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WO1999038980A3 - Tyrosylprotein sulfotransferase polypeptides and polynucleotides - Google Patents

Tyrosylprotein sulfotransferase polypeptides and polynucleotides Download PDF

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Publication number
WO1999038980A3
WO1999038980A3 PCT/US1999/001756 US9901756W WO9938980A3 WO 1999038980 A3 WO1999038980 A3 WO 1999038980A3 US 9901756 W US9901756 W US 9901756W WO 9938980 A3 WO9938980 A3 WO 9938980A3
Authority
WO
WIPO (PCT)
Prior art keywords
polynucleotides
polypeptides
enzyme
nucleic acids
expression system
Prior art date
Application number
PCT/US1999/001756
Other languages
French (fr)
Other versions
WO1999038980A2 (en
WO1999038980A9 (en
Inventor
Kevin L Moore
Original Assignee
Univ Oklahoma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US09/150,133 external-priority patent/US6060295A/en
Priority claimed from US09/150,141 external-priority patent/US6071732A/en
Application filed by Univ Oklahoma filed Critical Univ Oklahoma
Priority to EP99904344A priority Critical patent/EP1051499A2/en
Priority to AU24758/99A priority patent/AU2475899A/en
Priority to PCT/US1999/016750 priority patent/WO2000014250A1/en
Priority to AU52265/99A priority patent/AU5226599A/en
Publication of WO1999038980A2 publication Critical patent/WO1999038980A2/en
Publication of WO1999038980A9 publication Critical patent/WO1999038980A9/en
Publication of WO1999038980A3 publication Critical patent/WO1999038980A3/en
Priority to US11/336,497 priority patent/US7316912B2/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/13—Transferases (2.) transferring sulfur containing groups (2.8)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70596—Molecules with a "CD"-designation not provided for elsewhere
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/40—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/573—Immunoassay; Biospecific binding assay; Materials therefor for enzymes or isoenzymes

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Zoology (AREA)
  • Biomedical Technology (AREA)
  • Microbiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Urology & Nephrology (AREA)
  • Cell Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • Biotechnology (AREA)
  • Hematology (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Food Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Peptides Or Proteins (AREA)

Abstract

Tyrosylprotein sulfotransferases and nucleic acids encoding the tyrosylprotein sulfotransferases are described. Dual isotopes of the enzyme and of the nucleic acids encoding said enzymes have been identified in human, mouse and C. elegans. The polypeptides and polynucleotides exhibit a wide range of homologies. The polynucleotides can be used to transform or transfect host cells for producing substantially pure forms of the enzyme, or for use in an expression system for post-translational tyrosine sulfation of proteins or peptides produced within the expression system.
PCT/US1999/001756 1998-01-29 1999-01-28 Tyrosylprotein sulfotransferase polypeptides and polynucleotides WO1999038980A2 (en)

Priority Applications (5)

Application Number Priority Date Filing Date Title
EP99904344A EP1051499A2 (en) 1998-01-29 1999-01-28 Tyrosylprotein sulfotransferase polypeptides and polynucleotides
AU24758/99A AU2475899A (en) 1998-01-29 1999-01-28 Tyrosylprotein sulfotransferase polypeptides and polynucleotides
PCT/US1999/016750 WO2000014250A1 (en) 1998-09-09 1999-07-23 Tyrosylprotein sulfotransferase polypeptides and polynucleotides
AU52265/99A AU5226599A (en) 1998-09-09 1999-07-23 Tyrosylprotein sulfotransferase polypeptides and polynucleotides
US11/336,497 US7316912B2 (en) 1998-01-29 2006-01-20 Tyrosylprotein sulfotransferases and methods of use thereof

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US7299498P 1998-01-29 1998-01-29
US60/072,994 1998-01-29
US09/150,133 1998-09-09
US09/150,133 US6060295A (en) 1998-01-29 1998-09-09 Nucleic acids and expression systems encoding tyrosylprotein sulfo transferases
US09/150,141 1998-09-09
US09/150,141 US6071732A (en) 1998-01-29 1998-09-09 Tyrosylprotein sulfotransferases, nucleic acids encoding tyrosylprotein sulfotransferases, and methods of use thereof

Publications (3)

Publication Number Publication Date
WO1999038980A2 WO1999038980A2 (en) 1999-08-05
WO1999038980A9 WO1999038980A9 (en) 1999-10-21
WO1999038980A3 true WO1999038980A3 (en) 2000-03-30

Family

ID=27372205

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1999/001756 WO1999038980A2 (en) 1998-01-29 1999-01-28 Tyrosylprotein sulfotransferase polypeptides and polynucleotides

Country Status (3)

Country Link
EP (1) EP1051499A2 (en)
AU (1) AU2475899A (en)
WO (1) WO1999038980A2 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7919259B2 (en) 2004-06-14 2011-04-05 Galapagos N.V. Methods for identification, and compounds useful for the treatment of degenerative and inflammatory diseases

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0008326D0 (en) * 2000-04-06 2000-05-24 Shs International Ltd Diagnosis and treatment of autism and related disorders

Non-Patent Citations (19)

* Cited by examiner, † Cited by third party
Title
BEISSWANGER R ET AL: "Existence of distinct tyrosylprotein sulfotransferase genes: molecular characterization of tyrosylprotein sulfotransferase-2", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF USA., vol. 95, no. 19, 15 September 1998 (1998-09-15), pages 11134 - 11139, XP002111842 *
DATABASE EMEST 10 E.M.B.L Databases; 13 September 1996 (1996-09-13), KOHARA Y: "C.elegans cDNA clone yk166c1 : 5' end, single read", XP002126072 *
DATABASE EMEST 15 E.M.B.L. Databases; 5 June 1997 (1997-06-05), HILLIER L ET AL: "Homo sapiens cDNA clone 774175 5'similiar to WP:F42G9.8", XP002111846 *
DATABASE EMEST 18 E.M.B.L. Databases; 2 April 1997 (1997-04-02), MARRA M ET AL: "Soares mouse NML Mus musculus cDNA clone 737385 5' similar to WP:F42G9.8 CE07235", XP002126071 *
DATABASE EMEST 20 E.M.B.L. Databases; 16 February 1997 (1997-02-16), MARRA M ET AL: "Mus musculus cDNA clone 567635 5' similar to WP:F42G9.8 CE07235", XP002126067 *
DATABASE EMEST16 E.M.B.L. Databases; 19 January 1997 (1997-01-19), HILLIER ET AL: "Homo sapiens cDNA clone 625544 5' similar to WP:F42G9.8 CE07235", XP002126066 *
DATABASE EMHUM1 E.M.B.L. Databases; 23 June 1998 (1998-06-23), BENNETT E: "Homo sapiens mRNA for tyrosyl sulfotransferase-2", XP002126068 *
DATABASE EMHUM1 E.M.B.L. Databases; 30 April 1997 (1997-04-30), BRIDGEMAN A: "Human DNA sequence from BAC 445C9 on chromosome 22q12.1", XP002126070 *
DATABASE EMHUM1 E.M.B.L. Databases; 6 May 1998 (1998-05-06), BEISSWANGER R ET AL: "Homo sapiens tyrosylprotein sulfotransferase-2 mRNA, complete cds", XP002126086 *
DATABASE TRINV E.M.B.L. Databases; 1 November 1996 (1996-11-01), WILSON R ET AL: "COSMID F42G9 F42G9.8", XP002126069 *
FRIEDERICH E ET AL: "Inhibition of tyrosine sulfation in the trans-Golgi retards the transport of a constitutively secreted protein to the cell surface.", THE JOURNAL OF CELL BIOLOGY., vol. 107, no. 5, November 1988 (1988-11-01), pages 1655 - 1667, XP002111840 *
HILBERT T ET AL: "Cloning and expression of the cDNA encoding the human homologue of the DNA repair enzyme, Escherichia coli endonuclease III", JOURNAL OF BIOLOGICAL CHEMISTRY., vol. 272, no. 10, 7 March 1997 (1997-03-07), pages 6733 - 6740, XP002112050 *
LIN W ET AL: "Characterization of a tyrosylprotein sulfotransferase in human liver", BIOCHEM PHARMACOL, vol. 40, no. 3, 1 August 1990 (1990-08-01), pages 629 - 635, XP002112049 *
NIEHRS C AND HUTTNER W: "Purification and characterization of tyrosylprotein sulfotransferase", EMBO JOURNAL., vol. 9, no. 1, January 1990 (1990-01-01), pages 35 - 42, XP002111839 *
NIEHRS C ET AL: "Conversion of recombinant hirudin to the natural form by in vitro tyrosine sulfation. Differential substrate specificities of leech and bovine tyrosylprotein sulfotransferases", JOURNAL OF BIOLOGICAL CHEMISTRY., vol. 265, no. 16, 5 June 1990 (1990-06-05), pages 9314 - 9318, XP002111845 *
OUYANG Y AND MOORE K: "Molecular cloning and expression of human and mouse tyrosylprotein sulfotransferase-2 and a tyrosylprotein sulfotransferase homologue in Caenorhabditis elegans", JOURNAL OF BIOLOGICAL CHEMISTRY., vol. 273, no. 38, 18 September 1998 (1998-09-18), pages 24770 - 24774, XP002111844 *
OUYANG Y ET AL: "Tyrosylprotein sulfotransferase: purification and molecular cloning of an enzyme that catalyzes tyrosine O-sulfation, a common posttranslational modification of eukaryotic proteins", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF USA., vol. 95, no. 6, 17 March 1998 (1998-03-17), pages 2896 - 2901, XP002111843 *
WILKINS P ET AL: "Tyrosine sulfation of P-selectin glycoprotein ligand-1 is required for high affinity binding to P-selectin", JOURNAL OF BIOLOGICAL CHEMISTRY., vol. 270, no. 39, 29 September 1995 (1995-09-29), pages 22677 - 22680, XP002111841 *
WILLIAM S ET AL: "Purification of tyrosylprotein sulfotransferase from rat submandibular salivary gland", ARCH BIOCHEM BIOPHYS, vol. 338, no. 1, 1 February 1997 (1997-02-01), pages 90 - 96, XP002111838 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7919259B2 (en) 2004-06-14 2011-04-05 Galapagos N.V. Methods for identification, and compounds useful for the treatment of degenerative and inflammatory diseases

Also Published As

Publication number Publication date
WO1999038980A2 (en) 1999-08-05
AU2475899A (en) 1999-08-16
WO1999038980A9 (en) 1999-10-21
EP1051499A2 (en) 2000-11-15

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