[go: up one dir, main page]

WO2000044425A1 - Distributeur - Google Patents

Distributeur Download PDF

Info

Publication number
WO2000044425A1
WO2000044425A1 PCT/EP1999/009735 EP9909735W WO0044425A1 WO 2000044425 A1 WO2000044425 A1 WO 2000044425A1 EP 9909735 W EP9909735 W EP 9909735W WO 0044425 A1 WO0044425 A1 WO 0044425A1
Authority
WO
WIPO (PCT)
Prior art keywords
housing
container
dispenser
actuation
dispenser according
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/EP1999/009735
Other languages
English (en)
Inventor
Stanley George Bonney
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Glaxo Group Ltd
Original Assignee
Glaxo Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd
Priority to AU30367/00A priority Critical patent/AU3036700A/en
Publication of WO2000044425A1 publication Critical patent/WO2000044425A1/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/009—Inhalators using medicine packages with incorporated spraying means, e.g. aerosol cans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M16/00—Devices for influencing the respiratory system of patients by gas treatment, e.g. ventilators; Tracheal tubes
    • A61M16/0003—Accessories therefor, e.g. sensors, vibrators, negative pressure
    • A61M2016/0015—Accessories therefor, e.g. sensors, vibrators, negative pressure inhalation detectors
    • A61M2016/0018—Accessories therefor, e.g. sensors, vibrators, negative pressure inhalation detectors electrical
    • A61M2016/0021—Accessories therefor, e.g. sensors, vibrators, negative pressure inhalation detectors electrical with a proportional output signal, e.g. from a thermistor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/33—Controlling, regulating or measuring
    • A61M2205/3306—Optical measuring means
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/50—General characteristics of the apparatus with microprocessors or computers

Definitions

  • the present invention relates to an actuation recorder for recording the actuation profile of an inhalation device.
  • the invention relates to an actuation recorder for use with a metered dose inhaler by means of which medicament contained in an aerosol container may be administered to a patient.
  • medicaments contained in an aerosol for example, in bronchodilator therapy. It is also known to use for such therapy, medicaments which are contained in an aerosol and are administered to a patient by means of an inhalation device comprising a tubular housing or sleeve in which the aerosol container is located and an outlet tube leading out of the tubular housing.
  • the aerosol containers used in such inhalation devices are designed to deliver a predetermined dose of medicament upon each actuation by means of an outlet valve member at one end which can be opened either by depressing the valve member while the container is held stationary or by depressing the container while the valve member is held stationary.
  • the aerosol container is placed in the tubular housing with the outlet valve member of the container communicating via a support with the outlet tube, for example a nozzle or mouthpiece.
  • the housing is then held by the patient in a more or less upright condition and the mouthpiece or nozzle of the inhalation device is placed in the mouth or nose of the patient.
  • the aerosol container is pressed towards the support to dispense a dose of medicament from the container which is then inhaled by the patient.
  • customised inhalers or apparatus incorporating or connected to various means for providing the patient with information about their correct (or incorrect) usage of the inhaler.
  • customised inhalers or apparatus include the inhaler described in W093/12823 which incorporates various sensors and microprocessors; the inhalation apparatus described at US- A-4,495,944 which includes various visual indicators to guide the patient; the biofeedback and training evaluation system described at US-A-4,984,158; and the apparatus and visual display method described at US-A-5, 333,106.
  • a disadvantage associated with' the use of such customised inhalers and apparatus is that the patient is trained with this customised equipment but then takes home and uses a standard inhalation device which is likely to have different shape, size, look and feel characteristics. In essence, therefore, the training system trains the patient to use the customised equipment rather than the inhalation device that will be taken home for everyday use.
  • a dispenser for dispensing medicament comprising a housing; locatable within said housing, a container having an outlet member, wherein said container is movable relative to the housing to enable dispensing therefrom; and an actuation indicator for detecting movement of the container relative to the housing, wherein said actuation indicator is on a carrier sleeve which is mountable on the exterior of the housing and separable therefrom; with the proviso that the actuation indicator is not an inductive displacement transducer including one or more inductive elements, wherein said container is comprised of, or has attached thereto a component comprised of, a material capable of disturbing the magnetic field creatable by the flow of electric current in said one or more inductive elements.
  • the housing has a tubular portion
  • the container is movable within said tubular portion and said carrier sleeve is shaped for receipt by the tubular portion.
  • the carrier sleeve is snugly receivable by the tubular portion of the housing.
  • both ends of the carrier sleeve are open.
  • the first end opening enables mounting of the sleeve on the tubular portion.
  • the second end opening enables the user to access the container for movement relative to the housing.
  • one or more guide elements are provided to the tubular portion and/or the carrier sleeve to guide the receipt of the carrier sleeve by the tubular portion.
  • the guide elements may for example, be mechanical guides such as tongue and groove arrangements.
  • the guide elements may also for example, be visual guides such as colour coding arrangements.
  • a first end of the tubular portion has a lip to prevent over-receipt of the carrier sleeve.
  • the lip and the leading end of the carrier sleeve are shaped to be engagable.
  • the container is an aerosol container.
  • the dispenser as a whole is of the known metered dose inhaler type which delivers metered doses of medicament from a pressurised aerosol canister.
  • the container is not in physical contact with, or mechanically coupled to, the actuation indicator.
  • the movement of the container relative to the housing is thus, detected by a non-contact sensing technique.
  • the actuation indicator detects the movement of the container relative to the housing by means of a sensing technique selected from the group consisting of optical sensing, magnetic sensing or sensing using detection of capacitative effects.
  • Optical sensing may be used to detect movement of the container relative to the housing by providing the container with a patterned outer surface, for example strips in a barcode type arrangement, and locating an optical sensor on the housing so that it points towards the patterned surface. Movement of the container relative to the housing alters the amount of the light source which reflects back into the optical sensor as the beam passes over the patterned surface. The strips may be arranged so that the direction of movement of the container can be detected.
  • Magnetic sensing may be used to detect the movement of the container relative to the housing by the use of a magnetic switch device.
  • a reader is located on the sleeve and magnetic material positioned on the outer surface of the container. Movement of the can relative to the housing results in interruption of the magnetic signal of the magnetic material.
  • a hall effect device can be used whereby a semiconductor measures the strength of the magnetic field of the magnetic material on the container.
  • Detection of capactitative effects may be used to detect movement of the container by adding a conductive sleeve to the housing. On actuation of the dispenser, movement of the container relative to the conductive sleeve results in a change in capacitance which can be measured.
  • the housing is provided with an outlet, preferably in the form of a mouthpiece.
  • the dispenser comprises a passage through which dispensed doses may pass from the container to said outlet.
  • the container provides measured doses.
  • the dispenser additionally comprises a tube connectable to a pressure transducer for measurement of pressure within the housing.
  • the dispenser is actuable in response to the inward breath of a user.
  • a system for training users in the operation of a dispenser comprising a dispenser as described hereinabove in communication with a visual display unit capable of visually indicating actuation.
  • an actuation indicating device for use with a dispenser comprising a housing and a container which is movable relative to said housing, said actuation indicating device comprising a carrier sleeve which is mountable on the exterior of the housing of the dispenser and separable therefrom; and on said carrier sleeve, an actuation indicator for detecting movement of the container relative to the housing; with the proviso that the actuation indicator is not an inductive displacement transducer including one or more inductive elements, wherein said container is comprised of, or has attached thereto a component comprised of, a material capable of disturbing the magnetic field creatable by the flow of electric current in said one or more inductive elements.
  • the actuation indicator detects the movement of the container relative to the housing by means of a sensing technique selected from the group consisting of optical sensing, magnetic sensing and sensing using detection of capacitative effects. Examples of the use of these sensing techniques are provided above.
  • a tube connectable to a pressure transducer is provided to the carrier sleeve.
  • the actuation indicating device and dispenser is suppliable as a kit of parts.
  • the dispenser is used for dispensing medicament.
  • Fig. 1 is a sectional view of a known dispensing device
  • Fig. 2 is a side view of a kit of parts comprising a standard metered dose inhaler and an actuation indicating device in accord with the present invention
  • Fig. 3 is a side view of the assembled kit of parts of Fig. 2.
  • Fig. 4 is a schematic representation of a- system in accord with the present invention.
  • Fig. 5 is a perspective view of a training system in accord with the present invention.
  • the standard metered dose inhaler shown in Fig 1 comprises a tubular housing 1 in which an aerosol container 2 can be located.
  • the housing is open at one end (which will hereinafter be considered to be the top of the device for convenience of description) and is closed at the other.
  • An outlet 3 leads laterally from the closed end of the housing 1.
  • the outlet 3 is in the form of a mouthpiece intended for insertion into the mouth of the patient but it may, if desired, be designed as a nozzle for insertion into the patient's nostril.
  • the aerosol container 2 has an outlet valve stem 4 at one end.
  • This valve member can be depressed to release a measured dose from the aerosol container or, alternatively, the valve stem 4 can be fixed and the main body of the container can be moved relative to the valve member to release the dose.
  • the aerosol container 2 is located in the housing 1 so that one end protrudes from its open top. Spacer ribs (not shown) may be provided inside the housing to hold the external surface of the container 2 spaced from the internal surface of the housing 1.
  • a support 5 is provided at the lower end of the housing 1 and has a passage 6 in which the valve stem 4 of the aerosol container 2 can be located and supported.
  • a second passage 7 is provided in the support 5 and is directed towards the interior of the outlet 3.
  • the protruding portion of the aerosol container 2 can be depressed to move the container relative to the valve stem 4 to open the valve and a dose of medicament contained in the aerosol will be discharged through the passage 7 and into the outlet 3 from which it can be inhaled by a patient.
  • One dose will be released from the aerosol container each time it is fully depressed.
  • Fig. 2 shows a kit of parts comprising a standard metered dose dispenser (essentially identical to that shown in Fig. 1 ) and an actuation indicating device in accord with the present invention.
  • the metered dose inhaler comprises a tubular housing 101 containing an aerosol container 102 and having an outlet 103 in the form of a mouthpiece.
  • a lip 108 is provided to the exterior of the tubular housing 101 at the end of the tubular housing 101 which is closest to the outlet 103.
  • the actuation indicating device is seen to comprise a hollow tubular sleeve 110, which is sized and shaped to be Snugly receivable by the exterior of the tubular housing 101 of the dispenser. In the received position it may be seen that the leading end 112 of the sleeve 110 abuts the lip 108 on the exterior of the housing 101. In an improvement herein the leading end 112 of the sleeve 110 and the lip 108 are shaped for ease of engagement with each other.
  • the sleeve 110 is provided with an inductive element in the form of coil 120, which is tightly wrapped therearound.
  • the inductive coil 120 is connectable as the inductive element in an electronic oscillator (not shown).
  • the sleeve is also provided with a flexible tube 130, which is connectable to means for the measurement of pressure profile.
  • the inductive coil 120 uses inductance to measure the position of the container relative to the housing. Since the inductive coil 120 measures the relative proximity of the container 102 to the housing 101 it may also be thought of as an inductive proximity detector.
  • Fig. 3 shows the kit of parts of Fig. 2 in assembled form.
  • the aerosol container 102 On actuation of the dispenser, the aerosol container 102 is moved relative to the housing 101 and hence relative to the inductive coil 120. This movement is detectable by the inductive coil 120 since it causes a change in the inductance of the coil such that the circuit oscillates at a different frequency.
  • the actuation indicating devices of Fig 2 and Fig 3 are also provided with a first tube 130 positioned within the mouthpiece 103 wherein the first tube 130 is connectable to a first pressure transducer (not shown) for the measurement of pressure drop thereacross and hence, enabling measurement of airflow as the patient inhales.
  • the first pressure transducer relies for measurement on the use of the housing 101 and aerosol container 102 as a resistance element and deriving the pressure across this resistance as the patient inhales.
  • a second tube may also be provided to the devices of Fig 2 and Fig 3 for the measurement by connection to a second pressure transducer (not shown) of the pressure profile on propelled release of medicament from the aerosol container 102. Subtracting therefrom the profile obtained from the first pressure transducer allows for the provision, of a flat baseline for the release profile even in the presence of a pressure fluctuations resulting from the patients inhalation through the mouthpiece 103.
  • a differential pressure sensor could be used to subtract one pressure measurement from the other.
  • the inductive coil 120 and pressure transducers are each connectable to processing circuitry, which in turn is connectable to electronic computation or information storage means.
  • a typical system is represented schematically in Fig 4.
  • FIG. 5 shows a suitable training system in which the dispenser is connected to processing means 140.
  • the processing means 140 are in turn connected to a visual display unit 150 having a display screen 160 on which are represented traces for the release 162, inhalation 164 and actuation 166 profiles.
  • the dispenser of the invention is suitable for dispensing medicament, particularly for the treatment of respiratory disorders.
  • Appropriate medicaments may thus be selected from, for example, analgesics, e.g., codeine, dihydromorphine, ergotamine, fentanyl or morphine; anginal preparations, e.g., diltiazem; antiallergics, e.g., cromoglycate, ketotifen or nedocromil; antiinfectives e.g., cephalosporins, penicillins, streptomycin, sulphonamides, tetracyclines and pentamidine; antihistamines, e.g., methapyrilene; anti- inflammatories, e.g., beclomethasone dipropionate, fluticasone propionate, flunisolide, budesonide, rofleponide, mometasone furoate or triamcinolone
  • the medicaments may be used in the form of salts, (e.g., as alkali metal or amine salts or as acid addition salts) or as esters (e.g., lower alkyl esters) or as solvates (e.g., hydrates) to optimise the activity and/or stability of the medicament.
  • salts e.g., as alkali metal or amine salts or as acid addition salts
  • esters e.g., lower alkyl esters
  • solvates e.g., hydrates
  • Preferred medicaments are selected from albuterol, salmeterol, fluticasone propionate and beclomethasone dipropionate and salts or solvates thereof, e.g., the sulphate of albuterol and the xinafoate of salmeterol.
  • Medicaments can also be delivered in combinations.
  • Preferred formulations containing combinations of active ingredients contain salbutamol (e.g., as the free base or the sulphate salt) or salmeterol (e.g., as the xinafoate salt) in combination with an anti-inflammatory steroid such as a beclomethasone ester (e.g., the dipropionate) or a fluticasone ester (e.g., the propionate).
  • an anti-inflammatory steroid such as a beclomethasone ester (e.g., the dipropionate) or a fluticasone ester (e.g., the propionate).

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Containers And Packaging Bodies Having A Special Means To Remove Contents (AREA)

Abstract

L'invention concerne un distributeur de médicaments comprenant un logement (101). C logement (101) peut recevoir un récipient (102) équipé d'un système (103) de distribution. Le récipient (102) peut être déplacé par rapport au logement ce qui entraîne la distribution du contenant. Le distributeur comprend en outre et un indicateur (120) d'actionnement qui détecte le mouvement du récipient (102) par rapport au logement (101). L'indicateur (120) d'actionnement est monté sur un manchon (110) de support, ce dernier pouvant être fixé de manière amovible sur l'extérieur du logement (101). La restriction suivante s'applique concernant l'indicateur (120) : l'indicateur (120) ne doit pas être un capteur de déplacement à noyau inductif comprenant un ou plusieurs éléments inductifs. Le récipient (102) est constitué d'un élément en matériau capable de perturber le champ magnétique pouvant être créé par le courant électrique qui passe dans un ou plusieurs éléments inductifs, ou comprend un tel matériau. L'invention concerne également un système de formation permettant d'apprendre aux patients à utiliser ce distributeur.
PCT/EP1999/009735 1999-01-30 1999-12-10 Distributeur Ceased WO2000044425A1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU30367/00A AU3036700A (en) 1999-01-30 1999-12-10 Dispenser

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB9901988.7A GB9901988D0 (en) 1999-01-30 1999-01-30 Dispenser
GB9901988.7 1999-01-30

Publications (1)

Publication Number Publication Date
WO2000044425A1 true WO2000044425A1 (fr) 2000-08-03

Family

ID=10846732

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP1999/009735 Ceased WO2000044425A1 (fr) 1999-01-30 1999-12-10 Distributeur

Country Status (3)

Country Link
AU (1) AU3036700A (fr)
GB (1) GB9901988D0 (fr)
WO (1) WO2000044425A1 (fr)

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0448204A1 (fr) * 1990-02-20 1991-09-25 Pauline L. Dessertine Inhalateur avec compteur et minuterie
WO1992017231A1 (fr) * 1991-03-28 1992-10-15 Innomed, Inc. Inhalateur microelectronique possedant un compteur et un minuteur
US5411173A (en) * 1993-12-17 1995-05-02 Weinstein; Albert Counter attachment for product dispensers
EP0684047A2 (fr) * 1994-05-26 1995-11-29 William F. Walker Appareil de distribution de médicaments
US5544647A (en) * 1994-11-29 1996-08-13 Iep Group, Inc. Metered dose inhalator

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0448204A1 (fr) * 1990-02-20 1991-09-25 Pauline L. Dessertine Inhalateur avec compteur et minuterie
WO1992017231A1 (fr) * 1991-03-28 1992-10-15 Innomed, Inc. Inhalateur microelectronique possedant un compteur et un minuteur
US5411173A (en) * 1993-12-17 1995-05-02 Weinstein; Albert Counter attachment for product dispensers
EP0684047A2 (fr) * 1994-05-26 1995-11-29 William F. Walker Appareil de distribution de médicaments
US5544647A (en) * 1994-11-29 1996-08-13 Iep Group, Inc. Metered dose inhalator

Also Published As

Publication number Publication date
AU3036700A (en) 2000-08-18
GB9901988D0 (en) 1999-03-17

Similar Documents

Publication Publication Date Title
US6651651B1 (en) Dispenser
US6752145B1 (en) Medication dispenser
US6474331B1 (en) Dispenser with doses' counter
EP1255580B1 (fr) Boitier pour inhalateur
EP1159020B1 (fr) Systeme d'apport de medicament
EP1115443B1 (fr) Appareil inhalateur
CA2486894C (fr) Generateur d'aerosol et distributeur muni d'un indicateur de doses
WO2000044425A1 (fr) Distributeur

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A1

Designated state(s): AE AL AM AT AU AZ BA BB BG BR BY CA CH CN CR CU CZ DE DK DM EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX NO NZ PL PT RO RU SD SE SG SI SK SL TJ TM TR TT TZ UA UG US UZ VN YU ZA ZW

AL Designated countries for regional patents

Kind code of ref document: A1

Designated state(s): GH GM KE LS MW SD SL SZ TZ UG ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE BF BJ CF CG CI CM GA GN GW ML MR NE SN TD TG

DFPE Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101)
121 Ep: the epo has been informed by wipo that ep was designated in this application
REG Reference to national code

Ref country code: DE

Ref legal event code: 8642

122 Ep: pct application non-entry in european phase