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WO2000043750A3 - Imaging of tissue using polarized light - Google Patents

Imaging of tissue using polarized light Download PDF

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Publication number
WO2000043750A3
WO2000043750A3 PCT/US2000/001764 US0001764W WO0043750A3 WO 2000043750 A3 WO2000043750 A3 WO 2000043750A3 US 0001764 W US0001764 W US 0001764W WO 0043750 A3 WO0043750 A3 WO 0043750A3
Authority
WO
WIPO (PCT)
Prior art keywords
tissue
light
imaging
backscattered
polarized light
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2000/001764
Other languages
French (fr)
Other versions
WO2000043750A9 (en
WO2000043750A2 (en
Inventor
Stephen F Fulghum
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Newton Laboratories Inc
Original Assignee
Newton Laboratories Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to KR1020017009360A priority Critical patent/KR20010110346A/en
Priority to CA002371782A priority patent/CA2371782A1/en
Priority to AU26282/00A priority patent/AU2628200A/en
Priority to NZ513118A priority patent/NZ513118A/en
Priority to EP00904542A priority patent/EP1153280A2/en
Priority to JP2000595125A priority patent/JP2002535645A/en
Application filed by Newton Laboratories Inc filed Critical Newton Laboratories Inc
Priority to HK02103359.7A priority patent/HK1041727A1/en
Publication of WO2000043750A2 publication Critical patent/WO2000043750A2/en
Publication of WO2000043750A3 publication Critical patent/WO2000043750A3/en
Anticipated expiration legal-status Critical
Publication of WO2000043750A9 publication Critical patent/WO2000043750A9/en
Ceased legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B23/00—Telescopes, e.g. binoculars; Periscopes; Instruments for viewing the inside of hollow bodies; Viewfinders; Optical aiming or sighting devices
    • G02B23/24—Instruments or systems for viewing the inside of hollow bodies, e.g. fibrescopes
    • G02B23/2407—Optical details
    • G02B23/2461—Illumination
    • G02B23/2469—Illumination using optical fibres
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B1/00—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor
    • A61B1/00064—Constructional details of the endoscope body
    • A61B1/00071—Insertion part of the endoscope body
    • A61B1/0008—Insertion part of the endoscope body characterised by distal tip features
    • A61B1/00096—Optical elements
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B1/00—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor
    • A61B1/00064—Constructional details of the endoscope body
    • A61B1/00071—Insertion part of the endoscope body
    • A61B1/0008—Insertion part of the endoscope body characterised by distal tip features
    • A61B1/00097—Sensors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B1/00—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor
    • A61B1/00163—Optical arrangements
    • A61B1/00172—Optical arrangements with means for scanning
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B1/00—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor
    • A61B1/00163—Optical arrangements
    • A61B1/00186—Optical arrangements with imaging filters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
    • A61B5/0075—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence by spectroscopy, i.e. measuring spectra, e.g. Raman spectroscopy, infrared absorption spectroscopy
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B23/00—Telescopes, e.g. binoculars; Periscopes; Instruments for viewing the inside of hollow bodies; Viewfinders; Optical aiming or sighting devices
    • G02B23/24—Instruments or systems for viewing the inside of hollow bodies, e.g. fibrescopes
    • G02B23/2407—Optical details
    • G02B23/2423—Optical details of the distal end
    • G02B23/243—Objectives for endoscopes
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/47—Scattering, i.e. diffuse reflection
    • G01N2021/4704—Angular selective
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/47—Scattering, i.e. diffuse reflection
    • G01N2021/4792—Polarisation of scatter light
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/47—Scattering, i.e. diffuse reflection
    • G01N21/49—Scattering, i.e. diffuse reflection within a body or fluid

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Surgery (AREA)
  • General Health & Medical Sciences (AREA)
  • Optics & Photonics (AREA)
  • Pathology (AREA)
  • Biophysics (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Medical Informatics (AREA)
  • Molecular Biology (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Radiology & Medical Imaging (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Physics & Mathematics (AREA)
  • Astronomy & Astrophysics (AREA)
  • Analytical Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)
  • Endoscopes (AREA)
  • Eye Examination Apparatus (AREA)
  • Instruments For Viewing The Inside Of Hollow Bodies (AREA)

Abstract

The present invention relates to the differential detection of directly backscattered light from epithelial tissues in order to determine the cell nuclear size distribution for the purpose of detecting tissue dysplasia. Light directly backscattered from surface tissue is differentiated from the light backscattered from underlying tissue by means of polarization, angular distribution or both. Both point measurement embodiments and imaging embodiments are presented. Optical systems for delivery and collection of light include endoscopic and fiber optic systems.
PCT/US2000/001764 1999-01-25 2000-01-25 Imaging of tissue using polarized light Ceased WO2000043750A2 (en)

Priority Applications (7)

Application Number Priority Date Filing Date Title
CA002371782A CA2371782A1 (en) 1999-01-25 2000-01-25 Imaging of tissue using polarized light
AU26282/00A AU2628200A (en) 1999-01-25 2000-01-25 Imaging of tissue using polarized light
NZ513118A NZ513118A (en) 1999-01-25 2000-01-25 Imaging of a tissue by detecting polarized and unpolarized images to form a processed image of a region of interest
EP00904542A EP1153280A2 (en) 1999-01-25 2000-01-25 Imaging of tissue using polarized light
JP2000595125A JP2002535645A (en) 1999-01-25 2000-01-25 Imaging of tissue using polarized light
KR1020017009360A KR20010110346A (en) 1999-01-25 2000-01-25 Imaging of tissue using polarized light
HK02103359.7A HK1041727A1 (en) 1999-01-25 2000-01-25 Imaging of tissue using polarized light

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US11722199P 1999-01-25 1999-01-25
US60/117,221 1999-01-25

Publications (3)

Publication Number Publication Date
WO2000043750A2 WO2000043750A2 (en) 2000-07-27
WO2000043750A3 true WO2000043750A3 (en) 2000-11-23
WO2000043750A9 WO2000043750A9 (en) 2001-08-30

Family

ID=22371613

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2000/001764 Ceased WO2000043750A2 (en) 1999-01-25 2000-01-25 Imaging of tissue using polarized light

Country Status (9)

Country Link
EP (1) EP1153280A2 (en)
JP (1) JP2002535645A (en)
KR (1) KR20010110346A (en)
CN (1) CN1341209A (en)
AU (1) AU2628200A (en)
CA (1) CA2371782A1 (en)
HK (1) HK1041727A1 (en)
NZ (1) NZ513118A (en)
WO (1) WO2000043750A2 (en)

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WO2002018658A1 (en) * 2000-08-14 2002-03-07 Oralscan Laboratories, Inc. Detection of epithelial dysplasia
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WO2003062799A2 (en) * 2002-01-18 2003-07-31 Newton Laboratories, Inc. Spectroscopic diagnostic methods and system
EP1472517A1 (en) * 2002-01-18 2004-11-03 Newton Laboratories, Inc. Spectroscopic diagnostic methods and system
WO2003104775A1 (en) * 2002-06-08 2003-12-18 Korea Basic Science Institute Method for protein chip analysis by using surface plasmon resonance spectroscopic imaging technology
CN102749287B (en) * 2003-06-04 2015-08-19 广东永士达医疗科技有限公司 Utilize the optical heterogeneity in the communication mode measurement of species of light and other attributes
JP4535697B2 (en) * 2003-07-23 2010-09-01 オリンパス株式会社 Endoscope device for light scattering observation of biological tissue
CA2539184A1 (en) * 2003-09-19 2005-03-31 The General Hospital Corporation Fluorescence polarization imaging devices and methods
CN100443041C (en) * 2004-05-26 2008-12-17 吴冈 Endoscope system with measuring function and measuring method thereof
WO2007014213A2 (en) * 2005-07-25 2007-02-01 Massachusetts Institute Of Technology Tri modal spectroscopic imaging
WO2007044821A1 (en) * 2005-10-11 2007-04-19 Duke University Systems and method for endoscopic angle-resolved low coherence interferometry
DE602008006170D1 (en) * 2007-02-20 2011-05-26 Koninkl Philips Electronics Nv OPTICAL DEVICE FOR EVALUATING THE OPTICAL DEPTH OF A SAMPLE
US8374685B2 (en) * 2007-03-12 2013-02-12 Koninklijke Philips Electronics N.V. System, computer-readable medium, method, and use for combined epithelial early cancer diagnosis and staging
CN100506150C (en) * 2007-04-28 2009-07-01 马剑文 Living tissue optical detection device and working method thereof
DE202008009859U1 (en) * 2007-12-21 2009-03-05 Berthold Technologies Gmbh & Co. Kg Device for the optional measurement of in particular luminescence and / or fluorescence radiation
JP4575474B2 (en) * 2008-06-11 2010-11-04 国立大学法人東京工業大学 Biological tissue identification apparatus and method
KR101109968B1 (en) 2008-07-23 2012-02-17 올림푸스 메디칼 시스템즈 가부시키가이샤 Subject observation apparatus and subject observation method
JP2010025867A (en) * 2008-07-23 2010-02-04 Olympus Medical Systems Corp Subject observation apparatus and subject observation method
JP5191831B2 (en) * 2008-07-23 2013-05-08 オリンパスメディカルシステムズ株式会社 Subject observation device and method of operating subject observation device
WO2010064170A1 (en) * 2008-12-02 2010-06-10 Koninklijke Philips Electronics N.V. Sensor device for detecting target particles by frustrated total internal reflection
JP5532479B2 (en) * 2010-03-31 2014-06-25 住友化学株式会社 Mold inspection method, antiglare product haze prediction method, and antiglare product reflection image sharpness prediction method
WO2012057150A1 (en) * 2010-10-29 2012-05-03 オリンパス株式会社 Optical measurement device and probe
WO2013011778A1 (en) * 2011-07-15 2013-01-24 オリンパスメディカルシステムズ株式会社 Probe
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EP2822453B1 (en) 2012-03-08 2017-12-13 Koninklijke Philips N.V. Apparatus for determining a property of a tissue
JP6398093B2 (en) 2012-04-13 2018-10-03 ベイカー ハート アンド ダイアベーツ インスティテュート Detection of atherosclerotic plaque
EP2856921A4 (en) * 2012-05-25 2016-03-09 Olympus Corp Measuring probe
JP6173325B2 (en) * 2012-09-13 2017-08-02 オリンパス株式会社 Measuring probe and bio-optical measurement system
DE102012221527A1 (en) * 2012-11-26 2014-06-12 Heine Optotechnik Gmbh & Co Kg Optical diagnostic tool, particularly dermatoscope for investigating examination area of patient, has first polarizing filter unit downstream in illumination beam path of illumination unit in illuminating direction
AU2014257297B2 (en) 2013-04-21 2018-04-05 Mobileodt Ltd A polarized light imaging apparatus and methods thereof for separating light from a surface of a sample its deeper diffuse layers
CN104280350B (en) * 2013-07-03 2018-06-01 庞小峰 A kind of early diagnosis of cancer of special sharpening and the device of therapeutic effect inspection
KR101503272B1 (en) 2013-07-26 2015-03-18 연세대학교 원주산학협력단 Multi-modal imaging device for arthritis diagnosis
CN106725250A (en) * 2017-01-09 2017-05-31 清华大学深圳研究生院 Polarized imaging system and measuring method are peeped in a kind of head end modulation
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US5396329A (en) * 1987-01-23 1995-03-07 British Aerospace Plc Polarisation image detection systems
US5421339A (en) * 1993-05-12 1995-06-06 Board Of Regents, The University Of Texas System Diagnosis of dysplasia using laser induced fluoroescence
US5719399A (en) * 1995-12-18 1998-02-17 The Research Foundation Of City College Of New York Imaging and characterization of tissue based upon the preservation of polarized light transmitted therethrough
US5847394A (en) * 1995-12-18 1998-12-08 Research Foundation Of City College Of New York Imaging of objects based upon the polarization or depolarization of light

Also Published As

Publication number Publication date
CN1341209A (en) 2002-03-20
JP2002535645A (en) 2002-10-22
EP1153280A2 (en) 2001-11-14
WO2000043750A9 (en) 2001-08-30
AU2628200A (en) 2000-08-07
WO2000043750A2 (en) 2000-07-27
CA2371782A1 (en) 2000-07-27
KR20010110346A (en) 2001-12-13
NZ513118A (en) 2004-02-27
HK1041727A1 (en) 2002-07-19

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