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WO2000072828B1 - Procede de fabrication d'unites posologiques de principes actifs en comprimes - Google Patents

Procede de fabrication d'unites posologiques de principes actifs en comprimes

Info

Publication number
WO2000072828B1
WO2000072828B1 PCT/GB2000/002039 GB0002039W WO0072828B1 WO 2000072828 B1 WO2000072828 B1 WO 2000072828B1 GB 0002039 W GB0002039 W GB 0002039W WO 0072828 B1 WO0072828 B1 WO 0072828B1
Authority
WO
WIPO (PCT)
Prior art keywords
tablet
binder
microparticles
liquid
gelled
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/GB2000/002039
Other languages
English (en)
Other versions
WO2000072828A1 (fr
Inventor
Hiran Asoka Malinga Ratwatte
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Priority to AU50892/00A priority Critical patent/AU5089200A/en
Publication of WO2000072828A1 publication Critical patent/WO2000072828A1/fr
Publication of WO2000072828B1 publication Critical patent/WO2000072828B1/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2095—Tabletting processes; Dosage units made by direct compression of powders or specially processed granules, by eliminating solvents, by melt-extrusion, by injection molding, by 3D printing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J3/00—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms
    • A61J3/10—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms into the form of compressed tablets
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J13/00—Colloid chemistry, e.g. the production of colloidal materials or their solutions, not otherwise provided for; Making microcapsules or microballoons
    • B01J13/02—Making microcapsules or microballoons
    • B01J13/04—Making microcapsules or microballoons by physical processes, e.g. drying, spraying

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Dispersion Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Preparation (AREA)

Abstract

L'invention concerne un procédé de fabrication de comprimés consistant à former un mélange d'un principe actif, d'excipients et de microparticules contenant un liquide ou un gel de liaison encapsulés dans le noyau, puis à comprimer ledit mélange, ce qui provoque la désintégration des microparticules liantes et libère ainsi le liant liquide ou gélifié directement dans les interstices entre les particules du mélange du comprimé, formant un réseau de liant après séchage du comprimé. Les microparticules ont une taille individuelle inférieure à 3500 microns et peuvent être obtenues par encapsulation du liant dans un matériau relativement cassant comme la glace, un matériau organique ou inorganique ou un polymère cassant sous l'effet de la pression appliquée lors de la compression du comprimé. Ce procédé peut être utilisé dans la production de mélanges pour comprimés à écoulement libre et homogènes, à des températures supérieures et inférieures à 0 °C, et des comprimés rigides, poreux et possédant une résistance élevée à la rupture.
PCT/GB2000/002039 1999-06-01 2000-05-26 Procede de fabrication d'unites posologiques de principes actifs en comprimes Ceased WO2000072828A1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU50892/00A AU5089200A (en) 1999-06-01 2000-05-26 A method of tabletting dose units of active agents

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB9912683A GB2350582A (en) 1999-06-01 1999-06-01 A method of tableting
GB9912683.1 1999-06-01

Publications (2)

Publication Number Publication Date
WO2000072828A1 WO2000072828A1 (fr) 2000-12-07
WO2000072828B1 true WO2000072828B1 (fr) 2001-02-08

Family

ID=10854515

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB2000/002039 Ceased WO2000072828A1 (fr) 1999-06-01 2000-05-26 Procede de fabrication d'unites posologiques de principes actifs en comprimes

Country Status (3)

Country Link
AU (1) AU5089200A (fr)
GB (1) GB2350582A (fr)
WO (1) WO2000072828A1 (fr)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103191023B (zh) * 2013-03-22 2014-06-25 海南卫康制药(潜山)有限公司 一种快速崩解片剂的低温压制方法
CN103191069A (zh) * 2013-03-25 2013-07-10 海南卫康制药(潜山)有限公司 一种快速崩解片剂及其低温压制方法
CN109090319A (zh) * 2018-08-31 2018-12-28 迪拜尔特控股（北京）有限公司 乳矿物盐压片糖果

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3423489A (en) * 1966-11-01 1969-01-21 Minnesota Mining & Mfg Encapsulation process
DE2261426A1 (de) * 1972-12-15 1974-06-20 Manfred Dipl-Phys Lottermoser Verfahren zum getriggerten haerten von giessereiformteilen
DE3264450D1 (en) * 1981-12-11 1985-08-01 Wyeth John & Brother Ltd Process and apparatus for freezing a liquid medium
DE3711169A1 (de) * 1987-04-02 1988-10-20 Messer Griesheim Gmbh Vorrichtung zum kontrollierten einfrieren von zaehfliessenden fluessigkeiten
US4978483A (en) * 1987-09-28 1990-12-18 Redding Bruce K Apparatus and method for making microcapsules
ATE147261T1 (de) * 1992-01-13 1997-01-15 Pfizer Verfahren zur herstellung von tabletten mit hoher festigkeit
US5560927A (en) * 1995-07-28 1996-10-01 Isp Investments Inc. Co-processing method for making a free-flowing compressible powder and tablet therefrom

Also Published As

Publication number Publication date
WO2000072828A1 (fr) 2000-12-07
GB2350582A (en) 2000-12-06
AU5089200A (en) 2000-12-18
GB9912683D0 (en) 1999-07-28

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