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WO2000052173A3 - Cloned human sphingosine kinase homologues - Google Patents

Cloned human sphingosine kinase homologues Download PDF

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Publication number
WO2000052173A3
WO2000052173A3 PCT/CA2000/000223 CA0000223W WO0052173A3 WO 2000052173 A3 WO2000052173 A3 WO 2000052173A3 CA 0000223 W CA0000223 W CA 0000223W WO 0052173 A3 WO0052173 A3 WO 0052173A3
Authority
WO
WIPO (PCT)
Prior art keywords
sphingosine kinase
cloned human
human sphingosine
homologues
kinase homologues
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/CA2000/000223
Other languages
French (fr)
Other versions
WO2000052173A2 (en
Inventor
Donald Munroe
Ashwani Gupta
Germaine R Falzone
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
NPS Allelix Corp Canada
Original Assignee
NPS Allelix Corp Canada
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by NPS Allelix Corp Canada filed Critical NPS Allelix Corp Canada
Priority to AU28999/00A priority Critical patent/AU2899900A/en
Publication of WO2000052173A2 publication Critical patent/WO2000052173A2/en
Publication of WO2000052173A3 publication Critical patent/WO2000052173A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • C12N9/1205—Phosphotransferases with an alcohol group as acceptor (2.7.1), e.g. protein kinases

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)

Abstract

The present invention provides newly identified and isolated polynucleotides and their polypeptides and their uses and in particular to newly identified and isolated polynucleotides and polypeptides of the sphingosine kinase family. Three isolated polynucleotides and polypeptides for three human SK homologues are described: SKA, SKB and SKC.
PCT/CA2000/000223 1999-03-02 2000-03-02 Cloned human sphingosine kinase homologues Ceased WO2000052173A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU28999/00A AU2899900A (en) 1999-03-02 2000-03-02 Cloned human sphingosine kinase homologues

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US12251699P 1999-03-02 1999-03-02
US60/122,516 1999-03-02

Publications (2)

Publication Number Publication Date
WO2000052173A2 WO2000052173A2 (en) 2000-09-08
WO2000052173A3 true WO2000052173A3 (en) 2001-02-15

Family

ID=22403154

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/CA2000/000223 Ceased WO2000052173A2 (en) 1999-03-02 2000-03-02 Cloned human sphingosine kinase homologues

Country Status (2)

Country Link
AU (1) AU2899900A (en)
WO (1) WO2000052173A2 (en)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000070028A1 (en) 1999-05-13 2000-11-23 Johnson & Johnson Research Pty. Limited Sphingosine kinase enzyme
WO2001031029A2 (en) * 1999-10-28 2001-05-03 Warner-Lambert Company Human sphingosine kinase gene
EP1257637A2 (en) * 2000-02-14 2002-11-20 Curagen Corporation Sphingosine kinases
RU2002126264A (en) * 2000-04-03 2004-03-20 Санкио Компани, Лимитед (Jp) Isoforms of sphyngosine kinase TYPE 2 MAMMAL, CLONING, EXPRESSION AND WAYS OF THEIR APPLICATION
IL153331A0 (en) * 2000-06-14 2003-07-06 Sankyo Co A protein having ceramide kinase activity, dna encoding the same and methods for the preparation thereof
US20030125533A1 (en) * 2000-10-06 2003-07-03 Sophia Kossida Regulation of human sphingosine kinase-like protein
US7037700B2 (en) 2000-10-06 2006-05-02 Bayer Aktiengesellschaft Regulation of human ceramide kinase
AU2002239721C1 (en) 2000-12-22 2008-04-24 Medlyte, Inc. Compositions and methods for the treatment and prevention of cardiovascular diseases and disorders, and for identifying agents therapeutic therefor
DE10064899A1 (en) 2000-12-23 2002-07-25 Bosch Gmbh Robert Device for driving an output member
WO2003031627A1 (en) * 2001-09-28 2003-04-17 Hokkaido Technology Licensing Office Co., Ltd. Platelet-origin polypeptides having sphingosine kinase activity and sphingosine kinase genes encoding the same
JPWO2003031628A1 (en) * 2001-09-28 2005-01-27 北海道ティー・エル・オー株式会社 Secreted polypeptide having sphingosine kinase activity and sphingosine kinase gene encoding the same
US9274130B2 (en) 2006-05-31 2016-03-01 Lpath, Inc. Prevention and treatment of pain using antibodies to lysophosphatidic acid
US9217749B2 (en) 2006-05-31 2015-12-22 Lpath, Inc. Immune-derived moieties reactive against lysophosphatidic acid
US9274129B2 (en) 2006-05-31 2016-03-01 Lpath, Inc. Methods and reagents for detecting bioactive lipids
MX2009004532A (en) 2006-10-27 2009-09-04 Lpath Inc Compositions and methods for binding sphingosine-1-phosphate.
US8871202B2 (en) 2008-10-24 2014-10-28 Lpath, Inc. Prevention and treatment of pain using antibodies to sphingosine-1-phosphate
WO2019182191A1 (en) 2018-03-21 2019-09-26 경북대학교 산학협력단 Pharmaceutical composition for prevention or treatment of neurodegenerative disease and comprising cox2-acetylating agent as active ingredient

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
BANNO, Y. ET AL.: "Evidence for the presence of multiple forms of Sph kinase in human platelets", BIOCHEM. J., vol. 335, 1998, pages 301 - 304, XP002150782 *
KOHAMA, T. ET AL.: "Molecular Cloning and Functional Characterization of Murine Sphingosine Kinase", J. BIOL. CHEM., vol. 273, no. 37, 11 September 1998 (1998-09-11), pages 23722 - 23728, XP002150781 *
PITSON, S. M. ET AL.: "Human sphingosine kinase:purification, molecular cloning and characterization of the native and recombinant enzymes", BIOCHEMICAL J., vol. 350, Part 2, 1 September 2000 (2000-09-01), pages 429 - 441, XP000946990 *

Also Published As

Publication number Publication date
AU2899900A (en) 2000-09-21
WO2000052173A2 (en) 2000-09-08

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