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WO2000072853A1 - Chemical composition, fabrication procedure and treatment methodology based on it, as cancer medication - Google Patents

Chemical composition, fabrication procedure and treatment methodology based on it, as cancer medication Download PDF

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Publication number
WO2000072853A1
WO2000072853A1 PCT/RO1999/000014 RO9900014W WO0072853A1 WO 2000072853 A1 WO2000072853 A1 WO 2000072853A1 RO 9900014 W RO9900014 W RO 9900014W WO 0072853 A1 WO0072853 A1 WO 0072853A1
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WO
WIPO (PCT)
Prior art keywords
cancer
product
medication
cell
boric acid
Prior art date
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Ceased
Application number
PCT/RO1999/000014
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French (fr)
Inventor
Corneliu M. Niculescu
Corneliu C. Niculescu
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Individual
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Individual
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Publication of WO2000072853A1 publication Critical patent/WO2000072853A1/en
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Ceased legal-status Critical Current

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Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/21Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/235Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group
    • A61K31/24Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group having an amino or nitro group
    • A61K31/245Amino benzoic acid types, e.g. procaine, novocaine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00Medicinal preparations containing inorganic active ingredients
    • A61K33/22Boron compounds

Definitions

  • the object of invention refers to-
  • Appliance range of the product is cancer disease medication as a chemoterapy treatment.
  • Cancer chemoterapy also known as cytostatics enables the evolution delay of different neoplasical affections.
  • haematopoetic tissue cancer is relatively sensible and cancer tumor hardly sensible to chemoterapy, which does not save the patient life but scarcely improve his condition for an certain period of time, as additional medication beside the specific classical cancer treatment (surgery and radiotherapy) .Cytostatics do not destroy the cancer cell but slow down its evolution
  • the above mentioned substances are toxic, having side haematological effects, the harmful effects entailing mouth and intestine mucous membranes lesion, lever lesions, baldness, hypogonadism and immunology weakening which develop proper conditions for infections spreading. Furthermore, the price of these products is significantly high.
  • the procaine chlorine hydrate dose allowed for 24 hours is of 250 mg, boric acid dose being of 3,000 mg
  • Toxic noxious dose of procaine chlorine hydrate is of 2,500 mg and of boric acid of
  • Medication doses of our product are as follows 18mg of procaine chlorine hydrate per day and 54 mg boric acid per day
  • our product may be included within hemaeopatic medication products lacking toxicity
  • cancer cell induces deviations usually at nucleic acid level resulting in a mutation of genetic information, which determines the incapacity to control the cell metabolism and implicitly cells sizes and multiplication Consequently for this uncontrolled development, the cancer cell needs additional phosphoric acid (acid standing for the basis of nucleic acids) which is absorbed in very large quantities, even if its level in human organism is generally low
  • phosphoric acid ascid standing for the basis of nucleic acids
  • the boric acid replaces the phosphoric acid within the cancer cell metabolism, being , let us say, fond of it destroying it.
  • the normal cells of human body, other than cancer affected ones do not mistake the identification of the two acids, therefore they are not affected.
  • procaine chlorine hydrate has an anesthetic effect, determines blood vessel expansion, controls the plane muscles, enhances the tissues nutrition and it is a inter - cell free radicals inhibitor.
  • Cancer cells as well as ordinary old cells have a higher concentration of free radicals - idea agreed by dr. ASLAN as well when she introduced procaine chlorine hydrate in the composition of GEROVITAL Free radicals inhibition inside the cancer cell leads to a significant lowering of its vitality, as well as of its secretions, noxious to the organism. We consider it as well causes the cancer cell to mistake the identification of boric acid instead of phosphoric acid, and determines self-destruction.
  • the product is recommended in all cancer locations and stages of disease either as a single medication or together with any other classical treatment (surgery or chemotherapy).
  • the product medication is oral, following the quantities:
  • the treatment lasts two years, no matter the fact that the disease symptoms disappeares mean time and the laboratory tests and other medical investigations prove to have normalized the health condition.
  • the medication is associated w ; ⁇ n Po ⁇ dm muscle injected one ampouie D ⁇ ⁇ ay in series of 3 days consecutively at a period of 2 distance and V ⁇ amin C 200mg daily for own immunity system stimulation
  • the hereunto invention refers to a chemical medicament, a fabrication procedure and medication methodology on its basis, in case of cancer diagnostic
  • the active ingredients of the product modify the abnormal metabolism of cancer cell, determining its destruction
  • this innovation determines the production of cancer cell cytoiysis without being toxic to the human body and which allows parallel cancer classical medication, furthermore it determines a positive influence of classical medication

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Emergency Medicine (AREA)
  • Inorganic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

The present invention refers to a chemical medicament, a fabrication procedure and medicination methodology based thereon, in case of cancer. The medicine comprises boric acid, which replaces phosphoric acid in the cell nucleus, procaine hydrochloride, which unbalances the metabolism of cancer-affected cell by free radical control, and a normal saline solution as the circulating medium. The active ingredients of the product thus modify the abnormal metabolism of cancer cells, determining their destruction. As chemotherapy, this innovation leads to cancer cell cytolysis without being toxic to the human body. Furthermore, it allows a parallel classical cancer medication, thereby positively influencing the latter.

Description

INVENTION DESCRIPTION
The object of invention refers to-
CHEMICAL COMPOSTION, FABRICATION PROCEDURE AND TREATMENT
METHODOLOGY BASED ON IT, AS CANCER MEDICATION.
Appliance range of the product is cancer disease medication as a chemoterapy treatment.
Cancer chemoterapy also known as cytostatics enables the evolution delay of different neoplasical affections.
Actual cytostatic treatment available is no longer effective in all cancer cell locations and stages of development. Generally speaking, haematopoetic tissue cancer is relatively sensible and cancer tumor hardly sensible to chemoterapy, which does not save the patient life but scarcely improve his condition for an certain period of time, as additional medication beside the specific classical cancer treatment (surgery and radiotherapy) .Cytostatics do not destroy the cancer cell but slow down its evolution
The above mentioned substances are toxic, having side haematological effects, the harmful effects entailing mouth and intestine mucous membranes lesion, lever lesions, baldness, hypogonadism and immunology weakening which develop proper conditions for infections spreading. Furthermore, the price of these products is significantly high.
As a counter-part to those previously analyzed, our product develops an effective treatment of all cancer disease locations and its stages of evolution. It stands either as a single medication or together with any other classical medication, highly improving it to the benefit of the patient.
CHEMICAL COMPOSITION OF THE PRODUCT
1. Sodium chloride 9000 mg
2. Chlorine hydrate of 4 aminobenzoilethyleaminoethanole 200-300mg
1. Boric acid 700-800mg
2. Distilled water 1000 ml
The above composition has the important advantage of not being toxic
The procaine chlorine hydrate dose allowed for 24 hours is of 250 mg, boric acid dose being of 3,000 mg
Toxic noxious dose of procaine chlorine hydrate is of 2,500 mg and of boric acid of
8,000 mg
Medication doses of our product are as follows 18mg of procaine chlorine hydrate per day and 54 mg boric acid per day
Concluding, our product may be included within hemaeopatic medication products lacking toxicity
It is well known the fact that cancer cell induces deviations usually at nucleic acid level resulting in a mutation of genetic information, which determines the incapacity to control the cell metabolism and implicitly cells sizes and multiplication Consequently for this uncontrolled development, the cancer cell needs additional phosphoric acid (acid standing for the basis of nucleic acids) which is absorbed in very large quantities, even if its level in human organism is generally low We reached the conclusion that the boric acid replaces the phosphoric acid within the cancer cell metabolism, being , let us say, fond of it destroying it. The normal cells of human body, other than cancer affected ones, do not mistake the identification of the two acids, therefore they are not affected.
It is notorious that procaine chlorine hydrate has an anesthetic effect, determines blood vessel expansion, controls the plane muscles, enhances the tissues nutrition and it is a inter - cell free radicals inhibitor. Cancer cells as well as ordinary old cells have a higher concentration of free radicals - idea agreed by dr. ASLAN as well when she introduced procaine chlorine hydrate in the composition of GEROVITAL Free radicals inhibition inside the cancer cell leads to a significant lowering of its vitality, as well as of its secretions, noxious to the organism. We consider it as well causes the cancer cell to mistake the identification of boric acid instead of phosphoric acid, and determines self-destruction.
PRODUCT FABRICATION PROCEDURE
9000 mg of sodium chloride is dissolved into 1000 ml of distilled water. The solution is heated into a vessel up to 60 C degrees and 250 mg of procaine chlorine hydrate is added, stir for the solution homogenization; further to, the temperature is raised up to 90-95 C degrees (care shall be paid not to reach the boiling temperature), the 750 mg of boric acid is added, continuously stirring the solution. After dissolving the compounds and cooling of the solution, pH value of 6.5 is checked and controlled by adding a small quantity of boric acid (in case the distilled water has a neutral pH value the control is no longer required). The product such obtained is filled into properly clean bottles, not reacting with the product acidity (as a preference, food approved containers, dark colored or light- tight).
Product is best over 1 year, seal tight kept at a temperature Of 10-20 C degrees, light tight, as it is a light sensitive product. Lacking to follow these safety conditions leads to floes development, annihilating is properties.
TREATMENT METODOLOGY
The product is recommended in all cancer locations and stages of disease either as a single medication or together with any other classical treatment (surgery or chemotherapy).
The product medication is oral, following the quantities:
30 ml (two tablespoon) in the morning, 30 ml at noon and 15 ml (one tablespoon) in the evening, at least 20 minutes before having the respective meals.
During this 20 minutes period no liquid drinking is allowed.
The treatment lasts two years, no matter the fact that the disease symptoms disappeares mean time and the laboratory tests and other medical investigations prove to have normalized the health condition.
Even a 24 hours discontinuity of the medication may lead to negative evolution of the healing process, determining the involution of healing with several months.
As concerns the treatment discontinuity of several days period, it may lead to the complete inefficiency of the previous appliance of the treatment, and the disease may reinstall after several years. We specify that the respective medication is no longer effective in this case. The medication is associated w;τn Poϋdm muscle injected one ampouie DΘΓ αay in series of 3 days consecutively at a period of 2
Figure imgf000004_0001
distance and Vαamin C 200mg daily for own immunity system stimulation
SUMARY
The hereunto invention refers to a chemical medicament, a fabrication procedure and medication methodology on its basis, in case of cancer diagnostic The active ingredients of the product modify the abnormal metabolism of cancer cell, determining its destruction
As chemeoterpy, this innovation determines the production of cancer cell cytoiysis without being toxic to the human body and which allows parallel cancer classical medication, furthermore it determines a positive influence of classical medication

Claims

C L A I M S
I The hereunto described product is a cancer treating medicine action is characteπzed by cancer affected cell destruction through the replacement of a basic acid contained into the cell nucleus, namely, the phosphoric acid is replaced by bone acid contained by-our product Proc cnlonne hydrate unbalances the metabolism of the cancer-affected cell t radical control thus loweπng the cell discπmination and allowing it to mat two acids.
The normal saline solution represents the circulating medium f active substances and facilitates their penetration into the cancer-affecte osmosis The low actd pH of the product does not determine gastric juice intestine reaction and enables the product to reach neoplasical location unmodified.
The product attacks the tumor from the outside to inside, begin wrth the heaiing of metastasis stage down to the prime tumor, annihilatin all the young cancer cells, then proceeding wrth the others
H. Preparation procedure of the product characteristically consist, normal saline solution and procaine chlorehydrate 0 250 % at a temporal 60 C degree homogenization and boric acid 0 750 % at a temperature of C degrees (avoiding reaching the boiling temperature) After cooling, the value will be controlled, if case, by adding boric acid
The product is to be kept at room temperature - 10-20 C degre dark places (as it is photosensitive), it is highly stable in time under the t. conditions being best over 1 year
Hi. The product charactenstic medication is oral as follows 30 ml soupspoons) in the morning. 30 ml at noon and 15 ml (one soupspoon) n evening. 20 minutes before having the respective meals duπng this 20 n peπod neither liquid nor solid food is allowed
The medication is compulsory for 2 years long no matter the stage of the disease and, clinical and laboratory results normalization Tr medication stopping even for 24 hours during the 2 years period, may le treatment ineffectiveness when restarted
The medication is associated with Polidin in seπes of 3 days peπod of 2 weeks, one ampoule per day and Vitamin C 200 mg daily for ι immunity system stimulation
PCT/RO1999/000014 1999-05-26 1999-09-23 Chemical composition, fabrication procedure and treatment methodology based on it, as cancer medication Ceased WO2000072853A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
RO99-00605 1999-05-26
RO99-00605A RO116524B1 (en) 1999-05-26 1999-05-26 Antineoplastic pharmaceutical product for human and veterinary use, preparation process thereof and method of antineoplastic treatment

Publications (1)

Publication Number Publication Date
WO2000072853A1 true WO2000072853A1 (en) 2000-12-07

Family

ID=20107309

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/RO1999/000014 Ceased WO2000072853A1 (en) 1999-05-26 1999-09-23 Chemical composition, fabrication procedure and treatment methodology based on it, as cancer medication

Country Status (2)

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RO (1) RO116524B1 (en)
WO (1) WO2000072853A1 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001028550A1 (en) * 1999-10-15 2001-04-26 Mayo Foundation For Medical Education And Research Topical anesthetics useful for treating cancer, autoimmune diseases and ischemia

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2459659A1 (en) * 1979-06-23 1981-01-16 Centrala Ind Medicamente Synergistic anticancer compsns. - contg. 4-aminobenzoyl-di:ethyl-aminoethanol, boric acid and ascorbic acid
HUP9601450A1 (en) * 1996-05-30 1998-06-29 Benedek Juhász Process for producing pharmaceutical composition for treating neoplasmic syndromas

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2459659A1 (en) * 1979-06-23 1981-01-16 Centrala Ind Medicamente Synergistic anticancer compsns. - contg. 4-aminobenzoyl-di:ethyl-aminoethanol, boric acid and ascorbic acid
HUP9601450A1 (en) * 1996-05-30 1998-06-29 Benedek Juhász Process for producing pharmaceutical composition for treating neoplasmic syndromas

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
DATABASE WPI Week 199840, Derwent World Patents Index; AN 1998-459642, XP002133589, JUHASZ BENEDEK: "Process for producing pharmaceutical composition for treating neoplasmic syndromas" *

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001028550A1 (en) * 1999-10-15 2001-04-26 Mayo Foundation For Medical Education And Research Topical anesthetics useful for treating cancer, autoimmune diseases and ischemia
US6391888B1 (en) 1999-10-15 2002-05-21 Mayo Foundation For Medical Education And Research Topical anesthetics useful for treating cancer

Also Published As

Publication number Publication date
RO116524B1 (en) 2001-03-30

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