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WO2000012424A1 - Dispositif et procede de conditionnement et de distribution d'un materiau fluidifiable, en particulier d'un medicament - Google Patents

Dispositif et procede de conditionnement et de distribution d'un materiau fluidifiable, en particulier d'un medicament Download PDF

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Publication number
WO2000012424A1
WO2000012424A1 PCT/IL1999/000455 IL9900455W WO0012424A1 WO 2000012424 A1 WO2000012424 A1 WO 2000012424A1 IL 9900455 W IL9900455 W IL 9900455W WO 0012424 A1 WO0012424 A1 WO 0012424A1
Authority
WO
WIPO (PCT)
Prior art keywords
container
compartment
opening
valve member
flowable material
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/IL1999/000455
Other languages
English (en)
Inventor
Melvyn Rosenberg
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Innoscent Ltd
Original Assignee
Innoscent Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Innoscent Ltd filed Critical Innoscent Ltd
Priority to AU53845/99A priority Critical patent/AU5384599A/en
Priority to EP99939586A priority patent/EP1169262A1/fr
Publication of WO2000012424A1 publication Critical patent/WO2000012424A1/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01F—MEASURING VOLUME, VOLUME FLOW, MASS FLOW OR LIQUID LEVEL; METERING BY VOLUME
    • G01F11/00—Apparatus requiring external operation adapted at each repeated and identical operation to measure and separate a predetermined volume of fluid or fluent solid material from a supply or container, without regard to weight, and to deliver it
    • G01F11/10—Apparatus requiring external operation adapted at each repeated and identical operation to measure and separate a predetermined volume of fluid or fluent solid material from a supply or container, without regard to weight, and to deliver it with measuring chambers moved during operation
    • G01F11/26—Apparatus requiring external operation adapted at each repeated and identical operation to measure and separate a predetermined volume of fluid or fluent solid material from a supply or container, without regard to weight, and to deliver it with measuring chambers moved during operation wherein the measuring chamber is filled and emptied by tilting or inverting the supply vessel, e.g. bottle-emptying apparatus
    • G01F11/262—Apparatus requiring external operation adapted at each repeated and identical operation to measure and separate a predetermined volume of fluid or fluent solid material from a supply or container, without regard to weight, and to deliver it with measuring chambers moved during operation wherein the measuring chamber is filled and emptied by tilting or inverting the supply vessel, e.g. bottle-emptying apparatus for liquid or semi-liquid
    • G01F11/263—Apparatus requiring external operation adapted at each repeated and identical operation to measure and separate a predetermined volume of fluid or fluent solid material from a supply or container, without regard to weight, and to deliver it with measuring chambers moved during operation wherein the measuring chamber is filled and emptied by tilting or inverting the supply vessel, e.g. bottle-emptying apparatus for liquid or semi-liquid with valves
    • G01F11/265—Apparatus requiring external operation adapted at each repeated and identical operation to measure and separate a predetermined volume of fluid or fluent solid material from a supply or container, without regard to weight, and to deliver it with measuring chambers moved during operation wherein the measuring chamber is filled and emptied by tilting or inverting the supply vessel, e.g. bottle-emptying apparatus for liquid or semi-liquid with valves of the ball type
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D23/00—Details of bottles or jars not otherwise provided for
    • B65D23/04—Means for mixing or for promoting flow of contents
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01F—MEASURING VOLUME, VOLUME FLOW, MASS FLOW OR LIQUID LEVEL; METERING BY VOLUME
    • G01F11/00—Apparatus requiring external operation adapted at each repeated and identical operation to measure and separate a predetermined volume of fluid or fluent solid material from a supply or container, without regard to weight, and to deliver it
    • G01F11/10—Apparatus requiring external operation adapted at each repeated and identical operation to measure and separate a predetermined volume of fluid or fluent solid material from a supply or container, without regard to weight, and to deliver it with measuring chambers moved during operation
    • G01F11/26—Apparatus requiring external operation adapted at each repeated and identical operation to measure and separate a predetermined volume of fluid or fluent solid material from a supply or container, without regard to weight, and to deliver it with measuring chambers moved during operation wherein the measuring chamber is filled and emptied by tilting or inverting the supply vessel, e.g. bottle-emptying apparatus
    • G01F11/262—Apparatus requiring external operation adapted at each repeated and identical operation to measure and separate a predetermined volume of fluid or fluent solid material from a supply or container, without regard to weight, and to deliver it with measuring chambers moved during operation wherein the measuring chamber is filled and emptied by tilting or inverting the supply vessel, e.g. bottle-emptying apparatus for liquid or semi-liquid
    • G01F11/263—Apparatus requiring external operation adapted at each repeated and identical operation to measure and separate a predetermined volume of fluid or fluent solid material from a supply or container, without regard to weight, and to deliver it with measuring chambers moved during operation wherein the measuring chamber is filled and emptied by tilting or inverting the supply vessel, e.g. bottle-emptying apparatus for liquid or semi-liquid with valves

Definitions

  • the present invention relates to a device, and also to a method, for containing and dispensing flowable material requiring shaking before dispensing.
  • the invention is particularly useful for containing and dispensing medicines in the form of liquid mixtures which require shaking before being consumed, and is therefore described below with respect to this appl i cation.
  • While shaking before use is particularly important in medicines, there are many other materials which should also be shaken before use, including, for example, paints, mouthwashes, bathoils, eye make-up removers and other cosmetics, whitening correction fluids, salad dressings, and many other multiple-phase liquid products.
  • a device for containing and dispensing flowable material requiring shaking before dispensing comprising: a container having a substantially vertical axis in the upright and inverted positions of the container, a main compartment for containing the flowable material to a predetermined maximum level, and a cap normally closing the upper end of the container and removable to dispense material therefrom; characterized in that the container further includes: an auxiliary compartment at the upper end of the container above the predetermined maximum level of the main compartment, and normally closed by the cap; an opening defining a passageway from the main compartment into the auxiliary compartment also above the predetermined maximum level of the main compartment; and a valve member closing the opening when the container is in an inverted position, but alternately opening and closing the opening, to permit filling the auxiliary compartment from the main compartment, when the container is shaken repeatedly substantially parallel to the axis of the container.
  • Containers constructed in accordance with the foregoing features of the present invention are to be distinguished from the many known types of containers designed to dispense predetermined dosages, such as described in US Patents 4,489,859, 3,146,923, 3,115,993, 3,091,374, 2,419,769, 2,149,989, 2,038,418, 1,710,517, 1,555,591, and 298,778.
  • valve member is a ball freely movable within a ball compartment to open and close the passageway upon shaking the container.
  • the valve member comprises: a stem passing through the opening; a first valve element at the end of the stem located within the auxiliary compartment and effective to close the opening in the upright position of the container; and a second valve element at the end of the stem located within the main compartment and effective to close the opening in the inverted position of the container; the stem being sufficiently long to cause its valve element to alternately open and close the opening, to permit filling the auxiliary compartment from the main compartment, when the container is shaken repeatedly substantially parallel to the axis of the container.
  • valve member includes a spring normally urging the valve member to close the opening; the spring being deformable to cause the valve member to alternately open and close the opening when the container is shaken repeatedly substantially parallel to its longitudinal axis.
  • the auxiliary container may be of a predetermined volume to define a predetermined dosage of the flowable material to be dispensed.
  • the auxiliary compartment is provided with a drain opening permitting excess material therein, in excess of the predetermined volume, to drain back from the auxiliary compartment to the main compartment in the upright position of the container.
  • a method of dispensing a flowable material comprising: containing the flowable material in a container having a main compartment for containing the flowable material, a removable cap, an auxiliary compartment at the upper end of the container and normally closed by the cap, and a passageway from the main compartment to the auxiliary compartment; and blocking the passage of the flowable material from the main compartment to the auxiliary compartment when the container is in an inverted position, but alternately opening and closing the passageway to permit the flowable material to flow from the main compartment into the auxiliary compartment when the container is shaken repeatedly substantially parallel to its longitudinal axis.
  • the invention is particularly useful for containing and dispensing liquid medicines which require shaking before being consumed since the invention automatically enforces the "shake before use" instruction normally provided on such a container. It will be appreciated, however, that the invention could be used in other applications, e.g., for containing many other products, e.g., those mentioned earlier.
  • Fig.1 is an exploded, sectional, fragmentary view illustrating one form of container constructed in accordance with the present invention
  • Fig. la illustrates the external appearance of the container of Fig. 1 with the cap removed;
  • Fig. lb more particularly illustrates the auxiliary compartment and the valve member included in the container of Fig. 1;
  • Fig. 2 is a fragmentary, partially-sectional view illustrating a second form of container constructed in accordance with the present invention, with the cap removed;
  • Fig. 2a is a fragmentary view illustrating the container of Fig. 1 and its cap in the inverted position of the container;
  • Fig. 2b illustrates a modification in the valve member of Figs. 2 and 2a
  • Fig. 3 is a fragmentary view illustrating a third form of container constructed in accordance with the present invention.
  • Fig. 3a is an exploded view more particularly illustrating the valve member in the comntainer of Fig. 3.
  • FIG. 1 The embodiment illustrated in Fig. 1 includes a container, generally designated 10, having a vertical longitudinal axis LA in the normal upright position of the container, shown in Figs. 1 and la, as well as in its inverted position (not shown).
  • Container 10 further includes a main compartment 11 for containing its contents (e.g., a liquid mixture or other flowable material) to a maximum level 11a; a neck 12 at the upper end of the main compartment 11, through which the liquid contents are dispensed; and a removable non-apertured cap 13 normally closing the neck 12.
  • contents e.g., a liquid mixture or other flowable material
  • neck 12 at the upper end of the main compartment 11, through which the liquid contents are dispensed
  • a removable non-apertured cap 13 normally closing the neck 12.
  • the foregoing elements of the container 10 may be of the appropriate size and configuration for the particular application.
  • container 10 is provided with an auxiliary compartment 14 at its upper end, namely, in its neck 12 above the maximum level 11a of the container contents, which auxiliary compartment 14 is closed by the cap 13.
  • Container 10 is further provided with a passageway 15 from the main compartment 11 to the auxiliary compartment 14. As described below, passageway 15 is closed when the container is in its inverted position but is opened, to permit the liquid contents of the container to flow from the main compartment 11 into the auxiliary compartment 14, only when the container is shaken repeatedly substantially parallel to its longitudinal axis LA.
  • the auxiliary compartment 14 is defined by a cylindrical wall 14a open at the top and to be closed by cap 13.
  • the bottom wall 14b of the auxiliary compartment 14 is of circular configuration except a lateral segment thereof is open and bounded by an upstanding wall 16 closed at its upper end by an upper wall 16a formed with an opening 16b.
  • a disk 17 underlies wall 14b of the auxiliary compartment 14 and is formed with an opening 17a in alignment with opening 16b, to establish communication between the main compartment 11 and passageway 15.
  • Upstanding wall 16 defines passageway 15 and includes a valve member in the form of a ball 18 freely movable within passageway 15.
  • Wall 16 together with its upper end wall 16a formed with opening 16b and its lower end disk 17 formed with opening 17a, defines a ball compartment for ball 18 such that when the container 10 is in its upright position, ball 18 seats on opening 17a in disk 17, and when container 10 is in its inverted position (not shown), ball 18 seats on opening 16b in the upper wall 16a leading to compartment 14. In the latter position, ball 18 blocks communication between passageway 15 and the auxiliary compartment 14.
  • side wall 16 of the ball compartment containing passageway 15 is of cylindrical configuration, but its inner diameter gradually increases from its mid portion to its upper end wall 16a and its lower end wall defined by disk 17.
  • ball 18 closes by gravity one of the openings 16b or 17a when the container is in a horizontal position.
  • Disk 17 is preferably formed with further openings 17b (Fig. lb) laterally on both sides of opening 17a, so as to provide communication between the main compartment 11 and passageway 15 in the upright position of the container.
  • the purpose of these further openings 17b is to permit drainage of liquid from the auxiliary compartment 14 back to the main compartment 11 when the container 10 is in its upright position and the level of the liquid within the auxiliary compartment 14 is above the level of wall 16a.
  • These further openings 17b also speed-up the filling of the auxiliary compartment 14 during the shaking of the container, as will be described more particularly below.
  • Liquid can be passed from compartment 11 via passageway 15 into compartment 14 only by grasping the container 10, with cap 13 closing the container neck 12, and repeatedly shaking the container substantially parallel to its longitudinal axis LA.
  • ball 18 With each stroke of the container towards the container bottom, ball 18 will move away from opening 17a, permitting the liquid to flow, by its own momentum, from the main compartment 11 into passageway 15 via that opening, as well as via the lateral openings 17b; and with each stroke of the container in the opposite direction, i.e., towards cap 13, ball 18 will move away from opening 16b, to permit the liquid within passageway 15 to pass through opening 16b into the auxiliary compartment 14.
  • the liquid within the auxiliary compartment 14 is above the level of wall 16a, this excess liquid will drain via opening 16b into passageway 15, and through the lateral openings 17b, back into the main compartment 11, so that the liquid within the auxiliary compartment 14 will be a pre-measured volume, according to the volume of the auxiliary compartment up to wall 16a.
  • the liquid within the auxiliary compartment 14 to be dispensed upon removing cap 13 will not only be well-mixed, but will also be of a predetermined dosage, e.g., 5cc.
  • FIGs. 2 and 2a illustrate another construction of container, generally designated 20, also including a main compartment 21 for the container contents, a neck 22 closed by a cap 23, and an auxiliary compartment 24 at the upper end of the main compartment 21.
  • Container 20 further includes a passageway 25 defined by an upright wall 26 closed by an upper end wall 26a formed with an opening 26b for the flow of the container contents into the auxiliary compartment 24.
  • the flow of the container contents into the auxiliary compartment 24 is controlled by a valve member 28 including a stem 28a having a conical valve element 28b at one end on the auxiliary compartment 24 side of wall 26a; and a second conical valve element 28c, at its opposite end, on the main compartment 21 side of wall 26a.
  • Conical valve element 28b normally closes opening 26b in wall 26a in the upright position of container 20, as shown in Fig. 2; and conical valve element 28c normally closes opening 26b in the inverted position of the container.
  • concical valve elements 28b and 28c alternately open and close opening 26b to permit the material within the main compartment 21 to flow, under its own momentum, through opening 26b into the auxiliary compartment 24.
  • the container 20 illustrated in Fig. 2 and 2a also requires shaking before the container contents may be transferred from the main compartment 21 into the auxiliary compartment 24 for dispensing by removing the cap 23.
  • Fig. 2b illustrates a variation in the construction of the container illustrated in Figs. 2 and 2a, in that the valve elements at the opposite ends of the valve stem 28a are in the form of spheres, as shown at 28b' and 28c', respectively, rather than in the form of cones.
  • Figs. 2, 2a and 2b may also be provided with a drain opening to drain excess material from the auxiliary compartment 24 back to the main compartment 21 when the container is in its upright position, to better assure that a predetermined measure of the material will be dispensed according to the level of wall 26a formed with opening 26b.
  • the valve element e.g., conical element 28b in Figs. 2 and 2a (or spherical element 28b' in Fig. 2b) located on the side of wall 26a facing the auxiliary compartment 24, may be provided with a recess or groove, as shown at 29 in Fig. 2a, so that when that valve element is seated in opening 26b of wall 26a in the upright position of the container, any excess liquid above wall 26a will drain back via opening 26b into the main compartment 21 in the upright position of the container.
  • Figs. 2, 2a and 2b the construction illustrated in Figs. 2, 2a and 2b, is substantially the same, and operates in substantially the same manner, as described above with respect to Figs. 1, la and lb.
  • FIGs. 3 and 3a illustrate another container, generally designated 30, constructed in accordance with the present invention.
  • Container 30 is also provided with a main compartment 31 for the material to be dispensed, a neck 32 at the upper end of the main compartment 31 and closed by a cap 33, and an auxiliary compartment 34 defined by a wall 35 formed with an opening 36 which is controlled by a valve member 38 to permit the flow of material from the main compartment 31 into the auxiliary compartment 34 only when the container 30 is shaken parallel to its longitudinal axis, as in the above-described embodiments.
  • valve member 38 is in the form of a semi-sphere spring-urged to close opening 36 by a leaf spring 39.
  • One end of leaf spring 39 is secured to a ring 39a received within neck 32 of the container, and the opposite end carries the valve member 38.
  • valve member 38 normally closes valve opening 36 in the inverted position of the container (as well as in the upright position of the container), but alternately opens and closes opening 36 upon shaking the container substantially parallel to its longitudinal axis to transfer material from the main compartment 31 into the auxiliary compartment 34 via opening 36.
  • the container illustrated in Figs. 3 and 3a therefore, also requires vigorous shaking of the container before the cap 33 is removed, to transfer the material from the main compartment 31 to the auxiliary compartment 34, so that the material is received within the auxiliary compartment only after it has been well mixed by vigorous shaking, which material may be dispensed when the cap 33 is removed.
  • wall 35 may also be provided with one or more drain opening 35a, to permit drainage of the excess material within the auxiliary compartment 34, i.e., above the level of wall 35, when the container is in its upright position, to thereby better assure dispensing of a predetermined dosage of the material.
  • the invention has been described with respect to several preferred embodiments, it will be appreciated that these are set forth merely for purposes of example, and that the invention could include many modifications or could be applied in many other applications.
  • the invention could be used in applications requiring only "shake-before-use" , and not requiring measuring predetermined dosages.
  • the predetermined-dosage chamber could be of annular configuration, with the inlet opening located centrally of the chamber.
  • the invention is particularly useful in containing and dispensing medicines, it may be used in many other applications, such as those requiring mixing of multiple-phase liquids as briefly mentioned above.

Landscapes

  • Physics & Mathematics (AREA)
  • Fluid Mechanics (AREA)
  • General Physics & Mathematics (AREA)
  • Engineering & Computer Science (AREA)
  • Mechanical Engineering (AREA)
  • Closures For Containers (AREA)

Abstract

L'invention concerne un dispositif de distribution de matériau fluidifiable devant être secoué avant d'être distribué. Ce dispositif comprend un récipient (10) comprenant à son extrémité supérieure un compartiment (14) auxiliaire situé au dessus du compartiment (11) principal, et normalement fermé par un capuchon (13). Un élément (18) soupape ferme le passage (16b) entre les deux compartiments lorsque le récipient est en position retournée mais ouvre est ferme alternativement ce passage (16b) lorsque le récipient est secoué parallèlement à son axe longitudinal.
PCT/IL1999/000455 1998-08-26 1999-08-23 Dispositif et procede de conditionnement et de distribution d'un materiau fluidifiable, en particulier d'un medicament Ceased WO2000012424A1 (fr)

Priority Applications (2)

Application Number Priority Date Filing Date Title
AU53845/99A AU5384599A (en) 1998-08-26 1999-08-23 Device and method for containing and dispensing flowable material, particularly medicines
EP99939586A EP1169262A1 (fr) 1998-08-26 1999-08-23 Dispositif et procede de conditionnement et de distribution d'un materiau fluidifiable, en particulier d'un medicament

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IL12593898A IL125938A (en) 1998-08-26 1998-08-26 Device and method for containing and dispensing flowable material, particularly medicines
IL125938 1998-08-26

Publications (1)

Publication Number Publication Date
WO2000012424A1 true WO2000012424A1 (fr) 2000-03-09

Family

ID=11071892

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IL1999/000455 Ceased WO2000012424A1 (fr) 1998-08-26 1999-08-23 Dispositif et procede de conditionnement et de distribution d'un materiau fluidifiable, en particulier d'un medicament

Country Status (4)

Country Link
EP (1) EP1169262A1 (fr)
AU (1) AU5384599A (fr)
IL (1) IL125938A (fr)
WO (1) WO2000012424A1 (fr)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1233253A1 (fr) * 2001-02-14 2002-08-21 Yanagiya Co., Ltd. Doseur pour poudre à quantité constante comprenant une bille mobile vers et depuis un siège de soupape
WO2005039998A1 (fr) * 2003-10-28 2005-05-06 Ross Elliott Dalziel Unite de distribution pour decharge regulee d'un volume dose
EP1923676A1 (fr) * 2006-11-20 2008-05-21 Pont Emballage Récipient doseur comprenant un élément obturateur de réglage de dose et élément obturateur
WO2011085569A1 (fr) * 2010-01-14 2011-07-21 Peng Shi Dispositif de retenue de fluide pour robinet

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3844454A (en) * 1972-07-06 1974-10-29 D Buchtel Measured dispenser
US5927354A (en) * 1995-05-25 1999-07-27 Smithkline Beecham P.L.C. Container
US5967377A (en) * 1999-03-25 1999-10-19 Primary Delivery Systems, Inc. Metered liquid dispenser with lift fill mechanism

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3844454A (en) * 1972-07-06 1974-10-29 D Buchtel Measured dispenser
US5927354A (en) * 1995-05-25 1999-07-27 Smithkline Beecham P.L.C. Container
US5967377A (en) * 1999-03-25 1999-10-19 Primary Delivery Systems, Inc. Metered liquid dispenser with lift fill mechanism

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1233253A1 (fr) * 2001-02-14 2002-08-21 Yanagiya Co., Ltd. Doseur pour poudre à quantité constante comprenant une bille mobile vers et depuis un siège de soupape
WO2005039998A1 (fr) * 2003-10-28 2005-05-06 Ross Elliott Dalziel Unite de distribution pour decharge regulee d'un volume dose
EP1923676A1 (fr) * 2006-11-20 2008-05-21 Pont Emballage Récipient doseur comprenant un élément obturateur de réglage de dose et élément obturateur
WO2011085569A1 (fr) * 2010-01-14 2011-07-21 Peng Shi Dispositif de retenue de fluide pour robinet

Also Published As

Publication number Publication date
IL125938A (en) 2002-02-10
EP1169262A1 (fr) 2002-01-09
AU5384599A (en) 2000-03-21
IL125938A0 (en) 1999-04-11

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