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WO1999036553A3 - Regulation de phenomenes biologiques au moyen de proteines chimeres multimeres - Google Patents

Regulation de phenomenes biologiques au moyen de proteines chimeres multimeres Download PDF

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Publication number
WO1999036553A3
WO1999036553A3 PCT/US1999/000178 US9900178W WO9936553A3 WO 1999036553 A3 WO1999036553 A3 WO 1999036553A3 US 9900178 W US9900178 W US 9900178W WO 9936553 A3 WO9936553 A3 WO 9936553A3
Authority
WO
WIPO (PCT)
Prior art keywords
regulation
biological events
chimeric proteins
multimeric chimeric
multimeric
Prior art date
Application number
PCT/US1999/000178
Other languages
English (en)
Other versions
WO1999036553A2 (fr
Inventor
Timothy P Clackson
Michael Z Gilman
Dennis A Holt
Terence P Keenan
Leonard Rozamus
Wu Yang
Original Assignee
Ariad Gene Therapeutics Inc
Timothy P Clackson
Michael Z Gilman
Dennis A Holt
Terence P Keenan
Leonard Rozamus
Wu Yang
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US09/012,097 external-priority patent/US6187757B1/en
Application filed by Ariad Gene Therapeutics Inc, Timothy P Clackson, Michael Z Gilman, Dennis A Holt, Terence P Keenan, Leonard Rozamus, Wu Yang filed Critical Ariad Gene Therapeutics Inc
Priority to CA002318402A priority Critical patent/CA2318402A1/fr
Priority to AU22132/99A priority patent/AU755784B2/en
Priority to EP99902059A priority patent/EP1045915A2/fr
Priority to JP2000540254A priority patent/JP2002508971A/ja
Publication of WO1999036553A2 publication Critical patent/WO1999036553A2/fr
Publication of WO1999036553A3 publication Critical patent/WO1999036553A3/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D498/18—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/37—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from fungi
    • C07K14/39—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from fungi from yeasts
    • C07K14/395—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from fungi from yeasts from Saccharomyces
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/7051—T-cell receptor (TcR)-CD3 complex
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70578—NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • C12N9/1205—Phosphotransferases with an alcohol group as acceptor (2.7.1), e.g. protein kinases
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011—Details
    • C12N2710/16011—Herpesviridae
    • C12N2710/16611—Simplexvirus, e.g. human herpesvirus 1, 2
    • C12N2710/16622—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Toxicology (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Wood Science & Technology (AREA)
  • Cell Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Virology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Transplantation (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • General Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

L'invention concerne des matières et des procédés servant à réguler des phénomènes biologiques tels que la transcription et la croissance d'un gène cible, la prolifération ou la différenciation de cellules mises au point génétiquement.
PCT/US1999/000178 1998-01-15 1999-01-15 Regulation de phenomenes biologiques au moyen de proteines chimeres multimeres WO1999036553A2 (fr)

Priority Applications (4)

Application Number Priority Date Filing Date Title
CA002318402A CA2318402A1 (fr) 1998-01-15 1999-01-15 Regulation de phenomenes biologiques au moyen de proteines chimeres multimeres
AU22132/99A AU755784B2 (en) 1998-01-15 1999-01-15 Regulation of biological events using multimeric chimeric proteins
EP99902059A EP1045915A2 (fr) 1998-01-15 1999-01-15 Regulation de phenomenes biologiques au moyen de proteines chimeres multimeres
JP2000540254A JP2002508971A (ja) 1998-01-15 1999-01-15 多量体キメラ蛋白質を使用する生物学的イベントの調節

Applications Claiming Priority (8)

Application Number Priority Date Filing Date Title
US7159198P 1998-01-15 1998-01-15
US60/071,591 1998-01-15
US7201698P 1998-01-21 1998-01-21
US60/072,016 1998-01-21
US7221998P 1998-01-22 1998-01-22
US09/012,097 1998-01-22
US60/072,219 1998-01-22
US09/012,097 US6187757B1 (en) 1995-06-07 1998-01-22 Regulation of biological events using novel compounds

Publications (2)

Publication Number Publication Date
WO1999036553A2 WO1999036553A2 (fr) 1999-07-22
WO1999036553A3 true WO1999036553A3 (fr) 1999-10-21

Family

ID=27486136

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1999/000178 WO1999036553A2 (fr) 1998-01-15 1999-01-15 Regulation de phenomenes biologiques au moyen de proteines chimeres multimeres

Country Status (5)

Country Link
EP (1) EP1045915A2 (fr)
JP (1) JP2002508971A (fr)
AU (1) AU755784B2 (fr)
CA (1) CA2318402A1 (fr)
WO (1) WO1999036553A2 (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8426167B2 (en) 2001-06-22 2013-04-23 Roche Diagnostics Operations, Inc. Methods for producing fusion polypeptides or enhancing expression of fusion polypeptides

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WO2025007046A1 (fr) 2023-06-29 2025-01-02 The Trustees Of The University Of Pennsylvania Aav mutant à motifs de ciblage du système nerveux central et compositions les contenant
WO2025102034A1 (fr) 2023-11-10 2025-05-15 The Trustees Of The University Of Pennsylvania Thérapie génique pour le syndrome de barth
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EP1045915A2 (fr) 2000-10-25
CA2318402A1 (fr) 1999-07-22
JP2002508971A (ja) 2002-03-26
AU2213299A (en) 1999-08-02
WO1999036553A2 (fr) 1999-07-22

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