[go: up one dir, main page]

WO2000010007A3 - Dispositifs et procedes d'analyse de solutes non ioniques - Google Patents

Dispositifs et procedes d'analyse de solutes non ioniques Download PDF

Info

Publication number
WO2000010007A3
WO2000010007A3 PCT/US1999/018615 US9918615W WO0010007A3 WO 2000010007 A3 WO2000010007 A3 WO 2000010007A3 US 9918615 W US9918615 W US 9918615W WO 0010007 A3 WO0010007 A3 WO 0010007A3
Authority
WO
WIPO (PCT)
Prior art keywords
sensor composition
target molecule
sensor
electrode
concentration
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US1999/018615
Other languages
English (en)
Other versions
WO2000010007A2 (fr
WO2000010007A9 (fr
Inventor
Frances H Arnold
Alan S Michaels
Weigong Zheng
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
California Institute of Technology
Original Assignee
California Institute of Technology
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by California Institute of Technology filed Critical California Institute of Technology
Priority to AU55652/99A priority Critical patent/AU5565299A/en
Publication of WO2000010007A2 publication Critical patent/WO2000010007A2/fr
Publication of WO2000010007A9 publication Critical patent/WO2000010007A9/fr
Publication of WO2000010007A3 publication Critical patent/WO2000010007A3/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/28—Electrolytic cell components
    • G01N27/30—Electrodes, e.g. test electrodes; Half-cells
    • G01N27/327—Biochemical electrodes, e.g. electrical or mechanical details for in vitro measurements
    • G01N27/3271—Amperometric enzyme electrodes for analytes in body fluids, e.g. glucose in blood

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Electrochemistry (AREA)
  • Physics & Mathematics (AREA)
  • Hematology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Investigating Or Analyzing Materials By The Use Of Electric Means (AREA)

Abstract

La présente invention concerne des dispositifs et procédés de détection et de contrôle de la concentration, du niveau ou de la quantité d'une molécule cible dans une solution. Plus particulièrement, l'invention concerne des détecteurs évaluant des changements de conductivité produits par la réaction d'une molécule cible avec une composition de détection. L'invention est particulièrement appropriée pour déterminer la concentration de composés d'hydrates de carbone dans une solution, tels que des composés diols, de préférence des diols cis biologiquement importants tels que différents sucres, y compris le glucose. L'invention concerne également des détecteurs permettant de déterminer la quantité totale ou relative d'une molécule cible dans un échantillon, en particulier un échantillon biologique tel que le sang, l'urine ou d'autres liquides organiques. Un détecteur stratifié selon l'invention comprend une composition de détection appliquée sur une électrode métallique telle qu'une électrode en or interdigitée ou un support non conducteur. La composition de détection et l'électrode sont de préférence entourées d'une membrane bipolaire. Dans un mode de réalisation préférée, la composition de détection est formée d'un mélange de polymère d'acide borique et d'une matrice d'hydrogel non ionogène.
PCT/US1999/018615 1998-08-17 1999-08-16 Dispositifs et procedes d'analyse de solutes non ioniques Ceased WO2000010007A2 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU55652/99A AU5565299A (en) 1998-08-17 1999-08-16 Devices and methods for analysis of non-ionic solutes

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US9673998P 1998-08-17 1998-08-17
US60/096,739 1998-08-17
US30125299A 1999-04-28 1999-04-28
US09/301,252 1999-04-28

Publications (3)

Publication Number Publication Date
WO2000010007A2 WO2000010007A2 (fr) 2000-02-24
WO2000010007A9 WO2000010007A9 (fr) 2000-07-06
WO2000010007A3 true WO2000010007A3 (fr) 2000-08-17

Family

ID=26792028

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1999/018615 Ceased WO2000010007A2 (fr) 1998-08-17 1999-08-16 Dispositifs et procedes d'analyse de solutes non ioniques

Country Status (2)

Country Link
AU (1) AU5565299A (fr)
WO (1) WO2000010007A2 (fr)

Families Citing this family (45)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6544193B2 (en) 1996-09-04 2003-04-08 Marcio Marc Abreu Noninvasive measurement of chemical substances
US6287870B1 (en) * 1999-08-20 2001-09-11 Robert A. Levine Method and assembly for separating formed constituents from a liquid constituent in a complex biologic fluid sample
WO2001013783A1 (fr) 1999-08-26 2001-03-01 Novartis Ag Detecteur d'analyte dans un liquide oculaire
US7470420B2 (en) * 2000-12-05 2008-12-30 The Regents Of The University Of California Optical determination of glucose utilizing boronic acid adducts
US20020142306A1 (en) * 2001-03-28 2002-10-03 3M Innovative Properties Company Method of transferring molecules to a film laminate
US6952604B2 (en) 2001-12-21 2005-10-04 Becton, Dickinson And Company Minimally-invasive system and method for monitoring analyte levels
US10123732B2 (en) 2002-04-22 2018-11-13 Geelux Holdings, Ltd. Apparatus and method for measuring biologic parameters
US8328420B2 (en) 2003-04-22 2012-12-11 Marcio Marc Abreu Apparatus and method for measuring biologic parameters
US8849379B2 (en) 2002-04-22 2014-09-30 Geelux Holdings, Ltd. Apparatus and method for measuring biologic parameters
BR0309578A (pt) 2002-04-22 2007-03-06 Marcio Marc Aurelio Mart Abreu aparelho e método para a medição de parámetros biológicos
US7597793B2 (en) 2003-06-20 2009-10-06 Roche Operations Ltd. System and method for analyte measurement employing maximum dosing time delay
US7604721B2 (en) 2003-06-20 2009-10-20 Roche Diagnostics Operations, Inc. System and method for coding information on a biosensor test strip
US7452457B2 (en) 2003-06-20 2008-11-18 Roche Diagnostics Operations, Inc. System and method for analyte measurement using dose sufficiency electrodes
HRP20100303T1 (hr) 2003-11-05 2010-07-31 Roche Glycart Ag Cd20 antitijela s povećanim afinitetom vezivanja fc receptora i efektorskim djelovanjem
US10227063B2 (en) 2004-02-26 2019-03-12 Geelux Holdings, Ltd. Method and apparatus for biological evaluation
US7569126B2 (en) 2004-06-18 2009-08-04 Roche Diagnostics Operations, Inc. System and method for quality assurance of a biosensor test strip
US7556723B2 (en) 2004-06-18 2009-07-07 Roche Diagnostics Operations, Inc. Electrode design for biosensor
ES2399872T3 (es) 2005-10-24 2013-04-04 Marcio Marc Aurelio Martins Abreu Aparato para medir parámetros biológicos
DE102006026668B4 (de) 2006-06-08 2008-07-10 Technische Universität Dresden Sensor und Verfahren zur Messung der Konzentration von Komponenten in einer Flüssigkeit
CN101522094B (zh) * 2006-09-29 2013-12-18 皇家飞利浦电子股份有限公司 微型化阈值传感器
EP2118177A1 (fr) * 2007-03-05 2009-11-18 MIP Technologies AB Polymères à empreintes moléculaires
WO2008157325A2 (fr) * 2007-06-15 2008-12-24 Charles Stark Draper Laboratory, Inc. Dispositifs, systèmes, et procédés pour mesurer le glucose
US8181531B2 (en) 2008-06-27 2012-05-22 Edwin Carlen Accessible stress-based electrostatic monitoring of chemical reactions and binding
EP2323628B1 (fr) 2008-08-13 2022-04-13 California Institute of Technology Nanoparticules de support et compositions, procédés et systèmes apparentés
US9011670B2 (en) 2008-08-14 2015-04-21 The Charles Stark Draper Laboratory, Inc. Three-dimensional metal ion sensor arrays on printed circuit boards
WO2010077709A2 (fr) * 2008-12-30 2010-07-08 Bausch & Lomb Incorporated Dispositifs biomédicaux
US8706425B2 (en) 2011-07-20 2014-04-22 Veolia Water Solutions & Technologies Support Method for validation of polymer aqueous solutions concentration and activation in water treatment applications and polymer make-up unit therefor
EP3513812B1 (fr) * 2013-03-01 2020-07-15 California Institute of Technology Nanoparticules stabilisées avec des compositions d'acide nitrophénylboronique
US9468681B2 (en) 2013-03-01 2016-10-18 California Institute Of Technology Targeted nanoparticles
CA2927036A1 (fr) 2013-10-11 2015-04-16 Marcio Marc Abreu Procede et appareil pour evaluation biologique
EP3091894A4 (fr) 2014-01-10 2017-09-20 Marcio Marc Abreu Dispositifs pour surveiller et appliquer un traitement au niveau d'un tunnel cérébral abreu
CN106102566A (zh) 2014-01-10 2016-11-09 马尔西奥·马克·阿布雷乌 用于测量abreu脑热通道的红外输出的装置
US10238847B2 (en) 2014-01-22 2019-03-26 Geelux Holdings, Ltd. Devices and methods for transdermal drug delivery
JP5599012B1 (ja) * 2014-06-23 2014-10-01 国立大学法人 東京大学 採取部及びバイオセンサ
KR102255158B1 (ko) * 2014-10-21 2021-05-27 엘지전자 주식회사 당 검출용 센서와 이의 제조방법 및 이를 이용한 당화 혈색소 검출 방법
EP3267877A1 (fr) 2015-03-10 2018-01-17 Marcio Marc Abreu Dispositifs, appareils, systèmes et procédés pour mesurer la température d'une terminaison abtt
JP2016217929A (ja) * 2015-05-22 2016-12-22 セイコーエプソン株式会社 センサー用ゲルおよびセンサー
CN111643479B (zh) 2015-07-01 2023-10-27 加州理工学院 基于阳离子粘酸聚合物的递送系统
EP3334652A4 (fr) * 2015-08-14 2019-04-03 Razzberry Inc. Électrodes et procédé d'utilisation destiné à être utilisé dans la détection d'explosifs et d'autres matières volatiles
WO2019241327A1 (fr) 2018-06-13 2019-12-19 California Institute Of Technology Nanoparticules permettant de traverser la barrière hématoencéphalique et méthodes de traitement faisant appel à celle-ci
US20210181118A1 (en) * 2018-09-06 2021-06-17 AusMed Global Limited Systems, sensors and methods for determining a concentration of an analyte
CN112782251B (zh) * 2021-01-07 2022-03-25 安徽大学 一种定量检测重铬酸钾的方法
CA3225732A1 (fr) * 2021-07-16 2023-01-19 Proton Intelligence Inc. Capteur ayant une membrane profilee
US12442786B2 (en) 2021-10-14 2025-10-14 Medtronic Minimed, Inc. Sensors for 3-hydroxybutyrate detection
WO2025160347A1 (fr) * 2024-01-24 2025-07-31 1S1 Energy, Inc. Polymères échangeurs d'anions fonctionnalisés par acide boronique

Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4650547A (en) * 1983-05-19 1987-03-17 The Regents Of The University Of California Method and membrane applicable to implantable sensor
GB2194843A (en) * 1986-09-08 1988-03-16 Cambridge Life Sciences Enzyme electrode membrane and method of making same
JPH04124145A (ja) * 1990-09-13 1992-04-24 Nippon Oil & Fats Co Ltd 糖応答性高分子複合体
EP0539625A1 (fr) * 1991-10-28 1993-05-05 Dräger Medical Electronics B.V. Capteur électrochimique pour mesurer la teneur en glucose des fluides
JPH05262779A (ja) * 1992-03-18 1993-10-12 Nippon Oil & Fats Co Ltd ボロン酸基含有モノマーおよびそのポリマー
EP0596700A1 (fr) * 1992-11-03 1994-05-11 Hewlett-Packard Company Méthode de détection de cis-diol et supports solides
DE4437274A1 (de) * 1994-10-18 1996-04-25 Inst Chemo Biosensorik Analytselektiver Sensor
US5594111A (en) * 1994-01-28 1997-01-14 Prolinx, Inc. Phenylboronic acid complexes for bioconjugate preparation
WO1997033177A1 (fr) * 1996-03-04 1997-09-12 California Institute Of Technology Detecteurs de sucres et d'autres analytes se liant a des metaux

Patent Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4650547A (en) * 1983-05-19 1987-03-17 The Regents Of The University Of California Method and membrane applicable to implantable sensor
GB2194843A (en) * 1986-09-08 1988-03-16 Cambridge Life Sciences Enzyme electrode membrane and method of making same
JPH04124145A (ja) * 1990-09-13 1992-04-24 Nippon Oil & Fats Co Ltd 糖応答性高分子複合体
EP0539625A1 (fr) * 1991-10-28 1993-05-05 Dräger Medical Electronics B.V. Capteur électrochimique pour mesurer la teneur en glucose des fluides
JPH05262779A (ja) * 1992-03-18 1993-10-12 Nippon Oil & Fats Co Ltd ボロン酸基含有モノマーおよびそのポリマー
EP0596700A1 (fr) * 1992-11-03 1994-05-11 Hewlett-Packard Company Méthode de détection de cis-diol et supports solides
US5594111A (en) * 1994-01-28 1997-01-14 Prolinx, Inc. Phenylboronic acid complexes for bioconjugate preparation
DE4437274A1 (de) * 1994-10-18 1996-04-25 Inst Chemo Biosensorik Analytselektiver Sensor
WO1997033177A1 (fr) * 1996-03-04 1997-09-12 California Institute Of Technology Detecteurs de sucres et d'autres analytes se liant a des metaux

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
PATENT ABSTRACTS OF JAPAN vol. 016, no. 383 (C - 0974) 17 August 1992 (1992-08-17) *
PATENT ABSTRACTS OF JAPAN vol. 018, no. 032 (C - 1154) 18 January 1994 (1994-01-18) *

Also Published As

Publication number Publication date
WO2000010007A2 (fr) 2000-02-24
WO2000010007A9 (fr) 2000-07-06
AU5565299A (en) 2000-03-06

Similar Documents

Publication Publication Date Title
WO2000010007A3 (fr) Dispositifs et procedes d'analyse de solutes non ioniques
Wang et al. Engineering materials for electrochemical sweat sensing
EP1021720B1 (fr) Determination electrochimique de la fructosamine
Moser et al. Biosensor arrays for simultaneous measurement of glucose, lactate, glutamate, and glutamine
Guilbault et al. Non-invasive biosensors in clinical analysis
EP2909606B1 (fr) Dispositif et ses procédés d'utilisation pour le dépistage des aminoacidopathies
US20080177166A1 (en) Ultrasensitive amperometric saliva glucose sensor strip
CN1284652A (zh) 用于确定试样检测初始时间的电化学分析
EP1164925A1 (fr) Dispositif d'analyse permettant de determiner les caracteristiques d'un fluide en continu
CA2416249A1 (fr) Detecteur d'antioxydant
Sung et al. Glucose oxidase, lactate oxidase, and galactose oxidase enzyme electrode based on polypyrrole with polyanion/PEG/enzyme conjugate dopant
US20250076316A1 (en) Detection of creatine levels using enzyme compositions
US5567290A (en) Sensor devices
US20030146111A1 (en) Enzymatic-electrochemical measuring device
Kudo et al. Electrochemical Biosensor for Simplified Determination of Salivary Uric Acid.
Rhemrev-Boom et al. On-line continuous monitoring of glucose or lactate by ultraslow microdialysis combined with a flow-through nanoliter biosensor based on poly (m-phenylenediamine) ultra-thin polymer membrane as enzyme electrode
Ikariyama et al. Surface control of platinized platinum as a transducer matrix for micro-enzyme electrodes
WO2019176339A1 (fr) Matériau de film protecteur pour sonde de biocapteur
Dempsey et al. In vitro optimisation of a microdialysis system with potential for on-line monitoring of lactate and glucose in biological samples
Pfeiffer Commercial biosensors for medical application
Campanella et al. Enzyme-entrapping membranes for enzyme sensors
WO2019012262A1 (fr) Appareil de capteur de biomarqueur et procédé de mesure de biomarqueur dans le sang
Eggenstein et al. Potentiometric biosensor in double matrix membrane technology
Joseph A miniature enzyme electrode sensitive to urea
D’Orazio Electrochemical sensors: a review of techniques and applications in point of care testing

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A2

Designated state(s): AE AL AM AT AU AZ BA BB BG BR BY CA CH CN CR CU CZ DE DK DM EE ES FI GB GD GE HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MD MG MK MN MW MX NO NZ PL PT RO RU SD SE SG SI SK SL TJ TM TR TT UA UG US UZ VN YU ZA ZW

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): GH GM KE LS MW SD SL SZ UG ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE BF BJ CF CG CI CM GA GN GW ML MR NE SN TD TG

121 Ep: the epo has been informed by wipo that ep was designated in this application
AK Designated states

Kind code of ref document: C2

Designated state(s): AE AL AM AT AU AZ BA BB BG BR BY CA CH CN CR CU CZ DE DK DM EE ES FI GB GD GE HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MD MG MK MN MW MX NO NZ PL PT RO RU SD SE SG SI SK SL TJ TM TR TT UA UG US UZ VN YU ZA ZW

AL Designated countries for regional patents

Kind code of ref document: C2

Designated state(s): GH GM KE LS MW SD SL SZ UG ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE BF BJ CF CG CI CM GA GN GW ML MR NE SN TD TG

COP Corrected version of pamphlet

Free format text: PAGES 1/14-14/14, DRAWINGS, REPLACED BY NEW PAGES 1/21-21/21; DUE TO LATE TRANSMITTAL BY THE RECEIVING OFFICE

DFPE Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101)
AK Designated states

Kind code of ref document: A3

Designated state(s): AE AL AM AT AU AZ BA BB BG BR BY CA CH CN CR CU CZ DE DK DM EE ES FI GB GD GE HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MD MG MK MN MW MX NO NZ PL PT RO RU SD SE SG SI SK SL TJ TM TR TT UA UG US UZ VN YU ZA ZW

AL Designated countries for regional patents

Kind code of ref document: A3

Designated state(s): GH GM KE LS MW SD SL SZ UG ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE BF BJ CF CG CI CM GA GN GW ML MR NE SN TD TG

REG Reference to national code

Ref country code: DE

Ref legal event code: 8642

122 Ep: pct application non-entry in european phase