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WO1999038538A1 - Agent de contraste pour imagerie par resonance magnetique (irm) renfermant de l'acide ethylene diamine disuccinique en tant qu'agent chelatant - Google Patents

Agent de contraste pour imagerie par resonance magnetique (irm) renfermant de l'acide ethylene diamine disuccinique en tant qu'agent chelatant Download PDF

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Publication number
WO1999038538A1
WO1999038538A1 PCT/IB1999/000117 IB9900117W WO9938538A1 WO 1999038538 A1 WO1999038538 A1 WO 1999038538A1 IB 9900117 W IB9900117 W IB 9900117W WO 9938538 A1 WO9938538 A1 WO 9938538A1
Authority
WO
WIPO (PCT)
Prior art keywords
contrasting
ethylene diamine
disuccinic acid
agents
paramagnetic metal
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/IB1999/000117
Other languages
English (en)
Inventor
Anthony Joseph Simpson
Stephen Wayne Heinzman
Barry Thomas Ingram
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Procter and Gamble Co
Original Assignee
Procter and Gamble Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Procter and Gamble Co filed Critical Procter and Gamble Co
Publication of WO1999038538A1 publication Critical patent/WO1999038538A1/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations

Definitions

  • a well-known chelating agent thereto is, for example, EDTA and DTPA.
  • the complexing agents for use in the contrasting composition of the invention is N, N ethylene diamine disuccinic acid or its salts (EDDS).

Landscapes

  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Radiology & Medical Imaging (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

Cette invention a trait à des compositions de contraste renfermant un complexe constitué d'un ou de plusieurs ions métalliques sélectionnés et un agent chélatant spécifique. Elle concerne également l'utilisation qui est faite de complexes spécifiques aux fins de l'élaboration d'un agent de contraste à utiliser pour des IRM et elle porte, de surcroît, sur des techniques de préparation de compositions de contraste.
PCT/IB1999/000117 1998-01-31 1999-01-25 Agent de contraste pour imagerie par resonance magnetique (irm) renfermant de l'acide ethylene diamine disuccinique en tant qu'agent chelatant Ceased WO1999038538A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB9802050.6 1998-01-31
GB9802050A GB2333704A (en) 1998-01-31 1998-01-31 Contrasting compositions for magnetic resonance imaging comprising a complex of ethylene diamine disuccinic acid and one or more paramagnetic metal ions

Publications (1)

Publication Number Publication Date
WO1999038538A1 true WO1999038538A1 (fr) 1999-08-05

Family

ID=10826199

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB1999/000117 Ceased WO1999038538A1 (fr) 1998-01-31 1999-01-25 Agent de contraste pour imagerie par resonance magnetique (irm) renfermant de l'acide ethylene diamine disuccinique en tant qu'agent chelatant

Country Status (2)

Country Link
GB (1) GB2333704A (fr)
WO (1) WO1999038538A1 (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2465663A (en) * 2008-11-26 2010-06-02 Ge Healthcare As X-ray contrast agent compositions comprising an iodinated X-ray contrast agent and ethylenediamine-N,N-disuccinic acid

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0292761A2 (fr) * 1987-05-08 1988-11-30 Nycomed Salutar, Inc. Pyridoxamines utilisées pour chélater, chélates de manganèse (II) et leur utilisation comme agents de contraste RMNI
WO1995025159A1 (fr) * 1994-03-17 1995-09-21 The Procter & Gamble Company Blanchissage ameliore par l'ethylenediamine-n,n'-disuccianate de manganese
WO1996001804A1 (fr) * 1994-07-11 1996-01-25 Albemarle Corporation Procede de production de sels de calcium de l'acide [s,s]-ethylenediamine-n,n'-disuccinique
WO1997040827A1 (fr) * 1996-04-27 1997-11-06 Analyticon Ag Biotechnologie Pharmazie Utilisation de disuccinate de diamine d'ethylene pour preparer un medicament a proprietes antivirales
US5741555A (en) * 1995-05-22 1998-04-21 The Dow Chemical Company Succinic acid derivative degradable chelants, uses and compositions thereof

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0292761A2 (fr) * 1987-05-08 1988-11-30 Nycomed Salutar, Inc. Pyridoxamines utilisées pour chélater, chélates de manganèse (II) et leur utilisation comme agents de contraste RMNI
WO1995025159A1 (fr) * 1994-03-17 1995-09-21 The Procter & Gamble Company Blanchissage ameliore par l'ethylenediamine-n,n'-disuccianate de manganese
WO1996001804A1 (fr) * 1994-07-11 1996-01-25 Albemarle Corporation Procede de production de sels de calcium de l'acide [s,s]-ethylenediamine-n,n'-disuccinique
US5741555A (en) * 1995-05-22 1998-04-21 The Dow Chemical Company Succinic acid derivative degradable chelants, uses and compositions thereof
WO1997040827A1 (fr) * 1996-04-27 1997-11-06 Analyticon Ag Biotechnologie Pharmazie Utilisation de disuccinate de diamine d'ethylene pour preparer un medicament a proprietes antivirales

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
LU, ZHENG-RONG ET AL: "Synthesis and proton relaxation of Gd - EDDS and Gd -THEC", GAODENG XUEXIAO HUAXUE XUEBAO (1996), 17(1), 24-6 CODEN: KTHPDM;ISSN: 0251-0790, XP002096437 *
SCHOWANEK, DIEDERIK (1) ET AL: "Biodegradation of (S,S), (R,R) and mixed stereoisomers of ethylene-- diamine disuccinic acid ( EDDS ), a transition metal chelator.", CHEMOSPHERE, (1997) VOL. 34, NO. 11, PP. 2375-2391. ISSN: 0045-6535., XP002096438 *
TAKAHASHI R. ET AL: "Biodegradabilites of Ethylenediamine-N,N'-disuccinic acid (EDDS) and other chelating agents", BIOSCI. BIOTECH. BIOCHEM, vol. 61, no. 11, 1997, pages 1957 - 1959, XP002096204 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2465663A (en) * 2008-11-26 2010-06-02 Ge Healthcare As X-ray contrast agent compositions comprising an iodinated X-ray contrast agent and ethylenediamine-N,N-disuccinic acid

Also Published As

Publication number Publication date
GB9802050D0 (en) 1998-03-25
GB2333704A (en) 1999-08-04

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