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WO1999023466A3 - Apparatus and methods for measuring fluorescence polarization - Google Patents

Apparatus and methods for measuring fluorescence polarization Download PDF

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Publication number
WO1999023466A3
WO1999023466A3 PCT/US1998/023095 US9823095W WO9923466A3 WO 1999023466 A3 WO1999023466 A3 WO 1999023466A3 US 9823095 W US9823095 W US 9823095W WO 9923466 A3 WO9923466 A3 WO 9923466A3
Authority
WO
WIPO (PCT)
Prior art keywords
composition
methods
fluorescence polarization
measuring fluorescence
detector
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US1998/023095
Other languages
French (fr)
Other versions
WO1999023466A2 (en
Inventor
Douglas N Modlin
John C Owicki
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
LJL Biosystems Inc
Original Assignee
LJL Biosystems Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US09/062,472 external-priority patent/US6071748A/en
Priority claimed from US09/156,318 external-priority patent/US6258326B1/en
Priority claimed from US09/160,533 external-priority patent/US6097025A/en
Application filed by LJL Biosystems Inc filed Critical LJL Biosystems Inc
Priority to IL13567198A priority Critical patent/IL135671A0/en
Priority to AU15184/99A priority patent/AU1518499A/en
Priority to JP2000519281A priority patent/JP2003521670A/en
Priority to EP98959374A priority patent/EP1032813A2/en
Priority to AU23448/99A priority patent/AU2344899A/en
Priority to PCT/US1999/001656 priority patent/WO1999037203A2/en
Priority to IL13748599A priority patent/IL137485A0/en
Priority to JP2000528201A priority patent/JP2003526077A/en
Priority to EP99908291A priority patent/EP1060384A1/en
Priority to PCT/US1999/003678 priority patent/WO1999042817A1/en
Priority to IL13777799A priority patent/IL137777A0/en
Priority to JP2000532708A priority patent/JP2003526767A/en
Priority to AU27758/99A priority patent/AU2775899A/en
Publication of WO1999023466A2 publication Critical patent/WO1999023466A2/en
Publication of WO1999023466A3 publication Critical patent/WO1999023466A3/en
Anticipated expiration legal-status Critical
Priority to US09/643,221 priority patent/US6326605B1/en
Priority to US10/012,255 priority patent/US20020158212A1/en
Priority to US10/004,647 priority patent/US6498335B2/en
Priority to US10/445,292 priority patent/US6992761B2/en
Priority to US10/746,797 priority patent/US7745142B2/en
Ceased legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G01N33/588—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with semiconductor nanocrystal label, e.g. quantum dots
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y15/00—Nanotechnology for interacting, sensing or actuating, e.g. quantum dots as markers in protein assays or molecular motors
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/6408—Fluorescence; Phosphorescence with measurement of decay time, time resolved fluorescence
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/6445—Measuring fluorescence polarisation
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/645—Specially adapted constructive features of fluorimeters
    • G01N21/6452—Individual samples arranged in a regular 2D-array, e.g. multiwell plates
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/536—Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase
    • G01N33/542—Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase with steric inhibition or signal modification, e.g. fluorescent quenching
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G01N33/582—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with fluorescent label
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00279—Features relating to reactor vessels
    • B01J2219/00306—Reactor vessels in a multiple arrangement
    • B01J2219/00313—Reactor vessels in a multiple arrangement the reactor vessels being formed by arrays of wells in blocks
    • B01J2219/00315—Microtiter plates
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00279—Features relating to reactor vessels
    • B01J2219/00306—Reactor vessels in a multiple arrangement
    • B01J2219/00313—Reactor vessels in a multiple arrangement the reactor vessels being formed by arrays of wells in blocks
    • B01J2219/00315—Microtiter plates
    • B01J2219/00317—Microwell devices, i.e. having large numbers of wells
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00605—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00659—Two-dimensional arrays
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/0068—Means for controlling the apparatus of the process
    • B01J2219/00686—Automatic
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/0068—Means for controlling the apparatus of the process
    • B01J2219/00686—Automatic
    • B01J2219/00691—Automatic using robots
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/0068—Means for controlling the apparatus of the process
    • B01J2219/00702—Processes involving means for analysing and characterising the products
    • B01J2219/00707—Processes involving means for analysing and characterising the products separated from the reactor apparatus
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L9/00—Supporting devices; Holding devices
    • B01L9/52—Supports specially adapted for flat sample carriers, e.g. for plates, slides, chips
    • B01L9/523—Supports specially adapted for flat sample carriers, e.g. for plates, slides, chips for multisample carriers, e.g. used for microtitration plates
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B60/00—Apparatus specially adapted for use in combinatorial chemistry or with libraries
    • C40B60/14—Apparatus specially adapted for use in combinatorial chemistry or with libraries for creating libraries
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N2021/6417—Spectrofluorimetric devices
    • G01N2021/6419—Excitation at two or more wavelengths
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N2021/6417—Spectrofluorimetric devices
    • G01N2021/6421—Measuring at two or more wavelengths
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/645—Specially adapted constructive features of fluorimeters
    • G01N2021/6463—Optics
    • G01N2021/6471—Special filters, filter wheel
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2458/00—Labels used in chemical analysis of biological material
    • G01N2458/40—Rare earth chelates
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/02—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
    • G01N35/028—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations having reaction cells in the form of microtitration plates

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • General Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Pathology (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • Physics & Mathematics (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Nanotechnology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Materials Engineering (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Spectrometry And Color Measurement (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)

Abstract

An apparatus (90) for measuring polarized light emitted from a composition that includes a stage configured to hold a microplate (124) having an array of sample wells (126), a continuous high color temperature light source (100), and a detector (144). An excitation optical relay structure directs light from the light source (100) through an excitation polarizer (114) toward a composition in one of the sample wells (126). An emission optical relay structure directs light emitted from the composition through an emission polarizer (132) toward the detector (144).
PCT/US1998/023095 1997-09-15 1998-10-30 Apparatus and methods for measuring fluorescence polarization Ceased WO1999023466A2 (en)

Priority Applications (18)

Application Number Priority Date Filing Date Title
IL13567198A IL135671A0 (en) 1997-10-31 1998-10-30 Apparatus and methods for measuring fluorescence polarization
AU15184/99A AU1518499A (en) 1997-10-31 1998-10-30 Apparatus and methods for measuring fluorescence polarization
JP2000519281A JP2003521670A (en) 1997-10-31 1998-10-30 Apparatus and method for measuring fluorescence polarization
EP98959374A EP1032813A2 (en) 1997-10-31 1998-10-30 Apparatus and methods for measuring fluorescence polarization
AU23448/99A AU2344899A (en) 1998-01-26 1999-01-25 Apparatus and methods for improving signal resolution in optical spectroscopy
PCT/US1999/001656 WO1999037203A2 (en) 1998-01-26 1999-01-25 Apparatus and methods for improving signal resolution in optical spectroscopy
IL13748599A IL137485A0 (en) 1998-01-26 1999-01-25 Apparatus and method for improving signal resolution in optical spectroscopy
JP2000528201A JP2003526077A (en) 1998-01-26 1999-01-25 Apparatus and method for improving signal resolution in spectroscopy
IL13777799A IL137777A0 (en) 1998-02-20 1999-02-19 Broad range light detection system
JP2000532708A JP2003526767A (en) 1998-02-20 1999-02-19 Wide-area light detection system
AU27758/99A AU2775899A (en) 1998-02-20 1999-02-19 Broad range light detection system
EP99908291A EP1060384A1 (en) 1998-02-20 1999-02-19 Broad range light detection system
PCT/US1999/003678 WO1999042817A1 (en) 1998-02-20 1999-02-19 Broad range light detection system
US09/643,221 US6326605B1 (en) 1998-02-20 2000-08-18 Broad range light detection system
US10/012,255 US20020158212A1 (en) 1998-04-17 2001-11-12 Apparatus and methods for time-resolved optical spectroscopy
US10/004,647 US6498335B2 (en) 1998-02-20 2001-12-03 Broad range light detection system
US10/445,292 US6992761B2 (en) 1997-09-20 2003-05-22 Broad range light detection system
US10/746,797 US7745142B2 (en) 1997-09-15 2003-12-23 Molecular modification assays

Applications Claiming Priority (38)

Application Number Priority Date Filing Date Title
US6381197P 1997-10-31 1997-10-31
US60/063,811 1997-10-31
US7249998P 1998-01-26 1998-01-26
US60/072,499 1998-01-26
US7278098P 1998-01-27 1998-01-27
US60/072,780 1998-01-27
US7541498P 1998-02-20 1998-02-20
US60/075,414 1998-02-20
US7580698P 1998-02-24 1998-02-24
US60/075,806 1998-02-24
US8225398P 1998-04-17 1998-04-17
US60/082,253 1998-04-17
US09/062,472 US6071748A (en) 1997-07-16 1998-04-17 Light detection device
US09/062,472 1998-04-17
US8416798P 1998-05-04 1998-05-04
US60/084,167 1998-05-04
US8533598P 1998-05-13 1998-05-13
US60/085,335 1998-05-13
US8550098P 1998-05-14 1998-05-14
US60/085,500 1998-05-14
US8984898P 1998-06-19 1998-06-19
US60/089,848 1998-06-19
US9220398P 1998-07-09 1998-07-09
US60/092,203 1998-07-09
US9427598P 1998-07-27 1998-07-27
US9427698P 1998-07-27 1998-07-27
US60/094,276 1998-07-27
US60/094,275 1998-07-27
US10095198P 1998-09-18 1998-09-18
US10081798P 1998-09-18 1998-09-18
US60/100,817 1998-09-18
US09/156,318 US6258326B1 (en) 1997-09-20 1998-09-18 Sample holders with reference fiducials
US09/156,318 1998-09-18
US60/100,951 1998-09-18
US09/160,533 1998-09-24
US09/160,533 US6097025A (en) 1997-10-31 1998-09-24 Light detection device having an optical-path switching mechanism
US10496498P 1998-10-20 1998-10-20
US60/104,964 1998-10-20

Related Parent Applications (4)

Application Number Title Priority Date Filing Date
US09/062,472 Continuation US6071748A (en) 1997-07-16 1998-04-17 Light detection device
US09/160,533 Continuation-In-Part US6097025A (en) 1997-07-16 1998-09-24 Light detection device having an optical-path switching mechanism
US09/160,533 Continuation US6097025A (en) 1997-07-16 1998-09-24 Light detection device having an optical-path switching mechanism
PCT/US1999/001656 Continuation WO1999037203A2 (en) 1997-09-15 1999-01-25 Apparatus and methods for improving signal resolution in optical spectroscopy

Related Child Applications (5)

Application Number Title Priority Date Filing Date
US09/160,533 Continuation US6097025A (en) 1997-07-16 1998-09-24 Light detection device having an optical-path switching mechanism
PCT/US1999/001656 Continuation WO1999037203A2 (en) 1997-09-15 1999-01-25 Apparatus and methods for improving signal resolution in optical spectroscopy
PCT/US1999/001656 Continuation-In-Part WO1999037203A2 (en) 1997-09-15 1999-01-25 Apparatus and methods for improving signal resolution in optical spectroscopy
PCT/US1999/003678 Continuation WO1999042817A1 (en) 1997-09-15 1999-02-19 Broad range light detection system
US34973399A Continuation 1997-09-15 1999-07-08

Publications (2)

Publication Number Publication Date
WO1999023466A2 WO1999023466A2 (en) 1999-05-14
WO1999023466A3 true WO1999023466A3 (en) 1999-08-19

Family

ID=56289869

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1998/023095 Ceased WO1999023466A2 (en) 1997-09-15 1998-10-30 Apparatus and methods for measuring fluorescence polarization

Country Status (4)

Country Link
EP (1) EP1032813A2 (en)
JP (1) JP2003521670A (en)
AU (1) AU1518499A (en)
WO (1) WO1999023466A2 (en)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6982431B2 (en) 1998-08-31 2006-01-03 Molecular Devices Corporation Sample analysis systems
US6992761B2 (en) 1997-09-20 2006-01-31 Molecular Devices Corporation Broad range light detection system
US6991765B2 (en) 2000-11-17 2006-01-31 Flir Systems Boston, Inc. Apparatus and methods for infrared calorimetric measurements
US7070921B2 (en) 2000-04-28 2006-07-04 Molecular Devices Corporation Molecular modification assays
US7632651B2 (en) 1997-09-15 2009-12-15 Mds Analytical Technologies (Us) Inc. Molecular modification assays

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000075167A2 (en) 1999-06-09 2000-12-14 Ljl Biosystems, Inc. Phosphorylation assays
US6287774B1 (en) 1999-05-21 2001-09-11 Caliper Technologies Corp. Assay methods and system
US6472141B2 (en) 1999-05-21 2002-10-29 Caliper Technologies Corp. Kinase assays using polycations
US8264680B2 (en) 1999-05-28 2012-09-11 Yokogawa Electric Corporation Biochip reader and electrophoresis system
DE20214868U1 (en) * 2002-07-31 2003-03-13 Tecan Trading AG, Männedorf Device for measuring the lifetime of fluorescence from fluorophores in samples
WO2004017374A2 (en) * 2002-08-16 2004-02-26 Clinical Microarrays, Inc. Reading of fluorescent arrays
WO2009056669A1 (en) * 2007-10-31 2009-05-07 Wallac Oy Sample measurement system
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EP1032813A2 (en) 2000-09-06
AU1518499A (en) 1999-05-24
JP2003521670A (en) 2003-07-15

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