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WO1999033515A2 - Dispositif permettant de transporter du gaz radioactif vers un systeme de distribution - Google Patents

Dispositif permettant de transporter du gaz radioactif vers un systeme de distribution Download PDF

Info

Publication number
WO1999033515A2
WO1999033515A2 PCT/US1998/025129 US9825129W WO9933515A2 WO 1999033515 A2 WO1999033515 A2 WO 1999033515A2 US 9825129 W US9825129 W US 9825129W WO 9933515 A2 WO9933515 A2 WO 9933515A2
Authority
WO
WIPO (PCT)
Prior art keywords
gas
radiation
catheter
radioactive
balloon
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US1998/025129
Other languages
English (en)
Other versions
WO1999033515A3 (fr
Inventor
Marc G. Apple
Brian L. Bates
John A. Deford
Neal E. Fearnot
James D. Purdy
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Cook Inc
Cook Research Inc
Original Assignee
Cook Inc
MED Institute Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cook Inc, MED Institute Inc filed Critical Cook Inc
Priority to JP2000526261A priority Critical patent/JP2001526946A/ja
Priority to EP98960455A priority patent/EP1042030A2/fr
Priority to KR1020007007362A priority patent/KR20010033810A/ko
Priority to AU16040/99A priority patent/AU737096B2/en
Priority to CA002316963A priority patent/CA2316963A1/fr
Publication of WO1999033515A2 publication Critical patent/WO1999033515A2/fr
Publication of WO1999033515A3 publication Critical patent/WO1999033515A3/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M25/00—Catheters; Hollow probes
    • A61M25/10—Balloon catheters
    • A61M25/1018—Balloon inflating or inflation-control devices
    • A61M25/10181—Means for forcing inflation fluid into the balloon
    • A61M25/10182—Injector syringes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
    • A61N5/1001—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy using radiation sources introduced into or applied onto the body; brachytherapy
    • A61N5/1002—Intraluminal radiation therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M25/00—Catheters; Hollow probes
    • A61M25/10—Balloon catheters
    • A61M25/1018—Balloon inflating or inflation-control devices
    • A61M25/10184—Means for controlling or monitoring inflation or deflation
    • A61M25/10185—Valves
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
    • A61N5/1001—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy using radiation sources introduced into or applied onto the body; brachytherapy
    • A61N2005/1019—Sources therefor
    • A61N2005/1021—Radioactive fluid

Definitions

  • a radiation delivery system which would: a) deliver a predetermined totally-cumulative and homogenous dose of radiation to the lesion site, at a predetermined penetration depth, while minimizing the exposure of surrounding healthy tissue to the radiation; b) enable the treating physician or other health-care personnel to be bedside to the patient during the administration of the radiation therapy without exposing the physician or health care personnel to any unreasonable risk; c) use radiation material that is readily and inexpensively available from a commercial provider; d) use minimal special equipment storage, or delivery devices, except for routine facilities available in most nuclear medicine or radiation oncology departments; e) use a radiation carrier material that if applied as an unsealed free-gas form, the inert, noble gas properties essentially enable the molecules of the carrier material to rapidly dissipate throughout the body of the patient without any prolonged organ accumulation or chemical interaction, and rapid dilution of the carrier material is quickly re-released from the bloodstream through the lungs; f) minimize long term occlusion of normal
  • FIG. 3 is a detail sectional view of the fully-inflated catheter apparatus taken along line 3-3 of FIG. 2;
  • FIG. 4 is a detail sectional view of the deflated catheter apparatus taken along line 4-4 of FIG. 1 ;
  • FIG. 23 is a end view of the catheter system of FIG. 22;
  • phosphorus and/or other known fluorescent metals or alloys are implanted in the balloon material and/or catheter structure so that the combinations described in (a) and (b); radioemission, by-product decay energy and/or direct electrical stimulation can cause effect on the jimplanted/layered materials so as to create fluorescent, phosphorescent or luminescent energy delivery as these materials stabilize their electron structure after such stimulation.
  • the system of the present invention enables the treating therapeutic radiologist to address more than one vessel system or lesion even distal to the distribution of the primary lesion that may require subjective variation in post-dilatation balloon length and diameter due to sensitivity of distal ischemic-prone tissue from risk of prolonged diminished blood flow.
  • the sectioned, segmented or compartmentalized radioactive gas delivery tracks communicating with the end point expander balloons, will minimize the potential volume of gas leak should a balloon lose integrity.
  • the residual catheter gas volume may be withdrawn into the shielded syringe without further leakage.
  • the bloodstream released gas poses no real radiation or chemical threat to the patient, because of the physical and biological properties of the inert gas.
  • the length of the distal expandable component of the catheter apparatus 20 or 1 20 is covered by a thin, retroslidable or static sleeve 50 or 1 50, as shown in FIGs. 4 and 1 6, which is radiopaque for purposes of imaging localization.
  • the sleeve 50 or 1 50 is in direct continuity with and manipulatable externally by the physician.

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Radiology & Medical Imaging (AREA)
  • Hematology (AREA)
  • Pulmonology (AREA)
  • Anesthesiology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Biophysics (AREA)
  • Pathology (AREA)
  • Radiation-Therapy Devices (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)

Abstract

L'invention concerne un cathéter rempli d'un matériau support de rayonnement tel qu'un gaz radioactif inerte servant au traitement de la resténose après une angioplastie, et de pathologies malignes. Le cathéter gonflé peut se composer d'un seul élément ou, dans une autre version, d'une pluralité de compartiments discrets permettant de transporter le matériau support radioactif, à travers lesquels le sang peut continuer à circuler pendant l'application de la radiothérapie prescrite. Lorsque le support radioactif est un gaz tel que le Xénon 133, on peut se servir d'un dispositif (1400) d'injection qui permet l'utilisation d'un flacon (1401) de source gazeuse standard pouvant être chargé dans un boîtier ou un compartiment (1403) pour flacon de source radioactive. Les moyens entourant le flacon (1404) peuvent également servir de mécanisme (1442) de poussée servant à pousser le flacon (1401) contenant la source en direction d'une ou de plusieurs canule(s) (1406, 1454) de perçage qui permettent le passage du gaz radioactif dans le cathéter. Dans une série de versions, le gaz radioactif est retiré à travers des moyens (1409) sélecteurs tels qu'une soupape à positions multiples dans une chambre (1411) à volume variable étanche au gaz telle qu'une seringue, qui est alors déployée pour distribuer le gaz dans le cathéter. Après le traitement, le gaz est récupéré dans la seringue et retourné dans le flacon (1401) de source. Dans une autre série de versions, une seringue remplie d'un liquide est utilisée pour déplacer le gaz soit directement dans le cathéter (1422) de distribution, soit dans une seconde seringue qui injecte le gaz dans le cathéter (1422) de distribution.
PCT/US1998/025129 1997-12-31 1998-12-01 Dispositif permettant de transporter du gaz radioactif vers un systeme de distribution Ceased WO1999033515A2 (fr)

Priority Applications (5)

Application Number Priority Date Filing Date Title
JP2000526261A JP2001526946A (ja) 1997-12-31 1998-12-01 放射性ガス注入装置
EP98960455A EP1042030A2 (fr) 1997-12-31 1998-12-01 Dispositif permettant de transporter du gaz radioactif vers un systeme de distribution
KR1020007007362A KR20010033810A (ko) 1997-12-31 1998-12-01 전달용 기기로 방사성 가스를 공급하기 위한 장치
AU16040/99A AU737096B2 (en) 1997-12-31 1998-12-01 Apparatus for supplying radioactive gas to a delivery device
CA002316963A CA2316963A1 (fr) 1997-12-31 1998-12-01 Dispositif permettant de transporter du gaz radioactif vers un systeme de distribution

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US7026297P 1997-12-31 1997-12-31
US60/070,262 1997-12-31
US7528498P 1998-02-20 1998-02-20
US60/075,284 1998-02-20

Publications (2)

Publication Number Publication Date
WO1999033515A2 true WO1999033515A2 (fr) 1999-07-08
WO1999033515A3 WO1999033515A3 (fr) 1999-09-16

Family

ID=26750969

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1998/025129 Ceased WO1999033515A2 (fr) 1997-12-31 1998-12-01 Dispositif permettant de transporter du gaz radioactif vers un systeme de distribution

Country Status (6)

Country Link
EP (1) EP1042030A2 (fr)
JP (1) JP2001526946A (fr)
KR (1) KR20010033810A (fr)
AU (1) AU737096B2 (fr)
CA (1) CA2316963A1 (fr)
WO (1) WO1999033515A2 (fr)

Cited By (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001043826A1 (fr) * 1999-12-16 2001-06-21 Proxima Therapeutics, Inc. Appareil et procede permettant de doser des rayonnements asymetriques
WO2001047602A1 (fr) 1999-12-28 2001-07-05 Apple, Marc, G. Catheter a ballonnet pour radiotherapie a energie accrue
US6413204B1 (en) 1997-07-24 2002-07-02 Proxima Therapeutics, Inc. Interstitial brachytherapy apparatus and method for treatment of proliferative tissue diseases
US6589227B2 (en) 2000-01-28 2003-07-08 William Cook Europe Aps Endovascular medical device with plurality of wires
US6673006B2 (en) 2001-06-15 2004-01-06 Proxima Therapeutics, Inc. Tissue positioning apparatus and method for protecting tissue from radiotherapy
US6695760B1 (en) 2002-10-11 2004-02-24 Proxima Therapeutics Treatment of spinal metastases
US6749555B1 (en) 2003-02-13 2004-06-15 Proxima Therapeutics, Inc. System and method for the treatment of spinal metastases
WO2008025417A1 (fr) * 2006-08-31 2008-03-06 Reiner Szepan Procédé d'évacuation sans retard d'un cathéter à ballonnet avec un contenu radioatif
US7354391B2 (en) 2003-11-07 2008-04-08 Cytyc Corporation Implantable radiotherapy/brachytherapy radiation detecting apparatus and methods
US7494457B2 (en) 2003-11-07 2009-02-24 Cytyc Corporation Brachytherapy apparatus and method for treating a target tissue through an external surface of the tissue
US7524274B2 (en) 2003-11-07 2009-04-28 Cytyc Corporation Tissue positioning systems and methods for use with radiation therapy
US7524275B2 (en) 2003-11-14 2009-04-28 Cytyc Corporation Drug eluting brachytherapy methods and apparatus
EP1971400A4 (fr) * 2005-12-30 2010-03-31 Xoft Inc Applicateur et systeme de brachytherapie gynecologique
US7862497B2 (en) 2006-04-21 2011-01-04 Portola Medical, Inc. Brachytherapy device having seed tubes with individually-settable tissue spacings
US7905822B2 (en) 2003-11-20 2011-03-15 Cytyc Corporation Brachytherapy method and applicator for treatment of metastatic lesions in a load bearing region
US8226539B2 (en) 2005-12-16 2012-07-24 Portola Medical, Inc. Brachytherapy apparatus for asymmetrical body cavities
US8303477B2 (en) 2007-08-24 2012-11-06 Cytyc Corporation Fluid radiation shield for brachytherapy
US8328711B2 (en) 2007-12-18 2012-12-11 Cytyc Corporation Selectable multi-lumen brachytherapy devices and methods
US8382650B2 (en) 2009-05-11 2013-02-26 Cytyc Corporation Catheter marking for multi-lumen catheter identification
WO2014015286A1 (fr) * 2012-07-19 2014-01-23 Boston Scientific Scimed, Inc. Embase de cathéter de protection contre le rayonnement et procédés d'utilisation associés
US9623260B2 (en) 2004-11-05 2017-04-18 Theragenics Corporation Expandable brachytherapy device
US10022557B2 (en) 2010-09-30 2018-07-17 Hologic, Inc. Using a guided member to facilitate brachytherapy device swap
US10207126B2 (en) 2009-05-11 2019-02-19 Cytyc Corporation Lumen visualization and identification system for multi-lumen balloon catheter
US10342992B2 (en) 2011-01-06 2019-07-09 Hologic, Inc. Orienting a brachytherapy applicator
US10413750B2 (en) 2005-11-18 2019-09-17 Hologic, Inc. Brachytherapy device for facilitating asymmetrical irradiation of a body cavity
CN113241206A (zh) * 2021-05-13 2021-08-10 原子高科股份有限公司 放射源回收装置及放射源回收系统
US20240075259A1 (en) * 2022-09-06 2024-03-07 Osama Amine Balloon Angioplasty Inflation Device and Method of Preparing a Balloon for Angioplasty

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9579524B2 (en) 2009-02-11 2017-02-28 Hologic, Inc. Flexible multi-lumen brachytherapy device
US9248311B2 (en) 2009-02-11 2016-02-02 Hologic, Inc. System and method for modifying a flexibility of a brachythereapy catheter

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4192438A (en) * 1978-05-25 1980-03-11 Atomic Products Corporation Device for delivering radioactive gas from a sealed vial
US4565301A (en) * 1982-06-10 1986-01-21 Medi-Physics, Inc. Device for dispensing radioactive gas

Cited By (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6413204B1 (en) 1997-07-24 2002-07-02 Proxima Therapeutics, Inc. Interstitial brachytherapy apparatus and method for treatment of proliferative tissue diseases
EP1702651A3 (fr) * 1999-12-16 2008-11-26 Cytyc Corporation Appareil permettant de doser des rayonnements asymétriques
WO2001043826A1 (fr) * 1999-12-16 2001-06-21 Proxima Therapeutics, Inc. Appareil et procede permettant de doser des rayonnements asymetriques
WO2001047602A1 (fr) 1999-12-28 2001-07-05 Apple, Marc, G. Catheter a ballonnet pour radiotherapie a energie accrue
US6589227B2 (en) 2000-01-28 2003-07-08 William Cook Europe Aps Endovascular medical device with plurality of wires
US7494456B2 (en) 2001-06-15 2009-02-24 Cytyc Corporation Tissue positioning systems and methods for use with radiation therapy
US6673006B2 (en) 2001-06-15 2004-01-06 Proxima Therapeutics, Inc. Tissue positioning apparatus and method for protecting tissue from radiotherapy
US6976949B2 (en) 2002-10-11 2005-12-20 Proxima Therapeutics, Inc. Treatment of spinal metastases
US7381178B2 (en) 2002-10-11 2008-06-03 Cytyc Corporation Treatment of spinal metastases
US6695760B1 (en) 2002-10-11 2004-02-24 Proxima Therapeutics Treatment of spinal metastases
US6749555B1 (en) 2003-02-13 2004-06-15 Proxima Therapeutics, Inc. System and method for the treatment of spinal metastases
US7524274B2 (en) 2003-11-07 2009-04-28 Cytyc Corporation Tissue positioning systems and methods for use with radiation therapy
US7354391B2 (en) 2003-11-07 2008-04-08 Cytyc Corporation Implantable radiotherapy/brachytherapy radiation detecting apparatus and methods
US7494457B2 (en) 2003-11-07 2009-02-24 Cytyc Corporation Brachytherapy apparatus and method for treating a target tissue through an external surface of the tissue
US7524275B2 (en) 2003-11-14 2009-04-28 Cytyc Corporation Drug eluting brachytherapy methods and apparatus
US7905822B2 (en) 2003-11-20 2011-03-15 Cytyc Corporation Brachytherapy method and applicator for treatment of metastatic lesions in a load bearing region
US9623260B2 (en) 2004-11-05 2017-04-18 Theragenics Corporation Expandable brachytherapy device
US10413750B2 (en) 2005-11-18 2019-09-17 Hologic, Inc. Brachytherapy device for facilitating asymmetrical irradiation of a body cavity
US8226539B2 (en) 2005-12-16 2012-07-24 Portola Medical, Inc. Brachytherapy apparatus for asymmetrical body cavities
EP1971400A4 (fr) * 2005-12-30 2010-03-31 Xoft Inc Applicateur et systeme de brachytherapie gynecologique
US7862497B2 (en) 2006-04-21 2011-01-04 Portola Medical, Inc. Brachytherapy device having seed tubes with individually-settable tissue spacings
WO2008025417A1 (fr) * 2006-08-31 2008-03-06 Reiner Szepan Procédé d'évacuation sans retard d'un cathéter à ballonnet avec un contenu radioatif
US8303477B2 (en) 2007-08-24 2012-11-06 Cytyc Corporation Fluid radiation shield for brachytherapy
US8328711B2 (en) 2007-12-18 2012-12-11 Cytyc Corporation Selectable multi-lumen brachytherapy devices and methods
US8382650B2 (en) 2009-05-11 2013-02-26 Cytyc Corporation Catheter marking for multi-lumen catheter identification
US10207126B2 (en) 2009-05-11 2019-02-19 Cytyc Corporation Lumen visualization and identification system for multi-lumen balloon catheter
US10022557B2 (en) 2010-09-30 2018-07-17 Hologic, Inc. Using a guided member to facilitate brachytherapy device swap
US10342992B2 (en) 2011-01-06 2019-07-09 Hologic, Inc. Orienting a brachytherapy applicator
WO2014015286A1 (fr) * 2012-07-19 2014-01-23 Boston Scientific Scimed, Inc. Embase de cathéter de protection contre le rayonnement et procédés d'utilisation associés
CN113241206A (zh) * 2021-05-13 2021-08-10 原子高科股份有限公司 放射源回收装置及放射源回收系统
US20240075259A1 (en) * 2022-09-06 2024-03-07 Osama Amine Balloon Angioplasty Inflation Device and Method of Preparing a Balloon for Angioplasty
US12329920B2 (en) * 2022-09-06 2025-06-17 Osama Amine Balloon angioplasty inflation device and method of preparing a balloon for angioplasty

Also Published As

Publication number Publication date
CA2316963A1 (fr) 1999-07-08
AU1604099A (en) 1999-07-19
JP2001526946A (ja) 2001-12-25
KR20010033810A (ko) 2001-04-25
WO1999033515A3 (fr) 1999-09-16
AU737096B2 (en) 2001-08-09
EP1042030A2 (fr) 2000-10-11

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