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WO2000002874A3 - Integrin dependent cell adhesion inhibitors - Google Patents

Integrin dependent cell adhesion inhibitors Download PDF

Info

Publication number
WO2000002874A3
WO2000002874A3 PCT/GB1999/002219 GB9902219W WO0002874A3 WO 2000002874 A3 WO2000002874 A3 WO 2000002874A3 GB 9902219 W GB9902219 W GB 9902219W WO 0002874 A3 WO0002874 A3 WO 0002874A3
Authority
WO
WIPO (PCT)
Prior art keywords
cell adhesion
dependent cell
adhesion inhibitors
integrin dependent
integrin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/GB1999/002219
Other languages
French (fr)
Other versions
WO2000002874A2 (en
Inventor
Solomon Habtemariam
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Strathclyde
Original Assignee
University of Strathclyde
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of Strathclyde filed Critical University of Strathclyde
Publication of WO2000002874A2 publication Critical patent/WO2000002874A2/en
Publication of WO2000002874A3 publication Critical patent/WO2000002874A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/82—Benzo [b] furans; Hydrogenated benzo [b] furans with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
    • C07D307/83—Oxygen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

The present invention relates to euparin derivatives having broad spectrum integrin receptor inhibition activity and utility in the treatment of integrin mediated disease.
PCT/GB1999/002219 1998-07-09 1999-07-09 Integrin dependent cell adhesion inhibitors Ceased WO2000002874A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB9814801.8 1998-07-09
GBGB9814801.8A GB9814801D0 (en) 1998-07-09 1998-07-09 Integrin dependent cell adhesion inhibitors

Publications (2)

Publication Number Publication Date
WO2000002874A2 WO2000002874A2 (en) 2000-01-20
WO2000002874A3 true WO2000002874A3 (en) 2000-02-24

Family

ID=10835162

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB1999/002219 Ceased WO2000002874A2 (en) 1998-07-09 1999-07-09 Integrin dependent cell adhesion inhibitors

Country Status (2)

Country Link
GB (1) GB9814801D0 (en)
WO (1) WO2000002874A2 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100854424B1 (en) 2001-01-29 2008-08-27 3-디멘져널 파마슈티칼즈 인코오포레이티드 Their use as substituted indole and integrin antagonists
US6872730B2 (en) * 2001-04-27 2005-03-29 3-Dimensional Pharmaceuticals, Inc. Substituted benzofurans and benzothiophenes, methods of making and methods of use as integrin antagonists
CN104095840B (en) * 2014-06-23 2016-04-27 西安交通大学 The application of euparin in preparation treatment ischemic cardio cerebrovascular diseases medicine
CN105919991B (en) * 2016-05-18 2019-01-15 西安交通大学 Application of the euparin in preparation medicament for treatment of depression

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0132130A2 (en) * 1983-07-14 1985-01-23 Syntex (U.S.A.) Inc. Aroyl benzofuran and benzothiophene acetic and propionic acids processes for their production and pharmaceutical compositions containing them
WO1998009956A1 (en) * 1996-09-09 1998-03-12 Dainippon Pharmaceutical Co., Ltd. 2,3-dihydrobenzofuran derivative and hepatopathy remedy comprising the same as active ingredient
WO1998014440A1 (en) * 1996-10-04 1998-04-09 Eli Lilly And Company Antitumor compositions and methods of treatment

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0132130A2 (en) * 1983-07-14 1985-01-23 Syntex (U.S.A.) Inc. Aroyl benzofuran and benzothiophene acetic and propionic acids processes for their production and pharmaceutical compositions containing them
WO1998009956A1 (en) * 1996-09-09 1998-03-12 Dainippon Pharmaceutical Co., Ltd. 2,3-dihydrobenzofuran derivative and hepatopathy remedy comprising the same as active ingredient
WO1998014440A1 (en) * 1996-10-04 1998-04-09 Eli Lilly And Company Antitumor compositions and methods of treatment

Also Published As

Publication number Publication date
GB9814801D0 (en) 1998-09-09
WO2000002874A2 (en) 2000-01-20

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121 Ep: the epo has been informed by wipo that ep was designated in this application
DFPE Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101)
122 Ep: pct application non-entry in european phase