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WO2000060119A3 - Methods for detecting cancer cells - Google Patents

Methods for detecting cancer cells Download PDF

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Publication number
WO2000060119A3
WO2000060119A3 PCT/US2000/008588 US0008588W WO0060119A3 WO 2000060119 A3 WO2000060119 A3 WO 2000060119A3 US 0008588 W US0008588 W US 0008588W WO 0060119 A3 WO0060119 A3 WO 0060119A3
Authority
WO
WIPO (PCT)
Prior art keywords
methods
cancer cells
cancer
detecting cancer
detecting
Prior art date
Application number
PCT/US2000/008588
Other languages
French (fr)
Other versions
WO2000060119A2 (en
Inventor
Thomas Ried
Jonathan Uhr
Bijan M Ghadimi
Evelin Schrock
Gert Auer
Original Assignee
Us Gov Health & Human Serv
Thomas Ried
Jonathan Uhr
Bijan M Ghadimi
Evelin Schrock
Gert Auer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Us Gov Health & Human Serv, Thomas Ried, Jonathan Uhr, Bijan M Ghadimi, Evelin Schrock, Gert Auer filed Critical Us Gov Health & Human Serv
Priority to AU40565/00A priority Critical patent/AU4056500A/en
Publication of WO2000060119A2 publication Critical patent/WO2000060119A2/en
Publication of WO2000060119A3 publication Critical patent/WO2000060119A3/en

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6804—Nucleic acid analysis using immunogens
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6841—In situ hybridisation
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/156—Polymorphic or mutational markers
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/52—Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Analytical Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Molecular Biology (AREA)
  • Pathology (AREA)
  • Physics & Mathematics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Cell Biology (AREA)
  • Hospice & Palliative Care (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Oncology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

The invention relates to a highly sensitive assay for distinguishing between cancer and non-cancer epithelial cells in the blood that provides an improved diagnostic technique for detecting cancer and determining the organ-origin of the cancer.
PCT/US2000/008588 1999-04-01 2000-03-31 Methods for detecting cancer cells WO2000060119A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU40565/00A AU4056500A (en) 1999-04-01 2000-03-31 Methods for detecting cancer cells

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US12736799P 1999-04-01 1999-04-01
US60/127,367 1999-04-01

Publications (2)

Publication Number Publication Date
WO2000060119A2 WO2000060119A2 (en) 2000-10-12
WO2000060119A3 true WO2000060119A3 (en) 2002-01-10

Family

ID=22429747

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2000/008588 WO2000060119A2 (en) 1999-04-01 2000-03-31 Methods for detecting cancer cells

Country Status (2)

Country Link
AU (1) AU4056500A (en)
WO (1) WO2000060119A2 (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7034144B2 (en) 1997-05-13 2006-04-25 Erasmus Universiteit Rotterdam Molecular detection of chromosome aberrations
US7105294B2 (en) 1998-05-04 2006-09-12 Dako Denmark A/S Method and probes for the detection of chromosome aberrations

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1627083A2 (en) * 2003-05-07 2006-02-22 Agilent Technologies, Inc. Systems and methods for determining cell type composition of mixed cell populations using gene expression signatures
US20110046888A1 (en) * 2005-08-15 2011-02-24 Skobeltsina Evgeniya S Method of diagnosing tumor disorders in humans
US20080182253A1 (en) * 2006-10-25 2008-07-31 Ikonisys, Inc. Automated method for detecting cancers and high grade hyperplasias
US20090258365A1 (en) 2008-03-25 2009-10-15 Terstappen Leon W M M METHOD FOR DETECTING IGF1R/Chr 15 in CIRCULATING TUMOR CELLS USING FISH
DE102009059274B4 (en) * 2009-12-22 2012-07-19 Max-Joseph Kraus Method for measuring the dynamics of changes in platelets

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996002002A1 (en) * 1994-07-08 1996-01-25 Schalken Jack A Assay for increased invasiveness of epithelial cells
WO1997038313A1 (en) * 1996-04-05 1997-10-16 The Johns Hopkins University A method of enriching rare cells
WO1997046702A1 (en) * 1996-06-03 1997-12-11 The Regents Of The University Of California Genetic alterations associated with prostate cancer

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996002002A1 (en) * 1994-07-08 1996-01-25 Schalken Jack A Assay for increased invasiveness of epithelial cells
WO1997038313A1 (en) * 1996-04-05 1997-10-16 The Johns Hopkins University A method of enriching rare cells
WO1997046702A1 (en) * 1996-06-03 1997-12-11 The Regents Of The University Of California Genetic alterations associated with prostate cancer

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
GHADMI B ET AL: "Specific chromosomal abberations and amplification of the AIB1 nuclear receptor coactivator gene in pancreatic carcinomas", AMERICAN JOURNAL OF PATHOLOGY, vol. 154, no. 2, February 1999 (1999-02-01), pages 525 - 36, XP001024303 *
HESELMEYER-HADDAD K ET AL: "Interphase cytogenetics with tumor-stage specific probes for the detection of tumor progression in cervical and mammary carcinogenesis", PROCEEDINGS OF THE AMERICAN ASSOCIATION FOR CANCER RESEARCH, vol. 40, March 1999 (1999-03-01), pages 537, XP001024240 *
HEYSELMEYER K ET AL: "advanced-stage cervical cancer are defined by a reurrent pattern of chromosomal abberations revealing high genetic instability and a consistent gain of chromosome arm 3q", GENES, CHROMOSOMES AND CANCERTIGATIONS, vol. 19, no. 4, 1997, pages 233 - 40, XP001024299 *
MAKAROVSKIY A N ET AL: "APPLICATION OF IMMUNOMAGNETIC BEADS IN COMBINATION WITH RT-PCR FOR THE DETECTION OF CIRCULATING PROSTATE CANCER CELLS", JOURNAL OF CLINICAL LABORATORY ANALYSIS, NEW YORK, NY, US, vol. 11, 1997, pages 346 - 350, XP000872241 *
RACILA E ET AL: "Detection and charcterization of carcinoma cells in the blood", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF USA, NATIONAL ACADEMY OF SCIENCE. WASHINGTON, US, vol. 95, April 1998 (1998-04-01), pages 4589 - 4594, XP002132943, ISSN: 0027-8424 *

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7034144B2 (en) 1997-05-13 2006-04-25 Erasmus Universiteit Rotterdam Molecular detection of chromosome aberrations
US7105294B2 (en) 1998-05-04 2006-09-12 Dako Denmark A/S Method and probes for the detection of chromosome aberrations
US7368245B2 (en) 1998-05-04 2008-05-06 Dako Denmark A/S Method and probes for the detection of chromosome aberrations
US7642057B2 (en) 1998-05-04 2010-01-05 Dako Denmark A/S Method and probes for the detection of chromosome aberrations

Also Published As

Publication number Publication date
WO2000060119A2 (en) 2000-10-12
AU4056500A (en) 2000-10-23

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