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WO2000050048A3 - Bone marrow transplantation for hepatic regeneration and repair - Google Patents

Bone marrow transplantation for hepatic regeneration and repair Download PDF

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Publication number
WO2000050048A3
WO2000050048A3 PCT/US2000/004744 US0004744W WO0050048A3 WO 2000050048 A3 WO2000050048 A3 WO 2000050048A3 US 0004744 W US0004744 W US 0004744W WO 0050048 A3 WO0050048 A3 WO 0050048A3
Authority
WO
WIPO (PCT)
Prior art keywords
cells
hepatic
liver regeneration
bone marrow
oval
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2000/004744
Other languages
French (fr)
Other versions
WO2000050048A9 (en
WO2000050048A2 (en
Inventor
Bryon E Petersen
Julie P Goff
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Pittsburgh
Original Assignee
University of Pittsburgh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of Pittsburgh filed Critical University of Pittsburgh
Priority to EP00911954A priority Critical patent/EP1154780A2/en
Priority to AU33763/00A priority patent/AU3376300A/en
Priority to CA002366707A priority patent/CA2366707A1/en
Publication of WO2000050048A2 publication Critical patent/WO2000050048A2/en
Publication of WO2000050048A3 publication Critical patent/WO2000050048A3/en
Anticipated expiration legal-status Critical
Publication of WO2000050048A9 publication Critical patent/WO2000050048A9/en
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/28—Bone marrow; Haematopoietic stem cells; Mesenchymal stem cells of any origin, e.g. adipose-derived stem cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/067—Hepatocytes
    • C12N5/0672—Stem cells; Progenitor cells; Precursor cells; Oval cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K2035/124—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells the cells being hematopoietic, bone marrow derived or blood cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Cell Biology (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Zoology (AREA)
  • Veterinary Medicine (AREA)
  • Developmental Biology & Embryology (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Immunology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Hematology (AREA)
  • General Engineering & Computer Science (AREA)
  • Virology (AREA)
  • Epidemiology (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

The present invention relates to methods and compositions for stimulating liver regeneration in subjects with liver disorders. Specifically, the methods and compositions of the invention provide for the transplantation of bone marrow cells into a recipient host in amounts sufficient to result in the production of hepatocytes, bile ductal cells and oval cells during liver regeneration. The invention is based in the observation that bone-marrow derived cells, can participate in the production of hepatocytes, bile ductal cells and oval cells during liver regeneration. The present invention further provides methods for deriving enriched populations of hepatic oval cells, considered to be hepatic stem cells, utilizing antibodies that recognizes the Thy-1 cell surface antigen expressed on the surface of hepatic oval cells. The enriched populations of hepatic oval cells can be transplanted into a host for stimulating liver regeneration in subjects with liver disorders.
PCT/US2000/004744 1999-02-26 2000-02-25 Bone marrow transplantation for hepatic regeneration and repair Ceased WO2000050048A2 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
EP00911954A EP1154780A2 (en) 1999-02-26 2000-02-25 Bone marrow transplantation for hepatic regeneration and repair
AU33763/00A AU3376300A (en) 1999-02-26 2000-02-25 Bone marrow transplantation for hepatic regeneration and repair
CA002366707A CA2366707A1 (en) 1999-02-26 2000-02-25 Bone marrow transplantation for hepatic regeneration and repair

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US12225099P 1999-02-26 1999-02-26
US60/122,250 1999-02-26

Publications (3)

Publication Number Publication Date
WO2000050048A2 WO2000050048A2 (en) 2000-08-31
WO2000050048A3 true WO2000050048A3 (en) 2001-02-01
WO2000050048A9 WO2000050048A9 (en) 2002-03-14

Family

ID=22401591

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2000/004744 Ceased WO2000050048A2 (en) 1999-02-26 2000-02-25 Bone marrow transplantation for hepatic regeneration and repair

Country Status (4)

Country Link
EP (1) EP1154780A2 (en)
AU (1) AU3376300A (en)
CA (1) CA2366707A1 (en)
WO (1) WO2000050048A2 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8569471B2 (en) 2003-08-11 2013-10-29 University Of South Florida Stem cell beacon

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030082152A1 (en) * 1999-03-10 2003-05-01 Hedrick Marc H. Adipose-derived stem cells and lattices
US7473555B2 (en) 2000-04-27 2009-01-06 Geron Corporation Protocols for making hepatocytes from embryonic stem cells
US6458589B1 (en) * 2000-04-27 2002-10-01 Geron Corporation Hepatocyte lineage cells derived from pluripotent stem cells
US7256042B2 (en) 2000-04-27 2007-08-14 Geron Corporation Process for making hepatocytes from pluripotent stem cells
US7282366B2 (en) 2000-04-27 2007-10-16 Geron Corporation Hepatocytes for therapy and drug screening made from embryonic stem cells
US20040063204A1 (en) * 2002-08-14 2004-04-01 Lijun Yang Bone marrow cell differentiation
AU2003277205A1 (en) * 2002-10-02 2004-04-23 New York University Adult bone marrow derived stem cells
US7169608B2 (en) 2002-10-18 2007-01-30 University Of Florida Research Foundation, Inc. Bone marrow cell differentiation
WO2004096154A2 (en) * 2003-04-29 2004-11-11 Smithkline Beecham Corporation Methods for treating degenerative diseases/injuries
US7332336B2 (en) 2003-08-19 2008-02-19 Effector Cell Institute, Inc. Methods for inducing differentiation of pluripotent cells
JP4563705B2 (en) * 2004-03-19 2010-10-13 グンゼ株式会社 Base material for bile duct tissue regeneration
US8148151B2 (en) 2006-06-02 2012-04-03 Geron Corporation Differentiation of primate pluripotent cells to hepatocyte-lineage cells
AU2008232739B2 (en) 2007-03-30 2014-03-27 The Cleveland Clinic Foundation Method of treating ischemic disorders
CA2709398C (en) 2007-12-14 2017-11-07 The Cleveland Clinic Foundation Use of stromal cell-derived factor 1 for promoting wound healing
EP2473196B1 (en) 2009-08-28 2017-05-31 The Cleveland Clinic Foundation Sdf-1 delivery for treating ischemic tissue

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1991018972A1 (en) * 1990-05-30 1991-12-12 Cellco, Inc. Culturing bone marrow cells for adoptive immunotherapy
US5789246A (en) * 1991-08-07 1998-08-04 Albert Einstein College Of Medicine Compositions comprising hepatocyte precursors
WO1999039743A2 (en) * 1998-02-09 1999-08-12 University Of Southern California Method of promoting hepatic cell proliferation

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1991018972A1 (en) * 1990-05-30 1991-12-12 Cellco, Inc. Culturing bone marrow cells for adoptive immunotherapy
US5789246A (en) * 1991-08-07 1998-08-04 Albert Einstein College Of Medicine Compositions comprising hepatocyte precursors
WO1999039743A2 (en) * 1998-02-09 1999-08-12 University Of Southern California Method of promoting hepatic cell proliferation

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
ALISON MALCOLM ET AL: "Wound healing in the liver with particular reference to stem cells.", PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY OF LONDON B BIOLOGICAL, vol. 353, no. 1370, 29 June 1998 (1998-06-29), June 29, 1998, pages 877 - 894, XP000946107, ISSN: 0962-8436 *
PETERSEN B E ET AL: "Bone marrow as a potential source of hepatic oval cells.", SCIENCE (WASHINGTON D C), vol. 284, no. 5417, 14 May 1999 (1999-05-14), pages 1168 - 1170, XP002147735, ISSN: 0036-8075 *
PETERSEN BRYON E ET AL: "Hepatic oval cells express the hematopoietic stem cell marker Thy-1 in the rat.", HEPATOLOGY, vol. 27, no. 2, February 1998 (1998-02-01), pages 433 - 445, XP000946076, ISSN: 0270-9139 *
PETERSEN BRYON E ET AL: "Thy-1+ sorted hepatic oval cells in culture maintain oval cell phenotypic markers.", FASEB JOURNAL, vol. 12, no. 4, 17 March 1998 (1998-03-17), pages A468, XP002147734, ISSN: 0892-6638 *
YASUI OUKI ET AL: "Isolation of oval cells from Long-Evans Cinnamon rats and their transformation into hepatocytes in vivo in the rat liver.", HEPATOLOGY, vol. 25, no. 2, 1997, pages 329 - 334, XP000946193, ISSN: 0270-9139 *

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8569471B2 (en) 2003-08-11 2013-10-29 University Of South Florida Stem cell beacon
US9040676B2 (en) 2003-08-11 2015-05-26 University Of South Florida Vigilant cells

Also Published As

Publication number Publication date
WO2000050048A9 (en) 2002-03-14
EP1154780A2 (en) 2001-11-21
CA2366707A1 (en) 2000-08-31
AU3376300A (en) 2000-09-14
WO2000050048A2 (en) 2000-08-31

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