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WO2000060352A3 - Dispositifs fluidiques - Google Patents

Dispositifs fluidiques Download PDF

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Publication number
WO2000060352A3
WO2000060352A3 PCT/GB2000/001257 GB0001257W WO0060352A3 WO 2000060352 A3 WO2000060352 A3 WO 2000060352A3 GB 0001257 W GB0001257 W GB 0001257W WO 0060352 A3 WO0060352 A3 WO 0060352A3
Authority
WO
WIPO (PCT)
Prior art keywords
layer
define
fluid passages
fluidic devices
fluidic
Prior art date
Application number
PCT/GB2000/001257
Other languages
English (en)
Other versions
WO2000060352A2 (fr
Inventor
Peter Jones
Mark Tracey
Nicola Sutton
Neil Butt
Original Assignee
Whatman Plc
Peter Jones
Mark Tracey
Nicola Sutton
Neil Butt
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Whatman Plc, Peter Jones, Mark Tracey, Nicola Sutton, Neil Butt filed Critical Whatman Plc
Priority to AU35697/00A priority Critical patent/AU3569700A/en
Priority to EP00914303A priority patent/EP1166109A2/fr
Publication of WO2000060352A2 publication Critical patent/WO2000060352A2/fr
Publication of WO2000060352A3 publication Critical patent/WO2000060352A3/fr

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/416—Systems
    • G01N27/447—Systems using electrophoresis
    • G01N27/44756—Apparatus specially adapted therefor
    • G01N27/44791—Microapparatus
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502707—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the manufacture of the container or its components
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502723—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by venting arrangements
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502753—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by bulk separation arrangements on lab-on-a-chip devices, e.g. for filtration or centrifugation
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06—Fluid handling related problems
    • B01L2200/0647—Handling flowable solids, e.g. microscopic beads, cells, particles
    • B01L2200/0668—Trapping microscopic beads
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/10—Integrating sample preparation and analysis in single entity, e.g. lab-on-a-chip concept
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/06—Auxiliary integrated devices, integrated components
    • B01L2300/0681—Filter
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0809—Geometry, shape and general structure rectangular shaped
    • B01L2300/0816—Cards, e.g. flat sample carriers usually with flow in two horizontal directions
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
    • B01L2300/0874—Three dimensional network
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0887—Laminated structure
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
    • B01L2400/0415—Moving fluids with specific forces or mechanical means specific forces electrical forces, e.g. electrokinetic
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0475—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure
    • B01L2400/0487—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure fluid pressure, pneumatics
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502715—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by interfacing components, e.g. fluidic, electrical, optical or mechanical interfaces
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L7/00—Heating or cooling apparatus; Heat insulating devices
    • B01L7/52—Heating or cooling apparatus; Heat insulating devices with provision for submitting samples to a predetermined sequence of different temperatures, e.g. for treating nucleic acid samples

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Health & Medical Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Dispersion Chemistry (AREA)
  • Molecular Biology (AREA)
  • Clinical Laboratory Science (AREA)
  • Hematology (AREA)
  • Electrochemistry (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)

Abstract

La présente invention concerne un appareil pour effectuer des procédés chimiques et/ou biologiques comprenant: une première couche de matériau comportant des passages de fluide définissant une structure microfluidique, et une deuxième couche de matériau comportant des passages de fluide définissant un structure fluidique à plus grande échelle, les structures étant liées de sorte que les passages de fluide de la première couche communiquent avec ceux de la deuxième couche dans un dispositif fluidique.
PCT/GB2000/001257 1999-04-01 2000-04-03 Dispositifs fluidiques WO2000060352A2 (fr)

Priority Applications (2)

Application Number Priority Date Filing Date Title
AU35697/00A AU3569700A (en) 1999-04-01 2000-04-03 Fluidic devices
EP00914303A EP1166109A2 (fr) 1999-04-01 2000-04-03 Dispositifs fluidiques

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB9907665.5A GB9907665D0 (en) 1999-04-01 1999-04-01 Fluidic devices
GB9907665.5 1999-04-01

Publications (2)

Publication Number Publication Date
WO2000060352A2 WO2000060352A2 (fr) 2000-10-12
WO2000060352A3 true WO2000060352A3 (fr) 2001-08-09

Family

ID=10850916

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB2000/001257 WO2000060352A2 (fr) 1999-04-01 2000-04-03 Dispositifs fluidiques

Country Status (4)

Country Link
EP (1) EP1166109A2 (fr)
AU (1) AU3569700A (fr)
GB (1) GB9907665D0 (fr)
WO (1) WO2000060352A2 (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9354156B2 (en) 2007-02-08 2016-05-31 Emd Millipore Corporation Microfluidic particle analysis method, device and system

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6645359B1 (en) 2000-10-06 2003-11-11 Roche Diagnostics Corporation Biosensor
US6319719B1 (en) 1999-10-28 2001-11-20 Roche Diagnostics Corporation Capillary hematocrit separation structure and method
US6451264B1 (en) 2000-01-28 2002-09-17 Roche Diagnostics Corporation Fluid flow control in curved capillary channels
US7473398B2 (en) 2001-05-25 2009-01-06 Roche Diagnostics Operations, Inc. Biosensor
DE60125598T2 (de) * 2001-06-08 2007-10-04 Centre National De La Recherche Scientifique Methode zur herstellung einer mikroflüssigkeitsstruktur, insbesondere eines "biochips", und damit erzeugte struktur
SE0103110D0 (sv) * 2001-09-18 2001-09-18 Aamic Ab Microscale fluid handling system
US7338760B2 (en) 2001-10-26 2008-03-04 Ntu Ventures Private Limited Sample preparation integrated chip
US7069952B1 (en) 2001-11-14 2006-07-04 Caliper Life Sciences, Inc. Microfluidic devices and methods of their manufacture
WO2003085379A2 (fr) 2002-04-01 2003-10-16 Fluidigm Corporation Systemes d'analyse de particules microfluidiques
US20040086872A1 (en) * 2002-10-31 2004-05-06 Childers Winthrop D. Microfluidic system for analysis of nucleic acids
US8257964B2 (en) 2006-01-04 2012-09-04 Cell ASIC Microwell cell-culture device and fabrication method
US9388374B2 (en) 2005-07-07 2016-07-12 Emd Millipore Corporation Microfluidic cell culture systems
US9637715B2 (en) 2005-07-07 2017-05-02 Emd Millipore Corporation Cell culture and invasion assay method and system
US9260688B2 (en) 2005-07-07 2016-02-16 The Regents Of The University Of California Methods and apparatus for cell culture array
US8656949B2 (en) 2006-08-15 2014-02-25 University Of Maryland College Park Microfluidic devices and methods of fabrication
EP3173787B1 (fr) 2008-01-03 2021-06-02 EMD Millipore Corporation Système de réseau de culture de cellules pour épreuves automatisées et procédés de fonctionnement et de fabrication de celui-ci
JP5782384B2 (ja) * 2009-02-03 2015-09-24 ネットバイオ・インコーポレーテッドＮｅｔＢｉｏ， Ｉｎｃ． 未処理試料から核酸を単離するための自己完結型装置および精製方法
WO2011044116A2 (fr) * 2009-10-05 2011-04-14 The Charles Stark Draper Laboratory, Inc. Plateformes microfluidiques tridimensionnelles et leurs procédés d'utilisation et de fabrication
US9353342B2 (en) 2010-01-21 2016-05-31 Emd Millipore Corporation Cell culture and gradient migration assay methods and devices
US10526572B2 (en) 2011-04-01 2020-01-07 EMD Millipore Corporaticn Cell culture and invasion assay method and system
ES2870857T3 (es) 2011-12-03 2021-10-27 Emd Millipore Corp Sistema microfluídico para cultivo celular
EP2820394B1 (fr) 2012-02-29 2017-07-12 Fluidigm Corporation Procédés, systèmes et dispositifs pour la capture de cellules isolées multiples et le traitement à l'aide de produits microfluidiques
JP6493204B2 (ja) * 2013-05-08 2019-04-03 ソニー株式会社 流路デバイス、分析装置及び流体装置
CA2981990A1 (fr) * 2015-04-09 2016-10-13 Axela Inc. Cartouche de test biologique jetable et procede de realisation de plusieurs etapes de test et d'un transfert de fluide a l'interieur de la cartouche
GB2546233A (en) * 2015-08-19 2017-07-19 Cambsolv Ltd Modular microfluidic device for analytical bioassay
CA3006063A1 (fr) * 2015-11-24 2017-06-01 Vanderbilt University Bioreacteurs micro-fluidiques empilables et superposes a compartiments multiples et leurs applications
US20210008564A1 (en) * 2018-04-06 2021-01-14 Boehringer Ingelheim Vetmedica Gmbh Analysis device, cartridge, analysis system and method for testing a sample

Citations (5)

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Publication number Priority date Publication date Assignee Title
EP0382207A2 (fr) * 1989-02-09 1990-08-16 Fuji Photo Film Co., Ltd. Elément analytique pour analyser le sang entièrement
US5304487A (en) * 1992-05-01 1994-04-19 Trustees Of The University Of Pennsylvania Fluid handling in mesoscale analytical devices
WO1996015576A1 (fr) * 1994-11-10 1996-05-23 David Sarnoff Research Center, Inc. Systeme de distribution de liquide
WO1996014933A1 (fr) * 1994-11-14 1996-05-23 Trustees Of The University Of Pennsylvania Dispositifs a meso-echelle pour analyse de cellules mobiles
WO1998022811A1 (fr) * 1996-11-19 1998-05-28 Caliper Technologies Corporation Systemes microfluidiques ameliores

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0382207A2 (fr) * 1989-02-09 1990-08-16 Fuji Photo Film Co., Ltd. Elément analytique pour analyser le sang entièrement
US5304487A (en) * 1992-05-01 1994-04-19 Trustees Of The University Of Pennsylvania Fluid handling in mesoscale analytical devices
WO1996015576A1 (fr) * 1994-11-10 1996-05-23 David Sarnoff Research Center, Inc. Systeme de distribution de liquide
WO1996014933A1 (fr) * 1994-11-14 1996-05-23 Trustees Of The University Of Pennsylvania Dispositifs a meso-echelle pour analyse de cellules mobiles
WO1998022811A1 (fr) * 1996-11-19 1998-05-28 Caliper Technologies Corporation Systemes microfluidiques ameliores

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
WOOLLEY ADAM T ET AL: "Ultra-high-speed DNA fragment separations using microfabricated capillary array electrophoresis chips.", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES, vol. 91, no. 24, 1994, 1994, pages 11348 - 11352, XP002155992, ISSN: 0027-8424 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9354156B2 (en) 2007-02-08 2016-05-31 Emd Millipore Corporation Microfluidic particle analysis method, device and system

Also Published As

Publication number Publication date
EP1166109A2 (fr) 2002-01-02
GB9907665D0 (en) 1999-05-26
WO2000060352A2 (fr) 2000-10-12
AU3569700A (en) 2000-10-23

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