WO2000059507A1 - Obesity preventives - Google Patents

Abstract

To provide oral preparations having an effect of preventing obesity based on a principle different from promotion of exercise or restriction of caloric intake. By taking obesity preventives containing biotin as the active ingredient, undesirable weight gain is effectively prevented.

Description

 Specification

 Antiobesity agent

Technical field

 The present invention relates to an antiobesity agent containing piotin as an active ingredient. Background art

 One of the problems brought about by the high-strength diet of modern society is weight gain due to excessive intake of calories, so-called obesity. Obesity, combined with lack of exercise, is said to trigger various lifestyle-related diseases such as diabetes, arteriosclerosis, and high blood pressure.

 The basic principle of obesity is that the calorie intake exceeds the calorie consumption. Therefore, if caloric intake through diet is suppressed and caloric consumption is promoted by exercise or the like, it is theoretically eliminated. However, in practice it is often difficult. Particularly for those with motor function impairment, the above methods that require exercise are virtually impractical.

 Therefore, in addition to the method of eliminating obesity that requires exercise, there are many other methods of eliminating obesity, such as nutritional methods using natural food ingredients and non-degradable ingredients, and physical methods such as surgery. Has been proposed.

 Many methods for preventing obesity have also been proposed, but most of them are based on the suppression of caloric intake by ingesting non-extinguishing foods or low-strength foods. In this respect, there is no difference from the method of eliminating obesity. Disclosure of the invention

 The present inventors have found that in the course of a study on the physiological role of biotin, the rate of weight gain of a model animal to which biotin was administered was significantly suppressed, and completed the present invention based on such findings.

That is, the present invention is an antiobesity agent characterized by using biotin as an active ingredient. Pyotin is a type of coenzyme known as vitamin H. It is well known that it acts as an essential coenzyme of lupoxylase. In terms of physiological effects, effects on cell growth and DNA synthesis have been reported, and a wide variety of research reports have been made on deficiency of biotin, including dermatitis, hair loss, and ataxia.

 In the course of the study on the physiological role of biotin, the present inventors found that rats fed a high-calorie diet containing biotin showed an increase in body weight, and a high-calorie diet without biotin was consumed. It was found to be significantly lower than that of rats. Furthermore, when the correlation with the rate of body weight gain was examined by changing the amount of biotin in the diet, it was found that the rate of body weight gain also decreased in proportion to the amount of biotin taken.

 This is considered to indicate that biotin significantly suppresses undesired weight gain caused by ingesting a high calorie single meal, ie, that biotin has an obesity-preventing effect. That is, the prevention of obesity according to the present invention refers to an effect of suppressing an undesired increase in weight that is observed when calories are excessively consumed, as described above.

 There is still much to be understood about the physiological mechanism of the effect of biotin on obesity, that is, the effect of suppressing unwanted body weight gain during caloric overdose. The present inventors have confirmed that when rats are ingested with biotin, the activity of hepatic dalcokinase, which is a rate-limiting enzyme for glucose metabolism, increases. In addition, since the metabolism of the tricarboxylic acid cycle (TCA cycle) is expected to be activated by the action of biotin as a coenzyme, the aerobic metabolism of glucose in the body is promoted by ingestion of biotin. it is conceivable that. As a result, it is presumed that the synthesis of stored fats decreases and obesity does not result from the increase in stored fats.

 The antiobesity agent of the present invention can be prepared in the form of a solid preparation or a liquid preparation as long as it can be taken orally. In the preparation of a solid preparation containing biotin, any of powder, granule and tablet forms can be prepared by a general production method. Liquid preparations can also be prepared by mixing with commonly used bases and active ingredients.

In order to exert the anti-obesity effect of the present invention, the intake of It is preferably at least 200 g, preferably at least 400 g per day. With an intake of less than 200 X g, the effect of biotin on suppressing weight gain is not fully exerted. Industrial applicability

 According to the present invention, it is possible to provide a new anti-fertility agent having a different principle from that of conventional energy intake suppression. BEST MODE FOR CARRYING OUT THE INVENTION

 Hereinafter, the present invention will be described specifically with reference to Examples, but the present invention is not limited to the following Examples.

Example 1

 60 g of cane sugar

 20 g of egg white

 6 g soybean oil

 6 g of inorganic salt mixture

 2 g of vitamin mixture

 Crystalline cellulose 6 g

 Piotin 200 g

 100 g

 After preliminarily mixing crystalline cellulose and biotin, the other components were additionally mixed and granulated to prepare a high calorie granule.

Example 2

 60 g of cane sugar

 20 g of egg white

 6 g soybean oil

 6 g of inorganic salt mixture

 2 g of vitamin mixture

Crystalline cellulose 6 g Piotin 7 500 g

 100 g

 After microcrystalline cellulose and biotin were uniformly mixed in advance, other components were additionally mixed and granulated to prepare a high calorie granule.

Comparative example

 60 g sucrose

 20 g of egg white

 6 g soybean oil

 6 g of inorganic salt mixture

 2 g of vitamin mixture

 Crystalline cellulose 6 g

 Piotin 150 g

 100 g

 After microcrystalline cellulose and biotin were uniformly mixed in advance, other components were additionally mixed and granulated to prepare a high calorie granule.

Test example

 The following test was performed using an SD rat (oss) body weight of 400 g. The animals of Example 1, Example 2, and Comparative Example 1 were each fed 10 g Z days each in three groups of six animals each. Since egg white, which is a protein source in each diet, has the property of adsorbing biotin, the comparative example in which 150 g of biotin adsorbed on 2 O mg of egg white was added was used as a blank for the amount of biotin. . Therefore, the amount of effective biotin contained in each example is equivalent to 50 g / 100 g of the bait in Example 1 and to 600 g / 100 g of the bait in Example 2.

While feeding the diets shown in Example 1, Example 2, and Comparative Example, 30 rats were bred for 80 days, and weight gain and intake during that period were measured. As a result, although the intake was significantly increased in the group fed the diet of Example 2 (Fig. 1), it was shown that the weight gain was suppressed with an increase in the amount of biotin consumed. (Figure 2). BRIEF DESCRIPTION OF THE FIGURES FIG. 1 shows the average food consumption of the granules of Examples and Comparative Examples in each SD rat group from day 60 to day 70 after the start of the test. The vertical line on the graph indicates the standard deviation.

 FIG. 2 is a graph showing the average weight gain of the SD rats fed with biotin for 70 days, in which the vertical axis represents the weight gain and the horizontal axis represents the experimental period (weeks). In addition, 〇 indicates the results when the granules of Comparative Example 1 were used, Δ indicates the results when the granules of Example 1 were used, and 口 indicates the results when the granules of Example 2 were used.

Claims

The scope of the claims 1. An anti-obesity agent characterized by using biotin as an active ingredient