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WO2000006730A3 - Proteines humaines cytosquelettiques - Google Patents

Proteines humaines cytosquelettiques Download PDF

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Publication number
WO2000006730A3
WO2000006730A3 PCT/US1999/017167 US9917167W WO0006730A3 WO 2000006730 A3 WO2000006730 A3 WO 2000006730A3 US 9917167 W US9917167 W US 9917167W WO 0006730 A3 WO0006730 A3 WO 0006730A3
Authority
WO
WIPO (PCT)
Prior art keywords
cytoskeletal proteins
hcyt
provides
human cytoskeletal
human
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US1999/017167
Other languages
English (en)
Other versions
WO2000006730A2 (fr
Inventor
Olga Bandman
Y Tom Tang
Henry Yue
Neil C Corley
Karl J Guegler
Yalda Azimzai
Chandra Patterson
Preeti Lal
Mariah R Baughn
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Incyte Corp
Original Assignee
Incyte Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Incyte Pharmaceuticals Inc filed Critical Incyte Pharmaceuticals Inc
Priority to EP99938859A priority Critical patent/EP1100907A2/fr
Priority to CA002335656A priority patent/CA2335656A1/fr
Priority to AU53253/99A priority patent/AU5325399A/en
Priority to JP2000562512A priority patent/JP2003522519A/ja
Publication of WO2000006730A2 publication Critical patent/WO2000006730A2/fr
Publication of WO2000006730A3 publication Critical patent/WO2000006730A3/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4716—Muscle proteins, e.g. myosin, actin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
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    • A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
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    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
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    • A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A—HUMAN NECESSITIES
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    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
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    • A61P5/00—Drugs for disorders of the endocrine system
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    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

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  • Health & Medical Sciences (AREA)
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  • Orthopedic Medicine & Surgery (AREA)
  • Oncology (AREA)
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  • Communicable Diseases (AREA)
  • Endocrinology (AREA)
  • Urology & Nephrology (AREA)
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  • Cardiology (AREA)
  • Dermatology (AREA)
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  • Psychiatry (AREA)
  • Reproductive Health (AREA)
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Abstract

L'invention concerne des protéines humaines cytosquelettiques (HCYT) et des polynucléotides qui identifient et codent pour HCYT. L'invention concerne également des vecteurs d'expression, des cellules hôtes, des anticorps, des agonistes, et des antagonistes. L'invention concerne, en outre, des procédés permettant de diagnostiquer, de traiter ou de prévenir des troubles associés à l'expression de HCYT.
PCT/US1999/017167 1998-07-31 1999-07-30 Proteines humaines cytosquelettiques Ceased WO2000006730A2 (fr)

Priority Applications (4)

Application Number Priority Date Filing Date Title
EP99938859A EP1100907A2 (fr) 1998-07-31 1999-07-30 Proteines humaines cytosquelettiques
CA002335656A CA2335656A1 (fr) 1998-07-31 1999-07-30 Proteines humaines cytosquelettiques
AU53253/99A AU5325399A (en) 1998-07-31 1999-07-30 Human cytoskeletal proteins
JP2000562512A JP2003522519A (ja) 1998-07-31 1999-07-30 ヒト細胞骨格タンパク質

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US15518598P 1998-07-31 1998-07-31
US60/155,185 1998-07-31
US60/160,081 1998-08-04
US15522898P 1998-08-19 1998-08-19
US60/155,228 1998-08-19
US16008198P 1998-09-24 1998-09-24

Publications (2)

Publication Number Publication Date
WO2000006730A2 WO2000006730A2 (fr) 2000-02-10
WO2000006730A3 true WO2000006730A3 (fr) 2000-05-04

Family

ID=27387686

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1999/017167 Ceased WO2000006730A2 (fr) 1998-07-31 1999-07-30 Proteines humaines cytosquelettiques

Country Status (5)

Country Link
EP (1) EP1100907A2 (fr)
JP (1) JP2003522519A (fr)
AU (1) AU5325399A (fr)
CA (1) CA2335656A1 (fr)
WO (1) WO2000006730A2 (fr)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0413001D0 (en) 2004-06-10 2004-07-14 Johnson & Johnson Medical Ltd Diagnostic and prognostic
GB0512401D0 (en) * 2005-06-17 2005-07-27 Randox Lab Ltd Method

Non-Patent Citations (9)

* Cited by examiner, † Cited by third party
Title
A.R. MACLEOD ET AL.: "Characterization of a cDNA defining a gene family encoding TM30pl, a human fibroblast tropomyosin.", J. MOL. BIOL., vol. 194, 1987, pages 1 - 10, XP000853810 *
HARDY S ET AL: "The Xenopus laevis TM-4 gene encodes non-muscle and cardiac tropomyosin isoforms through alternative splicing", GENE,NL,ELSEVIER BIOMEDICAL PRESS. AMSTERDAM, vol. 156, no. 2, pages 265-270, XP004042365, ISSN: 0378-1119 *
K. TAKENAGA ET AL.: "Isolation and characterization of a cDNA that encodes mouse fibroblast tropomyosin isoform 2.", MOLECULAR AND CELLULAR BIOLOGY, vol. 8, no. 11, November 1988 (1988-11-01), pages 5561 - 5565, XP002122326 *
L.O. GOODWIN ET AL.: "Four fibroblast tropomyosin isoforms are expressed from the rat alpha-tropomyosin gene via alternative RNA splicing and the use of two promoters.", THE JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 266, 5 May 1991 (1991-05-05), pages 8408 - 8415, XP002122325 *
M. LEMONNIER ET AL.: "The chicken gene encoding the alpha isoform of tropomyosin of fast-twitch muscle fibers: organization, expression and identification of the major proteins synthesized.", GENE, vol. 107, 1991, pages 229 - 240, XP002122322 *
P.L. HALLAUER ET AL.: "Closely related alpha-tropomyosin in mRNAs in quail fibroblasts and skeletal muscle cells", THE JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 262, no. 8, 15 March 1987 (1987-03-15), pages 3590 - 3596, XP002122324 *
R-P. RYSECK ET AL.: "Coordinate induction of fibronectin, fibronectin receptor, tropomyosin and actin genes in serum-stimulated fibroblasts.", EXPERIMENTAL CELL RESEARCH, vol. 180, 1989, pages 537 - 545, XP002122319 *
S.H. PEARSON ET AL.: "A novel hybrid alpha-tropomyosin in fibroblasts is produced by alternative splicing of transcripts from the skeletal muscle alpha-tropomyosin gene.", THE JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 262, no. 33, 25 November 1987 (1987-11-25), pages 15998 - 16010, XP002122323 *
Y-C. WANG ET AL.: "Splicing of two alternative exon pairs in beta-tropomyosin pre-mRNA is independently controlled during myogenesis.", THE JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 267, no. 17, 15 June 1992 (1992-06-15), pages 12004 - 12010, XP002122321 *

Also Published As

Publication number Publication date
JP2003522519A (ja) 2003-07-29
WO2000006730A2 (fr) 2000-02-10
CA2335656A1 (fr) 2000-02-10
EP1100907A2 (fr) 2001-05-23
AU5325399A (en) 2000-02-21

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