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WO2000072802A8 - Water soluble multi-biotin-containing compounds - Google Patents

Water soluble multi-biotin-containing compounds

Info

Publication number
WO2000072802A8
WO2000072802A8 PCT/US2000/015081 US0015081W WO0072802A8 WO 2000072802 A8 WO2000072802 A8 WO 2000072802A8 US 0015081 W US0015081 W US 0015081W WO 0072802 A8 WO0072802 A8 WO 0072802A8
Authority
WO
WIPO (PCT)
Prior art keywords
biotin
water soluble
containing compounds
disclosed
moieties
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2000/015081
Other languages
French (fr)
Other versions
WO2000072802A2 (en
WO2000072802A3 (en
Inventor
Scott D Wilbur
Pradip M Pathare
Donald K Hamlin
Ananda S Weerawarna
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Washington
Original Assignee
University of Washington
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of Washington filed Critical University of Washington
Priority to EP00938025A priority Critical patent/EP1196199A4/en
Priority to AU53121/00A priority patent/AU5312100A/en
Publication of WO2000072802A2 publication Critical patent/WO2000072802A2/en
Publication of WO2000072802A8 publication Critical patent/WO2000072802A8/en
Anticipated expiration legal-status Critical
Publication of WO2000072802A3 publication Critical patent/WO2000072802A3/en
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

Abstract

Water soluble discrete multi-biotin-containing compounds with at least three (3) biotin moieties are disclosed. The water soluble biotin-containing compounds may additionally comprise one or more moieties that confer resistance to cleavage by biotinidase or that is cleavable in vitro or in vivo. The discrete multi-biotin-containing compounds may include a reactive moiety that provides a site for reaction with yet another moiety, such as a targeting, diagnostic or therapeutic functional moiety. Biotinylation reagents comprising water soluble linker moieties are also disclosed and may additionally comprise a biotinidase protective group. Methods for amplifying the number of sites for binding biotin-binding proteins at a selected target using multi-biotin compounds are also disclosed.
PCT/US2000/015081 1999-06-02 2000-06-01 Water soluble multi-biotin-containing compounds Ceased WO2000072802A2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
EP00938025A EP1196199A4 (en) 1999-06-02 2000-06-01 MULTI-BIOTIN WATER-SOLUBLE COMPOUNDS
AU53121/00A AU5312100A (en) 1999-06-02 2000-06-01 Water soluble multi-biotin-containing compounds

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US32426799A 1999-06-02 1999-06-02
US09/324,267 1999-06-02

Publications (3)

Publication Number Publication Date
WO2000072802A2 WO2000072802A2 (en) 2000-12-07
WO2000072802A8 true WO2000072802A8 (en) 2001-04-19
WO2000072802A3 WO2000072802A3 (en) 2002-02-07

Family

ID=23262837

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2000/015081 Ceased WO2000072802A2 (en) 1999-06-02 2000-06-01 Water soluble multi-biotin-containing compounds

Country Status (3)

Country Link
EP (1) EP1196199A4 (en)
AU (1) AU5312100A (en)
WO (1) WO2000072802A2 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20010023288A1 (en) 1999-07-07 2001-09-20 Wilbur D. Scott Trifunctional reagent for conjugation to a biomolecule
SE0002287D0 (en) 2000-06-16 2000-06-16 Department Of Radiation Oncolo biotin
DE10151158B4 (en) * 2001-10-19 2004-07-29 Esplora GmbH c/o TU Darmstadt Institut für Biochemie Compounds for labeling cell membrane proteins
FR2955111B1 (en) * 2010-01-12 2013-05-31 Biomerieux Sa PROCESS FOR THE PREPARATION OF POLYBIOTINYL COMPOUNDS

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4302241A1 (en) * 1993-01-27 1994-07-28 Boehringer Mannheim Gmbh New biotinylation reagent
US5482698A (en) * 1993-04-22 1996-01-09 Immunomedics, Inc. Detection and therapy of lesions with biotin/avidin polymer conjugates
PL182237B1 (en) * 1994-03-07 2001-11-30 Dow Chemical Co The method of carrying out cell transfection and achieving the bioavailability of the genetic material in vitro and ex vivo EN EN
US5750357A (en) * 1994-05-18 1998-05-12 Microquest Diagnostics, Inc. Method of rapid analyte detection
AU2052497A (en) * 1996-02-08 1997-08-28 Board Of Regents Of The University Of Washington, The Biotin-containing compounds, biotinylation reagents and methods

Also Published As

Publication number Publication date
AU5312100A (en) 2000-12-18
WO2000072802A2 (en) 2000-12-07
EP1196199A2 (en) 2002-04-17
WO2000072802A3 (en) 2002-02-07
EP1196199A4 (en) 2002-06-19

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