[go: up one dir, main page]

WO2000045724A1 - Vis a os - Google Patents

Vis a os Download PDF

Info

Publication number
WO2000045724A1
WO2000045724A1 PCT/CH1999/000049 CH9900049W WO0045724A1 WO 2000045724 A1 WO2000045724 A1 WO 2000045724A1 CH 9900049 W CH9900049 W CH 9900049W WO 0045724 A1 WO0045724 A1 WO 0045724A1
Authority
WO
WIPO (PCT)
Prior art keywords
bone screw
screw according
silver coating
compatible material
threadless
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/CH1999/000049
Other languages
German (de)
English (en)
Inventor
Michael Ahrens
Urs Schlegel
Silvia Beer
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
AO Technology AG
Synthes USA LLC
Original Assignee
Synthes AG Chur
Synthes USA LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Synthes AG Chur, Synthes USA LLC filed Critical Synthes AG Chur
Priority to PCT/CH1999/000049 priority Critical patent/WO2000045724A1/fr
Priority to CA002360904A priority patent/CA2360904C/fr
Priority to AU20446/99A priority patent/AU757391B2/en
Priority to EP99900870A priority patent/EP1148830A1/fr
Priority to JP2000596849A priority patent/JP4230668B2/ja
Priority to ZA200000450A priority patent/ZA200000450B/xx
Publication of WO2000045724A1 publication Critical patent/WO2000045724A1/fr
Priority to US09/920,730 priority patent/US6663634B2/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L31/16—Biologically active materials, e.g. therapeutic substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods
    • A61B17/56—Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor
    • A61B17/58—Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor for osteosynthesis, e.g. bone plates, screws or setting implements
    • A61B17/68—Internal fixation devices, including fasteners and spinal fixators, even if a part thereof projects from the skin
    • A61B17/84—Fasteners therefor or fasteners being internal fixation devices
    • A61B17/86—Pins or screws or threaded wires; nuts therefor
    • A61B17/866—Material or manufacture
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/08—Materials for coatings
    • A61L31/082—Inorganic materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/08—Materials for coatings
    • A61L31/082—Inorganic materials
    • A61L31/088—Other specific inorganic materials not covered by A61L31/084 or A61L31/086
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2310/00—Prostheses classified in A61F2/28 or A61F2/30 - A61F2/44 being constructed from or coated with a particular material
    • A61F2310/00389—The prosthesis being coated or covered with a particular material
    • A61F2310/00395—Coating or prosthesis-covering structure made of metals or of alloys
    • A61F2310/00419—Other metals
    • A61F2310/0052—Coating made of silver or Ag-based alloys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/10—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing inorganic materials
    • A61L2300/102—Metals or metal compounds, e.g. salts such as bicarbonates, carbonates, oxides, zeolites, silicates
    • A61L2300/104—Silver, e.g. silver sulfadiazine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/404—Biocides, antimicrobial agents, antiseptic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/60—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a special physical form
    • A61L2300/606—Coatings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2430/00—Materials or treatment for tissue regeneration
    • A61L2430/02—Materials or treatment for tissue regeneration for reconstruction of bones; weight-bearing implants

Definitions

  • the invention relates to a bone screw according to the preamble of claim 1 and an external fixator with such a bone screw according to claim 16.
  • CH 657 519 BLAETTLER has disclosed a surgical implant completely coated with silver.
  • the silver layer is not applied directly to the carrier material but to an intermediate layer made of copper.
  • the disadvantage of this known device is that silver can have an inhibiting influence on the osteoblasts, depending on the concentration (typically 1.42 ⁇ g / ml), so that a bone screw coated in this way is nevertheless subject to the risks of loosening.
  • Pins have also been proposed, through which a silver-coated plastic tube is pushed down to the depth of the tissue down to the bone.
  • the disadvantage of this device is the lack of sterilizability, which precludes reuse. Since the diameter of the pins is doubled due to the tube being put over them, longer incisions are also required to insert them into the soft tissues, which increases the soft tissue trauma.
  • the invention seeks to remedy this.
  • the invention is based on the problem of creating a bone screw, in particular for use in an external fixator, which prevents the occurrence of infections.
  • the invention solves this problem with a bone screw, which has the features of claim 1.
  • the pins can be used as normal as conventional (uncoated) pins;
  • the pins are reusable after reprocessing and sterilization
  • the bone screw is only partially coated with silver, at least in the soft tissue area to be protected against infections.
  • the threaded part is uncoated, since silver in direct contact with the bone can have an inhibiting effect on the osteoblasts.
  • the rear part of the bone screw which is mechanically stressed by the clamping jaws of the fixator is preferably also uncoated.
  • the silver coating acts as the anode and the steel (or titanium) acts as the cathode.
  • the steel or titanium acts as the cathode.
  • a bactericidal effect mainly occurs on the anode.
  • Current stimulation in bone fractures showed a stimulating effect on the bone cells on the cathode.
  • a further increase in the antibacterial effect of the bone screw according to the invention can be achieved by applying an electric current in low strengths, for example 0.25 microamps.
  • a current of 5 to 20 microamps and approximately 0.8 volts is typically used.
  • the layer thickness of the silver coating is preferably greater than 10 ⁇ and can be applied to the body-compatible material either electrochemically or as a metallic film without an intermediate layer. Another possibility is to stick on the silver coating.
  • the coatings can thus be applied by different methods, e.g. electrochemical (anodizing) using IADB (ion assisted beam deposition using a foil (with conductive or insulating
  • Adhesives The coating-free areas can be covered with stencils.
  • the foils can be applied using a heat-resistant adhesive before sterilization, or sterile directly before insertion by the surgical nurse.
  • the body-compatible material can be steel, titanium, tantalum or niobium. It can also consist of polylactides, polyurethanes, hydroxyapatites, glasses, ceramics or carbon fibers.
  • the threaded front part should be at least 3 mm long to ensure sufficient anchoring in the bone.
  • the threadless back part of the bone screw should be between 2 and 3 cm long, because the drill chuck of the drill used to screw in the pins needs about 2 cm to clamp the pins and another centimeter should remain silver-free so that the silver coating just slightly projects above the skin level, because in addition to the area for the drill chuck, the jaws also cause mechanical abrasion.
  • the coated surface 0 Aq should preferably make up 10% of the total surface O tot of the bone screw.
  • a preferred development of the invention consists in that the bone screws according to the invention are only partially provided with a silver coating even in the non-threaded shaft part, e.g. with rings alternating in the axial direction.
  • the alternating surface rings made of biocompatible material (e.g. steel) and silver initially cause silver ions to flow out into the soft tissue area. Since the difference in charge decreases with time and the exchanged ions, a predetermined amount of silver ions can be released. Although this embodiment no longer permits the pins to be re-sterilized, it does take account of the requirement for controllable release of silver ions.
  • FIG. 1 shows a schematic illustration of the bone screw according to the invention
  • FIG. 2 shows a further embodiment of the bone screw according to the invention
  • FIG. 3 shows a further embodiment of the bone screw according to the invention.
  • Fig. 4 shows a further embodiment of the bone screw according to the invention.
  • the thread-bearing front part 1 and the threadless rear part 2 are uncoated and only the threadless shaft part 3 lying between them has a silver coating.
  • galvanic currents only occur at the interfaces between the rear part 2 and the threadless shaft part 3 on the one hand and between the threadless shaft part 3 and the front part 1 on the other hand.
  • the bone screw shown in FIG. 2 differs from the embodiment according to FIG. 1 only in the design of the threadless shaft part 3.
  • the threadless shaft part 3 is alternating in the axial direction in the form of rings 4 with a Silver coating.
  • the galvanic element lies in the area of the threadless shaft part 3; it causes an even flow of silver ions as a prophylaxis against infection.
  • the bone screw shown in FIG. 3 differs from the embodiment according to FIG. 1 only in the design of the threadless shaft part 3.
  • the threadless shaft part 3 is provided with longitudinal strips 5 with a silver coating in the axial direction.
  • the galvanic element lies in the area of the threadless shaft part 3; it causes an even flow of silver ions as a prophylaxis against infection.
  • the bone screw shown in FIG. 4 differs from the embodiment according to FIG. 1 only in the design of the threaded front part 1.
  • the front part 1 is either completely coated with silver or only coated with silver on the threads.
  • the version with a front part 1 completely coated with silver is particularly suitable for use on an already infected bone, where a high silver concentration is required.
  • the front part 1 acts as a galvanic element.

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Surgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Inorganic Chemistry (AREA)
  • Epidemiology (AREA)
  • Vascular Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Neurology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medical Informatics (AREA)
  • Surgical Instruments (AREA)
  • Materials For Medical Uses (AREA)

Abstract

La vis à os présentée est faite en matériau biocompatible et comporte une partie avant filetée (1), une partie arrière non filetée (2) et une tige non filetée (3) située entre ces deux parties. Une partie OAg de la surface Otot de la vis à os est recouverte d'une couche d'argent, recouvrant au moins partiellement la tige non filetée (3). Le reste de la surface (Otot-OAg), comprenant au moins la partie avant filetée (1), n'est pas recouverte. La vis à os empêche l'apparition d'infections.
PCT/CH1999/000049 1999-02-04 1999-02-04 Vis a os Ceased WO2000045724A1 (fr)

Priority Applications (7)

Application Number Priority Date Filing Date Title
PCT/CH1999/000049 WO2000045724A1 (fr) 1999-02-04 1999-02-04 Vis a os
CA002360904A CA2360904C (fr) 1999-02-04 1999-02-04 Vis a os
AU20446/99A AU757391B2 (en) 1999-02-04 1999-02-04 Bone screw
EP99900870A EP1148830A1 (fr) 1999-02-04 1999-02-04 Vis a os
JP2000596849A JP4230668B2 (ja) 1999-02-04 1999-02-04 骨ねじ
ZA200000450A ZA200000450B (en) 1999-02-04 2000-04-17 Bone plate.
US09/920,730 US6663634B2 (en) 1999-02-04 2001-08-03 Bone screw

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/CH1999/000049 WO2000045724A1 (fr) 1999-02-04 1999-02-04 Vis a os

Related Child Applications (1)

Application Number Title Priority Date Filing Date
US09/920,730 Continuation US6663634B2 (en) 1999-02-04 2001-08-03 Bone screw

Publications (1)

Publication Number Publication Date
WO2000045724A1 true WO2000045724A1 (fr) 2000-08-10

Family

ID=4551653

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/CH1999/000049 Ceased WO2000045724A1 (fr) 1999-02-04 1999-02-04 Vis a os

Country Status (7)

Country Link
US (1) US6663634B2 (fr)
EP (1) EP1148830A1 (fr)
JP (1) JP4230668B2 (fr)
AU (1) AU757391B2 (fr)
CA (1) CA2360904C (fr)
WO (1) WO2000045724A1 (fr)
ZA (1) ZA200000450B (fr)

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001012246A1 (fr) * 1999-08-17 2001-02-22 St. Jude Medical, Inc. Dispositifs medicaux avec des composites de metal/polymere
WO2003005916A1 (fr) * 2001-07-09 2003-01-23 Smith & Nephew, Inc. Manchon pharmacologique
US8135466B2 (en) 2005-06-30 2012-03-13 Argentumcidalelectrics, Inc. Prophylactic bactericidal implant
US8858775B2 (en) 2007-10-03 2014-10-14 Accentus Medical Limited Method of manufacturing metal with biocidal properties
US8945363B2 (en) 2002-04-16 2015-02-03 Accentus Medical Limited Method of making metal implants
US9011665B2 (en) 2004-03-13 2015-04-21 Accentus Medical Limited Metal implants
US10682431B2 (en) 2006-12-28 2020-06-16 Aionx Antimicrobial Technologies, Inc. Ex vivo antimicrobial devices and methods

Families Citing this family (143)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9161793B2 (en) 1993-01-21 2015-10-20 Acumed Llc Axial tension screw
US8070786B2 (en) * 1993-01-21 2011-12-06 Acumed Llc System for fusing joints
GB0116341D0 (en) * 2001-07-04 2001-08-29 Smith & Nephew Biodegradable polymer systems
GB0202233D0 (en) * 2002-01-31 2002-03-20 Smith & Nephew Bioresorbable polymers
DE10243132B4 (de) 2002-09-17 2006-09-14 Biocer Entwicklungs Gmbh Antiinfektiöse, biokompatible Titanoxid-Beschichtungen für Implantate sowie Verfahren zu deren Herstellung
US7615070B2 (en) * 2002-10-11 2009-11-10 Spineco, Inc. Electro-stimulation and medical delivery device
US20040073221A1 (en) * 2002-10-11 2004-04-15 Spineco, Inc., A Corporation Of Ohio Electro-stimulation and medical delivery device
EP1596765A2 (fr) * 2003-02-10 2005-11-23 Smith & Nephew, Inc. Dispositifs resorbables
US8070785B2 (en) * 2003-09-16 2011-12-06 Spineco, Inc. Bone anchor prosthesis and system
US7141354B2 (en) * 2003-09-30 2006-11-28 Dai Nippon Printing Co., Ltd. Photo radical generator, photo sensitive resin composition and article
NL1024808C2 (nl) * 2003-11-18 2005-05-23 Hendrik Glastra In een lichaamsvat of -holte implanteerbaar therapeutisch werkzaam element.
GB0329654D0 (en) * 2003-12-23 2004-01-28 Smith & Nephew Tunable segmented polyacetal
US7608092B1 (en) 2004-02-20 2009-10-27 Biomet Sports Medicince, LLC Method and apparatus for performing meniscus repair
US20180228621A1 (en) 2004-08-09 2018-08-16 Mark A. Reiley Apparatus, systems, and methods for the fixation or fusion of bone
WO2006031397A1 (fr) * 2004-09-14 2006-03-23 Spineco, Inc. Implant
US7116794B2 (en) * 2004-11-04 2006-10-03 Patrik Westerkull Hearing-aid anchoring element
US7905903B2 (en) 2006-02-03 2011-03-15 Biomet Sports Medicine, Llc Method for tissue fixation
US7658751B2 (en) 2006-09-29 2010-02-09 Biomet Sports Medicine, Llc Method for implanting soft tissue
US8298262B2 (en) 2006-02-03 2012-10-30 Biomet Sports Medicine, Llc Method for tissue fixation
US9017381B2 (en) 2007-04-10 2015-04-28 Biomet Sports Medicine, Llc Adjustable knotless loops
US7857830B2 (en) 2006-02-03 2010-12-28 Biomet Sports Medicine, Llc Soft tissue repair and conduit device
US8840645B2 (en) 2004-11-05 2014-09-23 Biomet Sports Medicine, Llc Method and apparatus for coupling soft tissue to a bone
US7749250B2 (en) 2006-02-03 2010-07-06 Biomet Sports Medicine, Llc Soft tissue repair assembly and associated method
US8128658B2 (en) 2004-11-05 2012-03-06 Biomet Sports Medicine, Llc Method and apparatus for coupling soft tissue to bone
US7909851B2 (en) 2006-02-03 2011-03-22 Biomet Sports Medicine, Llc Soft tissue repair device and associated methods
US8118836B2 (en) 2004-11-05 2012-02-21 Biomet Sports Medicine, Llc Method and apparatus for coupling soft tissue to a bone
US8137382B2 (en) 2004-11-05 2012-03-20 Biomet Sports Medicine, Llc Method and apparatus for coupling anatomical features
US20060189993A1 (en) 2004-11-09 2006-08-24 Arthrotek, Inc. Soft tissue conduit device
US9801708B2 (en) 2004-11-05 2017-10-31 Biomet Sports Medicine, Llc Method and apparatus for coupling soft tissue to a bone
US8303604B2 (en) 2004-11-05 2012-11-06 Biomet Sports Medicine, Llc Soft tissue repair device and method
US7905904B2 (en) 2006-02-03 2011-03-15 Biomet Sports Medicine, Llc Soft tissue repair device and associated methods
US8088130B2 (en) 2006-02-03 2012-01-03 Biomet Sports Medicine, Llc Method and apparatus for coupling soft tissue to a bone
US8361113B2 (en) 2006-02-03 2013-01-29 Biomet Sports Medicine, Llc Method and apparatus for coupling soft tissue to a bone
US8034090B2 (en) 2004-11-09 2011-10-11 Biomet Sports Medicine, Llc Tissue fixation device
US7608098B1 (en) 2004-11-09 2009-10-27 Biomet Sports Medicine, Llc Bone fixation device
US7914539B2 (en) 2004-11-09 2011-03-29 Biomet Sports Medicine, Llc Tissue fixation device
US8998949B2 (en) 2004-11-09 2015-04-07 Biomet Sports Medicine, Llc Soft tissue conduit device
WO2007020432A2 (fr) * 2005-08-18 2007-02-22 Smith & Nephew, Plc Dispositifs et composites a resistance elevee
US8506597B2 (en) 2011-10-25 2013-08-13 Biomet Sports Medicine, Llc Method and apparatus for interosseous membrane reconstruction
US9271713B2 (en) 2006-02-03 2016-03-01 Biomet Sports Medicine, Llc Method and apparatus for tensioning a suture
US9538998B2 (en) 2006-02-03 2017-01-10 Biomet Sports Medicine, Llc Method and apparatus for fracture fixation
US9468433B2 (en) 2006-02-03 2016-10-18 Biomet Sports Medicine, Llc Method and apparatus for forming a self-locking adjustable loop
US8562647B2 (en) 2006-09-29 2013-10-22 Biomet Sports Medicine, Llc Method and apparatus for securing soft tissue to bone
US11311287B2 (en) 2006-02-03 2022-04-26 Biomet Sports Medicine, Llc Method for tissue fixation
US11259792B2 (en) 2006-02-03 2022-03-01 Biomet Sports Medicine, Llc Method and apparatus for coupling anatomical features
US8771352B2 (en) 2011-05-17 2014-07-08 Biomet Sports Medicine, Llc Method and apparatus for tibial fixation of an ACL graft
US9149267B2 (en) 2006-02-03 2015-10-06 Biomet Sports Medicine, Llc Method and apparatus for coupling soft tissue to a bone
US8251998B2 (en) 2006-08-16 2012-08-28 Biomet Sports Medicine, Llc Chondral defect repair
US10517587B2 (en) 2006-02-03 2019-12-31 Biomet Sports Medicine, Llc Method and apparatus for forming a self-locking adjustable loop
US8652171B2 (en) 2006-02-03 2014-02-18 Biomet Sports Medicine, Llc Method and apparatus for soft tissue fixation
US8597327B2 (en) 2006-02-03 2013-12-03 Biomet Manufacturing, Llc Method and apparatus for sternal closure
US8562645B2 (en) 2006-09-29 2013-10-22 Biomet Sports Medicine, Llc Method and apparatus for forming a self-locking adjustable loop
US8968364B2 (en) 2006-02-03 2015-03-03 Biomet Sports Medicine, Llc Method and apparatus for fixation of an ACL graft
US8652172B2 (en) 2006-02-03 2014-02-18 Biomet Sports Medicine, Llc Flexible anchors for tissue fixation
US8574235B2 (en) 2006-02-03 2013-11-05 Biomet Sports Medicine, Llc Method for trochanteric reattachment
US8801783B2 (en) 2006-09-29 2014-08-12 Biomet Sports Medicine, Llc Prosthetic ligament system for knee joint
US9078644B2 (en) 2006-09-29 2015-07-14 Biomet Sports Medicine, Llc Fracture fixation device
US7959650B2 (en) 2006-09-29 2011-06-14 Biomet Sports Medicine, Llc Adjustable knotless loops
WO2007103276A2 (fr) 2006-03-03 2007-09-13 Smith & Nephew, Inc. Systemes et procedes d'administration d'un medicament
US8361129B2 (en) 2006-04-28 2013-01-29 Depuy Spine, Inc. Large diameter bone anchor assembly
DK2026852T3 (da) * 2006-06-12 2011-04-04 Accentus Medical Plc Metalimplantater
US8672969B2 (en) 2006-09-29 2014-03-18 Biomet Sports Medicine, Llc Fracture fixation device
US9918826B2 (en) 2006-09-29 2018-03-20 Biomet Sports Medicine, Llc Scaffold for spring ligament repair
US8500818B2 (en) 2006-09-29 2013-08-06 Biomet Manufacturing, Llc Knee prosthesis assembly with ligament link
US11259794B2 (en) 2006-09-29 2022-03-01 Biomet Sports Medicine, Llc Method for implanting soft tissue
CN102274552B (zh) * 2006-11-30 2017-03-01 史密夫和内修有限公司 纤维增强的复合材料
CA2670762C (fr) * 2007-01-15 2015-03-31 Accentus Plc Implant metallique revetu d'un metal depose par pulverisation de poudre par plasma et incorporation d'un metal biocide dans celui-ci
US9815240B2 (en) 2007-04-18 2017-11-14 Smith & Nephew, Inc. Expansion moulding of shape memory polymers
EP2150288B1 (fr) 2007-04-19 2011-04-13 Smith & Nephew, Inc. Fixation de greffe
EP2142227B1 (fr) 2007-04-19 2012-02-29 Smith & Nephew, Inc. Polymères à mémoire de forme multimodaux
US20100168829A1 (en) 2007-08-30 2010-07-01 Liat Schwartz System for implanting, activating, and operating an implantable battery
US9247973B2 (en) * 2007-09-28 2016-02-02 DePuy Synthes Products, Inc. Anti-microbial implant
US8092505B2 (en) * 2008-01-28 2012-01-10 Acumed Llc Bone nail
US12245759B2 (en) 2008-08-22 2025-03-11 Biomet Sports Medicine, Llc Method and apparatus for coupling soft tissue to bone
US12419632B2 (en) 2008-08-22 2025-09-23 Biomet Sports Medicine, Llc Method and apparatus for coupling anatomical features
WO2010045487A1 (fr) * 2008-10-15 2010-04-22 Palmetto Biomedical, Inc. Dispositif et procédé destinés à fournir des agents thérapeutiques par le biais d'implants internes
US9642658B2 (en) * 2008-10-15 2017-05-09 Orthoclip Llc Device and method for delivery of therapeutic agents via internal implants
EP3251618B8 (fr) 2009-01-16 2019-11-13 Carbofix Orthopedics Ltd. Implant osseux de matériau composite
US8366719B2 (en) 2009-03-18 2013-02-05 Integrated Spinal Concepts, Inc. Image-guided minimal-step placement of screw into bone
US8343227B2 (en) 2009-05-28 2013-01-01 Biomet Manufacturing Corp. Knee prosthesis assembly with ligament link
US12096928B2 (en) 2009-05-29 2024-09-24 Biomet Sports Medicine, Llc Method and apparatus for coupling soft tissue to a bone
US8927004B1 (en) 2014-06-11 2015-01-06 Silver Bullet Therapeutics, Inc. Bioabsorbable substrates and systems that controllably release antimicrobial metal ions
US10265435B2 (en) 2009-08-27 2019-04-23 Silver Bullet Therapeutics, Inc. Bone implant and systems and coatings for the controllable release of antimicrobial metal ions
US9114197B1 (en) 2014-06-11 2015-08-25 Silver Bullett Therapeutics, Inc. Coatings for the controllable release of antimicrobial metal ions
US8221396B2 (en) 2009-08-27 2012-07-17 Silver Bullet Therapeutics, Inc. Bone implants for the treatment of infection
US9821094B2 (en) 2014-06-11 2017-11-21 Silver Bullet Therapeutics, Inc. Coatings for the controllable release of antimicrobial metal ions
US8361123B2 (en) 2009-10-16 2013-01-29 Depuy Spine, Inc. Bone anchor assemblies and methods of manufacturing and use thereof
EP2382960A1 (fr) 2010-04-19 2011-11-02 DERU GmbH Entwicklung von medizinischen Produkten Implant doté d'un revêtement antimicrobien
US10154867B2 (en) 2010-06-07 2018-12-18 Carbofix In Orthopedics Llc Multi-layer composite material bone screw
EP2575656B1 (fr) 2010-06-07 2019-04-10 Carbofix Orthopedics Ltd. Implant osseux en matériau composite et procédés
EP2637608B1 (fr) * 2010-11-12 2016-03-02 Silver Bullet Therapeutics Inc. Implant osseux et systèmes qui libèrent de l'argent de façon contrôlée
US12329373B2 (en) 2011-05-02 2025-06-17 Biomet Sports Medicine, Llc Method and apparatus for soft tissue fixation
US9357991B2 (en) 2011-11-03 2016-06-07 Biomet Sports Medicine, Llc Method and apparatus for stitching tendons
US9381013B2 (en) 2011-11-10 2016-07-05 Biomet Sports Medicine, Llc Method for coupling soft tissue to a bone
US9370350B2 (en) 2011-11-10 2016-06-21 Biomet Sports Medicine, Llc Apparatus for coupling soft tissue to a bone
US9314241B2 (en) 2011-11-10 2016-04-19 Biomet Sports Medicine, Llc Apparatus for coupling soft tissue to a bone
AR084499A1 (es) * 2011-11-16 2013-05-22 S L S A Lab Un dispositivo intramedular descartable de uso transitorio para el tratamiento de infecciones en extremidades
US9259217B2 (en) 2012-01-03 2016-02-16 Biomet Manufacturing, Llc Suture Button
US9526549B2 (en) 2012-01-16 2016-12-27 Carbofix Orthopedics Ltd. Bone screw with insert
IN2014DN06946A (fr) 2012-03-09 2015-04-10 Si Bone Inc
US10363140B2 (en) 2012-03-09 2019-07-30 Si-Bone Inc. Systems, device, and methods for joint fusion
EP4275618A3 (fr) 2012-05-04 2024-01-10 SI-Bone, Inc. Implant fenestré
US9757119B2 (en) 2013-03-08 2017-09-12 Biomet Sports Medicine, Llc Visual aid for identifying suture limbs arthroscopically
US9918827B2 (en) 2013-03-14 2018-03-20 Biomet Sports Medicine, Llc Scaffold for spring ligament repair
WO2014145902A1 (fr) 2013-03-15 2014-09-18 Si-Bone Inc. Implants de fixation ou de fusion vertébrale
US10194945B2 (en) 2013-03-15 2019-02-05 DePuy Synthes Products, Inc. External fixation system with radio frequency shielding
US10610123B2 (en) 2013-03-15 2020-04-07 DePuy Synthes Products, Inc. External fixation system with radio frequency shielding
US11147688B2 (en) 2013-10-15 2021-10-19 Si-Bone Inc. Implant placement
US10136886B2 (en) 2013-12-20 2018-11-27 Biomet Sports Medicine, Llc Knotless soft tissue devices and techniques
US9615822B2 (en) 2014-05-30 2017-04-11 Biomet Sports Medicine, Llc Insertion tools and method for soft anchor
US9700291B2 (en) 2014-06-03 2017-07-11 Biomet Sports Medicine, Llc Capsule retractor
US9452242B2 (en) 2014-06-11 2016-09-27 Silver Bullet Therapeutics, Inc. Enhancement of antimicrobial silver, silver coatings, or silver platings
US10039543B2 (en) 2014-08-22 2018-08-07 Biomet Sports Medicine, Llc Non-sliding soft anchor
ES3030703T3 (en) 2014-09-18 2025-07-01 Si Bone Inc Matrix implant
US10166033B2 (en) 2014-09-18 2019-01-01 Si-Bone Inc. Implants for bone fixation or fusion
US9955980B2 (en) 2015-02-24 2018-05-01 Biomet Sports Medicine, Llc Anatomic soft tissue repair
US9974534B2 (en) 2015-03-31 2018-05-22 Biomet Sports Medicine, Llc Suture anchor with soft anchor of electrospun fibers
US10376206B2 (en) * 2015-04-01 2019-08-13 Si-Bone Inc. Neuromonitoring systems and methods for bone fixation or fusion procedures
JP6592823B2 (ja) * 2015-06-30 2019-10-23 京セラ株式会社 生体インプラント
US9943337B2 (en) 2015-12-03 2018-04-17 Globus Medical, Inc. External fixator assembly
US10136919B2 (en) 2015-12-03 2018-11-27 Globus Medical, Inc. External fixator assembly
US9872707B2 (en) 2015-12-03 2018-01-23 Globus Medical, Inc. External fixator assembly
US10682160B2 (en) 2015-12-03 2020-06-16 Globus Medical, Inc. External fixator assembly
US10617458B2 (en) 2015-12-23 2020-04-14 Carbofix In Orthopedics Llc Multi-layer composite material bone screw
EP3424467A4 (fr) * 2016-02-29 2019-10-09 Medtronic Sofamor Danek, Co., Ltd. Appareil antibactérien pour implantation in vivo
JP6755301B2 (ja) * 2016-02-29 2020-09-16 メドトロニックソファモアダネック株式会社 抗菌性生体内埋込用器具用セットスクリュー
EP3424466B1 (fr) * 2016-02-29 2022-06-15 Medtronic Sofamor Danek, Co., Ltd. Appareil antibactérien pour implantation in vivo
AU2017226477A1 (en) * 2016-02-29 2018-08-16 Medtronic Sofamor Danek, Co., Ltd. Antimicrobial in vivo implantation device
WO2017150542A1 (fr) * 2016-02-29 2017-09-08 メドトロニックソファモアダネック株式会社 Instrument antibactérien destiné à être implanté dans un organisme vivant
CN106037916A (zh) * 2016-05-17 2016-10-26 复旦大学附属上海市第五人民医院 一种外固定支架用钛螺钉及其制备方法
US11116519B2 (en) 2017-09-26 2021-09-14 Si-Bone Inc. Systems and methods for decorticating the sacroiliac joint
WO2019191505A1 (fr) 2018-03-28 2019-10-03 Si-Bone Inc. Implants filetés et procédés d'utilisation à travers des segments osseux
US10405889B2 (en) * 2018-06-14 2019-09-10 New Standard Device, LLC Cold forged cutting tip for orthopedic wires and pins
AU2020223180B2 (en) 2019-02-14 2025-09-25 Si-Bone Inc. Implants for spinal fixation and or fusion
US11369419B2 (en) 2019-02-14 2022-06-28 Si-Bone Inc. Implants for spinal fixation and or fusion
EP4061262A1 (fr) 2019-11-21 2022-09-28 SI-Bone, Inc. Ensembles de couplage de tige pour constructions de stabilisation osseuse
US11672570B2 (en) 2019-11-27 2023-06-13 Si-Bone Inc. Bone stabilizing implants and methods of placement across SI Joints
JP2023504571A (ja) 2019-12-09 2023-02-03 エスアイ－ボーン・インコーポレイテッド 仙腸関節安定化インプラント及び埋込方法
CN115135261B (zh) * 2020-02-19 2025-06-20 奥林巴斯泰尔茂生物材料株式会社 植入物
EP4259015A4 (fr) 2020-12-09 2024-09-11 SI-Bone, Inc. Implants de stabilisation d'articulation sacro-iliaque et méthodes d'implantation
US12458413B2 (en) 2021-12-03 2025-11-04 Si-Bone Inc. Fusion cages and methods for sacro-iliac joint stabilization
EP4238584A1 (fr) 2022-03-04 2023-09-06 AMESPMTECH Center Appareil et procédé d'élimination de biofilm de dispositifs métalliques
WO2025038769A1 (fr) 2023-08-15 2025-02-20 Si-Bone Inc. Implants de stabilisation pelvienne, procédés d'utilisation et de fabrication

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4476590A (en) * 1980-03-27 1984-10-16 National Research Development Corporation Antimicrobial surgical implants
CH657519A5 (en) * 1985-05-17 1986-09-15 Ines Blaettler Surgical implants and repair plates
WO1989004674A1 (fr) * 1987-11-26 1989-06-01 Biocon Oy Articles destines a entrer en contact avec des tissus du corps et contenant un agent anti-microbien
US5108399A (en) * 1988-09-17 1992-04-28 Boehringer Ingelheim Gmbh Device for osteosynthesis and process for producing it
EP0792654A2 (fr) * 1996-02-27 1997-09-03 Gentamed AG Acticles à activité antibactérielle et leur utilisation en médecine et chirurgie
US5759564A (en) * 1996-04-16 1998-06-02 Implemed, Inc. Iontophoretic material
US5770255A (en) * 1992-05-19 1998-06-23 Westaim Technologies, Inc. Anti-microbial coating for medical devices

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4476590A (en) * 1980-03-27 1984-10-16 National Research Development Corporation Antimicrobial surgical implants
CH657519A5 (en) * 1985-05-17 1986-09-15 Ines Blaettler Surgical implants and repair plates
WO1989004674A1 (fr) * 1987-11-26 1989-06-01 Biocon Oy Articles destines a entrer en contact avec des tissus du corps et contenant un agent anti-microbien
US5108399A (en) * 1988-09-17 1992-04-28 Boehringer Ingelheim Gmbh Device for osteosynthesis and process for producing it
US5770255A (en) * 1992-05-19 1998-06-23 Westaim Technologies, Inc. Anti-microbial coating for medical devices
EP0792654A2 (fr) * 1996-02-27 1997-09-03 Gentamed AG Acticles à activité antibactérielle et leur utilisation en médecine et chirurgie
US5759564A (en) * 1996-04-16 1998-06-02 Implemed, Inc. Iontophoretic material

Cited By (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001012246A1 (fr) * 1999-08-17 2001-02-22 St. Jude Medical, Inc. Dispositifs medicaux avec des composites de metal/polymere
US6322588B1 (en) 1999-08-17 2001-11-27 St. Jude Medical, Inc. Medical devices with metal/polymer composites
WO2003005916A1 (fr) * 2001-07-09 2003-01-23 Smith & Nephew, Inc. Manchon pharmacologique
US8945363B2 (en) 2002-04-16 2015-02-03 Accentus Medical Limited Method of making metal implants
US9393349B2 (en) 2002-04-16 2016-07-19 Accentus Medical Limited Metal implants
US9011665B2 (en) 2004-03-13 2015-04-21 Accentus Medical Limited Metal implants
US8135466B2 (en) 2005-06-30 2012-03-13 Argentumcidalelectrics, Inc. Prophylactic bactericidal implant
US9849282B2 (en) 2005-06-30 2017-12-26 Aionx Antimicrobial Technologies, Inc. Prophylactic bactericidal medical device
US10682431B2 (en) 2006-12-28 2020-06-16 Aionx Antimicrobial Technologies, Inc. Ex vivo antimicrobial devices and methods
US8858775B2 (en) 2007-10-03 2014-10-14 Accentus Medical Limited Method of manufacturing metal with biocidal properties

Also Published As

Publication number Publication date
JP2002536048A (ja) 2002-10-29
CA2360904A1 (fr) 2000-08-10
US6663634B2 (en) 2003-12-16
JP4230668B2 (ja) 2009-02-25
AU2044699A (en) 2000-08-25
CA2360904C (fr) 2007-05-22
US20020029043A1 (en) 2002-03-07
AU757391B2 (en) 2003-02-20
EP1148830A1 (fr) 2001-10-31
ZA200000450B (en) 2000-09-06

Similar Documents

Publication Publication Date Title
EP1148830A1 (fr) Vis a os
EP2012869B1 (fr) Dispositif de stimulation pour ostéosynthèse et endoprothèse
DE69430441T2 (de) Katheter mit langwirkender antimikrobieller oberflächenbehandlung
DE20020649U1 (de) Vorrichtung für den chirurgischen oder therapeutischen Gebrauch, insbesondere Implantate und chirurgische Instrumente sowie deren Zubehör
EP2560604B1 (fr) Implant doté d'un revêtement antimicrobien
EP1847227A1 (fr) Système de clou électrique
DE102013201883B4 (de) Verwendung einer wässrigen Lösung einer Säure als Behandlungsflüssigkeit zur Reinigung eines Implantat-Teils
EP3323380B1 (fr) Système de traitement destiné à nettoyer un composant souillé par biofilm, en particulier d'une partie d'implant
EP4003221B1 (fr) Système de traitement avec système de mise en contact
DE60200884T2 (de) Implantat und verfahren zur veränderung von implantatoberflächen
DE102013201884A1 (de) Behandlungssystem zur Reinigung eines mit Biofilm verunreinigten Bauteils, insbesondere eines Implantat-Teils
WO2014023281A2 (fr) Ensemble d'électrodes utilisé pour un traitement au plasma et dispositif permettant de créer une liaison transcutanée
EP2421475B1 (fr) Prothèse de hanche électrique
EP1618918A1 (fr) Electrode implantable
DE102012210804B4 (de) Verfahren zur Erzeugung einer bakteriziden Schicht auf einem Grundkörper aus Titan oder einer Titanbasislegierung
DE102007046879B4 (de) Dentalimplantat
DE102014105732B3 (de) Verfahren zur Oberflächenbehandlung eines biokorrodierbaren Implantats und nach dem Verfahren erhaltenes Implantat
DE10356920A1 (de) In einen menschlichen Kiefer endostal einschraubbares Dentalimplantat zur Aufnahme und Fixierung eines Zahnersatzes
EP2260884A1 (fr) Système d'implant doté d'un implant temporaire et procédé d'influence du degré de corrosion d'un implant
DE102019219355B4 (de) Implantat, Implantatkomponente und Verfahren zu deren Herstellung
WO2024105067A1 (fr) Élément rapporté destiné au nettoyage d'implants
EP3831426B1 (fr) Dispositif d'application locale de fluides pharmaceutiques
DE102022205028A1 (de) Behandlungskopf für ein System zur Reinigung eines mit Biofilm verunreinigten Bauteils, insbesondere eines Implantat-Teils
Weber et al. Tracheaquerresektion: Langzeitergebnisse

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A1

Designated state(s): AU CA JP US

AL Designated countries for regional patents

Kind code of ref document: A1

Designated state(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE

DFPE Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101)
121 Ep: the epo has been informed by wipo that ep was designated in this application
WWE Wipo information: entry into national phase

Ref document number: 20446/99

Country of ref document: AU

WWE Wipo information: entry into national phase

Ref document number: 1999900870

Country of ref document: EP

ENP Entry into the national phase

Ref country code: JP

Ref document number: 2000 596849

Kind code of ref document: A

Format of ref document f/p: F

ENP Entry into the national phase

Ref document number: 2360904

Country of ref document: CA

Ref country code: CA

Ref document number: 2360904

Kind code of ref document: A

Format of ref document f/p: F

WWE Wipo information: entry into national phase

Ref document number: 09920730

Country of ref document: US

WWP Wipo information: published in national office

Ref document number: 1999900870

Country of ref document: EP

WWG Wipo information: grant in national office

Ref document number: 20446/99

Country of ref document: AU

WWR Wipo information: refused in national office

Ref document number: 1999900870

Country of ref document: EP

WWW Wipo information: withdrawn in national office

Ref document number: 1999900870

Country of ref document: EP