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WO2000009079A1 - Procedes et compositions permettant de blanchir les dents - Google Patents

Procedes et compositions permettant de blanchir les dents Download PDF

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Publication number
WO2000009079A1
WO2000009079A1 PCT/US1999/017949 US9917949W WO0009079A1 WO 2000009079 A1 WO2000009079 A1 WO 2000009079A1 US 9917949 W US9917949 W US 9917949W WO 0009079 A1 WO0009079 A1 WO 0009079A1
Authority
WO
WIPO (PCT)
Prior art keywords
composition
bleaching compound
agent
potassium
bleaching
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US1999/017949
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English (en)
Inventor
Gerald G. Mclaughlin
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Priority to AU53949/99A priority Critical patent/AU5394999A/en
Publication of WO2000009079A1 publication Critical patent/WO2000009079A1/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
    • A61K8/22—Peroxides; Oxygen; Ozone

Definitions

  • the present invention relates to the field of dentistry, and specifically to the whitening of the teeth.
  • Teeth generally become more darkly pigmented with age and exposure to such materials as tea and coffee, and it has long been a goal of dentistry to provide a means to safely and effectively reverse this darkening process.
  • a more recent innovation involves a method of using either hydrogen peroxide or hydrogen peroxide mixed with urea (also known as urea peroxide or carbamide peroxide) to penetrate into the tooth structure and bleach out the undersired pigmentation.
  • urea also known as urea peroxide or carbamide peroxide
  • the preferred method of application of the whitening agent utilizes either custom or stock trays that are shaped to hold the bleaching agent against the teeth to be whitened. These trays are then filled with the peroxide, and worn for long periods of time - sometimes even overnight. After a series of lengthy treatments, the teeth will usually begin to show the desired whitening effect. Naturally the length of treatment can be discouraging and increase the cost. While effective on both extrinsic and intrinsic discolorations, one additional major problem encountered with this approach stems directly from the materials used. The two major pathways of action of the peroxides are through liberation of either hydroxyl free radicals or oxygen free radicals.
  • the present invention overcomes the problems noted above, and provides a greatly improved method for whitening discolored teeth.
  • the treatment time can be substantially shortened at the same time that the concentration of free radicals is diminished.
  • other beneficial effects for the patient such as antisepsis and tissue debridement can be realized using the materials and methods described herein.
  • the present invention provides a composition for whitening teeth including a therapeutically effective amount of a non-peroxide ionic bleaching compound in a mouthrinse, toothpaste, gel dentrifice, chewing gum, wax or lozenge vehicle.
  • the bleaching compound is either an oxidizing or reducing agent, such as, for example persulfates.
  • concentration of the non-peroxide ionic bleaching compound can be from about 2 to 90% by weight, from about 20 to 85% by weight, or from about 50-80% by weight depending upon the formulation and application.
  • Other agents may be included in the composition including, but not limited to, flavorants, abrasives, fluoride, peroxides, and palliative agents.
  • the present invention provides a method for whitening teeth comprising contacting a tooth with a non-peroxide ionic bleaching compound.
  • the bleaching compound can be included in a composition for appropriate delivery including, for example, gels, pastes, sprays, and mouthrinses.
  • the bleaching compound can be contacted with the tooth either alone or in combination and either sequentially or contemporaneously with any number of additional agents well known in the art.
  • the methods and compositions of the invention utilize an oxygenating agent that uses ions rather than free radicals for the oxidation process.
  • the agent can be placed on the stained tooth structure and achieve as much whitening effect in one hour as has previously only been possible in the tray system through several weeks of wearing time. This is achieved because the lifespan of the free radicals employed in peroxide-based bleaching has a lifespan measured in nanoseconds, whereas the active lifespan of the ions (i.e., oxidizing or reducing) of the present invention are substantially longer sometimes hours or longer.
  • the whitening effect can be further accelerated through the application of energy, such as in the form of light, heat, electric potential, or electric current.
  • the process can be accelerated through the simultaneous application of electromagnetic energy, such as heat or light.
  • electromagnetic energy such as heat or light.
  • This can serve to excite the whitening agent, raise the activity level of the pigments to be whitened, and accelerate the chemical activity of the whole process.
  • a laser source as an example, can be made to strike the bleaching agent, causing it to more rapidly ionize or energize, and thus be more active in the bleaching process.
  • Another example would be to use a plasma arc lamp as the source of light and/or heat.
  • the invention provides a composition for whitening teeth consisting of a therapeutically effective amount of a bleaching compound or agent which is not of the peroxide class.
  • a “bleaching compound” or “bleaching agent” as used herein is any compound which has the ability of whitening teeth, but which is not of the peroxide class.
  • the peroxide class refers to any compound whose main bleaching action is derived from the breakdown of peroxide ions such as hydrogen peroxide, carbamide peroxide, urea peroxide, sodium percarbonate, and perhydrol urea. Examples of bleaching compounds not of the peroxide class are potassium monopersulfate and ozone.
  • non-peroxide ionic bleaching compound a bleaching compound that is not of the peroxide class and forms ions under the appropriate conditions.
  • the bleaching agent is preferably water soluble, such as, for example, peroxymonosulfate, normally an alkali metal peroxymonosulfate, such as potassium or sodium peroxymonosulfate.
  • potassium peroxymonosulfate potassium or sodium peroxymonosulfate.
  • Potassium peroxymonosulfate, KHSO 5 is available as the mixed salt 2KHSO 5 .KHSO 4 .K 2 SO 4 , sold by E. I. DuPont DeNemours and Company, Inc. under the trademark Oxone. That product has an active oxygen content of about 4.5%.
  • the active oxygen content of the mixed salt described is about 5.2% when the salt is pure and the corresponding active oxygen content of KHSO 5 is about 10.5%.
  • the pure mixed salt has half as much active oxygen in it as has the pure peroxymonosulfate and the 86.5% pure mixed salt (Oxone) has 43% as much.
  • peroxymonosulfate the single salt is intended, with its higher active oxygen content, but an equivalent proportion of the triple salt, such as that sold under the trademark Oxone, will normally be employed as the source of the active bleaching compound because of its ready availability, stability and desirable physical characteristics.
  • Potassium peroxymonosulfate may also be named as potassium monopersulfate and its triple salt may also be considered to be a monopersulfate compound within this invention.
  • Other oxidizing agents useful as bleaching agents include, for example, oxygen, persulfates, such as potassium peroxymonosulfate and potassium persulfate and sodium persulfate, peracids such as peracetic acid, peroxymonosulfuric acid (Caro's Acid), PXA (mixed peracids, such as a mixture of glacial acetic acid, concentrated sulfuric acid and hydrogen peroxide), and other peroxy compounds. Mixtures of oxidizing agents may be used.
  • a reducing agent is desired formamidine sulfinic acid (FAS) (also known as thiourea dioxide) may be used as the reducing agent
  • FAS formamidine sulfinic acid
  • other suitable reducing agents include, but are not limited to, sodium hydrosulfite and sodium borohydride. Mixtures of reducing agents may be used.
  • therapeutically effective amount is meant the quantity of bleaching agent, when placed in contact with the teeth of a subject according to the invention, necessary to whiten the teeth of the subject.
  • a subject is any mammal, preferably a human.
  • the bleaching agent employed is placed in the composition such that it will produce a strength in solution of at least 2% and can range up to a saturated solution.
  • One particularly useful active agent utilized in such compositions is formed from the combination of water and a potassium monopersulfate compound.
  • a useful potassium monopersulfate compound is produced by DuPont under the trade name "Oxone" and consists of a combination of materials as shown below:
  • magnesium carbonate is not essential although it is included in the mixture as an anti-caking agent.
  • Another particularly active agent is that of ozone in solution with water.
  • the teeth needing whitening are first cleaned in the usual fashion.
  • Some common methods include the use of a rotating brush and a mildly abrasive commercial tooth-cleaning material such as Oral-B Prophy Paste (Oral B, Inc.).
  • a mixture of whitening materials is made up immediately before use consisting of sufficient water to create a slurry with, for example, potassium monopersulfate (Oxone, Dupont Chemicals).
  • the teeth are then isolated from the soft tissues either with the use of a rubber dam or paint-on barrier material such as OpalDam (Ultradent).
  • the slurry is then placed on the teeth in need of whitening and let stand for a period of time. The longer the time of exposure, the greater the whitening effect.
  • a mixture as described can achieve as much whitening as is currently achievable through a normal two-week regimen of wearing bleaching trays with 10% carbamide peroxide.
  • other ingredients are added to the compound to enhance or modify its action.
  • one such mixture consists of 1 part potassium monopersulfate and a 1 part sodium fluoride.
  • the sodium fluoride both raises the pH, and at the same time increases the resistance of the tooth to any etching of its surface from contact with acidic materials.
  • it serves to help prevent sensitization of the tooth and strengthens the tooth against future tooth decay.
  • other compounds for example, potassium nitrate can be added to the mixture to prevent sensitivity of the whitened tooth.
  • a pigment or dye of the class called optical brighteners is added to the mixture.
  • the optical brighteners are materials that absorb electromagnetic energy of one portion of the spectrum (often in the ultra-violet range) and re-emit the energy as visible light in the blue portion of the spectrum.
  • the dye or pigment becomes incorporated into the structure of the tooth and the optical properties are thus enhanced.
  • the additional blue light given off by the tooth is perceived by the eye as having a whitening effect.
  • the pigment absorbs some of the ultra-violet energy and thereby protects the tissues form any untoward effects from exposure to that portion of the spectrum.
  • optical brighteners include Tinopal PT (Ciba-Geigy), Eastobright (Eastman Kodak), and Uvitex OB (Ciba-Geigy).
  • other chemical enhancers such as ammonium persulfate, sodium persulfate, and potassium persulfate are added to the mixture to increase the oxidizing activity of the mixture.
  • surfactants can be added to the mixture. It has been found that this allows greater uniformity in dispersion of materials in the mixture, while at the same time also increasing the wettability of the tooth surface and increasing the penetration of the mixture into the tooth.
  • surfactants include sodium lauryl sulfate, Pluroni 127 (BASF Corp.), Tween 20, Surfynal 485w (Air Products & Pluronic Chemicals, Inc.), and sodium dodecylbenzenesulfanate.
  • compositions of the invention can also contain materials added to give the mixture a consistency of paste or gel.
  • materials such as Carbopol (B.F. Goodrich), carboxymethyl cellulose, hydroxyethyl cellulose, gum arabic, sodium polyacrylate, potassium polyacrylate, and fused alumina silica can be used to give the compositions of the invention a consistency of a paste or gel.
  • the mixture can also contain materials to give the mixture a smooth or creamy consistency. Examples of such material include, but are not limited to, Gantrez MS955 (ISP Technologies, Inc.).
  • an abrasive material can be used with the composition of the invention.
  • a dicalcium phosphate abrasive may be incorporated into the composition (e.g., see U.S. Patent 5, 171, 564).
  • dicalcium phosphate abrasives include, but are not limited to dicalcium phosphate dihydrate, anhydrous dicalcium, or calcium pyrophosphate.
  • Other abrasives for use with the subject invention include siliceous materials.
  • silica abrasives such as precipitated amorphous hydrated silica
  • alumina abrasives such as alumina trihydrate, aluminum silicate, calcined alumina, and bentonite.
  • the vehicle may contain water, humectant, surfactant, and a thickener. Both mixtures of humectants and single humectants can be employed in the composition of the invention. Other materials from the class of humectants can be added to the compositions of the invention to serve as anti-drying agents.
  • a "humectant" is any material that when added to the mixture serves to keep the material from drying during use.
  • humectants include, but are not limited to, sorbitol, and polyethylene glycol (molecular weight 200-1000).
  • Thickeners may be incorporated in the abrasive component such as natural and synthetic gums such as carrageenan, xantham gum, sodium carboxymethyl cellulose, starch, polyvinylpyrrolidone, hydroxyethylpropylcellulose, hydroxybutyl methyl cellulose, hydroxypropyl methyl cellulose, and hydroxyethyl cellulose.
  • an agent for administering fluoride such as a fluorine providing salt, which has activity against cavities, may be incorporated into the composition of the subject invention. Such materials are characterized by their ability to release fluoride ions in water.
  • Agents for administering fluoride include, but are not limited to, inorganic metal salts such as sodium fluoride, potassium fluoride, and tin fluoride such as stannous fluoride or stannous chlorofluoride, sodium fluorosilicate, ammonium fluorosilicate, and sodium monofluorophosphate.
  • inorganic metal salts such as sodium fluoride, potassium fluoride, and tin fluoride
  • stannous fluoride or stannous chlorofluoride sodium fluorosilicate, ammonium fluorosilicate, and sodium monofluorophosphate.
  • the composition may also include palliative ingredients for periodontal tissues.
  • ingredients include, but are not limited to aloe, eugenol, and vitamin E.
  • Pigments, sweeteners, colors, and flavors may also be incorporated into the composition.
  • the flavorings or aromas include, for example, mint or pineapple to make the mixture more pleasant to the senses.
  • the mixture can contain oxidizing agents from the class of peroxides although these would act in a supplemental manner to the non-peroxide agent(s) rather than providing the majority of the whitening action.
  • the composition may further include an ingredient to decrease tooth sensitivity, such as potassium nitrate.
  • the addition of these components to dental creams, such as toothpaste, are well known in the art.
  • the mixture can contain materials to enhance the conversion of one form of energy to another.
  • materials to enhance the conversion of one form of energy to another.
  • the addition of certain materials will act to convert light energy to heat. Almost any colored material will produce this effect to one extent or another, and have been found to be useful in accelerating the whitening process.
  • Others such as benzoil peroxoide do not necessarily display color when exposed to white light.
  • compositions of the invention can also contain materials to either protect the soft tissues or to help them resist any ill effects of either the mixture or the external energy which is applied to the mixture.
  • examples of this group would be anti-oxidants such as melatonin, ascorbic acid, para amino benzoic acid, and aloe vera.
  • compositions described herein can be applied to teeth or other tissues by any number of methods.
  • administration may be performed by using a toothbrush device, a syringe, held in a tray into which the teeth are immersed, sprayed on the surface, used as a mouth rinse, applied as a foam, as a toothpaste, gel dentifrice, chewing gum, wax or lozenge vehicle or other methods known to those of skill in the art.
  • Techniques well known in the art of pharmaceutical compositions can be used to deliver the non-peroxide ionic bleaching agents of the invention in the form of a pharmaceutical carrier (see for example, Remington's Pharmaceutical
  • compositions of the present invention are useful in destaining or treating dentures, oral prosthetics, and retainers.
  • the chemicals and compositions of the invention can also be placed on the tooth prior to or contemporaneously with other composition or chemicals.
  • a slurry of potassium monopersulfate and water is first placed on the tooth and after several minutes it is followed by a solution of ozone and water.
  • the tooth is first washed with a mixture containing hydrogen peroxoide. This mixture is allowed to react with and penetrate the tooth before the application of an ozone solution.
  • the effectiveness and stability of the bleaching materials is effectuated by the pH. Accordingly, the effectiveness and stability can be modulated by first wetting the tissue or teeth to be contacted with a solution of high pH.
  • the first solution is rinsed off and a second material is placed on the surface and allowed to penetrate into the tooth structure whose pH has just been effectively altered.
  • EXAMPLE 1 A mixture of potassium monopersulfate compound such as that produced by Dupont under the trade name Oxone, was mixed with an equal amount of sodium fluoride into a slurry and placed on a human tooth for a period of one hour. During this time the adjacent soft tissues were protected from contact with the slurry by a rubber dam. As the slurry dried upon the teeth it was re-wetted using a small sable paintbrush that had been dipped in water. At the end of one hour the mixture was removed from the teeth and the teeth were rinsed with fresh water. The amount of whitening exhibited was approximately equal to that expected from a two-week regimen of wearing custom trays with peroxide gels.
  • Example 1 A slurry was made as in Example 1 except that in place of plain water, a solution of water and ozone in a concentration of 3-4% was mixed and applied to the tooth. As the mixture began to dry it was stirred on the tooth with a small sable paintbrush that had been dipped into the ozone solution. The result of this treatment were even more dramatic than that of Example 1.
  • EXAMPLE 3 Various mixtures of agents listed above were placed on stained bovine teeth and the brightness of the teeth were measured both before and after a five minute exposure to the agents. The table below lists some of the combination tested and the results. A higher delta number indicates a greater amount of change in brightness of the substrate as a result of the exposure:

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Inorganic Chemistry (AREA)
  • Epidemiology (AREA)
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  • Oral & Maxillofacial Surgery (AREA)
  • Cosmetics (AREA)

Abstract

L'invention concerne une composition pour blanchissement des dents, utilisant un composé d'oxygénation ionique non peroxydé. Les compositions présentent des formes et des consistances variées, telles que des pâtes, des gels, ou des solutions pouvant être mis en contact avec les dents, ou un dentifrice à traiter. Les ions et les radicaux des matériaux pénètrent dans la structure de la dent, et produisent un effet de blanchissement à la fois sur la surface et sous la surface. L'invention concerne également un procédé permettant de blanchir les dents au moyen d'un agent de blanchissement, de compositions, ou d'un dentifrice à traiter.
PCT/US1999/017949 1998-08-11 1999-08-10 Procedes et compositions permettant de blanchir les dents Ceased WO2000009079A1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU53949/99A AU5394999A (en) 1998-08-11 1999-08-10 Methods and compositions for whitening teeth

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US9604798P 1998-08-11 1998-08-11
US60/096,047 1998-08-11

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WO2000009079A1 true WO2000009079A1 (fr) 2000-02-24

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Cited By (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2007217323A (ja) * 2006-02-15 2007-08-30 Sun Medical Co Ltd 歯牙漂白剤組成物
WO2014092730A1 (fr) * 2012-12-14 2014-06-19 Colgate-Palmolive Company Procédés de blanchiment des dents
WO2015084295A1 (fr) * 2013-12-02 2015-06-11 Colgate-Palmolive Company Système d'oxydation pour compositions de soin buccal
CN105792896A (zh) * 2013-12-02 2016-07-20 高露洁-棕榄公司 用于口腔护理组合物的两部分氧化体系
WO2017106073A1 (fr) * 2015-12-18 2017-06-22 Colgate-Palmolive Company Composition de peroxymonosulfate à dissolution rapide
WO2017112672A1 (fr) * 2015-12-23 2017-06-29 Colgate-Palmolive Company Composition solide stable en stockage de peroxymosulfate
US20180133129A1 (en) * 2016-11-16 2018-05-17 Colgate-Palmolive Company Oral Care Composition
WO2018093356A1 (fr) * 2016-11-16 2018-05-24 Colgate-Palmolive Company Composition de soin buccal
CN109689165A (zh) * 2016-08-11 2019-04-26 高露洁-棕榄公司 针对顽渍的过一硫酸盐牙粉组合物
US10543154B2 (en) 2016-12-20 2020-01-28 Colgate-Palmolive Company Oral care composition
US10548826B2 (en) 2016-12-20 2020-02-04 Colgate-Palmolive Company Oral care compositions
US10716741B1 (en) 2018-12-26 2020-07-21 Colgate-Palmolive Company Oral care compositions and methods for the same
US10716742B2 (en) 2016-11-16 2020-07-21 Colgate-Palmolive Company Oral care composition
US10744075B2 (en) 2017-06-19 2020-08-18 Colgate-Palmolive Company Oral care products and whitening compositions thereof
US20220347068A1 (en) * 2013-12-10 2022-11-03 Colgate-Palmolive Company Bleaching Gel
US20230210731A1 (en) * 2022-01-04 2023-07-06 Cao Group, Inc. Reduction resistant hydrogel thickeners
US12023402B2 (en) 2016-12-20 2024-07-02 Colgate-Palmolive Company Oral care compositions
US12214063B2 (en) 2021-02-19 2025-02-04 Colgate-Palmolive Company Peroxymonosulfate whitening strips

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Cited By (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2007217323A (ja) * 2006-02-15 2007-08-30 Sun Medical Co Ltd 歯牙漂白剤組成物
US9974634B2 (en) 2012-12-14 2018-05-22 Colgate-Palmolive Company Methods for whitening teeth
WO2014092730A1 (fr) * 2012-12-14 2014-06-19 Colgate-Palmolive Company Procédés de blanchiment des dents
AU2012396798B2 (en) * 2012-12-14 2016-02-25 Colgate-Palmolive Company Methods for whitening teeth
WO2015084295A1 (fr) * 2013-12-02 2015-06-11 Colgate-Palmolive Company Système d'oxydation pour compositions de soin buccal
CN105792799A (zh) * 2013-12-02 2016-07-20 高露洁-棕榄公司 用于口腔护理组合物的氧化体系
CN105792896A (zh) * 2013-12-02 2016-07-20 高露洁-棕榄公司 用于口腔护理组合物的两部分氧化体系
AU2013406827B2 (en) * 2013-12-02 2017-05-18 Colgate-Palmolive Company Oxidizing system for oral care compositions
CN105792896B (zh) * 2013-12-02 2019-08-13 高露洁-棕榄公司 用于口腔护理组合物的两部分氧化体系
US20220347068A1 (en) * 2013-12-10 2022-11-03 Colgate-Palmolive Company Bleaching Gel
WO2017106073A1 (fr) * 2015-12-18 2017-06-22 Colgate-Palmolive Company Composition de peroxymonosulfate à dissolution rapide
AU2016370380B2 (en) * 2015-12-18 2019-03-14 Colgate-Palmolive Company Fast dissolving peroxymonosulfate composition
US10729626B2 (en) 2015-12-23 2020-08-04 Colgate-Palmolive Company Storage-stable solid peroxymonosulfate composition
CN108601957A (zh) * 2015-12-23 2018-09-28 高露洁-棕榄公司 储存稳定的固体过一硫酸盐组合物
AU2016378548B2 (en) * 2015-12-23 2019-04-04 Colgate-Palmolive Company Storage-stable solid peroxymonosulfate composition
CN108601957B (zh) * 2015-12-23 2021-12-10 高露洁-棕榄公司 储存稳定的固体过一硫酸盐组合物
AU2016378548C1 (en) * 2015-12-23 2019-07-25 Colgate-Palmolive Company Storage-stable solid peroxymonosulfate composition
US11229588B2 (en) 2015-12-23 2022-01-25 Colgate-Palmolive Company Storage-stable solid peroxymonosulfate composition
WO2017112672A1 (fr) * 2015-12-23 2017-06-29 Colgate-Palmolive Company Composition solide stable en stockage de peroxymosulfate
CN109689165A (zh) * 2016-08-11 2019-04-26 高露洁-棕榄公司 针对顽渍的过一硫酸盐牙粉组合物
US11166890B2 (en) * 2016-08-11 2021-11-09 Colgate-Palmolive Company Peroxymonosulfate toothpowder composition for tenacious stains
US12161739B2 (en) 2016-08-11 2024-12-10 Colgate-Palmolive Company Peroxymonosulfate toothpowder composition for tenacious stains
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