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WO2000044285A1 - Dispositif d'extraction de tissu en surface, en particulier pour les biopsies - Google Patents

Dispositif d'extraction de tissu en surface, en particulier pour les biopsies Download PDF

Info

Publication number
WO2000044285A1
WO2000044285A1 PCT/GB2000/000177 GB0000177W WO0044285A1 WO 2000044285 A1 WO2000044285 A1 WO 2000044285A1 GB 0000177 W GB0000177 W GB 0000177W WO 0044285 A1 WO0044285 A1 WO 0044285A1
Authority
WO
WIPO (PCT)
Prior art keywords
recesses
core
biopsies
cutting head
sheath
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/GB2000/000177
Other languages
English (en)
Inventor
Charles Alexander Mosse
Christopher Paul Swain
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University College London
Original Assignee
University College London
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University College London filed Critical University College London
Priority to JP2000595592A priority Critical patent/JP2002535063A/ja
Priority to AU30665/00A priority patent/AU3066500A/en
Priority to EP00900743A priority patent/EP1148818A1/fr
Publication of WO2000044285A1 publication Critical patent/WO2000044285A1/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B10/00—Instruments for taking body samples for diagnostic purposes; Other methods or instruments for diagnosis, e.g. for vaccination diagnosis, sex determination or ovulation-period determination; Throat striking implements
    • A61B10/02—Instruments for taking cell samples or for biopsy
    • A61B10/04—Endoscopic instruments, e.g. catheter-type instruments
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B10/00—Instruments for taking body samples for diagnostic purposes; Other methods or instruments for diagnosis, e.g. for vaccination diagnosis, sex determination or ovulation-period determination; Throat striking implements
    • A61B10/02—Instruments for taking cell samples or for biopsy
    • A61B10/0233—Pointed or sharp biopsy instruments
    • A61B10/0266—Pointed or sharp biopsy instruments means for severing sample
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B10/00—Instruments for taking body samples for diagnostic purposes; Other methods or instruments for diagnosis, e.g. for vaccination diagnosis, sex determination or ovulation-period determination; Throat striking implements
    • A61B10/02—Instruments for taking cell samples or for biopsy
    • A61B10/0233—Pointed or sharp biopsy instruments
    • A61B10/0283—Pointed or sharp biopsy instruments with vacuum aspiration, e.g. caused by retractable plunger or by connected syringe
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods
    • A61B17/32—Surgical cutting instruments
    • A61B17/3205—Excision instruments
    • A61B17/3207—Atherectomy devices working by cutting or abrading; Similar devices specially adapted for non-vascular obstructions
    • A61B17/320783—Atherectomy devices working by cutting or abrading; Similar devices specially adapted for non-vascular obstructions through side-hole, e.g. sliding or rotating cutter inside catheter
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B10/00—Instruments for taking body samples for diagnostic purposes; Other methods or instruments for diagnosis, e.g. for vaccination diagnosis, sex determination or ovulation-period determination; Throat striking implements
    • A61B10/02—Instruments for taking cell samples or for biopsy
    • A61B2010/0225—Instruments for taking cell samples or for biopsy for taking multiple samples
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods
    • A61B17/30—Surgical pincettes, i.e. surgical tweezers without pivotal connections
    • A61B2017/306—Surgical pincettes, i.e. surgical tweezers without pivotal connections holding by means of suction

Definitions

  • This invention relates to a device for taking biopsies and is particularly concerned with a device for taking a plurality of biopsies, more particularly for taking a plurality of biopsies from patients with Barrett's oesophagus.
  • Barrett's oesophagus is a pre-malignant condition in which specialized intestinal metaplasia occurs in gastric mucosa which has developed in the oesophagus, usually as a result of chronic gastro-oesophageal reflux disease.
  • the incidence of cancer in patients with Barrett's oesophagus is about 10%.
  • Segments of Barrett's oesophagus may extend from 3 to 10 centimetres or more above the gastro- oesophageal junction. Segments of Barrett's oesophagus shorter than 3 cms used to be regarded as a normal finding at endoscopy but probably also have a risk of progression to cancer. It has been recommended that biopsies are taken from four quadrants of Barrett's oesophagus at either 1 or 2 centimetre intervals on alternate years for histological assessment to look for changes such as dysplasia which may predict or indicate the development of cancer.
  • Devices for taking a plurality of biopsies, but none of these enables the locations from which the biopsies have come to be reliably related to the biopsies themselves, and none enables a plurality of biopsies to be taken simultaneously.
  • Such known devices are described, for example, in US Patents 4651753 and 5601585.
  • a device for taking biopsies which comprises a cutting head having a surface in which are defined a plurality of recesses, means for communicating suction to the recesses to draw tissue therein, and means for severing the drawn in tissue to form biopsies each of which is held in a respective recess.
  • the device according to the invention can be used to take multiple biopsies from the oesophagus in an oriented fashion, and retain the biopsies in their orientation so that the pathologist can examine these in a numbered sequence which relates to the pathology, e.g. with the first biopsy coming from the lowest margin of the Barrett's segment oriented at 12 o'clock and with the other biopsies being related precisely to the orientation of the biopsy position.
  • the cutting head comprises a core which includes the recesses for holding the biopsies and an outer sheath which includes a plurality of openings for cooperation with the recesses, the core and the sheath being axially slidable with respect to each other to perform the severing operation.
  • Figure 1 is a perspective view of one embodiment of the device
  • Figure 2 shows schematically one form of cutting head for use in the device and the components making up the head
  • Figure 3a and 3b show in greater detail the cutting head of Figure 2, in longitudinal section, before and after taking biopsies, respectively;
  • Figure 4 shows another form of cutting head for use in the device
  • Figure 5 shows a further form of cutting head for use in the device, and the components making up the device
  • Figure 6 shows, in a cutaway view, a component of which a plurality can be assembled to make a complete cutting head.
  • the device comprises a cutting head 1, having a plurality of recesses 2 in its surface.
  • the illustrated device is one which has four longitudinally extending rows of recesses, with four recesses in each row, i.e. sixteen recesses in all, with the recesses in each row being aligned axially with the corresponding recesses in the other rows.
  • other patterns can be used, involving more or fewer recesses, and either aligned or offset with respect to one another.
  • one end of the cutting head which forms its proximal end, is attached to the distal end of a wire/sheath cable 3, commonly known as a Bowden cable.
  • the proximal end of the cable 3 is connected to a handle 5 which is operated in basically the same way as the handle of a bicycle brake (which also employs a Bowden cable).
  • An additional hollow tube 6 may be mounted on the handle 5 to provide a storage receptacle for the cutting head when it is not in use.
  • the proximal end of the cutting head is also connected to a tube 4 for carrying suction to the head.
  • the suction could be conveyed through the Bowden cable, using the region between the wire and the sheath.
  • the distal end of the cutting head 1 may be fitted with a resiliently flexible guide member 7 to assist in guiding the head when it is inserted in the patient's body.
  • FIG 2 shows schematically one embodiment of cutting head.
  • Fig. 2a The complete head 11 is shown in Fig. 2a, the head 11 with the outer tube 13 removed to reveal the core 12 is shown in Fig. 2b (Fig. 2c is a cross-section through the core).
  • Fig. 2d The outer tube 13 of the head is shown in Fig. 2d, and Fig. 2e shows an optional split sleeve 14
  • FIG. 2f is a cross-section through the sleeve of Fig. 2e).
  • the main body of the core 12 is generally tubular in form, and may be of metal, preferably stainless steel or brass. Typically, the core has an outside diameter of 14mm.
  • the core has a plurality of parallel longitudinally extending rows of recesses 15 in the surface thereof, the particular example here having four rows disposed at 90° intervals around the circumference of the core, each row consisting of four recesses of circular cross- section.
  • a longitudinal suction passage 16 runs along the centre line of the core 12, and the base of each recess communicates with it via a respective radial passage 17. Whereas the diameter d r of the recesses at their outer surfaces is about 4 to 6mm, the diameter of the passage is about 1mm. The reason for this difference will be apparent from the following description.
  • a further longitudinal passage 18 runs through the core to enable it to be threaded on a guide wire.
  • the passage 18 is defined by a conduit running coaxially within the suction passage 16.
  • the core 12 has a tapered cone 19, to which is attached a guide member (not shown), similar or identical to the guide member 7 shown in Figure 1 and which plugs into a recess 21.
  • the head 11 has a connector 20 to enable it to be connected to the wire of Bowden cable (or other control mechanism) and (if provided in addition) a suction tube.
  • the outer tube 13 is sized to be a tight but sliding fit on the main body of the core 12, and is preferably of metal, preferably of stainless steel.
  • a plurality of openings 21 extend through the wall of the tube, and are so disposed that each can be aligned with a respective recess 15 in the core 12. As illustrated, the openings are somewhat smaller than the recesses, being typically from 3 to 5mm in diameter d 0 .
  • the outer tube may be coated externally with polytetrafluoroethylene (PTFE) to ease its insertion into the oesophagus.
  • PTFE polytetrafluoroethylene
  • the assembly comprises a compression spring 30, shown in Fig. 2b.
  • This serves to bias the core 12 in a direction away from the connector 20 and towards the cone 19, so that the openings 21 in the outer tube 13 are aligned with the recesses 15 in the core 12.
  • the spring 30 also keeps the Bowden cable in tension.
  • a mechanism such as a key-way is provided (but not shown) for ensuring circumferential alignment of core 12 and tube 13.
  • an eccentric bore may run longitudinally through the core, and a rod projecting from the cone may then pass through the bore to provide circumferential alignment.
  • the wire 32 of the Bowden cable is secured to the core 12 to enable control of the relative positions of the core 12 and tube 13.
  • the head In operation of the device, with the head 11, the head is introduced into the oesophagus by threading a previously introduced guide wire, extending out of the patient's mouth, through the passage 18, and pushing it to the desired position using the Bowden cable 3. Accurate positioning of the device is achieved using an endoscope or x-ray imaging. In its contracted condition the oesophagus is of relatively narrow diameter, and the external diameter of the outer tube is such that it is in contact with the wall of the oesophagus over most of the surface of the outer tube. Suction is then applied to the head, and this is transmitted via the longitudinal suction passage 16 and the radial passages 17 to the recesses 15 and in the core 12 and the openings 21 in the outer tube 13.
  • the recesses 15 and openings 21 are aligned with one another.
  • the suction draws into each recess a piece of the tissue nearest the surface of the oesophagus, namely the mucosa and submucosa.
  • the recesses are made sufficiently shallow that deep muscle tissue is not drawn in.
  • the handle is then used to operate the Bowden cable, causing the core 12 to move longitudinally relative to the outer tube 13 towards the connector 20. This takes the openings 21 out of alignment with the recesses 15, and the resulting shearing action severs the drawn-in tissue portions from the remainder of the oesophagus, so giving one biopsy in each recess.
  • the core 12 is then kept in this new position, so that the biopsies remain securely in the recesses.
  • the head is then withdrawn from the patient's body.
  • the outer tube is moved back to its original position and the biopsies are then transferred from the cutting head for examination.
  • This transfer should be effected in such a way as to retain the information which their position in particular recesses provides, as to whereabouts in the oesophagus each came from. This can be achieved, or assisted, in various ways.
  • the split sleeve 40 shown in Figs. 2e and 2f can be slid over the outer tube before the removal procedure starts, to cover up three of the four rows of recesses. Each row of biopsies can then be removed, and appropriately labelled, separately.
  • Another possibility is to wrap around the outer tube a piece of absorbent paper or similar material, for example cellulose acetate, hold it in place, for example, using a clam-shell design of clamp, and then apply a blowing action, in place of suction, in the longitudinal passage 16 to transfer the biopsies to the paper.
  • a device may be provided for insertion inside the cutting head to push the biopsies out.
  • the paper can be pre-marked with indicia so that each biopsy is located next to a respective indicium.
  • the head 11 is shown in greater detail in cross section.
  • the same reference numerals are used as in Fig. 2.
  • the wire 32 of the Bowden cable is connected to core 12 and the sheath 34 is connected via the connector 20 to the outer tube 13.
  • Suction is provided to the suction passage 16 by a suction tube 40.
  • a conduit 36 running within the suction passage 16 provides the passage 18 through which a guide wire can be threaded.
  • the conduit 36 comprises part of the cone 19 and is a tight fit in the hole in the connector 20, and grease may be added to further ensure that suction is not lost past the outside of the conduit.
  • the force required to move the core 12 relative to the outer tube 13 is provided by the Bowden cable.
  • it could alternatively be provided by other means, such as a pre-loaded spring or an hydraulic piston.
  • Figure 4 shows an alternative arrangement for the head 11 in which the outer tube 13 is slidably received over the core 12, so that the core 12 remains stationary with respect to the connector 20 and the cone 19. Furthermore, the force for movement of the outer tube 13 is provided by a pre-compressed spring 30a, shown as a spring washer in Figure 4.
  • a detent pin 31 is released to enable the stored energy in the spring 30a to provide movement of the outer tube 13 into a new position (not shown) in which the openings 21 are out of alignment with the recesses 15.
  • the detent pin 31 may be released using the Bowden cable, or another arrangement which may enable the Bowden cable to be omitted.
  • FIG. 5 A further alternative form of cutting head is shown in Figure 5. In most respects it is the same as that of Figure 2, and so will not be described here in detail. Integers in Figure 5 corresponding to integers of Fig. 2 are again denoted by the same reference numerals, but with the addition of 100. The difference is that rather than relying on a shearing action to sever the biopsies, the core is provided with blades 50 each held in a respective groove 51. The cross-section of Fig. 5c shows a blade 50 in one of the grooves 51. In practice, there would, of course, be blades in all of them.
  • the device of Figure 5 achieves its cutting action by having the core 112 and tube 113 rotate with respect to one another rather than move longitudinally.
  • these two components are rotationally biassed with respect to one another by a torsion spring and relative movement occurs in response to operation of a trigger.
  • the cutting head used in the present invention may be made sterilisable for reuse, though preferably it is disposable, since sterilising such cables may be difficult.
  • An important feature of the present invention is the ability to take a number of biopsies simultaneously whose position relative to one another in the oesophagus is known.
  • the outer sheath of the Bowden cable it is desirable for the outer sheath of the Bowden cable to be relatively stiff as regards torque transmission, whilst remaining flexible in terms of its ability to bend. Techniques for achieving this are known in the field of endoscopes, involving winding two helical coils, of opposite hand, around the endoscope, and these techniques can be employed here.
  • Orientation can be assisted by inserting a mouth guard between the patient's teeth, the guard having a mark on it for alignment with a line extending along the length of the Bowden cable parallel to its longitudinal axis.
  • the cutting head can be provided with a marker, for example, a coloured arrow, which can be oriented to line up with the arrow normally provided in the viewing window of an endoscope.
  • the device is described above on the basis that it would be used in front of a conventional endoscope.
  • an alternative possibility would be for the cutting head and Bowden cable to be small enough to pass through a large channel endoscope.
  • Another possibility would be to make the device annular so that it could fit over an endoscope.
  • each section can be made entirely of plastic, except for the blades.
  • each section comprises an annular blade 60 held in a mounting 61. Openings 62 are defined in the mounting which form the recesses into which the samples are drawn. The sections are bonded together to form the core.
  • Each opening 62 has a wide part 62a corresponding to the recesses 15 in the embodiments described with reference to Figures 2 to 4, and a narrow part 62b corresponding to the passage 17. The narrow part 62b allows suction of tissue.
  • the device of the invention could be used for other purposes, for example, shaving off the mucosa from a section of the oesophagus.

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  • Health & Medical Sciences (AREA)
  • Surgery (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pathology (AREA)
  • Radiology & Medical Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medical Informatics (AREA)
  • Molecular Biology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Surgical Instruments (AREA)

Abstract

L'invention concerne un dispositif à biopsies, qui comprend une tête de découpe (1) présentant une surface sur laquelle sont définies une pluralité de renfoncements (2). Par une succion intervenant dans ces renfoncements, le tissu est aspiré puis découpé sous forme de biopsies, chacune dans son renfoncement respectif (2). La découpe est effectuée par un mouvement relatif entre le coeur interne (12) et le manchon externe (13) de la tête de découpe (1).
PCT/GB2000/000177 1999-01-29 2000-01-24 Dispositif d'extraction de tissu en surface, en particulier pour les biopsies Ceased WO2000044285A1 (fr)

Priority Applications (3)

Application Number Priority Date Filing Date Title
JP2000595592A JP2002535063A (ja) 1999-01-29 2000-01-24 特に生検用検体を採取するための、表面組織を除去する装置
AU30665/00A AU3066500A (en) 1999-01-29 2000-01-24 Device for removing surface tissue, in particular for taking biopsies
EP00900743A EP1148818A1 (fr) 1999-01-29 2000-01-24 Dispositif d'extraction de tissu en surface, en particulier pour les biopsies

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB9902045.5 1999-01-29
GBGB9902045.5A GB9902045D0 (en) 1999-01-29 1999-01-29 Device for removing surface tissue,in particular for taking biopsies

Publications (1)

Publication Number Publication Date
WO2000044285A1 true WO2000044285A1 (fr) 2000-08-03

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ID=10846772

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB2000/000177 Ceased WO2000044285A1 (fr) 1999-01-29 2000-01-24 Dispositif d'extraction de tissu en surface, en particulier pour les biopsies

Country Status (5)

Country Link
EP (1) EP1148818A1 (fr)
JP (1) JP2002535063A (fr)
AU (1) AU3066500A (fr)
GB (1) GB9902045D0 (fr)
WO (1) WO2000044285A1 (fr)

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002062230A1 (fr) * 2001-02-05 2002-08-15 Tyco Healthcare Group Lp Instrument et methode de biopsie
WO2003086198A1 (fr) * 2002-04-05 2003-10-23 Scimed Life Systems, Inc. Dispositif de biopsie multiple
WO2004010874A1 (fr) * 2002-07-26 2004-02-05 Brown Stuart B Dispositif d'echantillonnage de tissu et de fluide
WO2004016177A1 (fr) * 2002-08-15 2004-02-26 Scimed Life Systems, Inc. Appareil de biopsie multiple et procede d'utilisation associe
US20090143697A1 (en) * 2007-11-29 2009-06-04 Olympus Medical Systems Corp. Capsule medical device and body-tissue obtaining method
WO2010042214A1 (fr) * 2008-10-10 2010-04-15 Endogastric Solutions, Inc. Procédés et dispositifs de prélèvement d'échantillons multiples de biopsie de l'œsophage
US9375202B2 (en) 2012-05-04 2016-06-28 Given Imaging Ltd. Device and method for in vivo cytology acquisition

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2003535622A (ja) * 2000-05-09 2003-12-02 ユナイテッド ステーツ エンドスコピー グループ インコーポレイテッド バレット食道細胞学デバイス
JP5264921B2 (ja) * 2007-10-25 2013-08-14 エピトーム・フアーマシユーテイカルズ・リミテツド 組織分割生検針

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4454887A (en) * 1981-04-15 1984-06-19 Krueger Christian Medical instruments for introduction into the respiratory tract of a patient
US4651753A (en) 1984-10-12 1987-03-24 Jayco Pharmaceuticals Endoscopic multiple biopsy instrument
US5106364A (en) * 1989-07-07 1992-04-21 Kabushiki Kaisha Topcon Surgical cutter
US5409012A (en) * 1993-12-30 1995-04-25 Boston Scientific Corporation Sample collection using catheter with expandable member
US5458112A (en) * 1994-08-15 1995-10-17 Arrow Precision Products, Inc. Biliary biopsy device
WO1996024289A2 (fr) * 1995-02-10 1996-08-15 Biopsys Medical, Inc. Procedes et dispositifs de biopsie automatique et prelevement de tissu mou
US5601585A (en) 1994-02-08 1997-02-11 Boston Scientific Corporation Multi-motion side-cutting biopsy sampling device

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4454887A (en) * 1981-04-15 1984-06-19 Krueger Christian Medical instruments for introduction into the respiratory tract of a patient
US4651753A (en) 1984-10-12 1987-03-24 Jayco Pharmaceuticals Endoscopic multiple biopsy instrument
US5106364A (en) * 1989-07-07 1992-04-21 Kabushiki Kaisha Topcon Surgical cutter
US5409012A (en) * 1993-12-30 1995-04-25 Boston Scientific Corporation Sample collection using catheter with expandable member
US5601585A (en) 1994-02-08 1997-02-11 Boston Scientific Corporation Multi-motion side-cutting biopsy sampling device
US5458112A (en) * 1994-08-15 1995-10-17 Arrow Precision Products, Inc. Biliary biopsy device
WO1996024289A2 (fr) * 1995-02-10 1996-08-15 Biopsys Medical, Inc. Procedes et dispositifs de biopsie automatique et prelevement de tissu mou

Cited By (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002062230A1 (fr) * 2001-02-05 2002-08-15 Tyco Healthcare Group Lp Instrument et methode de biopsie
WO2003086198A1 (fr) * 2002-04-05 2003-10-23 Scimed Life Systems, Inc. Dispositif de biopsie multiple
US6858014B2 (en) 2002-04-05 2005-02-22 Scimed Life Systems, Inc. Multiple biopsy device
US7794409B2 (en) 2002-04-05 2010-09-14 Boston Scientific Scimed, Inc. Multiple biopsy device
US7740595B2 (en) 2002-07-26 2010-06-22 Stuart Brown Tissue and fluid sampling device
WO2004010874A1 (fr) * 2002-07-26 2004-02-05 Brown Stuart B Dispositif d'echantillonnage de tissu et de fluide
WO2004016177A1 (fr) * 2002-08-15 2004-02-26 Scimed Life Systems, Inc. Appareil de biopsie multiple et procede d'utilisation associe
US6986748B2 (en) 2002-08-15 2006-01-17 Scimed Life Systems, Inc. Multiple biopsy apparatus and related method of use
US7828745B2 (en) 2002-08-15 2010-11-09 Boston Scientific Scimed, Inc. Multiple biopsy apparatus and related method of use
US20110021949A1 (en) * 2002-08-15 2011-01-27 Boston Scientific Scimed, Inc. Multiple Biopsy Apparatus and Related Method of Use
US8262587B2 (en) 2002-08-15 2012-09-11 Boston Scientific Scimed, Inc. Multiple biopsy apparatus and related method of use
US20090143697A1 (en) * 2007-11-29 2009-06-04 Olympus Medical Systems Corp. Capsule medical device and body-tissue obtaining method
US8444572B2 (en) * 2007-11-29 2013-05-21 Olympus Medical Systems Corp. Capsule medical device and body-tissue obtaining method
WO2010042214A1 (fr) * 2008-10-10 2010-04-15 Endogastric Solutions, Inc. Procédés et dispositifs de prélèvement d'échantillons multiples de biopsie de l'œsophage
US9375202B2 (en) 2012-05-04 2016-06-28 Given Imaging Ltd. Device and method for in vivo cytology acquisition

Also Published As

Publication number Publication date
JP2002535063A (ja) 2002-10-22
GB9902045D0 (en) 1999-03-17
AU3066500A (en) 2000-08-18
EP1148818A1 (fr) 2001-10-31

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