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WO1999036100A3 - Polymeric carrier - Google Patents

Polymeric carrier Download PDF

Info

Publication number
WO1999036100A3
WO1999036100A3 PCT/IL1999/000023 IL9900023W WO9936100A3 WO 1999036100 A3 WO1999036100 A3 WO 1999036100A3 IL 9900023 W IL9900023 W IL 9900023W WO 9936100 A3 WO9936100 A3 WO 9936100A3
Authority
WO
WIPO (PCT)
Prior art keywords
polymeric carrier
bioactive
bioreactive
molecule
bioreactive molecule
Prior art date
Application number
PCT/IL1999/000023
Other languages
French (fr)
Other versions
WO1999036100A2 (en
Inventor
Avraham J Domb
Zeev Zehavi
Original Assignee
Efrat Biopolymers Ltd
Avraham J Domb
Zeev Zehavi
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Efrat Biopolymers Ltd, Avraham J Domb, Zeev Zehavi filed Critical Efrat Biopolymers Ltd
Priority to AU18889/99A priority Critical patent/AU1888999A/en
Priority to CA002283648A priority patent/CA2283648C/en
Priority to JP53697199A priority patent/JP2001515522A/en
Priority to EP99900284A priority patent/EP0967998A2/en
Publication of WO1999036100A2 publication Critical patent/WO1999036100A2/en
Publication of WO1999036100A3 publication Critical patent/WO1999036100A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
    • A61K9/1647—Polyesters, e.g. poly(lactide-co-glycolide)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Inorganic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Other Resins Obtained By Reactions Not Involving Carbon-To-Carbon Unsaturated Bonds (AREA)
  • Cosmetics (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)

Abstract

The invention provides a polymeric carrier for delivery of a bioactive or bioreactive molecule, comprising a stereocomplex of at least one biocompatible stereoselective polymer and a bioactive or bioreactive molecule.
PCT/IL1999/000023 1998-01-14 1999-01-14 Polymeric carrier WO1999036100A2 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
AU18889/99A AU1888999A (en) 1998-01-14 1999-01-14 Polymeric carrier
CA002283648A CA2283648C (en) 1998-01-14 1999-01-14 Polymeric carrier
JP53697199A JP2001515522A (en) 1998-01-14 1999-01-14 Polymer carrier
EP99900284A EP0967998A2 (en) 1998-01-14 1999-01-14 Polymeric carrier

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IL122933 1998-01-14
IL12293398A IL122933A (en) 1998-01-14 1998-01-14 Polymeric carrier for delivery of a bioactive molecule

Publications (2)

Publication Number Publication Date
WO1999036100A2 WO1999036100A2 (en) 1999-07-22
WO1999036100A3 true WO1999036100A3 (en) 1999-09-23

Family

ID=11071088

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IL1999/000023 WO1999036100A2 (en) 1998-01-14 1999-01-14 Polymeric carrier

Country Status (6)

Country Link
EP (1) EP0967998A2 (en)
JP (1) JP2001515522A (en)
AU (1) AU1888999A (en)
CA (1) CA2283648C (en)
IL (1) IL122933A (en)
WO (1) WO1999036100A2 (en)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2220406T3 (en) * 1999-02-19 2004-12-16 Universiteit Utrecht HYDROGELS STEREOCOMPLEJOS.
EP1156812A4 (en) * 1999-02-23 2004-09-29 Isis Pharmaceuticals Inc Multiparticulate formulation
WO2002083166A1 (en) * 2001-04-10 2002-10-24 Santen Pharmaceutical Co., Ltd. Interferon-polymer complexes and medicinal use thereof
DE10154924A1 (en) * 2001-11-08 2003-05-28 Medinnova Ges Med Innovationen Biodegradable copolymers
MXPA04010778A (en) * 2002-05-03 2005-03-07 Janssen Pharmaceutica Nv Polymeric microemulsions.
EP1857462B9 (en) * 2005-02-18 2013-02-13 Nof Corporation Polyoxyalkylene derivative
EP1902084A2 (en) * 2005-06-01 2008-03-26 Yissum Research Development Company, of The Hebrew University of Jerusalem Biodegradable polymers having a pre-determined chirality
JP5216995B2 (en) * 2006-02-03 2013-06-19 国立大学法人北海道大学 Nanodisks made of block copolymers
DE602008004124D1 (en) 2008-06-18 2011-02-03 Inst Biopolimerow I Wlokien Chemicznych Process for the preparation of a polylactic acid ester complex powder
EP2591792B1 (en) * 2010-07-09 2016-12-21 The University of Tokyo Composition for nucleic acid delivery, carrier composition, pharmaceutical composition using the composition for nucleic acid delivery or the carrier composition, and method for delivering nucleic acid
CN108559084B (en) * 2018-04-13 2020-12-04 华东理工大学 A kind of preparation method of polylactic acid-based hydrophobic film
CN109908106A (en) * 2019-03-04 2019-06-21 北京化工大学 A kind of methotrexate nanocapsule for intravenous injection and preparation method thereof
JP7050734B2 (en) * 2019-09-30 2022-04-08 鳥居薬品株式会社 Film preparation for sublingual allergen immunotherapy
CN115785471B (en) * 2022-12-16 2023-08-08 华中科技大学 A kind of carbon dioxide-based supramolecular polymer and its preparation method and application

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1990003783A1 (en) * 1988-10-12 1990-04-19 E.I. Du Pont De Nemours And Company Polylactide compositions
EP0467389A2 (en) * 1990-07-19 1992-01-22 University Of Kentucky Research Foundation Drug delivery system involving interaction between protein or polypeptide and hydrophobic biodegradable polymer

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6136321A (en) * 1984-07-27 1986-02-21 Daicel Chem Ind Ltd Novel polymer and its resin composition

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1990003783A1 (en) * 1988-10-12 1990-04-19 E.I. Du Pont De Nemours And Company Polylactide compositions
EP0467389A2 (en) * 1990-07-19 1992-01-22 University Of Kentucky Research Foundation Drug delivery system involving interaction between protein or polypeptide and hydrophobic biodegradable polymer

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
J.S, HRKACH ET AL.: "synthesis of poy (l-lactic acid-co-L-lysine) graft copolymers", MACROMOLECULES, vol. 28, no. 13, 19 June 1995 (1995-06-19), Easton (US), pages 4736 - 4739, XP000512312 *

Also Published As

Publication number Publication date
CA2283648A1 (en) 1999-07-22
CA2283648C (en) 2007-04-17
IL122933A (en) 2005-03-20
JP2001515522A (en) 2001-09-18
IL122933A0 (en) 1998-08-16
AU1888999A (en) 1999-08-02
EP0967998A2 (en) 2000-01-05
WO1999036100A2 (en) 1999-07-22

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