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WO2000068209A3 - 1,5-benzodiazepine derivatives as cck-a receptor agonists - Google Patents

1,5-benzodiazepine derivatives as cck-a receptor agonists Download PDF

Info

Publication number
WO2000068209A3
WO2000068209A3 PCT/EP2000/003982 EP0003982W WO0068209A3 WO 2000068209 A3 WO2000068209 A3 WO 2000068209A3 EP 0003982 W EP0003982 W EP 0003982W WO 0068209 A3 WO0068209 A3 WO 0068209A3
Authority
WO
WIPO (PCT)
Prior art keywords
cck
receptor agonists
benzodiazepine derivatives
benzodiazepine
derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/EP2000/003982
Other languages
French (fr)
Other versions
WO2000068209A2 (en
Inventor
David Colclough
Anne Hodgson
Jerzy Ryszard Szewczyk
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Glaxo Group Ltd
Original Assignee
Glaxo Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9910366.5A external-priority patent/GB9910366D0/en
Priority claimed from GBGB0008179.4A external-priority patent/GB0008179D0/en
Priority to IL14612400A priority Critical patent/IL146124A0/en
Priority to BR0010338-1A priority patent/BR0010338A/en
Priority to MXPA01011267A priority patent/MXPA01011267A/en
Priority to KR1020017014075A priority patent/KR20020012567A/en
Priority to AU47548/00A priority patent/AU4754800A/en
Priority to CA002370801A priority patent/CA2370801A1/en
Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd
Priority to NZ515048A priority patent/NZ515048A/en
Priority to HK02107684.4A priority patent/HK1046138A1/en
Priority to HU0201181A priority patent/HUP0201181A3/en
Priority to EP00929488A priority patent/EP1212305A2/en
Priority to JP2000617189A priority patent/JP2002544200A/en
Publication of WO2000068209A2 publication Critical patent/WO2000068209A2/en
Publication of WO2000068209A3 publication Critical patent/WO2000068209A3/en
Priority to NO20015397A priority patent/NO20015397L/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
    • C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
    • C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D243/12—1,5-Benzodiazepines; Hydrogenated 1,5-benzodiazepines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Diabetes (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Child & Adolescent Psychology (AREA)
  • Epidemiology (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

An enantiomerically enriched compound of Formula (I) is disclosed, processes for its preparation, pharmaceutical compositions containing it and the use therefore, for the treatment of CCK-A mediated diseases or conditions, such as obesity.
PCT/EP2000/003982 1999-05-06 2000-05-04 1,5-benzodiazepine derivatives as cck-a receptor agonists Ceased WO2000068209A2 (en)

Priority Applications (12)

Application Number Priority Date Filing Date Title
EP00929488A EP1212305A2 (en) 1999-05-06 2000-05-04 1,5-benzodiazepine derivatives as cck-a receptor agonists
JP2000617189A JP2002544200A (en) 1999-05-06 2000-05-04 1,5-benzodiazepine derivative
HU0201181A HUP0201181A3 (en) 1999-05-06 2000-05-04 1,5-benzodiazepine derivatives, process for producing it and pharmaceutical composition containing it
MXPA01011267A MXPA01011267A (en) 1999-05-06 2000-05-04 1,5-benzodiazepine derivatives.
KR1020017014075A KR20020012567A (en) 1999-05-06 2000-05-04 1,5-Benzodiazepine Derivatives
AU47548/00A AU4754800A (en) 1999-05-06 2000-05-04 1,5-benzodiazepine derivatives as CCK-A receptor agonists
CA002370801A CA2370801A1 (en) 1999-05-06 2000-05-04 1,5-benzodiazepine derivatives as cck-a receptor agonists
IL14612400A IL146124A0 (en) 1999-05-06 2000-05-04 1,5-benzodiazepine derivatives
NZ515048A NZ515048A (en) 1999-05-06 2000-05-04 1,5-benzodiazepine derivatives
HK02107684.4A HK1046138A1 (en) 1999-05-06 2000-05-04 1,5-benzodiazepine derivatives
BR0010338-1A BR0010338A (en) 1999-05-06 2000-05-04 Enanciomerically enriched compound, pharmaceutical composition, method for treating a disease or condition mediated by cck-a, use of a compound, and process for the preparation of a compound
NO20015397A NO20015397L (en) 1999-05-06 2001-11-05 1,5-Benzodiazepine derivatives

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GB9910366.5 1999-05-06
GBGB9910366.5A GB9910366D0 (en) 1999-05-06 1999-05-06 1,5-Benzodiazepine Derivatives
GB0008179.4 2000-04-05
GBGB0008179.4A GB0008179D0 (en) 2000-04-05 2000-04-05 Chemical process

Publications (2)

Publication Number Publication Date
WO2000068209A2 WO2000068209A2 (en) 2000-11-16
WO2000068209A3 true WO2000068209A3 (en) 2001-03-01

Family

ID=26244033

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2000/003982 Ceased WO2000068209A2 (en) 1999-05-06 2000-05-04 1,5-benzodiazepine derivatives as cck-a receptor agonists

Country Status (21)

Country Link
EP (1) EP1212305A2 (en)
JP (1) JP2002544200A (en)
KR (1) KR20020012567A (en)
CN (1) CN1161345C (en)
AR (1) AR022044A1 (en)
AU (1) AU4754800A (en)
BR (1) BR0010338A (en)
CA (1) CA2370801A1 (en)
CO (1) CO5170461A1 (en)
CZ (1) CZ20013988A3 (en)
HK (1) HK1046138A1 (en)
HU (1) HUP0201181A3 (en)
IL (1) IL146124A0 (en)
MX (1) MXPA01011267A (en)
MY (1) MY138319A (en)
NO (1) NO20015397L (en)
NZ (1) NZ515048A (en)
PE (1) PE20010110A1 (en)
PL (1) PL351546A1 (en)
TR (1) TR200103169T2 (en)
WO (1) WO2000068209A2 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005035793A2 (en) * 2003-10-09 2005-04-21 Decode Genetics Ehf. Cckar markers and haplotypes associated with extreme weight conditions
GEP20094723B (en) 2004-05-25 2009-07-10 Pfizer Prod Inc Tetraazabenzo [e] azulene derivatives and analogs thereof
MX2022004142A (en) 2019-10-07 2022-09-21 Kallyope Inc Gpr119 agonists.
TW202140440A (en) 2020-02-28 2021-11-01 美商克力歐普股份有限公司 Gpr40 agonists

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5646140A (en) * 1993-04-15 1997-07-08 Glaxo Wellcome Inc. 1,5-benzodiazepine derivatives having CCK antagonistic or agonistic activity

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5646140A (en) * 1993-04-15 1997-07-08 Glaxo Wellcome Inc. 1,5-benzodiazepine derivatives having CCK antagonistic or agonistic activity

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
BRISTOL, J. A.: "Annual reports in medicinal chemistry", 1990, ACADEMIC PRESS, INC., SAN DIEGO,, XP002150744 *
GAVIN C. HIRST ET AL.: "Discovery of 1,5-benzodiazepines with peripheral cholecystokinin (CCK-A) receptor agonist activity (II): optimization of the C3 amino substituent", JOURNAL OF MEDICINAL CHEMISTRY., vol. 39, no. 26, - 1996, AMERICAN CHEMICAL SOCIETY. WASHINGTON., US, pages 5236 - 5245, XP002150743, ISSN: 0022-2623 *

Also Published As

Publication number Publication date
MXPA01011267A (en) 2002-05-06
NO20015397D0 (en) 2001-11-05
HUP0201181A3 (en) 2003-10-28
IL146124A0 (en) 2002-07-25
AR022044A1 (en) 2002-09-04
HUP0201181A2 (en) 2002-12-28
NO20015397L (en) 2001-11-05
AU4754800A (en) 2000-11-21
CA2370801A1 (en) 2000-11-16
EP1212305A2 (en) 2002-06-12
BR0010338A (en) 2002-02-13
TR200103169T2 (en) 2002-04-22
JP2002544200A (en) 2002-12-24
MY138319A (en) 2009-05-29
CO5170461A1 (en) 2002-06-27
CN1161345C (en) 2004-08-11
NZ515048A (en) 2004-01-30
PL351546A1 (en) 2003-05-05
KR20020012567A (en) 2002-02-16
CZ20013988A3 (en) 2002-02-13
WO2000068209A2 (en) 2000-11-16
PE20010110A1 (en) 2001-03-05
CN1362949A (en) 2002-08-07
HK1046138A1 (en) 2002-12-27

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