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WO2000052147A3 - Bacterial prolyl peptidases and methods of use - Google Patents

Bacterial prolyl peptidases and methods of use Download PDF

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Publication number
WO2000052147A3
WO2000052147A3 PCT/US2000/005551 US0005551W WO0052147A3 WO 2000052147 A3 WO2000052147 A3 WO 2000052147A3 US 0005551 W US0005551 W US 0005551W WO 0052147 A3 WO0052147 A3 WO 0052147A3
Authority
WO
WIPO (PCT)
Prior art keywords
methods
peptidases
active
prolyl tripeptidyl
isolated
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2000/005551
Other languages
French (fr)
Other versions
WO2000052147A9 (en
WO2000052147A2 (en
Inventor
James Travis
Jan Potempa
Agnieszka Banbula
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Georgia Research Foundation Inc UGARF
Original Assignee
University of Georgia Research Foundation Inc UGARF
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of Georgia Research Foundation Inc UGARF filed Critical University of Georgia Research Foundation Inc UGARF
Priority to AU38639/00A priority Critical patent/AU3863900A/en
Publication of WO2000052147A2 publication Critical patent/WO2000052147A2/en
Publication of WO2000052147A3 publication Critical patent/WO2000052147A3/en
Anticipated expiration legal-status Critical
Publication of WO2000052147A9 publication Critical patent/WO2000052147A9/en
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Peptides Or Proteins (AREA)

Abstract

The present invention provides isolated polypeptides, prolyl tripeptidyl-peptidases, and active analogs, active fragments or active modifications thereof, having amidolytic activity for cleavage of a peptide bond present in a target peptide having at least 30 amino acids. Isolated nucleic acid fragments encoding isolated prolyl tripeptidyl-peptidases are also provided, as are methods of reducing growth of a bacterium by inhibiting a prolyl tripeptidyl-peptidase.
PCT/US2000/005551 1999-03-05 2000-03-03 Bacterial prolyl peptidases and methods of use Ceased WO2000052147A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU38639/00A AU3863900A (en) 1999-03-05 2000-03-03 Prolyl peptidases and methods of use

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US12314899P 1999-03-05 1999-03-05
US60/123,148 1999-03-05

Publications (3)

Publication Number Publication Date
WO2000052147A2 WO2000052147A2 (en) 2000-09-08
WO2000052147A3 true WO2000052147A3 (en) 2001-04-12
WO2000052147A9 WO2000052147A9 (en) 2001-11-01

Family

ID=22406979

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2000/005551 Ceased WO2000052147A2 (en) 1999-03-05 2000-03-03 Bacterial prolyl peptidases and methods of use

Country Status (2)

Country Link
AU (1) AU3863900A (en)
WO (1) WO2000052147A2 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6875851B1 (en) 1999-03-05 2005-04-05 University Of Georgia Research Foundation, Inc. Prolyl tripeptidyl peptidases nucleic acid of Porphyromonas gingivalis
WO2002038742A2 (en) 2000-11-08 2002-05-16 The University Of Georgia Research Foundation, Inc. Dipeptidylpeptidases and methods of use
WO2003102195A1 (en) * 2002-06-04 2003-12-11 Dsm Ip Assets B.V. Protein hydrolysate rich in tripeptides
FR3042192B1 (en) 2015-10-09 2017-12-08 Inst Europeen De Biologie Cellulaire PEPTIDES USEFUL IN THE PREVENTIVE AND CURATIVE TREATMENT OF ALOPECIA

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH025880A (en) * 1988-06-27 1990-01-10 Sunstar Inc Dna coding post prolyl peptidase

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH025880A (en) * 1988-06-27 1990-01-10 Sunstar Inc Dna coding post prolyl peptidase

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
BANBULA, A. ET AL.: "Prolyl Tripetidyl Peptidase from Porphyromonas gingivalis", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 274, no. 14, April 1999 (1999-04-01), pages 9246 - 9252, XP002149297 *
DATABASE WPI Section Ch Derwent World Patents Index; Class B04, AN 1990-053917, XP002149298 *
KABASHIMA, T. ET AL.: "Cloning, Sequencing, and Expression of the Dipeptidyl Peptidase IV Gene from Flavobacterium meningosepticum in Escherichia coil", ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, vol. 320, no. 1, 20 June 1995 (1995-06-20), pages 123 - 128, XP000925965 *
KIYAMA, M. ET AL.: "Sequence analysis of the Porphyromonas gingivalis dipeptidyl peptidase IV gene", BIOCHIMICA ET BIOPHYSICA ACTA, vol. 1396, no. 1, 4 March 1998 (1998-03-04), pages 39 - 46, XP000925951 *
KURAMITSU, H.K.: "Proteases of Porphyromonas gingivalis: what don't they do?", ORAL MICROBIOLOGY AND IMMUNOLOGY, vol. 13, no. 5, October 1998 (1998-10-01), pages 263 - 270, XP000925947 *

Also Published As

Publication number Publication date
WO2000052147A9 (en) 2001-11-01
WO2000052147A2 (en) 2000-09-08
AU3863900A (en) 2000-09-21

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