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WO2000003681A3 - Process for the synthesis of benzopyran derivatives - Google Patents

Process for the synthesis of benzopyran derivatives Download PDF

Info

Publication number
WO2000003681A3
WO2000003681A3 PCT/US1999/015993 US9915993W WO0003681A3 WO 2000003681 A3 WO2000003681 A3 WO 2000003681A3 US 9915993 W US9915993 W US 9915993W WO 0003681 A3 WO0003681 A3 WO 0003681A3
Authority
WO
WIPO (PCT)
Prior art keywords
synthesis
benzopyran derivatives
formula
benzopyran
compounds represented
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US1999/015993
Other languages
French (fr)
Other versions
WO2000003681A2 (en
Inventor
James Guy Breitenbucher
Hon C Hui
Gianine M Figliozzi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Axys Pharmaceuticals Inc
Original Assignee
Axys Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Axys Pharmaceuticals Inc filed Critical Axys Pharmaceuticals Inc
Priority to AU49971/99A priority Critical patent/AU4997199A/en
Publication of WO2000003681A2 publication Critical patent/WO2000003681A2/en
Publication of WO2000003681A3 publication Critical patent/WO2000003681A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
    • C07D311/68—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4 with nitrogen atoms directly attached in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

The present invention provides a process for the synthesis of benzopyran based compounds represented by Formula (1). Also disclosed are novel benzopyran based compounds represented by Formula (E) and Formula (3).
PCT/US1999/015993 1998-07-16 1999-07-14 Process for the synthesis of benzopyran derivatives Ceased WO2000003681A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU49971/99A AU4997199A (en) 1998-07-16 1999-07-14 Process for the synthesis of benzopyran derivatives

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US9314298P 1998-07-16 1998-07-16
US60/093,142 1998-07-16

Publications (2)

Publication Number Publication Date
WO2000003681A2 WO2000003681A2 (en) 2000-01-27
WO2000003681A3 true WO2000003681A3 (en) 2000-04-20

Family

ID=22237427

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1999/015993 Ceased WO2000003681A2 (en) 1998-07-16 1999-07-14 Process for the synthesis of benzopyran derivatives

Country Status (2)

Country Link
AU (1) AU4997199A (en)
WO (1) WO2000003681A2 (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU6396600A (en) * 1999-08-04 2001-03-05 Chemrx Advanced Technologies, Inc. Solid phase synthesis of oxa- and thiazoles
US7842703B2 (en) * 2005-10-07 2010-11-30 Glenmark Pharmaceuticals S.A. Substituted benzofused derivatives and their use as vanilloid receptor ligands
WO2007063385A2 (en) * 2005-12-01 2007-06-07 Pfizer Products Inc. Spirocyclic amine histamine-3 receptor antagonists
NZ595776A (en) * 2007-12-18 2013-08-30 Glenmark Pharmaceuticals Sa Chromane derivatives as trpv3 modulators
IL271149B2 (en) 2017-06-14 2024-05-01 Trevena Inc Compounds for modulating S1P1 activity and methods of using them

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5401848A (en) * 1990-11-26 1995-03-28 E. R. Squibb & Sons, Inc. Indane and quinoline derivatives
US5453421A (en) * 1992-09-11 1995-09-26 E. R. Squibb & Sons, Inc. Aryl and heterocyclic substituted propenamide derivatives
US5612370A (en) * 1995-06-07 1997-03-18 Bristol-Myers Squibb Company Phenylglycine and phenylalaninen amido benzopyran derivatives
US5889044A (en) * 1991-06-13 1999-03-30 Smithkline Beecham P.L.C. Benzo- and pyridopyran derivatives having anxiolytic and anti-convulsant activity

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5401848A (en) * 1990-11-26 1995-03-28 E. R. Squibb & Sons, Inc. Indane and quinoline derivatives
US5889044A (en) * 1991-06-13 1999-03-30 Smithkline Beecham P.L.C. Benzo- and pyridopyran derivatives having anxiolytic and anti-convulsant activity
US5453421A (en) * 1992-09-11 1995-09-26 E. R. Squibb & Sons, Inc. Aryl and heterocyclic substituted propenamide derivatives
US5612370A (en) * 1995-06-07 1997-03-18 Bristol-Myers Squibb Company Phenylglycine and phenylalaninen amido benzopyran derivatives

Also Published As

Publication number Publication date
WO2000003681A2 (en) 2000-01-27
AU4997199A (en) 2000-02-07

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