[go: up one dir, main page]

WO1999032086A1 - Composition insecticide a appliquer par deversement constituee de solvant(s) et de tensioactif(s) - Google Patents

Composition insecticide a appliquer par deversement constituee de solvant(s) et de tensioactif(s) Download PDF

Info

Publication number
WO1999032086A1
WO1999032086A1 PCT/AU1998/001045 AU9801045W WO9932086A1 WO 1999032086 A1 WO1999032086 A1 WO 1999032086A1 AU 9801045 W AU9801045 W AU 9801045W WO 9932086 A1 WO9932086 A1 WO 9932086A1
Authority
WO
WIPO (PCT)
Prior art keywords
formulation
igr
solvent
surfactant
animal
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/AU1998/001045
Other languages
English (en)
Inventor
Stanley Shepherd
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Schering Plough Animal Health Ltd Australia
Intervet Inc
Original Assignee
Schering Plough Animal Health Ltd Australia
Schering Plough Animal Health Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Plough Animal Health Ltd Australia, Schering Plough Animal Health Corp filed Critical Schering Plough Animal Health Ltd Australia
Priority to AU16509/99A priority Critical patent/AU1650999A/en
Publication of WO1999032086A1 publication Critical patent/WO1999032086A1/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A61K9/0017—Non-human animal skin, e.g. pour-on, spot-on

Definitions

  • the present invention relates to a pour-on formulation of Insect Growth Regulator (IGR) insecticides, and a method of treating or controlling insects and parasites on animals.
  • IGR Insect Growth Regulator
  • the present invention relates to a pour-on formulation of water insoluble IGR in a non-aqueous blend of solvent (s) and surfactant (s) .
  • IGR formulations described in the invention kill the majority of lice (>96%) within 10 weeks of application, with the remainder being killed within 15 weeks of treatment.
  • the formulations of this invention are able to tolerate up to 10% by volume of water before the water insoluble IGR begins to slowly precipitate from the carrier solvents .
  • This compatibility with water means that if the formulation is added to a wet animal, the active ingredient will start to spread around, but not run off, the animal. This will help to increase the efficacy of the formulation.
  • the formulations also are efficacious when applied to the animal and no rain occurs for several weeks. In all these instances, it is believed that the surfactants aid the spread of active over the surface of the animal. These beneficial effects are not obtainable at the moment with traditional solvent based formulations.
  • the present invention provides a pour-on formulation adapted for localised application to an animal, which formulation includes an effective amount of an insect growth regulator (IGR) in a blend of at least one non-aqueous solvent and at least one surfactant, wherein said solvent is chemically and physically stable, non- flammable, of low mammalian toxicity and is a non-irritant to the animal .
  • IGR insect growth regulator
  • the present invention provides a method for treating or controlling insects or parasites on an animal, which method includes externally applying to an animal an effective amount of a formulation including an IGR in a blend of at least one non-aqueous solvent and at least one surfactant, wherein said solvent is chemically and physically stable, non-flammable, of low mammalian toxicity and is a non-irritant to the animal.
  • the present invention provides a method for formulating a pour-on formulation adapted for localised application to an animal, which method comprises dissolving an insect growth regulator (IGR) in a solvent by stirring at ambient temperature; adding a surfactant or mixtures of surfactants and dissolving with stirring; and adding a further solvent or solvents to the mixture with stirring.
  • IGR insect growth regulator
  • IGR insoluble IGR
  • Suitable IGRs include diflubenzuron, triflumuron, fluazuron, and methoprene.
  • a particularly preferred IGR is diflubenzuron .
  • the major solvent is preferably N-methyl-2- pyrrolidone.
  • the other solvents may include butyl digol and/or polyethylene glycol . Any other glycol ether or high molecular weight polyethylene glycol could also be used. Any anionic or nonionic surfactant could be used in this formulation.
  • the preferred surfactants are alkyl polysaccharides, and an alkoxylated bisphenol surfactant blend.
  • Formulations intended for pour-on application (which term includes localised application by spraying) almost invariably include a colouring agent to enable the farmer or grazier to visually monitor the application of the formulation to the animal . The nature of the colouring agent is unimportant, and a wide variety of suitable dyes and pigments will be known to the skilled person.
  • the colouring agent may be soluble or insoluble in water .
  • the IGR is insoluble in water .
  • water solubility is insufficient for an effective amount of the agent to be dissolved in a normal pour-on dose of the formulation.
  • Active ingredients in addition to the IGR may also be incorporated in the formulation.
  • Such actives may include actives which have an immediate effect, rather than the relatively slowly acting IGR.
  • ingredients that may be included in the formulations of the present invention are: actives which have an immediate "knock down effect” (eg synthetic pyrethroids or organophosphates) ; antioxidants (eg Vitamin E) ; UV protectants (eg Oxybenzone) ; perfumes; and thickeners (eg polyvinyl pyrrolidone) .
  • actives which have an immediate "knock down effect”
  • antioxidants eg Vitamin E
  • UV protectants eg Oxybenzone
  • perfumes eg polyvinyl pyrrolidone
  • Suitable ranges for the ingredients are as follows : a) Active 5 - 50g/L b) Primary solvent 200 - 600g/L c) Secondary solvent (1) 100 - 500g/L d) Secondary solvent (2) 50 - 200g/L e) Nonionic or anionic surfactant 100 - 400g/L
  • the ratio of active : pour-on solvents : surfactants is about 1:30:10.
  • alkoxylated bisphenol surfactant blend N-methol pyrrolidone
  • alkyl polysaccharide PEG 400 and butyl digol.
  • the ingredients are formulated as follows. Technical grade diflubenzuron is dissolved in N-methyl-2- pyrrolidone with stirring at ambient temperature in a tared manufacturing vessel. The surfactant or mixtures of surfactants are added into the vessel and dissolved with stirring. Finally, the secondary solvent or solvents are added to the mixture with stirring followed by the colouring agent.
  • the pour-on formulation may be applied by methods known in the art .
  • the formulation may be formulated for application by a particular method, for example spraying, in which case the formulation may be presented as an aerosol using a liquid or gas propellent.
  • the method according to the present invention may be used to treat ticks, fleas, flies (for example, sheep blowfly, buffalo fly, nuisance fly), lice (for example, cattle and sheep lice) and mites (for example, sheep mites) .
  • ticks for example, fleas, flies (for example, sheep blowfly, buffalo fly, nuisance fly), lice (for example, cattle and sheep lice) and mites (for example, sheep mites) .
  • ticks, fleas, flies for example, sheep blowfly, buffalo fly, nuisance fly
  • lice for example, cattle and sheep lice
  • mites for example, sheep mites
  • the method may be used to treat or control insects and parasites on a variety of animals including sheep, cattle, deer, goats, pigs, dogs, and cats. The animal may also be a bird.
  • Efficacy trials are suitably carried out as follows. Sheep to be studied are assessed for the number of lice at various sites. They are then treated with the formulation of this invention at varying concentrations of active ingredient and the lice count at various sites carried out at different periods .
  • the method requires examination of twenty partings each 10cm long, along two contours on the left and right sides covering the wool growing regions of the animal. At each of the 40 recorded sites all live adult lice are counted. Site counts are summed to give a total count for the animal .
  • Assessing lice populations in this manner also allows the production of a map, showing how the lice are distributed over the body of the tracer sheep.
  • the delivery apparatus for each formulation was a commercial applicator set to deliver 1 x 20mL dose to the sheep backline.
  • the gun was calibrated using a volumetric cylinder and checked twice before and once after treatment. To avoid the possibility of rain complicating the post treatment situation the sheep were kept in pens for a minimum of 48 hours. Then on the morning of the 25th day of the trial, they were placed into their paddocks.
  • Example 3 Effect of diflubenzuron in formulations at concentrations of 12.5 and 25.0 g/L on sheep lice [group arithmetic mean lice counts (standard deviations)].

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Dermatology (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Zoology (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

L'invention concerne une formulation aqueuse à appliquer par déversement, tolérée de façon topique, adaptée pour être appliquée extérieurement de façon localisée sur un animal, dont la formule comporte une quantité efficace d'un régulateur de la croissance des insectes non soluble dans l'eau, un agent de suspension, un tensioactif ou un mélange de tensioactifs, et un vecteur aqueux.
PCT/AU1998/001045 1997-12-19 1998-12-18 Composition insecticide a appliquer par deversement constituee de solvant(s) et de tensioactif(s) Ceased WO1999032086A1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU16509/99A AU1650999A (en) 1997-12-19 1998-12-18 Solvent/surfactant insecticidal pour-on formulation

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
AUPP1055 1997-12-19
AUPP1055A AUPP105597A0 (en) 1997-12-19 1997-12-19 Solvent/surfactant insecticidal pour-on formulation

Publications (1)

Publication Number Publication Date
WO1999032086A1 true WO1999032086A1 (fr) 1999-07-01

Family

ID=3805337

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/AU1998/001045 Ceased WO1999032086A1 (fr) 1997-12-19 1998-12-18 Composition insecticide a appliquer par deversement constituee de solvant(s) et de tensioactif(s)

Country Status (2)

Country Link
AU (1) AUPP105597A0 (fr)
WO (1) WO1999032086A1 (fr)

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002005639A3 (fr) * 2000-07-14 2002-08-01 Akzo Nobel Nv Composition pesticide
WO2004043446A3 (fr) * 2002-11-14 2004-06-17 Novartis Ag Composition
CN102349513A (zh) * 2011-10-31 2012-02-15 湖南中烟工业有限责任公司 一种含有烯虫酯的生物杀虫剂及其制备和应用方法
US8242161B2 (en) 2003-12-17 2012-08-14 Merial Limited Topical formulations comprising 1-N-arylpyrazole derivatives and amitraz
US8450357B2 (en) 2008-11-19 2013-05-28 Merial Limited Compositions comprising an aryl pyrazole and/or a formamidine, methods and uses thereof
US9173728B2 (en) 2008-11-19 2015-11-03 Merial Inc. Multi-cavity container having offset indentures for dispensing fluids

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4272398A (en) * 1978-08-17 1981-06-09 The United States Of America As Represented By The Secretary Of Agriculture Microencapsulation process
US5169846A (en) * 1989-10-12 1992-12-08 Crooks Michael J Non-aqueous micellar solutions of anthelmintic benzimidazoles, closantel, or phenothiazine, and insect growth regulators
US5612047A (en) * 1994-03-08 1997-03-18 Duffy; Eric P. Pesticidal microemulsion formulation

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4272398A (en) * 1978-08-17 1981-06-09 The United States Of America As Represented By The Secretary Of Agriculture Microencapsulation process
US5169846A (en) * 1989-10-12 1992-12-08 Crooks Michael J Non-aqueous micellar solutions of anthelmintic benzimidazoles, closantel, or phenothiazine, and insect growth regulators
US5612047A (en) * 1994-03-08 1997-03-18 Duffy; Eric P. Pesticidal microemulsion formulation

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
DERWENT ABSTRACT, Accession No. 91-070463/10, Class C03; & JP 03020201 A (DOW CHEM NIPPON KK) 29 January 1991. *

Cited By (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002005639A3 (fr) * 2000-07-14 2002-08-01 Akzo Nobel Nv Composition pesticide
AU2001289651B2 (en) * 2000-07-14 2006-01-19 Intervet International B.V. Pesticidal composition
WO2004043446A3 (fr) * 2002-11-14 2004-06-17 Novartis Ag Composition
AU2003293685B2 (en) * 2002-11-14 2007-04-19 Novartis Ag Combination product for controlling insect pests
US8242161B2 (en) 2003-12-17 2012-08-14 Merial Limited Topical formulations comprising 1-N-arylpyrazole derivatives and amitraz
US9066515B2 (en) 2003-12-17 2015-06-30 Merial, Inc. Topical formulations comprising 1-N-arylpyrazole derivatives and amitraz
US8450357B2 (en) 2008-11-19 2013-05-28 Merial Limited Compositions comprising an aryl pyrazole and/or a formamidine, methods and uses thereof
US8921408B2 (en) 2008-11-19 2014-12-30 Merial Limited Compositions comprising an aryl pyrazole and/or a formamidine, methods and uses thereof
US9173728B2 (en) 2008-11-19 2015-11-03 Merial Inc. Multi-cavity container having offset indentures for dispensing fluids
CN102349513A (zh) * 2011-10-31 2012-02-15 湖南中烟工业有限责任公司 一种含有烯虫酯的生物杀虫剂及其制备和应用方法

Also Published As

Publication number Publication date
AUPP105597A0 (en) 1998-01-15

Similar Documents

Publication Publication Date Title
AU2009201916A1 (en) Aqueous insecticidal pour-on formulation
NL192289C (nl) Werkwijze en opgietpreparaat voor het bestrijden van insecten en/of parasieten op een dier, waarbij het dier uitwendig wordt behandeld.
JP2003520779A (ja) 局所用有機外部寄生虫駆除製剤
JPH0629161B2 (ja) 殺外部寄生虫製剤、その製造法および外部寄生虫の防除法
Bowen et al. Long‐lasting prevention against blowfly strike using the insect growth regulator dicyclanil
RU2384065C2 (ru) Инсектоакарицидное средство
EP0680339B1 (fr) Formulation ectoparasiticide
WO1999032086A1 (fr) Composition insecticide a appliquer par deversement constituee de solvant(s) et de tensioactif(s)
JP2003313104A (ja) 動物の外部寄生虫駆除用スポットオン剤
AU2003293685B2 (en) Combination product for controlling insect pests
CN102651967B (zh) 杀虫剂组合物和用其防治昆虫的方法
AU2014262231A1 (en) Aqueous insecticidal pour-on formulation
AU693082B2 (en) Ectoparasiticidal formulation
EP0756485B1 (fr) Formulations veterinaires contenant de l'octaborate disodique tetrahydrate
AU2016244321A1 (en) Aqueous insecticidal pour-on formulation
AU2012203102A1 (en) Aqueous insecticidal pour-on formulation
US20210345621A1 (en) Scent neutralizing formulation and method of making and using the same
CZ356097A3 (cs) Způsob zlepšeného potlačování ektoparazitů
MXPA00006039A (en) Aqueous insecticidal pour-on formulation
CZ20021611A3 (cs) Veterinární přípravek na ochranu psů proti ektoparazitům

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A1

Designated state(s): AL AM AT AU AZ BA BB BG BR BY CA CH CN CU CZ DE DK EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MD MG MK MN MW MX NO NZ PL PT RO RU SD SE SG SI SK SL TJ TM TR TT UA UG US UZ VN YU ZW

AL Designated countries for regional patents

Kind code of ref document: A1

Designated state(s): GH GM KE LS MW SD SZ UG ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE BF BJ CF CG CI CM GA GN GW ML MR NE SN TD TG

121 Ep: the epo has been informed by wipo that ep was designated in this application
REG Reference to national code

Ref country code: DE

Ref legal event code: 8642

122 Ep: pct application non-entry in european phase