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WO2000004364A3 - Dispositifs et procedes d'illumination de champ evanescent - Google Patents

Dispositifs et procedes d'illumination de champ evanescent Download PDF

Info

Publication number
WO2000004364A3
WO2000004364A3 PCT/US1999/016057 US9916057W WO0004364A3 WO 2000004364 A3 WO2000004364 A3 WO 2000004364A3 US 9916057 W US9916057 W US 9916057W WO 0004364 A3 WO0004364 A3 WO 0004364A3
Authority
WO
WIPO (PCT)
Prior art keywords
methods
illumination devices
field illumination
evanescent field
devices
Prior art date
Application number
PCT/US1999/016057
Other languages
English (en)
Other versions
WO2000004364A9 (fr
WO2000004364A8 (fr
WO2000004364A2 (fr
Inventor
Douglas N Modlin
Original Assignee
Ljl Biosystems Inc
Douglas N Modlin
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/US1998/014575 external-priority patent/WO1999004228A2/fr
Priority claimed from US09/160,533 external-priority patent/US6097025A/en
Application filed by Ljl Biosystems Inc, Douglas N Modlin filed Critical Ljl Biosystems Inc
Priority to AU49990/99A priority Critical patent/AU4999099A/en
Publication of WO2000004364A2 publication Critical patent/WO2000004364A2/fr
Publication of WO2000004364A3 publication Critical patent/WO2000004364A3/fr
Priority to US09/759,711 priority patent/US20030205681A1/en
Publication of WO2000004364A8 publication Critical patent/WO2000004364A8/fr
Publication of WO2000004364A9 publication Critical patent/WO2000004364A9/fr
Priority to US10/445,292 priority patent/US6992761B2/en

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/645—Specially adapted constructive features of fluorimeters
    • G01N21/6452—Individual samples arranged in a regular 2D-array, e.g. multiwell plates
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y15/00—Nanotechnology for interacting, sensing or actuating, e.g. quantum dots as markers in protein assays or molecular motors
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/6408—Fluorescence; Phosphorescence with measurement of decay time, time resolved fluorescence
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/645—Specially adapted constructive features of fluorimeters
    • G01N21/648—Specially adapted constructive features of fluorimeters using evanescent coupling or surface plasmon coupling for the excitation of fluorescence
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/02—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
    • G01N35/028—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations having reaction cells in the form of microtitration plates

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Physics & Mathematics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Engineering & Computer Science (AREA)
  • Nanotechnology (AREA)
  • Molecular Biology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Optical Measuring Cells (AREA)

Abstract

La présente invention concerne des dispositifs et procédés de détection de luminescence de molécules situées aux surfaces ou voisines des surfaces d'une pluralité de puits d'échantillons par réflexion interne totale.
PCT/US1999/016057 1997-09-20 1999-07-15 Dispositifs et procedes d'illumination de champ evanescent WO2000004364A2 (fr)

Priority Applications (3)

Application Number Priority Date Filing Date Title
AU49990/99A AU4999099A (en) 1998-07-15 1999-07-15 Evanescent field illumination devices and methods
US09/759,711 US20030205681A1 (en) 1998-07-22 2001-01-12 Evanescent field illumination devices and methods
US10/445,292 US6992761B2 (en) 1997-09-20 2003-05-22 Broad range light detection system

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
PCT/US1998/014575 WO1999004228A2 (fr) 1997-07-16 1998-07-15 Dispositif de detection de lumiere
USPCT/US98/14575 1998-07-15
US9383898P 1998-07-22 1998-07-22
US60/093,838 1998-07-22
US09/160,533 1998-09-24
US09/160,533 US6097025A (en) 1997-10-31 1998-09-24 Light detection device having an optical-path switching mechanism

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
US09/160,533 Continuation US6097025A (en) 1997-07-16 1998-09-24 Light detection device having an optical-path switching mechanism

Related Child Applications (1)

Application Number Title Priority Date Filing Date
US09/759,711 Continuation US20030205681A1 (en) 1997-09-20 2001-01-12 Evanescent field illumination devices and methods

Publications (4)

Publication Number Publication Date
WO2000004364A2 WO2000004364A2 (fr) 2000-01-27
WO2000004364A3 true WO2000004364A3 (fr) 2000-09-08
WO2000004364A8 WO2000004364A8 (fr) 2001-03-01
WO2000004364A9 WO2000004364A9 (fr) 2001-06-28

Family

ID=27377585

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1999/016057 WO2000004364A2 (fr) 1997-09-20 1999-07-15 Dispositifs et procedes d'illumination de champ evanescent

Country Status (2)

Country Link
AU (1) AU4999099A (fr)
WO (1) WO2000004364A2 (fr)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7070921B2 (en) 2000-04-28 2006-07-04 Molecular Devices Corporation Molecular modification assays
US6992761B2 (en) 1997-09-20 2006-01-31 Molecular Devices Corporation Broad range light detection system
US6486947B2 (en) * 1998-07-22 2002-11-26 Ljl Biosystems, Inc. Devices and methods for sample analysis
ATE497164T1 (de) 1999-06-09 2011-02-15 Molecular Devices Inc Testverfahren zur messung der phosphorylierung
JP3783826B2 (ja) * 2000-01-17 2006-06-07 横河電機株式会社 バイオチップ読み取り装置
US20020132360A1 (en) 2000-11-17 2002-09-19 Flir Systems Boston, Inc. Apparatus and methods for infrared calorimetric measurements
WO2002044425A2 (fr) 2000-12-01 2002-06-06 Visigen Biotechnologies, Inc. Synthese d'acides nucleiques d'enzymes, et compositions et methodes modifiant la fidelite d'incorporation de monomeres
JP2006254838A (ja) * 2005-03-18 2006-09-28 Toppan Printing Co Ltd 検出チップ及びこれを用いた物質の検出方法
DE202008009859U1 (de) * 2007-12-21 2009-03-05 Berthold Technologies Gmbh & Co. Kg Vorrichtung zur wahlweisen Messung von insbesondere Lumineszenz- und/oder Fluoreszenzstrahlung
EP2271914B1 (fr) * 2008-04-23 2013-03-13 Österlund, Lars Unité de détection optique pour spectroscopie à ondes évanescentes
FI20095064A0 (fi) 2009-01-26 2009-01-26 Wallac Oy Järjestely ja menetelmä optisen mittauslaitteen mittapään ohjaamiseksi
FI20095061A0 (fi) * 2009-01-26 2009-01-26 Wallac Oy Optisen mittauslaitteen runkomoduuli

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4979821A (en) * 1988-01-27 1990-12-25 Ortho Diagnostic Systems Inc. Cuvette for receiving liquid sample
US5341215A (en) * 1991-06-08 1994-08-23 Hewlett-Packard Company Method and apparatus for detecting the presence and/or concentration of biomolecules
US5677196A (en) * 1993-05-18 1997-10-14 University Of Utah Research Foundation Apparatus and methods for multi-analyte homogeneous fluoro-immunoassays
US5738825A (en) * 1993-07-20 1998-04-14 Balzers Aktiengesellschaft Optical biosensor matrix
US5750410A (en) * 1994-08-26 1998-05-12 Kyoto Dai-Ichi Kagaku Co., Ltd. Method of and apparatus for immune analysis

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4979821A (en) * 1988-01-27 1990-12-25 Ortho Diagnostic Systems Inc. Cuvette for receiving liquid sample
US5341215A (en) * 1991-06-08 1994-08-23 Hewlett-Packard Company Method and apparatus for detecting the presence and/or concentration of biomolecules
US5677196A (en) * 1993-05-18 1997-10-14 University Of Utah Research Foundation Apparatus and methods for multi-analyte homogeneous fluoro-immunoassays
US5738825A (en) * 1993-07-20 1998-04-14 Balzers Aktiengesellschaft Optical biosensor matrix
US5750410A (en) * 1994-08-26 1998-05-12 Kyoto Dai-Ichi Kagaku Co., Ltd. Method of and apparatus for immune analysis

Also Published As

Publication number Publication date
WO2000004364A9 (fr) 2001-06-28
WO2000004364A8 (fr) 2001-03-01
WO2000004364A2 (fr) 2000-01-27
AU4999099A (en) 2000-02-07

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