WO2000000025A1 - Germicidal composition - Google Patents
Germicidal composition Download PDFInfo
- Publication number
- WO2000000025A1 WO2000000025A1 PCT/GB1999/001991 GB9901991W WO0000025A1 WO 2000000025 A1 WO2000000025 A1 WO 2000000025A1 GB 9901991 W GB9901991 W GB 9901991W WO 0000025 A1 WO0000025 A1 WO 0000025A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- germicidal
- composition
- germicidal composition
- agent
- liquid polymer
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
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Classifications
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/72—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms
- A01N43/80—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms five-membered rings with one nitrogen atom and either one oxygen atom or one sulfur atom in positions 1,2
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
- A01N25/24—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests containing ingredients to enhance the sticking of the active ingredients
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08K—Use of inorganic or non-macromolecular organic substances as compounding ingredients
- C08K5/00—Use of organic ingredients
- C08K5/0008—Organic ingredients according to more than one of the "one dot" groups of C08K5/01 - C08K5/59
- C08K5/0058—Biocides
Definitions
- This invention concerns germicidal compositions, which term is used herein to mean compositions containing bactericides, fungicides, algaecides, yeasticides, moldicides, and the like, and combinations thereof.
- a germicidal composition comprising a liquid polymer composition and a germicidal agent.
- a method of treating a substantially solid material so that it becomes germicidal comprises applying to said material a germicidal composition comprising a liquid polymer composition and a germicidal agent so that said agent is deposited at a surface of said material.
- the germicidal agent is preferably in a non-volatile solvent carrier.
- the germicidal composition is preferably not toxic to humans or animals in its liquid or dry state.
- the liquid polymer composition may comprise polydimethylsiloxane, possibly as a mixture of isopropanol, butyl acetate and polydimethylsiloxane.
- the germicidal composition may comprise a cleansing agent for cleansing such surface to improve adherence.
- the cleansing agent may be an acid such as phosphoric, sulphonic or sulphuric acid but preferred cleansing agents are amine ethoxylate surfactants.
- the germicidal agent may comprise one or more of an amphoteric compound, an iodophore, a phenolic compound, a quaternary ammonium compound, a hypochlorite and a nitrogen-based heterocyclic antibacterial compound.
- the present invention enables the production and treatment of products with long term germicidal efficacy. This is because the germicidal composition of the invention continues to be effective after it has dried, in contrast with previous germicides which cease to work after drying. This is believed to be because, after the germicidal composition of the present invention dries substantially, it retains at the micro-surface a low concentration of the composition in solution. Products treated in accordance with the invention do not require repeated wiping down with disinfectant to prevent build-up of bacteria and the like.
- a liquid polymer composition was prepared to comprise: Component % bv volume
- Stage 3 A quantity of a first germicidal agent was prepared to comprise 5-chloro-2-methyl-4-isothiazolin-3-one and 2-methyl-4- isothiazolin-3-one with 83.5% MPG.
- Stage 4 A similar quantity of a second germicidal agent was prepared to comprise an alkyldimethyl-benzylammonium chloride with 50%
- Stage 5 100ml of the diluted mixture produced in Stage 4 was mixed with 200ml of the detergent composition produced in Stage 2 and then with 100ml of the liquid polymer composition produced in Stage 1.
- Stage 6 600ml of water was added to the product of Stage 5, resulting in 11 of the germicidal composition designated 42AP. Testing the germicidal composition designated 42AP Example 1
- MRSA Methicillin Resistant Staphylococcus Aureus
- Dilution 1 contained 14000 organisms per 20 ⁇ l and Dilution 3 contained 140 organisms per 20 ⁇ l. Volumes of 20 ⁇ l of each dilution were applied to each of the three glass plates and left in contact for a range of times up to six hours. After the designated time the liquid from each inoculation was aspirated and pipetted on to the surface of a blood agar plate. (If the inoculum had dried, 20 ⁇ l of sterile distilled water was applied, carefully mixed and then aspirated). The aspirate was spread over the agar surface using a sterile spreader. The glass plates were then incubated at 30°C for eighteen hours and colonies were then counted. Counts are shown in the following tables.
- Plate 1 showed a reduction in count over 5 minutes with no recovery after ten minutes.
- Plate 1 showed a 97.98% reduction within five minutes and a 100% reduction within ten minutes.
- Plate 2 showed a 99.95% reduction within one minute and 100% within two minutes.
- a 1mi volume of the liquid was inoculated with 20 ⁇ l of an undiluted overnight broth of MRSA, this inoculum being estimated to contain 10 7 -10 8 organisms.
- a 20 ⁇ l volume was withdrawn immediately and then further 20 ⁇ l volumes withdrawn after one, two, five, ten, thirty and sixty minutes.
- Each withdrawn volume was then spread over the surface of a blood agar plate, the plates incubated at 30°C for twenty hours, and the plates then examined for the presence of colonies.
- test used a dilution neutralisation method as specified in Section 5.5.2.2 of Appendix 1 under the following conditions:
- the neutraliser comprised 30g/l polysorbate 80 and 3g/l lecithin;
- the composition 42AP may be used to treat a wide range of substantially solid objects such as work surfaces and windows, by coating or incorporation. It may also be incorporated in paints or varnishes, and where these are oil- based Stage 6 of the illustrative preparation method above may be omitted.
- a wide range of germicidal agents may be employed in the invention including without prejudice to the generality of the invention:
- - Amphoteric compounds including long chain N-alkyl derivatives of amino acids such as glycine, alanine and beta-amino butyric acid, particular examples being dodecyl beta-alanine, dodecyl beta-aminobutyric acid, dodecylamino-di ⁇ aminoethylamino ⁇ glycine and N-(3-dodecylyamino) propylglycine; - lodophores (meaning herein complexes of iodine or triodide with a carrier, such as a neutral polymer, typically one increasing the solubility of iodine in water, providing a sustained release of such iodine and reducing the equilibrium concentrations of free iodine) which may be made from polyvinylpyrolidone (notably povidone iodine), polyether glycols such as polyethylene glycols, polyvinyl alcohols, polyacrylates, polyamides, polyalky
- Quaternary ammonium compounds including compounds of the general formula R 1 R 2 N + R 3 R 4 X wherein one or two of the R groups are alkyl chains optionally substituted by an aryl group, or optionally interrupted by an aryl group or a heteroatom such as oxygen, and the other R groups are the same or different and are C C 4 alkyl groups and in particular methyl groups, which compounds include benzalkonium halides, aryl ring substituted benzalkonium halides such as ethyl-substituted benzalkonium halides (eg Barquat 4250 available from Lonza), and twin chain quaternary ammonium compounds such as dialkyldimethyl ammonium compounds wherein the two non-methyl alkyl groups are selected from medium and long chain alkyl groups such as octyl groups and dodecyl groups, quaternary ammonium compounds in which an alkyl group R contains a heteroatom such as domiphen bromide, benz
- hypochlorites including alkali-metal and alkaline earth metal hypochlorites such as lithium hypochlorite, sodium hypochlorite, potassium hypochlorite, calcium hypochlorite, and chlorinated trisodium phosphate, their various hydrates, chlorine-containing or chlorine -releasing agents such as chlorine dioxide and its precursors, 4-sulpho-dichioroamidobenzoic acid ⁇ halazone ⁇ , 1 ,3-dichloro-5-5dimethylhydantoin ⁇ halane ⁇ , and various chlorisocyanuric acid derivatives; and - Nitrogen-containing antibacterial agents including pyridine derivatives such as 4-pyridine carboxylic acid hydrazide, sodium 2- pyridinethiol-1 -oxide (Sodium OmadineTM), bis-(2-pyridylthio)zinc 1 ,1'- dioxide (Zinc Omadine), triazoles and imidazoles such as 2-(4-thiazole) benzimidazole (
- the germicidal agent will be selected according to the polymer and the intended use of the germicidal composition and may comprise a synergistic combination of two or more germicidal components.
- a co-solvent or a co-diluent which evaporates rapidly may be included in the germicidal composition. This may be aqueous or non- aqueous according to the nature of the material with which it is to be mixed.
- a germicidal composition according to the invention has a wide range of applications including without prejudice to the generality of the invention:
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- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Dentistry (AREA)
- Chemical & Material Sciences (AREA)
- Environmental Sciences (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Agronomy & Crop Science (AREA)
- Pest Control & Pesticides (AREA)
- Plant Pathology (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Biodiversity & Conservation Biology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Polymers & Plastics (AREA)
- Medicinal Chemistry (AREA)
- Toxicology (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
A germicidal composition comprises a liquid polymer composition and a germicidal agent. The liquid polymer composition may comprise polydimethylsiloxane and the germicidal agent is preferably in a non-volatile solvent carrier. In use the germicidal composition retains its germ killing capability when dry. It may therefore be used to impart long term sterility to a wide range of products for environments required to be germ free, such as hospitals and food preparation areas.
Description
GERMICIDAL COMPOSITION
This invention concerns germicidal compositions, which term is used herein to mean compositions containing bactericides, fungicides, algaecides, yeasticides, moldicides, and the like, and combinations thereof.
A great deal of research has been devoted to countering infection and cross-infection in hospitals, surgeries, kitchens, food factories and so on, and a very wide range of germicidal compositions has been developed. However the application of previously known compositions raises a number of problems. First, they are effective only when wet: they may be applied wet but after they dry they have little or no residual action. Second, and partly at least in an attempt to ensure effectiveness during a short period of wet application, many previous compositions are toxic to animals or humans or are made strong in concentration to the point of being toxic or otherwise hazardous in application. Third, previously known compositions may, by staining or etching, damage surfaces to which they are applied. It is an object of the present invention to tackle these problems. According to a first aspect of the invention there is provided a germicidal composition comprising a liquid polymer composition and a germicidal agent.
According to a second aspect of the invention there is provided a method of treating a substantially solid material so that it becomes germicidal, which method comprises applying to said material a germicidal composition comprising a liquid polymer composition and a germicidal agent so that said agent is deposited at a surface of said material.
The germicidal agent is preferably in a non-volatile solvent carrier. The germicidal composition is preferably not toxic to humans or
animals in its liquid or dry state.
The liquid polymer composition may comprise polydimethylsiloxane, possibly as a mixture of isopropanol, butyl acetate and polydimethylsiloxane. Especially for application as a coating to a glass or other hard surface, the germicidal composition may comprise a cleansing agent for cleansing such surface to improve adherence. The cleansing agent may be an acid such as phosphoric, sulphonic or sulphuric acid but preferred cleansing agents are amine ethoxylate surfactants. The germicidal agent may comprise one or more of an amphoteric compound, an iodophore, a phenolic compound, a quaternary ammonium compound, a hypochlorite and a nitrogen-based heterocyclic antibacterial compound. It may be incorporated in a non-volatile carrier, preferably a glycol such as monopropylene glycol (MPG). The present invention enables the production and treatment of products with long term germicidal efficacy. This is because the germicidal composition of the invention continues to be effective after it has dried, in contrast with previous germicides which cease to work after drying. This is believed to be because, after the germicidal composition of the present invention dries substantially, it retains at the micro-surface a low concentration of the composition in solution. Products treated in accordance with the invention do not require repeated wiping down with disinfectant to prevent build-up of bacteria and the like.
The invention will now be described by way of example only with reference to a particular germicidal composition, as follows:
Preparing a germicidal composition designated 42AP Stage 1 : A liquid polymer composition was prepared to comprise:
Component % bv volume
Isopropanol 87-91%
Butyl acetate 1-6%
Amine ethoxylate 1.5-3%
Polydimethylsiloxane 3-6%
Stage 2: A detergent composition was preparec
Component % bv volume
Anionic surfactant 15-30%
Non-ionic surfactant 1-5%
Amphoteric surfactant 1-5%
Ethanol 1-5%
Preservative 1-5%
Water 50-80%
Stage 3: A quantity of a first germicidal agent was prepared to comprise 5-chloro-2-methyl-4-isothiazolin-3-one and 2-methyl-4- isothiazolin-3-one with 83.5% MPG.
Stage 4: A similar quantity of a second germicidal agent was prepared to comprise an alkyldimethyl-benzylammonium chloride with 50%
MPG and mixed with the first germicidal agent. The mixture was then diluted by water in the ratio of two parts of water by volume to one part of mixture by volume.
Stage 5: 100ml of the diluted mixture produced in Stage 4 was mixed with 200ml of the detergent composition produced in Stage 2 and then with 100ml of the liquid polymer composition produced in Stage 1. Stage 6: 600ml of water was added to the product of Stage 5, resulting in 11 of the germicidal composition designated 42AP. Testing the germicidal composition designated 42AP
Example 1
Two plates of glass were coated with 42AP, which was then allowed to dry and the plates sealed in bags. An un-coated plate of glass was similarly sealed in a bag to serve as a control. The plates were then stored for three weeks before being submitted to an independent laboratory for microbiological testing.
The micro-organism used was Methicillin Resistant Staphylococcus Aureus (MRSA). A broth culture of a wild strain of MRSA was grown in peptone saline diluent for 20-24 hours. Serial decimal dilutions were then prepared in peptone saline diluent and a surface drop (Miles and Misra) count performed on blood agar. Plates were incubated at 30°C for 18 hours, colonies counted and counts estimated for each dilution.
Two dilutions (1 and 3) were used for inoculation. Dilution 1 contained 14000 organisms per 20μl and Dilution 3 contained 140 organisms per 20μl. Volumes of 20μl of each dilution were applied to each of the three glass plates and left in contact for a range of times up to six hours. After the designated time the liquid from each inoculation was aspirated and pipetted on to the surface of a blood agar plate. (If the inoculum had dried, 20μl of sterile distilled water was applied, carefully mixed and then aspirated). The aspirate was spread over the agar surface using a sterile spreader. The glass plates were then incubated at 30°C for eighteen hours and colonies were then counted. Counts are shown in the following tables.
Plate 1 showed a reduction in count over 5 minutes with no recovery after ten minutes. For the heavier inoculum of Diluent 1 , Plate 1 showed a 97.98% reduction within five minutes and a 100% reduction within ten minutes. Plate 2 showed a 99.95% reduction within one minute and 100%
within two minutes.
The slight reduction apparent on the control plate over time is believed to be due to the effect of drying, as all inocula had dried out after one to one-and-a-half hours. Example 2
Approximately 50ml of 42AP (as a clear colourless liquid) was placed in a clear plastic screw-top bottle and submitted to an independent laboratory for microbiological testing.
A 1mi volume of the liquid was inoculated with 20μl of an undiluted overnight broth of MRSA, this inoculum being estimated to contain 107-108 organisms. Using a fresh sterile pipette each time, a 20μl volume was withdrawn immediately and then further 20μl volumes withdrawn after one, two, five, ten, thirty and sixty minutes. Each withdrawn volume was then spread over the surface of a blood agar plate, the plates incubated at 30°C for twenty hours, and the plates then examined for the presence of colonies.
No colonies of MRSA were found on any of the plates. An inoculum of approximately 107 organisms was killed within ten seconds when added to 1ml of germicidal composition 42AP. Example 3
Three samples of the germicidal composition 42AP mixed with detergent/cleaner were subjected to bacterial activity suspension tests in an independent laboratory. The three samples used respectively three different proprietary detergent/cleaners called Enviroclene, Deep-Clean and MGMx. In each case the detergent/cleaner was obtained in concentrated form and
30ml of the concentrate was diluted 15:1 with water. 30ml of 42AP was then added to the diluted detergent/cleaner.
Each sample was tested for compliance with Appendix 1 of
European Standard (Final Draft) Pr EN 1276, November 1995, which demands that test samples, diluted in hard water, demonstrate at least 105 reduction in viable count under simulated clean conditions (0.3g/l bovine albumin) and dirty conditions (3g/l bovine albumin).
The test used a dilution neutralisation method as specified in Section 5.5.2.2 of Appendix 1 under the following conditions:
- The neutraliser comprised 30g/l polysorbate 80 and 3g/l lecithin;
- The tests were carried out at 10°C rather than the specified 20°C, to reflect more accurately likely temperatures in use (eg in food processing) and to give a conservative allowance for the possibility of reduced biocidal activity at lower temperatures; and
- Only one organism, namely Pseudomonas aeruginosa, was used. All of the samples, exposed to the test organism Pseudomonas aeruginosa for five minutes at 10°C, showed a reduction of greater than 105 as required by the test method, in each case total kill was achieved.
The tests demonstrate that the invention provides a germicidal composition which has long term efficacy. (Further tests not detailed herein demonstrate a continuing efficacy after as long as three years). The composition 42AP may be used to treat a wide range of substantially solid objects such as work surfaces and windows, by coating or incorporation. It may also be incorporated in paints or varnishes, and where these are oil- based Stage 6 of the illustrative preparation method above may be omitted. A wide range of germicidal agents may be employed in the invention including without prejudice to the generality of the invention:
- Amphoteric compounds including long chain N-alkyl derivatives of
amino acids such as glycine, alanine and beta-amino butyric acid, particular examples being dodecyl beta-alanine, dodecyl beta-aminobutyric acid, dodecylamino-di {aminoethylamino} glycine and N-(3-dodecylyamino) propylglycine; - lodophores (meaning herein complexes of iodine or triodide with a carrier, such as a neutral polymer, typically one increasing the solubility of iodine in water, providing a sustained release of such iodine and reducing the equilibrium concentrations of free iodine) which may be made from polyvinylpyrolidone (notably povidone iodine), polyether glycols such as polyethylene glycols, polyvinyl alcohols, polyacrylates, polyamides, polyalkylenes and polysaccharides;
- Quaternary ammonium compounds including compounds of the general formula R1R2N+ R3R4X wherein one or two of the R groups are alkyl chains optionally substituted by an aryl group, or optionally interrupted by an aryl group or a heteroatom such as oxygen, and the other R groups are the same or different and are C C4 alkyl groups and in particular methyl groups, which compounds include benzalkonium halides, aryl ring substituted benzalkonium halides such as ethyl-substituted benzalkonium halides (eg Barquat 4250 available from Lonza), and twin chain quaternary ammonium compounds such as dialkyldimethyl ammonium compounds wherein the two non-methyl alkyl groups are selected from medium and long chain alkyl groups such as octyl groups and dodecyl groups, quaternary ammonium compounds in which an alkyl group R contains a heteroatom such as domiphen bromide, benzalkonium chloride and methylbenzalkonium chloride, alkylpyridinium compounds such as cetylpyridinium chloride, and bridged cyclic amino compounds such as N- (3-chlorallyl) hexaminium chloride;
- Methyl, halo and aryl substituted phenolic compounds such as 2- phenylphenol, 2-benzyl-4-chlorphenol, 2-cyclopentyl-4-chlorophenol, 4-t- amylphenol, 4-t-butylphenoi, 4-chloro-2-pentylphenol, 6-chloro-2- pentylphenol, p-chloro-meta-xylenol, 2,4,4'-trichloro-2'-hydroxydiphenol, thymol {2-l-propyl-3-methylphenol}, chlorothymol, 3-methyl-4-chlorophenol,
2,6-dichloro-4-n-alkylphenol, 2,4-dichloro-meta-xylenol, 2,4,5- trichlorophenol and 2-benzyl-4-chlorophenol;
- Hypochlorites including alkali-metal and alkaline earth metal hypochlorites such as lithium hypochlorite, sodium hypochlorite, potassium hypochlorite, calcium hypochlorite, and chlorinated trisodium phosphate, their various hydrates, chlorine-containing or chlorine -releasing agents such as chlorine dioxide and its precursors, 4-sulpho-dichioroamidobenzoic acid {halazone}, 1 ,3-dichloro-5-5dimethylhydantoin {halane}, and various chlorisocyanuric acid derivatives; and - Nitrogen-containing antibacterial agents including pyridine derivatives such as 4-pyridine carboxylic acid hydrazide, sodium 2- pyridinethiol-1 -oxide (Sodium Omadine™), bis-(2-pyridylthio)zinc 1 ,1'- dioxide (Zinc Omadine), triazoles and imidazoles such as 2-(4-thiazole) benzimidazole (Metasol T K-100), 12 benzisothiazoline-3-one (Proxel™), 2- n-octyl-4-isothiazoiine-3-one (Kathen™), 2-bromo-2-nitro-1-3-propanediol
(Bromonopol™), 3-trifluoromethyl-4,4'-dichlorocarbanilide (Irgasan™), quinacrine hydrochloride (Atabrine™), ciproflaxacin and nalidixic acid and its various derivatives.
The germicidal agent will be selected according to the polymer and the intended use of the germicidal composition and may comprise a synergistic combination of two or more germicidal components.
A co-solvent or a co-diluent which evaporates rapidly may be
included in the germicidal composition. This may be aqueous or non- aqueous according to the nature of the material with which it is to be mixed. A germicidal composition according to the invention has a wide range of applications including without prejudice to the generality of the invention:
- Coating walls, windows, work surfaces and ducts;
- Incorporation in paints, varnishes, fillers, grouts, etc;
- incorporation in building products such as floor and wall tiles, door and window furniture, bathroom and kitchen fittings, and ventilation equipment;
- Incorporation in or treatment of hospital equipment and furnishings; and
- Incorporation in or treatment of bandaging, dressing, wrapping, cladding and packaging materials.
Claims
1. A germicidal composition comprising a liquid polymer and a germicidal agent.
2. A germicidal composition as claimed in claim 1 wherein the germicidal agent is in a non-volatile solvent carrier.
3. A germicidal composition as claimed in claim 2 wherein said non-volatile solvent carrier comprises a glycol.
4. A germicidal composition as claimed in claim 3 wherein said non-volatile solvent carrier comprises monopropylene glycol (MPG).
5. A germicidal composition as claimed in any preceding claim which is not toxic to humans or animals.
6. A germicidal composition as claimed in any preceding claim wherein the liquid polymer composition comprises polydimethylsiloxane.
7. A germicidal composition as claimed in claim 6 wherein said liquid polymer composition comprises a mixture of isopropanol, butyl acetate and polydimethylsiloxane.
8. A germicidal composition as claimed in claim 7 wherein said mixture comprises 87-91% by volume isopropanol, 1-6% by volume butyl acetate and 3-6% by volume polydimethylsiloxane.
9. A germicidal composition as claimed in any of claims 6 to 8 wherein said liquid polymer composition includes a cleansing agent to promote adherence to a surface.
10. A germicidal composition as claimed in claim 9 wherein said cleansing agent comprises a surfactant.
11. A germicidal composition as claimed in claim 10 wherein said surfactant comprises an amine ethoxylate.
12. A germicidal composition as claimed in claim 9 wherein said cleansing agent comprises phosphoric and/or sulphonic and/or sulphuric acid.
13. A germicidal composition as claimed in any preceding claim wherein said germicidal agent comprises one or more of an amphoteric compound, an iodophore, a phenolic compound, a quaternary ammonium compound, a hypochlorite and a nitrogen-based heterocyclic antibacterial compound.
14. A germicidal composition as claimed in any preceding claim and including a detergent composition.
15. A germicidal composition as claimed in any preceding claim and including a co-solvent.
16. A germicidal composition as claimed in claim 15 wherein said co-solvent is aqueous.
17. A method of treating a substantially solid material so that it becomes germicidal, which method comprises applying to said material a germicidal composition comprising a liquid polymer composition and a germicidal agent so that said agent is deposited at a surface of said material.
18. A method of treating a substantially solid material as claimed in claim 16 wherein said germicidal composition is a germicidal composition according to any of claims 1 to 16.
19. A method of making a germicidal composition comprising: preparing a liquid polymer composition; preparing a detergent composition; preparing a germicidal agent in solution in a non-volatile solvent carrier; and mixing the germicidal agent in solution with the detergent composition and then with the liquid polymer composition.
20. A method of making a germicidal composition as claimed in claim 19 including diluting with water one or more of the intermediate products and/or the final product of said method.
21. A germicidal composition substantially as hereinbefore described with reference to and as illustrated by the accompanying examples.
22. A method of treating a substantially solid material so that it becomes germicidal substantially as hereinbefore described with reference to and as illustrated by the accompanying examples.
23. A method of making a germicidal composition substantially as hereinbefore described with reference to and as illustrated by the accompanying examples.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AU45215/99A AU4521599A (en) | 1998-06-27 | 1999-06-24 | Germicidal composition |
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB9813827.4 | 1998-06-27 | ||
| GB9813827A GB2338651A (en) | 1998-06-27 | 1998-06-27 | Liquid polymer composition |
| GBGB9901850.9A GB9901850D0 (en) | 1998-06-27 | 1999-01-29 | Killing microorganisms |
| GB9901850.9 | 1999-01-29 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| WO2000000025A1 true WO2000000025A1 (en) | 2000-01-06 |
Family
ID=26313934
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PCT/GB1999/001991 Ceased WO2000000025A1 (en) | 1998-06-27 | 1999-06-24 | Germicidal composition |
Country Status (3)
| Country | Link |
|---|---|
| AU (1) | AU4521599A (en) |
| GB (1) | GB9901850D0 (en) |
| WO (1) | WO2000000025A1 (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1223200A1 (en) * | 2001-01-12 | 2002-07-17 | Vionnet, Jacques | Composition for protecting a solid substrate and its use |
| US6649569B2 (en) | 2001-01-12 | 2003-11-18 | Jacques Vionnet | Composition intended for the protection of a solid substrate and its use |
Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS6385181A (en) * | 1986-09-22 | 1988-04-15 | 大和化学工業株式会社 | Washing resistance sanitary processing method for textile products |
| WO1991013608A1 (en) * | 1990-03-05 | 1991-09-19 | Roella Gunnar | Dentifrice inhibiting dental plaque |
| US5147575A (en) * | 1988-04-13 | 1992-09-15 | Hampton Sr Ronald S | Composition and method for cleaning and lubricating hair shears |
| EP0689767A2 (en) * | 1994-06-27 | 1996-01-03 | Becton, Dickinson and Company | Skin disinfecting formulations |
| CA2212901A1 (en) * | 1996-08-26 | 1998-02-26 | Wacker Silicones Corporation | Polish composition |
| WO1999018784A1 (en) * | 1997-10-15 | 1999-04-22 | Rhodia Chimie | System based on a biocide and a polyether silicon for disinfecting hard surfaces |
-
1999
- 1999-01-29 GB GBGB9901850.9A patent/GB9901850D0/en not_active Ceased
- 1999-06-24 AU AU45215/99A patent/AU4521599A/en not_active Abandoned
- 1999-06-24 WO PCT/GB1999/001991 patent/WO2000000025A1/en not_active Ceased
Patent Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS6385181A (en) * | 1986-09-22 | 1988-04-15 | 大和化学工業株式会社 | Washing resistance sanitary processing method for textile products |
| US5147575A (en) * | 1988-04-13 | 1992-09-15 | Hampton Sr Ronald S | Composition and method for cleaning and lubricating hair shears |
| WO1991013608A1 (en) * | 1990-03-05 | 1991-09-19 | Roella Gunnar | Dentifrice inhibiting dental plaque |
| EP0689767A2 (en) * | 1994-06-27 | 1996-01-03 | Becton, Dickinson and Company | Skin disinfecting formulations |
| CA2212901A1 (en) * | 1996-08-26 | 1998-02-26 | Wacker Silicones Corporation | Polish composition |
| US5882387A (en) * | 1996-08-26 | 1999-03-16 | Wacker Silicones Corporation | Polish composition |
| WO1999018784A1 (en) * | 1997-10-15 | 1999-04-22 | Rhodia Chimie | System based on a biocide and a polyether silicon for disinfecting hard surfaces |
Non-Patent Citations (1)
| Title |
|---|
| DATABASE WPI Derwent World Patents Index; AN 1988-143759, XP002118187, DAIWA KAGAKU KOGYO KK: "Washing-resistant sanitary finishing of textile material-by polymerizing polydimethylsiloxane on textile and applying bactericide and /or fungicide" * |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1223200A1 (en) * | 2001-01-12 | 2002-07-17 | Vionnet, Jacques | Composition for protecting a solid substrate and its use |
| WO2002064686A1 (en) * | 2001-01-12 | 2002-08-22 | Vionnet, Jacques | Composition intended for the protection of a solid substrate and its use |
| US6649569B2 (en) | 2001-01-12 | 2003-11-18 | Jacques Vionnet | Composition intended for the protection of a solid substrate and its use |
Also Published As
| Publication number | Publication date |
|---|---|
| AU4521599A (en) | 2000-01-17 |
| GB9901850D0 (en) | 1999-03-17 |
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