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WO2000008134A3 - HUMAN HtrA SERINE PROTEASE - Google Patents

HUMAN HtrA SERINE PROTEASE Download PDF

Info

Publication number
WO2000008134A3
WO2000008134A3 PCT/EP1999/005528 EP9905528W WO0008134A3 WO 2000008134 A3 WO2000008134 A3 WO 2000008134A3 EP 9905528 W EP9905528 W EP 9905528W WO 0008134 A3 WO0008134 A3 WO 0008134A3
Authority
WO
WIPO (PCT)
Prior art keywords
compounds
invention concerns
human
serine protease
methods
Prior art date
Application number
PCT/EP1999/005528
Other languages
French (fr)
Other versions
WO2000008134A2 (en
Inventor
Robert Mitchell Crowl
Shou-Ih Hu
Rajendra Durgaprasad Ghai
Jane Vivienne Peppard
Original Assignee
Novartis Ag
Novartis Erfind Verwalt Gmbh
Robert Mitchell Crowl
Hu Shou Ih
Rajendra Durgaprasad Ghai
Jane Vivienne Peppard
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag, Novartis Erfind Verwalt Gmbh, Robert Mitchell Crowl, Hu Shou Ih, Rajendra Durgaprasad Ghai, Jane Vivienne Peppard filed Critical Novartis Ag
Priority to AU52904/99A priority Critical patent/AU5290499A/en
Publication of WO2000008134A2 publication Critical patent/WO2000008134A2/en
Publication of WO2000008134A3 publication Critical patent/WO2000008134A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

The subject invention concerns novel materials and methods for the detection of human osteoarthritis and cancer. Specifically, a human HtrA gene and gene product are disclosed which are differentially expressed when comparing osteoarthritic tissue to non-osteoarthritic tissue. A further aspect of the invention concerns compounds which antagonize the biological activity of HtrA protein and methods for identifying these compounds. Another aspect of the present invention concerns pharmaceutical compositions comprising such compounds.
PCT/EP1999/005528 1998-08-03 1999-07-31 HUMAN HtrA SERINE PROTEASE WO2000008134A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU52904/99A AU5290499A (en) 1998-08-03 1999-07-31 Human htra serine protease

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US12861998A 1998-08-03 1998-08-03
US09/128,619 1998-08-03

Publications (2)

Publication Number Publication Date
WO2000008134A2 WO2000008134A2 (en) 2000-02-17
WO2000008134A3 true WO2000008134A3 (en) 2000-05-11

Family

ID=22436199

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP1999/005528 WO2000008134A2 (en) 1998-08-03 1999-07-31 HUMAN HtrA SERINE PROTEASE

Country Status (2)

Country Link
AU (1) AU5290499A (en)
WO (1) WO2000008134A2 (en)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20100166743A1 (en) * 2006-10-06 2010-07-01 University Of Utah Research Foundation Method of detecting ocular diseases and pathologic conditions and treatment of same
US20120142608A1 (en) 2007-11-01 2012-06-07 University of Iowa Research Foundation Corporation Rca locus analysis to assess susceptibility to amd and mpgnii
HRP20181457T1 (en) 2011-10-14 2018-11-16 F. Hoffmann - La Roche Ag ANTI-HTRA1 ANTIBODIES AND USE PROCEDURES
DK3368578T3 (en) 2015-10-30 2021-05-25 Hoffmann La Roche Anti-HtrA1 Antibodies and Methods of Using Them
DK3472149T3 (en) 2016-06-21 2023-11-27 Orion Ophthalmology LLC HETEROCYCLIC PROLINE MID DERIVATIVES
US10526315B2 (en) 2016-06-21 2020-01-07 Orion Ophthalmology LLC Carbocyclic prolinamide derivatives
EP3478839A1 (en) 2016-07-01 2019-05-08 H. Hoffnabb-La Roche Ag Antisense oligonucleotides for modulating htra1 expression
US20190055564A1 (en) * 2017-06-01 2019-02-21 F. Hoffmann-La Roche Ag Antisense oligonucleotides for modulating htra1 expression
AU2018390167A1 (en) * 2017-12-21 2020-06-11 F. Hoffmann-La Roche Ag Companion diagnostic for HTRA1 RNA antagonists

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH09107980A (en) * 1995-08-17 1997-04-28 Japan Tobacco Inc New physiologically active protein
EP0828003A2 (en) * 1996-09-06 1998-03-11 Smithkline Beecham Plc Human serine protease

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH09107980A (en) * 1995-08-17 1997-04-28 Japan Tobacco Inc New physiologically active protein
EP0828003A2 (en) * 1996-09-06 1998-03-11 Smithkline Beecham Plc Human serine protease

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
HU ET AL.: "Human HtrA, an evolutionarily conserved serine protease identified as a differentially expressed gene product in osteoarthritic cartilage", J. BIOL. CHEM., vol. 273, no. 51, 18 December 1998 (1998-12-18), pages 34406 - 34412, XP002127797 *
PATENT ABSTRACTS OF JAPAN vol. 1997, no. 08 29 August 1997 (1997-08-29) *
ZUMBRUNN ET AL.: "Primary structure of a putative serine protease specific for IGF-binding proteins", FEBS LETTERS, vol. 398, 1996, pages 187 - 192, XP002127796 *

Also Published As

Publication number Publication date
WO2000008134A2 (en) 2000-02-17
AU5290499A (en) 2000-02-28

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