrolatum and mineral oil were weighed into a 250 ml beaker.
  • the beaker was placed in a circulating oil bath heated to 67°C.
  • the contents were stirred at speed 0 with an electric mixer having two V ⁇ " dia. propellers spaced V ⁇ ' apart on the shaft.
  • contents were 65°C, the polymer was added slowly while adjusting the mixer speed to maintain a vortex in the mixture. Mixing was continued for one hour.
  • Phase II was added to Phase I while mixing and cooled to 80°C.
  • a fragrance would be added at this point and allowed to mix well.
  • the product was poured into a 1 oz. glass jars and allowed to cool overnight. After cooling overnight, the samples were tested for physical and chemical properties.
  • Phase 1 Phase 1:
  • DC-345 (cyclodimethicone) was used in place of phenyl trimethicone (DC-556).
  • TEA-lauryl sulfate (40% active) (Stepanol WAT) 15.00 75.00 Sodium lauroamphoacetate (and) sodium trideceth sulfate (Miranol MHT) 10.00 50.00
  • Glycol stearate (Emerest 2400) 1.20 6.00 Propylene glycol (and) diazolidinyl urea (and) methylparaben (and) propylparaben (Germaben II) 0.75 3.75
  • the N-Hance® was dispersed by adding slowly to the vortex of well-agitated water in the container. The pH was reduced to 7.0 with citric acid solution to promote dissolution of the surface-treated N-Hance. Heated to 50°C. 2. Natrosol was slowly sifted into the N-Hance solution and mixed until fully dissolved. 3. The temperature was raised to 70°C. Next, the TEALS and glycol stearate were added, one at a time. Between each addition the mixture was well agitated. Heat was turned off once it looked homogeneous. The mixing was continued. 4. When the temperature reached 55°C, the remaining ingredients were added, one at a time.
  • Cyclodimethicone (DC-345) was used in place of 50% of mineral oil.
  • Disodium EDTA (EDETA BD, BASF) 0.10 0.50
  • Phase C Micronized the pigment grind and added the remaining Phase C ingredients. Combined Phase C and Phase B. Added Phase B and C mixture to Phase A at 70°C (158°F) while mixing with a cage mixer or side-sweep mixer. Stir-cooled at 28°C (82°F) Liquid Make-Up
  • Phase B Water 56.0 PEG-8 Polyglycol E-400 5.0 Glycereth-26 Liponic EG-1/Lipo 5.0 Tetrahydroxypropyl Quadrol/BASF 0.5
  • Phase B Micronized the pigment grind and combined with Phase B. Heated both Phase A and Phase Be separately to 75°C (167°F) while mixing with a cage mixer or side- sweep mixer. Cooled with mixing. At 48°C (118°F) product begins to become thicker and should be packaged at about 38°C (100°F). Make-Up Cover Stick
  • Stearamide MEA Stearate Witcamide MAS/Witco 8.3 2-Octyldodecanol 2.0
  • Procedure Combined Phase B ingredients at 50°C (122°F) with propeller agitation, then heated to 80°C (176°F). Heated Phase A to 80°C and added to Phase B, mixing until uniform. Reduced temperature to 60°C (140°F) and added Phase C. Casted into stick molds and cooled to room temperature.
  • Formulation A heated petrolatum and microcrystalline wax until melted. Added remaining ingredients.
  • Formulation B heated petrolatum and paraffin wax until melted. Added remaining ingredients.
  • Formulation C melted together microcrystalline wax, petrolatum and mink wax. In a separate container, mixed Nimelesterol and Dow Corning 556 fluid. Added to first mixture. Eye Shadow Stick Base
  • Phase A Mix the Phase A ingredients in a suitable vessel and measured the phases refractive index.
  • Phase B ingredients and measured the refractive index. Adjusted the refractive index of Phase A appropriately.
  • the refractive indices mixed Phase A with a Gifford-Wood Eppenbach mixer using moderate shear and slowly added to Phase B.
  • Phase B sheared the emulsion to uniformity. It is suggested that high one-pass shearing be applied to improve stability.
  • Phase B Aluminum Zirconium 58.0 Tetrachlorohydrex-Gly (and) Water Water 3.3 Propylene Glycol 100.0
  • Phase A Mix the Phase A ingredients in a suitable vessel and measured the phases refractive index.
  • Phase B Mix the Phase B ingredients and measured this phases refractive index. Adjusted the refractive index of Phase B to match Phase A by adding propylene glycol to increase its refractive or adding water to lower it.
  • Phase A When the refractive indices matched, mixed Phase A with a Gifford-Wood Eppenbach mixer using moderate shear and slowly added to Phase B. When all of Phase B is added, sheared the emulsion to uniformity.

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Abstract

L'invention concerne des compositions à rhéologie modifiée et des procédés relatifs à leur élaboration, qui sont utiles pour obtenir certaines propriétés recherchées, y compris la viscosité, dans des formulations cosmétiques, pharmaceutiques ou dans des formulations propres à différents produits ménagers.
PCT/US1999/021210 1998-09-11 1999-09-09 Compositions a rheologie modifiee et procedes correspondants Ceased WO2000015180A1 (fr)

Priority Applications (4)

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EP99969018A EP1112054A1 (fr) 1998-09-11 1999-09-09 Compositions a rheologie modifiee et procedes correspondants
CA002341433A CA2341433A1 (fr) 1998-09-11 1999-09-09 Compositions a rheologie modifiee et procedes correspondants
BR9913617-1A BR9913617A (pt) 1998-09-11 1999-09-09 Composições de reologia modificada e seus processos
AU60414/99A AU6041499A (en) 1998-09-11 1999-09-09 Rheology modified compositions and processes thereof

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US09/154,531 1998-09-11

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Cited By (27)

* Cited by examiner, † Cited by third party
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WO2001085117A1 (fr) * 2000-04-28 2001-11-15 Henkel Kommanditgesellschaft Auf Aktien Composition antitranspirante anhydride contenant des polysaccharides
EP1264589A1 (fr) * 2001-06-07 2002-12-11 L'oreal Utilisation d'un additif polaire dans une composition cosmétique comprenant une phase grasse liquide structurée par au moins un organogelateur pour donner à la composition un caractére thixotrope
JP2003146833A (ja) * 2001-10-24 2003-05-21 Clariant Internatl Ltd シリコーン油と有機性油との均一混合物
EP1040821B2 (fr) † 1999-03-31 2005-10-12 L'oreal Composition cosmétique comprenant au moins une phase pulvérulente, un hydratant et un dérivé de galactomannane et utilisations
EP1745773A1 (fr) * 2005-07-11 2007-01-24 L'Oréal Composition photoprotectrice comprenant une phase aqueuse et une cire apolaire de bas point de fusion
EP2022475A1 (fr) * 2007-08-07 2009-02-11 KPSS-Kao Professional Salon Services GmbH Composition pour fibres de kératine
EP2022485A1 (fr) * 2007-08-07 2009-02-11 KPSS-Kao Professional Salon Services GmbH Composition de nettoyage
US7521593B2 (en) 2002-05-09 2009-04-21 Commonwealth Scientific And Industrial Research Organisation Barley with altered branching enzyme activity and starch and starch containing products with an increased amylose content
WO2009098476A1 (fr) * 2008-02-07 2009-08-13 Reckitt Benckiser Inc. Compositions antimicrobiennes topiques
EP2100582A1 (fr) * 2008-03-10 2009-09-16 The Procter and Gamble Company Composition cosmétique
US8518381B2 (en) 2008-03-28 2013-08-27 The Procter & Gamble Company Processes of making oral compositions containing gel networks
US8636918B2 (en) 2011-08-05 2014-01-28 Ecolab Usa Inc. Cleaning composition containing a polysaccharide hybrid polymer composition and methods of controlling hard water scale
US8674021B2 (en) 2006-07-21 2014-03-18 Akzo Nobel N.V. Sulfonated graft copolymers
US8679366B2 (en) 2011-08-05 2014-03-25 Ecolab Usa Inc. Cleaning composition containing a polysaccharide graft polymer composition and methods of controlling hard water scale
US8841246B2 (en) 2011-08-05 2014-09-23 Ecolab Usa Inc. Cleaning composition containing a polysaccharide hybrid polymer composition and methods of improving drainage
US8853144B2 (en) 2011-08-05 2014-10-07 Ecolab Usa Inc. Cleaning composition containing a polysaccharide graft polymer composition and methods of improving drainage
US8945314B2 (en) 2012-07-30 2015-02-03 Ecolab Usa Inc. Biodegradable stability binding agent for a solid detergent
US9005585B2 (en) 2006-09-29 2015-04-14 The Procter & Gamble Company Oral compositions containing gel networks
US9051406B2 (en) 2011-11-04 2015-06-09 Akzo Nobel Chemicals International B.V. Graft dendrite copolymers, and methods for producing the same
US9109068B2 (en) 2005-07-21 2015-08-18 Akzo Nobel N.V. Hybrid copolymer compositions
US9365805B2 (en) 2014-05-15 2016-06-14 Ecolab Usa Inc. Bio-based pot and pan pre-soak
US9622951B2 (en) 2012-10-29 2017-04-18 The Procter & Gamble Company Personal care compositions
US9630206B2 (en) 2005-05-12 2017-04-25 Innovatech, Llc Electrosurgical electrode and method of manufacturing same
FR3048178A1 (fr) * 2016-02-29 2017-09-01 Oreal Composition comprenant un alkylether de polysaccharide et des huiles incompatibles et procede la mettant en oeuvre
US9988526B2 (en) 2011-11-04 2018-06-05 Akzo Nobel Chemicals International B.V. Hybrid dendrite copolymers, compositions thereof and methods for producing the same
US20220395445A1 (en) * 2019-10-23 2022-12-15 Shiseido Company, Ltd. Water-in-oil emulsion sunscreen cosmetic
US20230201103A1 (en) * 2020-05-26 2023-06-29 L'oreal Cosmetic composition comprising at least 30% by weight of branched alkane and a combination of particular silicones

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EP0804924A2 (fr) * 1996-04-29 1997-11-05 L'oreal S.A. Composition pour la protection de la peau, pour améliorer les parfums et pour la délivrance de vitamine

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EP0281360A1 (fr) * 1987-03-02 1988-09-07 STEIN, HALL & CO., INC. Ethers non ioniques de polygalactomannes modifiés par des groupes hydrophobes
EP0795322A1 (fr) * 1996-03-12 1997-09-17 L'oreal Composition épaissie par un alkyléther de polysaccharide
EP0795323A1 (fr) * 1996-03-12 1997-09-17 L'oreal Composition gélifiée stable contenant des actifs lipophiles sensibles à l'oxygène et/ou à l'eau
EP0804924A2 (fr) * 1996-04-29 1997-11-05 L'oreal S.A. Composition pour la protection de la peau, pour améliorer les parfums et pour la délivrance de vitamine

Cited By (45)

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Publication number Priority date Publication date Assignee Title
EP1040821B2 (fr) † 1999-03-31 2005-10-12 L'oreal Composition cosmétique comprenant au moins une phase pulvérulente, un hydratant et un dérivé de galactomannane et utilisations
US6849251B2 (en) 2000-04-28 2005-02-01 Henkel Kommanditgesellschaft Auf Aktien Anhydrous antiperspirant composition containing polysaccharides
WO2001085117A1 (fr) * 2000-04-28 2001-11-15 Henkel Kommanditgesellschaft Auf Aktien Composition antitranspirante anhydride contenant des polysaccharides
EP1264589A1 (fr) * 2001-06-07 2002-12-11 L'oreal Utilisation d'un additif polaire dans une composition cosmétique comprenant une phase grasse liquide structurée par au moins un organogelateur pour donner à la composition un caractére thixotrope
FR2825618A1 (fr) * 2001-06-07 2002-12-13 Oreal Utilisation d'un additif polaire dans une composition cosmetique comprenant une phase grasse liquide structuree par au moins un organogelateur pour donner a la composition un caractere thixotrope
JP2003146833A (ja) * 2001-10-24 2003-05-21 Clariant Internatl Ltd シリコーン油と有機性油との均一混合物
EP1306072A3 (fr) * 2001-10-24 2003-06-11 Clariant International Ltd. Mélanges homogènes d'huiles de silicone et d'huile organiques
US7521593B2 (en) 2002-05-09 2009-04-21 Commonwealth Scientific And Industrial Research Organisation Barley with altered branching enzyme activity and starch and starch containing products with an increased amylose content
US9630206B2 (en) 2005-05-12 2017-04-25 Innovatech, Llc Electrosurgical electrode and method of manufacturing same
US11246645B2 (en) 2005-05-12 2022-02-15 Innovatech, Llc Electrosurgical electrode and method of manufacturing same
US10463420B2 (en) 2005-05-12 2019-11-05 Innovatech Llc Electrosurgical electrode and method of manufacturing same
EP1745773A1 (fr) * 2005-07-11 2007-01-24 L'Oréal Composition photoprotectrice comprenant une phase aqueuse et une cire apolaire de bas point de fusion
US9109068B2 (en) 2005-07-21 2015-08-18 Akzo Nobel N.V. Hybrid copolymer compositions
US9321873B2 (en) 2005-07-21 2016-04-26 Akzo Nobel N.V. Hybrid copolymer compositions for personal care applications
US8674021B2 (en) 2006-07-21 2014-03-18 Akzo Nobel N.V. Sulfonated graft copolymers
US10130567B2 (en) 2006-09-29 2018-11-20 The Procter & Gamble Company Oral compositions containing gel networks
US9655819B2 (en) 2006-09-29 2017-05-23 The Procter & Gamble Company Oral compositions containing gel networks
US9393188B2 (en) 2006-09-29 2016-07-19 The Procter & Gamble Company Oral compositions containing gel networks
US9005585B2 (en) 2006-09-29 2015-04-14 The Procter & Gamble Company Oral compositions containing gel networks
EP2025325A1 (fr) * 2007-08-07 2009-02-18 KPSS-Kao Professional Salon Services GmbH Composition pour fibres de kératine
US8044007B2 (en) 2007-08-07 2011-10-25 Kpss-Kao Professional Salon Services Gmbh Composition for keratin fibres comprising an arylated silicone
US7662760B2 (en) 2007-08-07 2010-02-16 Kpss - Kao Professional Salon Services Gmbh Cleansing composition comprising a ternary surfactant mixture and polyaryl siloxane
EP2022485A1 (fr) * 2007-08-07 2009-02-11 KPSS-Kao Professional Salon Services GmbH Composition de nettoyage
EP2025330A3 (fr) * 2007-08-07 2015-07-29 Kao Germany GmbH Composition de nettoyage
EP2022475A1 (fr) * 2007-08-07 2009-02-11 KPSS-Kao Professional Salon Services GmbH Composition pour fibres de kératine
WO2009098476A1 (fr) * 2008-02-07 2009-08-13 Reckitt Benckiser Inc. Compositions antimicrobiennes topiques
EP2100582A1 (fr) * 2008-03-10 2009-09-16 The Procter and Gamble Company Composition cosmétique
WO2009112970A3 (fr) * 2008-03-10 2009-11-05 The Procter & Gamble Company Composition cosmétique
US8980230B2 (en) 2008-03-28 2015-03-17 The Procter & Gamble Company Processes of making oral compositions containing gel networks
US8518381B2 (en) 2008-03-28 2013-08-27 The Procter & Gamble Company Processes of making oral compositions containing gel networks
US8853144B2 (en) 2011-08-05 2014-10-07 Ecolab Usa Inc. Cleaning composition containing a polysaccharide graft polymer composition and methods of improving drainage
US8841246B2 (en) 2011-08-05 2014-09-23 Ecolab Usa Inc. Cleaning composition containing a polysaccharide hybrid polymer composition and methods of improving drainage
US9309489B2 (en) 2011-08-05 2016-04-12 Ecolab Usa Inc Cleaning composition containing a polysaccharide hybrid polymer composition and methods of improving drainage
US8636918B2 (en) 2011-08-05 2014-01-28 Ecolab Usa Inc. Cleaning composition containing a polysaccharide hybrid polymer composition and methods of controlling hard water scale
US8679366B2 (en) 2011-08-05 2014-03-25 Ecolab Usa Inc. Cleaning composition containing a polysaccharide graft polymer composition and methods of controlling hard water scale
US9051406B2 (en) 2011-11-04 2015-06-09 Akzo Nobel Chemicals International B.V. Graft dendrite copolymers, and methods for producing the same
US9988526B2 (en) 2011-11-04 2018-06-05 Akzo Nobel Chemicals International B.V. Hybrid dendrite copolymers, compositions thereof and methods for producing the same
US8945314B2 (en) 2012-07-30 2015-02-03 Ecolab Usa Inc. Biodegradable stability binding agent for a solid detergent
US9622951B2 (en) 2012-10-29 2017-04-18 The Procter & Gamble Company Personal care compositions
US10053652B2 (en) 2014-05-15 2018-08-21 Ecolab Usa Inc. Bio-based pot and pan pre-soak
US9365805B2 (en) 2014-05-15 2016-06-14 Ecolab Usa Inc. Bio-based pot and pan pre-soak
FR3048178A1 (fr) * 2016-02-29 2017-09-01 Oreal Composition comprenant un alkylether de polysaccharide et des huiles incompatibles et procede la mettant en oeuvre
WO2017148848A1 (fr) * 2016-02-29 2017-09-08 L'oreal Composition comprenant un alkyléther de polysaccharide et des huiles incompatibles et son procédé d'utilisation
US20220395445A1 (en) * 2019-10-23 2022-12-15 Shiseido Company, Ltd. Water-in-oil emulsion sunscreen cosmetic
US20230201103A1 (en) * 2020-05-26 2023-06-29 L'oreal Cosmetic composition comprising at least 30% by weight of branched alkane and a combination of particular silicones

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CA2341433A1 (fr) 2000-03-23
EP1112054A1 (fr) 2001-07-04
BG105437A (en) 2006-10-31

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