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WO1999025817A3 - Systeme de transposon a base d'adn permettant d'introduire un acide nucleique dans l'adn d'une cellule - Google Patents

Systeme de transposon a base d'adn permettant d'introduire un acide nucleique dans l'adn d'une cellule Download PDF

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Publication number
WO1999025817A3
WO1999025817A3 PCT/US1998/024348 US9824348W WO9925817A3 WO 1999025817 A3 WO1999025817 A3 WO 1999025817A3 US 9824348 W US9824348 W US 9824348W WO 9925817 A3 WO9925817 A3 WO 9925817A3
Authority
WO
WIPO (PCT)
Prior art keywords
transposon vectors
traps
based transposon
vectors
gene
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US1998/024348
Other languages
English (en)
Other versions
WO1999025817A2 (fr
WO1999025817A9 (fr
Inventor
Perry B Hackett
Karl J Clark
Adam J Dupuy
Stephen C Ekker
David A Largaespada
Zoltan Ivics
Zsuzsanna Izsvak
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Minnesota Twin Cities
University of Minnesota System
Original Assignee
University of Minnesota Twin Cities
University of Minnesota System
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of Minnesota Twin Cities, University of Minnesota System filed Critical University of Minnesota Twin Cities
Priority to EP98957974A priority Critical patent/EP1034258A2/fr
Priority to JP2000521183A priority patent/JP2001523450A/ja
Priority to CA002309000A priority patent/CA2309000A1/fr
Priority to AU14103/99A priority patent/AU1410399A/en
Publication of WO1999025817A2 publication Critical patent/WO1999025817A2/fr
Publication of WO1999025817A3 publication Critical patent/WO1999025817A3/fr
Publication of WO1999025817A9 publication Critical patent/WO1999025817A9/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
    • C12N15/90—Stable introduction of foreign DNA into chromosome
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034—Isolating an individual clone by screening libraries
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2800/00—Nucleic acids vectors
    • C12N2800/60—Vectors containing traps for, e.g. exons, promoters
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2800/00—Nucleic acids vectors
    • C12N2800/90—Vectors containing a transposable element
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2830/00—Vector systems having a special element relevant for transcription
    • C12N2830/001—Vector systems having a special element relevant for transcription controllable enhancer/promoter combination
    • C12N2830/005—Vector systems having a special element relevant for transcription controllable enhancer/promoter combination repressible enhancer/promoter combination, e.g. KRAB
    • C12N2830/006—Vector systems having a special element relevant for transcription controllable enhancer/promoter combination repressible enhancer/promoter combination, e.g. KRAB tet repressible
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2840/00—Vectors comprising a special translation-regulating system
    • C12N2840/20—Vectors comprising a special translation-regulating system translation of more than one cistron
    • C12N2840/203—Vectors comprising a special translation-regulating system translation of more than one cistron having an IRES
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2840/00—Vectors comprising a special translation-regulating system
    • C12N2840/44—Vectors comprising a special translation-regulating system being a specific part of the splice mechanism, e.g. donor, acceptor

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  • Genetics & Genomics (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • Organic Chemistry (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Mycology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)

Abstract

La présente invention concerne des vecteurs de transposon codant pour des pièges à gènes et des pièges à régions de commande d'expression. La présente invention concerne également des vecteurs dicistroniques. Selon certains modes de réalisation, l'invention concerne, en outre, des sites d'entrée de ribosome interne.
PCT/US1998/024348 1997-11-13 1998-11-13 Systeme de transposon a base d'adn permettant d'introduire un acide nucleique dans l'adn d'une cellule Ceased WO1999025817A2 (fr)

Priority Applications (4)

Application Number Priority Date Filing Date Title
EP98957974A EP1034258A2 (fr) 1997-11-13 1998-11-13 Systeme de transposon a base d'adn permettant d'introduire un acide nucleique dans l'adn d'une cellule
JP2000521183A JP2001523450A (ja) 1997-11-13 1998-11-13 細胞のｄｎａへの核酸の導入のための核酸転移ベクター
CA002309000A CA2309000A1 (fr) 1997-11-13 1998-11-13 Systeme de transposon a base de tc1
AU14103/99A AU1410399A (en) 1997-11-13 1998-11-13 Nucleic acid transfer vector for the introduction of nucleic acid into the dna of a cell

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US6530397P 1997-11-13 1997-11-13
US60/065,303 1997-11-13

Publications (3)

Publication Number Publication Date
WO1999025817A2 WO1999025817A2 (fr) 1999-05-27
WO1999025817A3 true WO1999025817A3 (fr) 1999-08-05
WO1999025817A9 WO1999025817A9 (fr) 1999-09-10

Family

ID=22061760

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1998/024348 Ceased WO1999025817A2 (fr) 1997-11-13 1998-11-13 Systeme de transposon a base d'adn permettant d'introduire un acide nucleique dans l'adn d'une cellule

Country Status (5)

Country Link
EP (1) EP1034258A2 (fr)
JP (1) JP2001523450A (fr)
AU (1) AU1410399A (fr)
CA (1) CA2309000A1 (fr)
WO (1) WO1999025817A2 (fr)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE466948T1 (de) 1997-03-11 2010-05-15 Univ Minnesota Dns-basiertes transposon-system für die einführung von nucleinsäure in die dns einer zelle
US7160682B2 (en) 1998-11-13 2007-01-09 Regents Of The University Of Minnesota Nucleic acid transfer vector for the introduction of nucleic acid into the DNA of a cell
JP2002543792A (ja) * 1999-05-11 2002-12-24 リージェンツ オブ ザ ユニバーシティ オブ ミネソタ ベクターによるトランスポゾン配列の供給及び組込み
WO2001029205A2 (fr) * 1999-10-19 2001-04-26 Minos Biosystems Limited Procede de manipulation genetique
AU1100201A (en) 1999-10-28 2001-05-08 Board Of Trustees Of The Leland Stanford Junior University Methods of in vivo gene transfer using a sleeping beauty transposon system
BR0107930A (pt) 2000-01-28 2004-06-15 Scripps Research Inst Métodos de identificação de elementos reguladores transcricionais e translacionais sintéticos, e composições relativas aos mesmos
WO2001081565A2 (fr) * 2000-04-27 2001-11-01 Max-Delbrück-Centrum für Molekulare Medizin Sleeping beauty, un vecteur transposon a large gamme d'hotes pour la transformation genetique chez les vertebres
EP1286699A2 (fr) * 2000-05-19 2003-03-05 Regents Of The University Of Minnesota Composition pour l'introduction de composes dans des cellules
WO2003089618A2 (fr) 2002-04-22 2003-10-30 Regents Of The University Of Minnesota Systeme de transposons, et procedes d'utilisation
DE10224242A1 (de) * 2002-05-29 2003-12-11 Max Delbrueck Centrum Frog Prince, ein Transposonvektor für den Gentransfer bei Wirbeltieren
US7985739B2 (en) 2003-06-04 2011-07-26 The Board Of Trustees Of The Leland Stanford Junior University Enhanced sleeping beauty transposon system and methods for using the same
US7919583B2 (en) 2005-08-08 2011-04-05 Discovery Genomics, Inc. Integration-site directed vector systems
WO2009003671A2 (fr) 2007-07-04 2009-01-08 Max-Delbrück-Centrum für Molekulare Medizin Variantes hyperactives de la protéine transposase du système de transposon sleeping beauty
WO2011153440A2 (fr) 2010-06-04 2011-12-08 Regents Of The University Of Minnesota Système de mutagenèse par transposons et ses méthodes d'utilisation
RU2688485C2 (ru) 2014-01-07 2019-05-21 Фундасио Привада Институт Де Медисина Предиктива И Персоналицада Дель Кансер Способы получения библиотек двухцепочечных днк и способы секвенирования для идентификации метилированных цитозинов
BR112020000406A2 (pt) * 2017-07-10 2022-09-13 Inst De Biologia Molecular Do Parana Ibmp Plataforma genética para superexpressão heteróloga associada à seleção de células altamente produtoras de proteínas
US20230242654A1 (en) 2017-07-29 2023-08-03 Juno Therapeutics, Inc. Reagents for expanding cells expressing recombinant receptors
BR112020008340A2 (pt) 2017-11-01 2020-11-17 Juno Therapeutics Inc processo para gerar composições terapêuticas de células modificadas
JP7258899B2 (ja) 2017-11-01 2023-04-17 ジュノー セラピューティクス インコーポレイテッド Ｔ細胞組成物を作製するための方法
MX2020005908A (es) 2017-12-08 2020-10-07 Juno Therapeutics Inc Proceso para producir una composicion de celulas t modificadas.
JP2022554348A (ja) 2019-11-05 2022-12-28 ジュノー セラピューティクス インコーポレイテッド 治療用ｔ細胞組成物の属性を決定する方法
WO2021197342A1 (fr) * 2020-03-30 2021-10-07 Institute Of Zoology, Chinese Academy Of Sciences Systèmes de transposon d'adn actif et leurs procédés d'utilisation
US20230178239A1 (en) 2020-05-13 2023-06-08 Juno Therapeutics, Inc. Methods of identifying features associated with clinical response and uses thereof
AU2022241654A1 (en) 2021-03-22 2023-09-28 Juno Therapeutics, Inc. Methods of determining potency of a therapeutic cell composition
US20250051735A1 (en) 2021-12-22 2025-02-13 Vanderbilt University Next generation transpososomes
US20250345432A1 (en) 2022-05-25 2025-11-13 Celgene Corporation Method for predicting response to a t cell therapy
JP2025517371A (ja) 2022-05-27 2025-06-05 カイト ファーマ インコーポレイテッド 細胞療法構築物の非ウイルス送達
WO2024220588A1 (fr) 2023-04-18 2024-10-24 Juno Therapeutics, Inc. Essai cytotoxique pour évaluer la puissance de compositions de cellules thérapeutiques
WO2024243365A2 (fr) 2023-05-23 2024-11-28 Juno Therapeutics, Inc. Marqueurs d'activation de lymphocytes t et procédé d'évaluation de l'activation de lymphocytes t

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997029202A1 (fr) * 1996-02-09 1997-08-14 Het Nederlands Kanker Instituut Vecteurs et methodes afferentes permettant d'apporter a des cellules des acides nucleiques supplementaires s'integrant dans leur genome
WO1998040510A1 (fr) * 1997-03-11 1998-09-17 Regents Of The University Of Minnesota Systeme transposon a base d'adn permettant d'introduire de l'acide nucleique dans l'adn d'une cellule

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997029202A1 (fr) * 1996-02-09 1997-08-14 Het Nederlands Kanker Instituut Vecteurs et methodes afferentes permettant d'apporter a des cellules des acides nucleiques supplementaires s'integrant dans leur genome
WO1998040510A1 (fr) * 1997-03-11 1998-09-17 Regents Of The University Of Minnesota Systeme transposon a base d'adn permettant d'introduire de l'acide nucleique dans l'adn d'une cellule

Non-Patent Citations (10)

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Title
CLARKE N J ET AL: "pPV: a novel IRES-containing vector to facilitate plasmid immunization and antibody response characterization", IMMUNOTECHNOLOGY, vol. 3, no. 2, June 1997 (1997-06-01), pages 145-153, XP004126677 *
GURTU V ET AL: "IRES bicistronic expression vectors for efficient creation of stable mammalian cell lines.", BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, (1996 DEC 4) 229 (1) 295-8. JOURNAL CODE: 9Y8. ISSN: 0006-291X., United States, XP002100809 *
IVICS Z ET AL: "IDENTIFICATION OF FUNCTIONAL DOMAINS AND EVOLUTION OF TC1-LIKE TRANSPOSABLE ELEMENTS", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF USA, vol. 93, 14 May 1996 (1996-05-14), pages 5008 - 5013, XP002072767 *
IVICS Z ET AL: "MOLECULAR RECONSTRUCTION OF SLEEPING BEAUTY, A TC1-LIKE TRANSPOSON FROM FISH, AND ITS TRANSPOSITION IN HUMAN CELLS", CELL, vol. 91, no. 4, 14 November 1997 (1997-11-14), pages 501 - 510, XP002072766 *
IZSVAK Z ET AL: "CHARACTERIZATION OF A TC1-LIKE TRANSPOSABLE ELEMENT IN ZEBRAFISH (DANIO RERIO)", MOLECULAR AND GENERAL GENETICS, vol. 247, no. 3, 1995, pages 312 - 322, XP002072765 *
J C VOS ET AL: "Transposase is the only nematode protein required for in vitro transposition of TC1", GENES AND DEVELOPMENT, vol. 10, no. 6, 15 March 1996 (1996-03-15), pages 755-61, XP002088205 *
RADICE, ANTHONY D. ET AL: "Widespread occurrence of the Tc1 transposon family: Tc1-like transposons from teleost fish", MOL. GEN. GENET. (1994), 244(6), 606-12 CODEN: MGGEAE;ISSN: 0026-8925, 1994, XP002100807 *
SCHOUTEN, GOVERT J. ET AL: "Transposon Tc1 of the nematode Caenorhabditis elegans jumps in human cells.", NUCLEIC ACIDS RESEARCH, (JUNE 15, 1998) VOL. 26, NO. 12, PP. 3013-3017. ISSN: 0305-1048., XP002088087 *
SZEKELY A A ET AL: "P element mediated germ line transformation of Drosophila melanogaster with the Tc1 transposable DNA element from Caenorhabditis elegans.", GENOME, (1994 JUN) 37 (3) 356-66. JOURNAL CODE: FNP. ISSN: 0831-2796., Canada, XP002100808 *
URABE M ET AL: "A novel dicistronic AAV vector using a short IRES segment derived from hepatitis C virus genome", GENE: AN INTERNATIONAL JOURNAL ON GENES AND GENOMES, vol. 200, no. 1-2, 24 October 1997 (1997-10-24), pages 157-162, XP004126490 *

Also Published As

Publication number Publication date
AU1410399A (en) 1999-06-07
JP2001523450A (ja) 2001-11-27
WO1999025817A2 (fr) 1999-05-27
EP1034258A2 (fr) 2000-09-13
CA2309000A1 (fr) 1999-05-27
WO1999025817A9 (fr) 1999-09-10

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