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WO2000077031A3 - Muc1 ligands - Google Patents

Muc1 ligands Download PDF

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Publication number
WO2000077031A3
WO2000077031A3 PCT/CA2000/000711 CA0000711W WO0077031A3 WO 2000077031 A3 WO2000077031 A3 WO 2000077031A3 CA 0000711 W CA0000711 W CA 0000711W WO 0077031 A3 WO0077031 A3 WO 0077031A3
Authority
WO
WIPO (PCT)
Prior art keywords
muc1
ligands
muc1 ligands
ligand
bind
Prior art date
Application number
PCT/CA2000/000711
Other languages
French (fr)
Other versions
WO2000077031A2 (en
Inventor
Jean Gariepy
Shaoxian Yang
Original Assignee
Univ Health Network
Jean Gariepy
Shaoxian Yang
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Health Network, Jean Gariepy, Shaoxian Yang filed Critical Univ Health Network
Priority to AU53822/00A priority Critical patent/AU5382200A/en
Publication of WO2000077031A2 publication Critical patent/WO2000077031A2/en
Publication of WO2000077031A3 publication Critical patent/WO2000077031A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

Novel ligands that bind to MUC1 are disclosed. The ligands were isolated using an improved phage display technique using MUC1 tandem repeat as a target. Uses of the ligand to detect, monitor or treat cancer as well as to prepare antibodies is also described.
PCT/CA2000/000711 1999-06-15 2000-06-15 Muc1 ligands WO2000077031A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU53822/00A AU5382200A (en) 1999-06-15 2000-06-15 Muc1 ligands

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US13926399P 1999-06-15 1999-06-15
US60/139,263 1999-06-15

Publications (2)

Publication Number Publication Date
WO2000077031A2 WO2000077031A2 (en) 2000-12-21
WO2000077031A3 true WO2000077031A3 (en) 2001-04-19

Family

ID=22485831

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/CA2000/000711 WO2000077031A2 (en) 1999-06-15 2000-06-15 Muc1 ligands

Country Status (2)

Country Link
AU (1) AU5382200A (en)
WO (1) WO2000077031A2 (en)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2452445C (en) * 2000-06-29 2011-02-15 North Shore-Long Island Jewish Health System Modulators of cellular proliferation and angiogenesis, methods for use and identification thereof
AU2002246791C1 (en) 2000-12-22 2008-04-03 Dana-Farber Cancer Institute, Inc. Regulation of cell growth by MUC1
WO2002090373A1 (en) * 2001-05-04 2002-11-14 The Uab Research Foundation Human sperm activator peptides
ATE469648T1 (en) * 2001-09-05 2010-06-15 Minerva Biotechnologies Corp COMPOSITIONS AND USE THEREOF FOR TREATING CANCER
WO2005042573A1 (en) 2003-10-24 2005-05-12 Dana-Farber Cancer Institute, Inc. Modulation of the interaction of muc1 with muc1 ligands
ES2381118T3 (en) * 2004-12-23 2012-05-23 Campina Nederland Holding B.V. Protein hydrolyzate enriched in DPP-IV inhibition peptides and their use
TW200803751A (en) 2005-11-30 2008-01-16 Campina Nederland Holding Bv Use of a protein hydrolysate for enhancing activity of glucagon-like peptide-1
US7871784B2 (en) 2007-02-02 2011-01-18 Dana-Farber Cancer Institute, Inc. Methods and compositions relating to the regulation of apoptosis by MUC1 and BH3-containing proapoptotic proteins
WO2008097840A2 (en) 2007-02-02 2008-08-14 Dana-Farber Cancer Institute, Inc. Methods and compositions relating to the regulation of muc1 by hsf1 and stat3
WO2014152831A2 (en) * 2013-03-14 2014-09-25 Health Research, Inc. Targeting peptides and uses thereof

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1992018534A1 (en) * 1991-04-23 1992-10-29 Antisoma Limited Minimum recognition unit of a pem mucin tandem repeat specific monoclonal antibody
WO1996009411A1 (en) * 1994-09-21 1996-03-28 Cytogen Corporation Antigen binding peptides (abtides) from peptide libraries
WO1997011715A1 (en) * 1995-09-27 1997-04-03 The Austin Research Institute Mimicking peptides in cancer therapy

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1992018534A1 (en) * 1991-04-23 1992-10-29 Antisoma Limited Minimum recognition unit of a pem mucin tandem repeat specific monoclonal antibody
WO1996009411A1 (en) * 1994-09-21 1996-03-28 Cytogen Corporation Antigen binding peptides (abtides) from peptide libraries
WO1997011715A1 (en) * 1995-09-27 1997-04-03 The Austin Research Institute Mimicking peptides in cancer therapy

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
APOSTOLOPOULOS V ET AL: "CELLULAR MUCINS: TARGETS FOR IMMUNOTHERAPY", CRITICAL REVIEWS IN IMMUNOLOGY,XX,CRC PRESS, INC, vol. 14, no. 3/04, 1994, pages 293 - 309, XP002071247, ISSN: 1040-8401 *
GARIEPY JEAN ET AL: "Identification of short peptide ligands that bind specifically to the breast tumor-associated MUC1 epitope.", PROCEEDINGS OF THE AMERICAN ASSOCIATION FOR CANCER RESEARCH ANNUAL, no. 41, March 2000 (2000-03-01), 91st Annual Meeting of the American Association for Cancer Research.;San Francisco, California, USA; April 01-05, 2000, March, 2000, pages 101 - 102, XP000949494, ISSN: 0197-016X *
LAING P ET AL: "SELECTION OF PEPTIDE LIGANDS FOR THE ANTIMUCIN CORE ANTIBODY C595 USING PHAGE DISPLAY TECHNOLOGY: DEFINITION OF CANDIDATE EPITOPES FOR A CANCER VACCINE", JOURNAL OF CLINICAL PATHOLOGY,GB,LONDON, vol. 48, no. 3, 1995, pages M136 - M141, XP000906851, ISSN: 0021-9746 *
MANOUTCHARIAN KAREN ET AL: "Characterization of cerebrospinal fluid antibody specificities in neurocysticercosis using phage display peptide library.", CLINICAL IMMUNOLOGY (ORLANDO), vol. 91, no. 1, April 1999 (1999-04-01), pages 117 - 121, XP000946486, ISSN: 1521-6616 *

Also Published As

Publication number Publication date
WO2000077031A2 (en) 2000-12-21
AU5382200A (en) 2001-01-02

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