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WO1999036048A1 - Preparations dentaires ou buccales stables pouvant eliminer les taches dues au goudron du tabac et aux aliments ordinaires et rafraichir l'haleine - Google Patents

Preparations dentaires ou buccales stables pouvant eliminer les taches dues au goudron du tabac et aux aliments ordinaires et rafraichir l'haleine Download PDF

Info

Publication number
WO1999036048A1
WO1999036048A1 PCT/US1998/027760 US9827760W WO9936048A1 WO 1999036048 A1 WO1999036048 A1 WO 1999036048A1 US 9827760 W US9827760 W US 9827760W WO 9936048 A1 WO9936048 A1 WO 9936048A1
Authority
WO
WIPO (PCT)
Prior art keywords
formulation
oral cavity
tar
mouth
weight
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US1998/027760
Other languages
English (en)
Inventor
Jin Xu
Marissa K. Mercado
Bala C. Nayar
Kuo-Chen Yeh
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Block Drug Co Inc
Original Assignee
Block Drug Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Block Drug Co Inc filed Critical Block Drug Co Inc
Priority to AU19491/99A priority Critical patent/AU1949199A/en
Publication of WO1999036048A1 publication Critical patent/WO1999036048A1/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/37—Esters of carboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
    • A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
    • A61K2800/52—Stabilizers

Definitions

  • This invention relates to formulations for maintaining oral hygiene.
  • the invention can solubilize, disperse and remove tobacco tar and other common stains, such as coffee, tea and blueberry stains, from the oral cavity, including teeth (or dentures) .
  • the invention also relates to methods for making and using such formulations.
  • Staining of teeth and dentures by foods, beverages and tobacco products is a common problem.
  • good solutions to the staining problem are not as common.
  • Tobacco tar is loosely defined as a dark, oily, viscid blend of polycyclic aromatic and aliphatic hydrocarbons, although tar also contains other compounds .
  • the tar Due to the hydrophobic nature of the compounds contained within the tar, the tar is not easily dissolved or dispersed by commonly available over-the-counter mouth treatments such as toothpastes, gels, and oral rinses. As a result, tar can build up on the teeth, dentures, denture plates, artificial teeth and other surfaces of the smoker's mouth causing, among other things, staining of plaque and calculus and an aesthetically displeasing appearance of the smoker's teeth and mouth. Additionally, since the compounds in tar have an unpleasant aroma, deposition of these compounds in the oral cavity can cause halitosis.
  • scratches can make the teeth more susceptible to decay and endanger the softer interior layers of the teeth. Also, the scratches can act to increase the surface area of the teeth, thereby increasing the number of places where bacteria can attach to the surface of the tooth and potentially cause tooth decay.
  • abrasive cleaners are also not capable of removing deposits from areas in the oral cavity that are either too small for the abrasives to enter or that are not reached by mechanical brushing, such as the interproximal spaces between teeth and some gingival spaces between the teeth and gums .
  • Diamond states that its oral preparation removes tar from all surfaces in the mouth of a smoker and does not physically harm the tooth surface. It acts by dissolving and/or dispersing the tobacco tar, thereby removing it from the surface without any of the adverse effects associated with abrasive materials.
  • Diamond formulation offers many advantages, it may not be fully stable in all circumstances. Products in aqueous environments, such as water-based dentifrices and mouthwashes, may require special precautions to prevent interactions among the various ingredients in the formulation. Such interactions occur even more readily in a homogeneous aqueous solution. For example, hydrolysis of methyl salicylate or various esters mentioned in Diamond can lower the tar-removal and anti-bacterial efficacy of the formulation and degrade the taste profile of the product .
  • the principal object of the invention therefore is to provide a stabilized oral health care formulation for the removal of hydrophobic materials from surfaces found in the oral cavity.
  • Another object of the invention is to provide methods for using such oral health care formulations.
  • such formulations may also comprise ingredients to improve the overall oral health of a user of the formulation.
  • such formulations may also contain ingredients to clean the oral cavity.
  • such formulations may provide excellent organoleptic qualities to enhance the attractiveness of the product.
  • the invention provides a formulation comprising at least one material for dissolving or dispersing hydrophobic deposits from surfaces found in the oral cavity.
  • the material is subject to degradation over time in an aqueous environment, so the formulation also comprises a buffering agent to retard degradation of the material.
  • the invention comprises a method of removing deposits from a surface found in the oral cavity, comprising the steps of: exposing the surface to a formulation comprising: (a) at least one material for dissolving or dispersing hydrophobic deposits from surfaces found in the oral cavity, wherein the material is subject to degradation over time in an aqueous environment; and (b) a buffering agent to retard degradation of the material, for a time sufficient to dissolve or disperse the deposit; and removing the dissolved or dispersed deposit from the surface.
  • a formulation comprising: (a) at least one material for dissolving or dispersing hydrophobic deposits from surfaces found in the oral cavity, wherein the material is subject to degradation over time in an aqueous environment; and (b) a buffering agent to retard degradation of the material, for a time sufficient to dissolve or disperse the deposit; and removing the dissolved or dispersed deposit from the surface.
  • the formulations of the invention remove deposits on the teeth, gums, tongue, and other surfaces in the oral cavity.
  • the formulations of the invention preferably include at least one surfactant and at least one cyclic, preferably aromatic, essential oil. At least one of these ingredients should be susceptible to degradation over time in an aqueous environment.
  • the formulation of the present invention may be included in a mouthwash or oral rinse, but it may also be part of a dentifrice, gel, or powder, or in any other effective form. Those skilled in the art will recognize that different weight percentages of ingredients will be required for an effective dentifrice, because less dentifrice material is used in each application by the user than is found with mouthwashes .
  • the invention may comprise a nonionic surfactant component.
  • the nonionic surfactant may act as a tar solubilizer and/or flavor solubilizer, among other things. Any pharmaceutically or orally acceptable nonionic surfactant may be used in the invention.
  • nonionic surfactants examples include, but are not limited to, glycerol- polyethylene glycol oxystearate (PEG 40, Cremophor ® RH40 and 60 available from BASF) , polyoxyethylene esters or sorbitol laurate esters, such as polyoxyethylene sorbitan monolaurate, polyoxyethylene sorbitan monoisostearate, polyoxyethylene sorbitan monostearate, polyoxyethylene sorbitan monooleate, polyoxyethylene or sorbitol laurate esters including polysorbates, and block polymers of polyoxyethylene, polyoxypropylene (Pluronic ® 127) and polyoxyethylene hydrogenated castor oil.
  • PEG 40 glycerol- polyethylene glycol oxystearate
  • polyoxyethylene esters or sorbitol laurate esters such as polyoxyethylene sorbitan monolaurate, polyoxyethylene sorbitan monoisostearate, polyoxyethylene sorbitan monostearate, polyoxyethylene
  • the amount of nonionic surfactants included in the formulations of the invention is from about 0.1% to about 8% by weight, preferably 0.2% to about 7% by weight and most preferably from about 0.3% to about 6.5% by weight of the overall formulation.
  • the invention may also include at least one anionic surfactant.
  • the anionic surfactant component of the invention may act as a sudsing agent and tar co-solubilizer, among other things. Any pharmaceutically or orally acceptable anionic surfactant may be used in the invention. Examples of anionic surfactants that may be used in the present invention include, but are not limited to, sodium lauryl sulfate and a pharmaceutical or oral grade of sodium ether lauryl sulfate.
  • the anionic surfactant is present in formulations of the invention at from about 0.1% to about 6.0% by weight, preferably from about 0.2% to about 5.0% by weight, and most preferably from about 0.3% to about 4.5% by weight of the overall formulation.
  • the invention also comprises at least one aromatic essential oil such as methyl salicylate.
  • aromatic essential oil component of the invention may act as a tar solubilizer, among other things. Any pharmaceutically or orally acceptable aromatic essential oil may be used in the invention.
  • aromatic essential oils which may be used in the present invention include, in addition to methyl salicylate, anise, anethole, bergamot, camphor, cinnaminic anhydrides, clove, eucalyptol, peppermint, spearmint, and thyme, among others.
  • all the aromatic essential oils included in the present invention comprise from about 0.01% to about 5% by weight of the formulation, preferably from about 0.02% to about 4% by weight, and most preferably from about 0.03% to about 3.75% by weight of the overall formulation.
  • the overall amount of tar solubilizing agents comprises from about 0.1% to about 20% by weight of the overall formulation, preferably from about 0.2% to about 15% by weight, and most preferably from about 0.3% to about 11.0% by weight.
  • the invention also preferably includes a combination of anionic and nonionic surfactants, including at least one of each.
  • the stabilizing portion of the formulation preferably includes a pH buffering system comprising from about 0.01% to about 6% by weight of the overall composition, preferably from about 0.05% to about 5% by weight, and most preferably from about 0.2% to about 0.5% by weight of the overall composition.
  • the pH buffering system comprises at least one acid such as citric, benzoic, acetic, lactic, phosphoric, tartaric, oxalic and ethylenediamine N, N, N' ,N' tetraacetic acids.
  • the pH buffering system also comprises at least one base such as mono-, di- and tri- sodium, ammonium and potassium salts of phosphoric acid; sodium, ammonium and potassium hydroxides; calcium hydroxide; sodium, ammonium and potassium carbonates and hydrogen carbonates; sodium, ammonium and potassium salts of acetic, citric, benzoic, lactic, tartaric, oxalic and ethylenediamine-N, N, N' , N' tetraacetic acids.
  • the acids are citric, benzoic, and acetic acids.
  • the bases are di- and trisodium phosphate, sodium hydroxide, and sodium carbonate .
  • the buffering system should be used in proportions sufficient to stabilize the formulation at a pH from about 6.5 to about 7.5, preferably from about 6.8 to about 7.2 and most preferably about 7.0.
  • ingredients useful in the invention include a vehicle for the formulation, solvents, humectants, sweeteners, flavors, and preservatives.
  • the preferred vehicle for an oral rinse prepared according to the present invention is water or a water/alcohol mixture. When water is used as the vehicle to prepare such a rinse, the water comprises from about 50% to about 85% by weight of the overall composition.
  • Additional vehicles include pastes and gels, which allow the invention to be formulated as a tooth paste or other solid or semi-solid form. The relative amounts of vehicle and active ingredients will be easily adjusted by those skilled in the art to account for the differing amounts and conditions of use.
  • the invention may also include a solvent in a concentration range of from about 3.0% to about 30.0% by weight.
  • Ethanol is a preferred solvent, but any pharmaceutically or orally acceptable solvent may be used.
  • Humectants may also be included in the invention from about 3% to about 15% by weight. Humectants help to stabilize the water content of the solution. Humectants which may be used in the present invention include, among others, glycerine and sorbitol. However, any pharmaceutically or orally acceptable humectant may be used in the invention. The humectant also helps to give the invention a better mouthfeel.
  • the invention may also include additional essential oils as flavoring components in addition to the methyl salicylate and, optionally, at least one other essential oil discussed above as tar solubilizers .
  • flavoring essential oils should also aid in solubilizing tar and other hydrophobic materials, but any essential oils known in the art for flavoring may be used.
  • the invention may include a preservative at from about 0.05% to about 2.0% by weight of the overall formulation.
  • preservatives include benzoic acid and sodium benzoate, among others. Any pharmaceutically or orally acceptable preservative may be used to prepare the invention.
  • the invention may include a sweetener, such as sodium saccharin, in a concentration from about 0.01% to about 0.7% by weight.
  • a color may also be added to the preparation of the invention in a concentration range of from about 0.001% to about 0.5% by weight.
  • the preparation of the present invention may be included in gels or pastes utilizing thickening or gelling agents.
  • agents include, among others, silica aerogels, pyrogenic silica, silica precipitates, carboxymethyl cellulose, carboxyvinyl polymers, xanthan gum, and carrageenan.
  • gels or pastes may contain other conventional dentifrice ingredients. Even though these ingredients may include some abrasives and polishing agents, the invention will provide additional cleaning for areas not reached by conventional toothbrushes .
  • an oral rinse form of the invention is prepared by adding the following ingredients in the following sequence.
  • the vehicle is provided, and any sudsing agent in the formulation is added.
  • the surfactants and other hydrophobic materials are added to the solvent.
  • any flavoring is added to the solvent/surfactant mixture.
  • the vehicle and solvent solutions are mixed together.
  • formulations of the invention are also suitable for use on denture material .
  • the ingredients set forth herein may be incorporated into effervescent denture tablets or powders or may be formulated as a denture cream or paste .
  • formulations of the invention can also dissolve and/or disperse food oils and other hydrophobic materials found in the oral cavity. Examples include essential oils from onions and garlic.
  • An oral rinse in accordance with the invention was prepared by placing 13,179.7 Kg water into a first tank. 32.385 Kg disodium phosphate (anhydrous) and 7.62 Kg sodium saccharin were added to the water with mixing.
  • the contents of the second tank were added to the contents of the first tank and mixed until a homogeneous solution was obtained.
  • This formulation is expected to show significant improvement in slowing the loss of methyl salicylate during shelf storage of the formulation.

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Birds (AREA)
  • Epidemiology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Chemical & Material Sciences (AREA)
  • Emergency Medicine (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Cosmetics (AREA)

Abstract

L'invention concerne une formulation capable d'éliminer des dépôts sur des surfaces situées dans la cavité buccale, et comprenant au moins une matière pouvant éliminer des dépôts hydrophobes de surfaces situées dans la cavité buccale. Ladite matière se dégrade après un laps de temps passé dans un milieu aqueux. La formulation comprend également un tampon pouvant retarder la dégradation de ladite matière.
PCT/US1998/027760 1998-01-15 1998-12-24 Preparations dentaires ou buccales stables pouvant eliminer les taches dues au goudron du tabac et aux aliments ordinaires et rafraichir l'haleine Ceased WO1999036048A1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU19491/99A AU1949199A (en) 1998-01-15 1998-12-24 Stable dental and oral preparations for removing tobacco tar and common food stains, as well as refreshing the mouth

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US750798A 1998-01-15 1998-01-15
US09/007,507 1998-01-15

Publications (1)

Publication Number Publication Date
WO1999036048A1 true WO1999036048A1 (fr) 1999-07-22

Family

ID=21726604

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1998/027760 Ceased WO1999036048A1 (fr) 1998-01-15 1998-12-24 Preparations dentaires ou buccales stables pouvant eliminer les taches dues au goudron du tabac et aux aliments ordinaires et rafraichir l'haleine

Country Status (2)

Country Link
AU (1) AU1949199A (fr)
WO (1) WO1999036048A1 (fr)

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3947570A (en) * 1972-11-06 1976-03-30 Colgate-Palmolive Company Oral product
US4150151A (en) * 1977-12-12 1979-04-17 Lever Brothers Company Mouthwash
US4314990A (en) * 1979-10-15 1982-02-09 The Procter & Gamble Company Toothpaste compositions
US4545979A (en) * 1982-02-22 1985-10-08 Warner-Lambert Company Dental hygiene compositions
US4550018A (en) * 1984-02-22 1985-10-29 Warner-Lambert Company Dental hygiene compositions
US5514366A (en) * 1993-04-07 1996-05-07 Diamond; Jeffrey H. Dental and oral preparation for smokers for solubilizing and removing tobacco tars as well as onion and garlic essential oils

Patent Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3947570A (en) * 1972-11-06 1976-03-30 Colgate-Palmolive Company Oral product
US4150151A (en) * 1977-12-12 1979-04-17 Lever Brothers Company Mouthwash
US4314990A (en) * 1979-10-15 1982-02-09 The Procter & Gamble Company Toothpaste compositions
US4314990B1 (fr) * 1979-10-15 1991-09-03 Procter & Gamble
US4545979A (en) * 1982-02-22 1985-10-08 Warner-Lambert Company Dental hygiene compositions
US4550018A (en) * 1984-02-22 1985-10-29 Warner-Lambert Company Dental hygiene compositions
US5514366A (en) * 1993-04-07 1996-05-07 Diamond; Jeffrey H. Dental and oral preparation for smokers for solubilizing and removing tobacco tars as well as onion and garlic essential oils
US5662888A (en) * 1993-04-07 1997-09-02 Jeffrey Mitchell Laboratories Toothpaste for smokers for solubilizing and removing tobacco tars

Also Published As

Publication number Publication date
AU1949199A (en) 1999-08-02

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