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WO1999022861B1 - Biomimetic materials for filtration, chemical processing and detoxification - Google Patents

Biomimetic materials for filtration, chemical processing and detoxification

Info

Publication number
WO1999022861B1
WO1999022861B1 PCT/US1998/023589 US9823589W WO9922861B1 WO 1999022861 B1 WO1999022861 B1 WO 1999022861B1 US 9823589 W US9823589 W US 9823589W WO 9922861 B1 WO9922861 B1 WO 9922861B1
Authority
WO
WIPO (PCT)
Prior art keywords
filter
hydrogel material
contaminant
porous skeleton
hydrogel
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US1998/023589
Other languages
French (fr)
Other versions
WO1999022861A1 (en
Inventor
Donald E Ingber
Quing Liu
Zewen Liu
Antonios G Mikos
Raman V Bahulekar
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
William Marsh Rice University
Original Assignee
William Marsh Rice University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by William Marsh Rice University filed Critical William Marsh Rice University
Publication of WO1999022861A1 publication Critical patent/WO1999022861A1/en
Publication of WO1999022861B1 publication Critical patent/WO1999022861B1/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D53/00—Separation of gases or vapours; Recovering vapours of volatile solvents from gases; Chemical or biological purification of waste gases, e.g. engine exhaust gases, smoke, fumes, flue gases, aerosols
    • B01D53/02—Separation of gases or vapours; Recovering vapours of volatile solvents from gases; Chemical or biological purification of waste gases, e.g. engine exhaust gases, smoke, fumes, flue gases, aerosols by adsorption, e.g. preparative gas chromatography
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/22—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof comprising organic material
    • B01J20/26—Synthetic macromolecular compounds
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/30—Processes for preparing, regenerating, or reactivating
    • B01J20/32—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating
    • B01J20/3202—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating characterised by the carrier, support or substrate used for impregnation or coating
    • B01J20/3204—Inorganic carriers, supports or substrates
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/30—Processes for preparing, regenerating, or reactivating
    • B01J20/32—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating
    • B01J20/3202—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating characterised by the carrier, support or substrate used for impregnation or coating
    • B01J20/3206—Organic carriers, supports or substrates
    • B01J20/3208—Polymeric carriers, supports or substrates
    • B01J20/3212—Polymeric carriers, supports or substrates consisting of a polymer obtained by reactions otherwise than involving only carbon to carbon unsaturated bonds
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/30—Processes for preparing, regenerating, or reactivating
    • B01J20/32—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating
    • B01J20/3231—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating characterised by the coating or impregnating layer
    • B01J20/3242—Layers with a functional group, e.g. an affinity material, a ligand, a reactant or a complexing group
    • B01J20/3268—Macromolecular compounds
    • B01J20/3272—Polymers obtained by reactions otherwise than involving only carbon to carbon unsaturated bonds
    • B01J20/3274—Proteins, nucleic acids, polysaccharides, antibodies or antigens
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/30—Processes for preparing, regenerating, or reactivating
    • B01J20/32—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating
    • B01J20/3231—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating characterised by the coating or impregnating layer
    • B01J20/3287—Layers in the form of a liquid
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/30—Processes for preparing, regenerating, or reactivating
    • B01J20/32—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating
    • B01J20/3291—Characterised by the shape of the carrier, the coating or the obtained coated product

Landscapes

  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Biochemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Inorganic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)
  • Filtering Materials (AREA)

Abstract

Materials that utilize porous skeleton materials coated with hydrogels to provide an improved, low resistance filtration capability for removal of pathogens, toxins, or other contaminants from a contaminated gas or liquid and an enhanced capacity for binding, sequestering, or catalytic processing of chemical, biological, or molecular substrates.

Claims

AMENDED CLAIMS[received by the International Bureau on 4 June 1999 (04.06.99); ,. original claims 1-31 replaced by new claims 1-59 (6 pages)]
1. A filter for removing a contaminant from a fluid, comprising: a porous skeleton coated with a hydrogel material in which the pore size of the porous skeleton is greater in dimension than a contaminant to be removed from an environment.
2. The filter of claim 1 , wherein the pore size is of a dimension effective to remove biological pathogens and toxins.
3. The filter of claim 1 , wherein the pore size is of a dimension effective to remove molecular and chemical contaminants.
4. The filter of claim 1 , wherein the pore size is of a dimension effective to remove vaporous or gaseous contaminants.
5. The filter of claim 1, wherein the hydrogel material is selected from the group consisting of poly(2-ethylhydroxyethyl methacrylate), poly(2-hydroxyethylmethacrylate-co- methyl methacrylate), poly(methacrylic acid) (MAA), poly(acrylic acid) (AA), linear polyesters, cellulosics, poly(vinylalcohols) (PVA), poly(acrylamides), poly(n- vinylpyrollidone), poly(vinylacetates), poly(ethyleneoxide) (PEO), poly(ethylene glycol) (PEG), and copolymers and terpolymers thereof.
6. The filter of claim 1 , wherein the hydrogel material further comprises additives selected to enhance removal of the contaminants.
7. The filter of claim 6, wherein the additive comprises an affinity binding ligand selected to have a binding affinity to a contaminant to be removed.
8. The filter of claim 7, wherein the affinity binding ligand is selected from the group consisting of sugars, carbohydrates, proteins, lipids and nucleic acid, membrane phospholipids and plastic antibodies.
9. The filter of claim 6, wherein the additive is reactive with a contaminant in order to inactivate or destroy the contaminant.
26
10. The filter of claim 9, wherein the reactive additive is selected from the group consisting of enzymes, antimicrobials, chemical substrates reactive with a contaminant, proteins, lipids, nucleic acids, oxidants, free radical generators, photosensitive molecules capable of free radicals generation, sterilizing radiation, peroxides, potassium permanganate, iodine, aldehydes, magainins, dendrimers, novasomes and liposomes.
11. The filter of claim 6, wherein the additive is capable of adsorbing contaminants from the fluid.
12. The filter of claim 11, wherein the additive is selected from the group consisting of charcoal particles and zeolites.
13. The filter of claim 6, wherein the additive is located in a liquid phase of the hydrogel.
14. The filter of claim 6, wherein the additive is chemically bound or coordinated to a polymer comprising the hydrogel.
15. The filter of claim 6, wherein the additive is chemically bound or coordinated to the porous skeleton.
16. The filter of claim 1, wherein the pore size of the porous skeleton is in the range of about 5 μm to 5 cm.
17. The filter of claim 1 , wherein the pore size of the porous skeleton is in the range of about 25 μm to 5 cm.
18. The filter of claim 1 , wherein the filter is incorporated into a face mask and the pore size the porous skeleton is in the range of 100 μm - 1 cm.
19. The filter of claim 1 , wherein the filter is incorporated into a fabric and the
27 pore size the porous skeleton is in the range of 25 μm - 250 μm.
20. The filter of claim 1 , wherein the hydrogel is porous.
21. The filter of claim 20, wherein the hydrogel pore size [porosity] is in the range of 5-150 μm.
22. The filter of claim 1 , wherein the porous skeleton is selected from the group consisting of fabrics, textiles, felts, nets, foams, honeycombs, screens, and meshes of two or three dimensional materials.
23. The filter of claim 1 , wherein the porous skeleton is comprised of a material selected from the group consisting of inorganic or organic polymers (non-erodible or erodible), metals, ceramics, glasses, carbon, proteins, lipids, nucleic acids, carbohydrates, collagens, elastins and spectrins.
24. The filter of claim 1 , wherein the porous skeleton is comprised of a geodesic material or a material which can rearrange to form a fully geodesic material.
25. The filter of claim 1 , wherein the porous skeleton comprises a predetermined arrangement of integrally connected modules, each said module comprised of a plurality of integrally connected elongated members forming at least a portion of a polyhedron, the members arranged such that at least a portion of said members form geodesic or tensegrity elements.
26. The filter of claim 1 , wherein the filter is incorporated into an device selected from the group consisting of a face mask, protective fabric, air filter, water filter, breathing apparatus and catalytic air detoxification system.
27. A scaffold for chemical processing, catalysis, or detoxification, comprising: porous skeleton coated with a hydrogel material, said scaffolding being porous, such that a fluid medium comprising a chemical substrate may pass freely therethrough, said
28 hydrogel selected to transform [on] said chemical substrate into a desired product.
28. A scaffold for biological processing, comprising: porous skeleton coated with a hydrogel material, said scaffolding being porous, such that a fluid medium comprising a living organism may pass freely therethrough, said hydrogel selected to be compatible with viability of the living organism.
29. The scaffold of claim 28, further comprising a molecule capable of interacting with or exerting an effect on the living organism.
30. The scaffold of claim 29, wherein said molecule comprises an enzyme.
31. A method of filtration, comprising: contacting a fluid with a filter comprising a porous skeleton coated with a hydrogel material in which the porosity of the filter is greater in size than a contaminant to be removed, whereby the contaminant is removed from the fluid.
32. The filter of claim 1, wherein the porous skeleton comprises an integrally connected structure.
33. The filter of claim 1, wherein the hydrogel material includes a liquid phase.
34. The filter of claim 1, wherein the hydrogel material is swollen with water.
35. The filter of claim 1, wherein the hydrogel material is dehydrated.
36. The filter of claim 1, wherein the hydrogel material has a thickness in the range of 10 μm to 500 μm.
37. The filter of claim 1 , wherein the hydrogel material removes the contaminant.
38. The filter of claim 1, wherein the contaminant is removed from a gas medium.
29
39. The scaffold of claim 27, wherein the porous skeleton comprises an integrally connected structure.
40. The scaffold of claim 27, wherein the hydrogel material includes a liquid phase.
41. The scaffold of claim 27, wherein the hydrogel material is swollen with water.
42. The scaffold of claim 27, wherein the hydrogel material is dehydrated.
43. The scaffold of claim 27, wherein the hydrogel material has a thickness in the range of 10 μm to 500 μm.
44. The scaffold of claim 27, wherein the hydrogel material removes the contaminant.
45. The scaffold of claim 27, wherein the contaminant is removed from a gas medium.
46. The filter of claim 28, wherein the porous skeleton comprises an integrally connected structure.
47. The filter of claim 28, wherein the hydrogel material includes a liquid phase.
48. The filter of claim 28, wherein the hydrogel material is swollen with water.
49. The filter of claim 28, wherein the hydrogel material is dehydrated.
50. The filter of claim 28, wherein the hydrogel material has a thickness in the range of 10 μm to 500 μm.
51. The filter of claim 28, wherein the hydrogel material removes the contaminant.
30
52. The filter of claim 28, wherein the contaminant is removed from a gas medium.
53. The method of claim 31 , wherein the porous skeleton comprises an integrally connected structure.
54. The method of claim 31 , wherein the hydrogel material includes a liquid phase.
55. The method of claim 31 , wherein the hydrogel material is swollen with water.
56. The method of claim 31 , wherein the hydrogel material is dehydrated.
57. The method of claim 31 , wherein the hydrogel material has a thickness in the range of 10 μm to 500 μm.
58. The method of claim 31 , wherein the hydrogel material removes the contaminant.
59. The method of claim 31 , wherein the contaminant is removed from a gas medium.
31
PCT/US1998/023589 1997-11-05 1998-11-05 Biomimetic materials for filtration, chemical processing and detoxification Ceased WO1999022861A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US96477697A 1997-11-05 1997-11-05
US08/964,776 1997-11-05

Publications (2)

Publication Number Publication Date
WO1999022861A1 WO1999022861A1 (en) 1999-05-14
WO1999022861B1 true WO1999022861B1 (en) 1999-07-22

Family

ID=25508983

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1998/023589 Ceased WO1999022861A1 (en) 1997-11-05 1998-11-05 Biomimetic materials for filtration, chemical processing and detoxification

Country Status (1)

Country Link
WO (1) WO1999022861A1 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8690981B2 (en) 2011-06-15 2014-04-08 Porex Corporation Sintered porous plastic liquid barrier media and applications thereof

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6602410B1 (en) 2000-11-14 2003-08-05 The Procter & Gamble Comapny Water purifying kits
FR2840548B1 (en) 2002-06-07 2005-03-18 Inst Francais Du Petrole HOMOGENEOUS CATALYST BED AND PROCESS FOR PROCESSING HYDROCARBONS INTO AROMATIC COMPOUNDS WITH SUCH BED
EP1607134B1 (en) 2004-05-27 2009-11-18 Gerstel Systemtechnik GmbH & Co. KG Polyorganosiloxane-based sorbent trap
MY148625A (en) 2006-08-18 2013-05-15 Porex Corp Sintered polymeric materials and applications thereof
US20160075567A1 (en) * 2013-05-02 2016-03-17 William Marsh Rice University Manufacture of oxidatively modified carbon (omc) and its use for capture of radionuclides and metals from water
JP6292438B2 (en) * 2013-12-05 2018-03-14 ナガセケムテックス株式会社 Disaccharide compounds, modified organopolysiloxane compounds and surfactants
KR101752960B1 (en) 2015-02-11 2017-07-19 한국기계연구원 Liquid Filtration Structure Based on Artificial Membrane with Funcitonal Groups
WO2017015489A1 (en) * 2015-07-22 2017-01-26 Ask Chemicals, L.P. Ceramic filter and method for forming the filter
FR3047242B1 (en) * 2016-01-29 2019-11-15 Commissariat A L'energie Atomique Et Aux Energies Alternatives HYDROGEL MATERIAL FOR SEQUESTRATION OF ORGANOPHOSPHORUS COMPOUNDS
CN110523238B (en) * 2018-05-24 2020-08-18 厦门大学 A bionic intelligent air purification system and method
TR201807916A2 (en) * 2018-06-04 2018-06-21 Filkim Filtre Ve Kimya San Tic A S ULTRA HIGH EFFICIENCY ORGANIC GEL MICROBIAL AIR FILTRATION AND PRODUCTION SYSTEM
CN112399829A (en) * 2018-06-07 2021-02-23 辛辛那提大学 Hydrogel- and aerogel-based methods and devices for sample pretreatment
WO2020172304A1 (en) * 2019-02-20 2020-08-27 Resprana, Inc. A 3-dimensional nasal filter
US12397282B2 (en) 2020-08-28 2025-08-26 Echo Scientific LLC Trapping and sequestering of contaminants with prehydrated microparticles
KR102826538B1 (en) * 2022-12-22 2025-06-26 숭실대학교산학협력단 Manufacturing method of high purity biopolymer grafted hyper branched nanocellulose
CN118563569A (en) * 2024-08-05 2024-08-30 中国科学院宁波材料技术与工程研究所 A multilayer low-resistance anti-pollution porous composite material and its preparation method and application

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JPS53123391A (en) * 1977-04-04 1978-10-27 Mitsubishi Rayon Co Ltd Harmful gas purifying method
SE452336B (en) * 1978-06-16 1987-11-23 Boehringer Mannheim Gmbh PROCEDURE FOR DISPOSAL OF DISEASE-BREATHING MICROORGANISMS WHICH ADSORBATED EXTRACORPORAL ON A SELECTIVE BINDING ADSORBENT
JPS56115727A (en) * 1980-02-19 1981-09-11 Kuraray Co Ltd Carrier for immobilizing physiologically active substance
US5277915A (en) * 1987-10-30 1994-01-11 Fmc Corporation Gel-in-matrix containing a fractured hydrogel
US5443727A (en) * 1990-10-30 1995-08-22 Minnesota Mining And Manufacturing Company Articles having a polymeric shell and method for preparing same
US5252762A (en) * 1991-04-03 1993-10-12 W. R. Grace & Co.-Conn. Use of base-treated inorganic porous adsorbents for removal of contaminants
US5529609A (en) * 1994-11-07 1996-06-25 Georgia Tech Research Corporation Air cleaner having a three dimensional visco-elastic matrix of material

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8690981B2 (en) 2011-06-15 2014-04-08 Porex Corporation Sintered porous plastic liquid barrier media and applications thereof
US9370731B2 (en) 2011-06-15 2016-06-21 Porex Corporation Sintered porous plastic liquid barrier media and applications thereof

Also Published As

Publication number Publication date
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